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47篇 您的检索式：作者名="Hierlemann"

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	题名	作者	年代	出处	被引量
1	Resorbable polymer fibers for ligament augmentation显示文摘	Durseln L Dauner M Hierlemann H	2001	J Biomed Mater Res2001，58，6：	1
2	CMOSmonolithic Microelectrode Array forthe Monitoring of Electrogenic Cells显示文摘	Heer F Franks W Blau A Taschini S Ziegler C Hierlemann A Baltes B	2004	Biosensor & Bioelectronics2004，20，：	1
3	Multi-analyte biosensor interface for real-time monitoring of 3D microtissue spheroids in hanging-drop networks显示文摘Microfluidics is becoming a technology of growing interest for building microphysiological systems with integrated read-out functionalities.Here we present the integration of enzyme-based multi-analyte biosensors into a multi-tissue culture platform for‘body-on-a-chip’applications.The microfluidic platform is based on the technology of hanging-drop networks,which is designed for the formation,cultivation,and analysis of fluidically interconnected organotypic spherical three-dimensional(3D)microtissues of multiple cell types.The sensor modules were designed as small glass plug-ins featuring four platinum working electrodes,a platinum counter electrode,and an Ag/AgCl reference electrode.They were placed directly into the ceiling substrate from which the hanging drops that host the spheroid cultures are suspended.The electrodes were functionalized with oxidase enzymes to enable continuous monitoring of lactate and glucose through amperometry.The biosensors featured high sensitivities of 322±41 nA mM^(−1) mm^(−2) for glucose and 443±37 nA mM^(−1) mm^(−2) for lactate;the corresponding limits of detection were below 10μM.The proposed technology enabled tissue-size-dependent,real-time detection of lactate secretion from single human colon cancer microtissues cultured in the hanging drops.Furthermore,glucose consumption and lactate secretion were monitored in parallel,and the impact of different culture conditions on the metabolism of cancer microtissues was recorded in real-time.	Patrick M.Misun Jörg Rothe Yannick R.F.Schmid Andreas Hierlemann Olivier Frey	2016	Microsystems & Nanoengineering2016，2，1：	1
4	Microfabrication techniques for ehemieal/biosensors显示文摘	HIERLEMANN A BRAND O HAGLEITNER C H	2003	Proceedings of the IEEE2003，91，6：	1
5	Selective detection of nitrogen and oxygen containing volatile organic compounds: use of metal-modified polysiloxanes as sensor coatings显示文摘	HIERLEMANN A K BODENHOFER M F SCHURIG V	1997	Anal Chim Acta1997，346，3：	1
6	Characterization of magnetically actuated resonant cantilevers in viscous fluids 显示文摘	VANCURA C LICHTENBERG J HIERLEMANN A	2005	Applied Physics Letters2005，87，16：	1
7	Performences of mass-sensitive devices for gas sensing: thinkness shear mode and surface acoustic wave tranducers 显示文摘	Hierlemann A Noetzel G	1996	Analyt Chem1996，68，13：	1
8	CMOS- based chemical microsensors 显示文摘	Hierlemann A Baltes H	2003	Analyst2003，128，：	1
9	Innovative barriers for peritoneal adhesion prevention:liquid or solid? A rat uterine horn model显示文摘	Wallwiener M Brucker S Hierlemann H	2006	Fertil Steril2006，86，4：	1
10	Control of material stiffness during degradation for constructs made of absorbable polymer fibers 显示文摘	Durselen L Dauner M Hierlemann H	2003	J Biomed Mater Res Part B: Appl Biomater2003，67，2：	1
11	Smart single-chip gas sensor microsystem 显示文摘	Hagleitner C Hierlemann A Lange D	2001	Nature2001，，414：	1
12	Smart single-chip gas sen sor microsystem显示文摘	C Hagleitner A Hierlemann D Lange A Kummer N Kemess O Brand H Baltes	2001	Nature2001，，：	1
13	Smart single-chip gas sensor microsystem 显示文摘	Hierlemann A	2001	NATURE2001，414，：	1
14	Smart singlechip gas sensor microsystem显示文摘	Hagleitner C Hierlemann A Iange D		Nature4140，200，：	1
15	Microfabrication tech-niques for chemical/biosensors显示文摘	Hierlemann A Brand O Hagleitner C	2003	Proceeding of the IEEE2003，91，6：	1
16	Complementary metal oxide semiconductor cantilever arrays on a single chip:Mass-sensitive detection of volatile organic compounds 显示文摘	Lange D Hagleitner C Hierlemann A	2002	Anal Chem2002，，74：	1
17	显示文摘	Thomas R C Hierlemann A Staton A W	1999	Analytical Chemistry1999，71，16：	1
18	A new technique for reconstruction of the common bile duct by an au- tologous vein graf! and a biodegradable endoluminal stent 显示文摘	Heistermann HP Stratmann U Hierlemann H	2006	J Invest Surg2006，19，1：	1
19	Higher - order chemical sensing 显示文摘	Hierlemann A Gutierrez - Osuna R	2008	Chemical Reviews2008，108，2：	1
20	Complementary metal oxide semiconductor cantilever array on a single chip:Mass-sensitive detection of volatile organic compounds显示文摘	Lange D Hagleitner C Hierlemann A	2002	Anal Chem2002，74，：	1

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