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65篇 您的检索式:作者名="Hiipakka"
    题名 作者 年代 出处 被引量
1Up-regulation of Bcl-2 is required for the progression of prostate cancer cells from an androgen-dependent to an androgen-independent growth stage显示文摘Bcl-2 是 anti-apoptotic oncoprotein,它的蛋白质层次相反地在许多癌症与预后被相关。然而,在前列腺癌症的前进的 Bcl-2 的角色不是清楚的。这里,我们报导 Bcl-2 从一个雄激素依赖者为 LNCaP 前列腺癌症细胞的前进被要求到一个雄激素无关的生长阶段。Bcl-2 的信使 rna 和蛋白质层次显著地在雄激素无关的前列腺癌症被增加在雄激素无关的前列腺癌症房间的 Bcl-2 的调停 cells.shRNA 的基因 silencing 导致 promotesUV 的 apoptosis 并且压制前列腺肿瘤的生长体内。在在形成的雄激素剥夺条件结果下面的 Growingandrogen 依赖的房间 ofandrogen 独立的殖民地;并且到 androgen-independentgrowth 的从雄激素依赖者的转变被 Bcl-2 对手 Bax 或 Bcl-2 shRNA 的宫外的表示堵住。因此,我们的结果证明 Bcl-2 为 androgen-independentprostate 癌症细胞的幸存是批评的不仅,但是也为前列腺癌症细胞的前进被要求从对一个雄激素无关的生长阶段 anandrogen 依赖。Yuting Lin Junichi Fukuchi Richard A Hiipakka John M Kokontis Jialing Xiang 2007Cell Research2007,17,6:5
2Modulation of endocrine systems and food intake by green tea epigalloeatechin gallate 显示文摘Kao Y H Hiipakka R A IAao S 2000Endocrinology2000,141,98:1
3Structure-activity relationships for inhibition of human 5α-reductases by polyphenols显示文摘Hiipakka R A Zhang H-Z 2002Biochem Pharm2002,63,:1
4Rat and human maspins: structures, metastatic suppressor activity and mutation in prostate cancer cells 显示文摘Umekita Y Hiipakka RA Liao S 1997Cancer Lett1997,113,:1
5Structure-activity relationships for inhibition of human 5alpha-reductases by polyphenols显示文摘Hiipakka R A Zhang H Z Dai W 2002Biochem Pharmacol2002,63,:1
6Rat and human maspins: Structures, metastatic suppressor activity and mutation in prostate cancer cells显示文摘Umekita Y Hiipakka RA Liao S 1997Cancer Lett1997,113,12:1
7Modulation of endocrine systems and food intake by green tea epigallocatechin gallate显示文摘Kao Y H Hiipakka R A Liao S 2000Endocrinology2000,141,3:1
8Modulation of obesity by a green tea eateehin显示文摘Kao Y H Hiipakka R A Liao S 2000Am J Clin Nutr2000,72,5:1
9Antiatherosclerotic effects of a novel synthetic tissue-selective steroidal liver X receptor agonist in low-density lipoprotein receptor deficient mice显示文摘Peng D Hiipakka RA Dai Q 2008J Pharmacol Exp Ther2008,327,2:1
10Green tea: biochemical and biological basis for health benefits显示文摘Liao S Kao Y H Hiipakka R A 2001Vitam Horm2001,62,:1
11Differential anti atherosclerotic effects in the innominate artery and aortic sinus by the liver X receptor agonist T0901317 显示文摘Peng D Hiipakka RA Reardon CA 2009Atherosclerosis2009,203,1:1
12A novel potent synthetic steroidal liver X receptor agonist lowers plasma cholesterol and triglycerides and reduces atherosclerosis in LDLR (--/--) mice 显示文摘Peng D Hiipakka RA Xie JT 2011Br J Pharmaeol2011,162,8:1
13Antiatherosclerotic effects of anovel synthetic tissue-selective steroidal liver X receptor agonist inlow-density lipoprotein receptor-deficient mice显示文摘Peng D Hiipakka RA Dai Q 2008J PharmacolExp Ther2008,327,2:1
14Androgenic suppression of ATP-binding cassette transporter A1 expression in LNCaP human prostate cancer cells 显示文摘Fukuchi J Hiipakka R A Kokontis J M 2004Cancer Res2004,64,21:1
15Antiatherosclemtic effects of a novel syn- thetic tissue-selective steroidal liver X receptor agonist in low-density lipoprotein receptor-deficient mice显示文摘Peng D Hiipakka RA Dai Q 2008J Pharmacol Exp Ther2008,327,2:1
16Rat and human maspins: structures, metastatic suppressor activity and mutation in prostate cancer cells 显示文摘Umekita Y Hiipakka RA Liao S 1997Cancer Lett1997,113,:1
17Modulation of endocrine systems and food intake by green tea epigallocatechin gallate 显示文摘Kao Y H Hiipakka R A Liao S 2000Endocrinology2000,141,3:1
18Modulation of endocrinesystems and food intake by green tea epigallocatechin gallate显示文摘KAO Y H HIIPAKKA R A LIAO S 2000Endocrinology2000,141,3:1
19Antiproliferativeeffect of liver X receptor agonists on LNCaP human prostate cancer cells显示文摘Fukuchi J Kokontis JM Hiipakka RA et at 2004Cancer Res2004,64,21:1
20Modulation of liver X receptor signaling as novel therapy for prostate cancer 显示文摘Chuu CP Kokontis JM Hiipakka RA 2007J Biomed Sci2007,14,5:1
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