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| 1 | Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial显示文摘 | Yung-Jue Bang Eric Van Cutsem Andrea Feyereislova Hyun C Chung Lin Shen Akira Sawaki Florian Lordick Atsushi Ohtsu Yasushi Omuro Taroh Satoh Giuseppe Aprile Evgeny Kulikov Julie Hill Michaela Lehle Josef Rüschoff Yoon-Koo Kang | 2010 | The Lancet2010，，9742： | 20 |
| 2 | 冠状动脉内影像学临床应用专家共识(第一部分):对冠状动脉介入治疗的指导与优化显示文摘欧洲心血管介入协会(EAPCI)专家组系统总结了血管内超声(IVUS)和光学相干断层成像(OCT)这两种血管内影像学检查临床应用指征的现有证据,提供了关于IVUS和OCT指导经皮冠状动脉介入治疗(PCI)的应用价值,并明确了最可能从腔内影像学指导的介入治疗中获得临床收益的患者或病变类型,同时详细论述了PCI前如何使用IVUS或OCT优化支架尺寸(支架长度和直径)和手术策略的选择。此外,专家推荐对支架失败(支架内再狭窄或支架内血栓形成)的患者应常规进行冠状动脉内影像学检查,并首选OCT。最后,重点论述了IVUS和OCT在指导PCI和评估支架失败两个方面的优势和局限性,并对未来需要深入研究的领域进行了展望。 | Lorenz Raber Gary S Mintz Konstantinos C Koskinas Thomas W Johnson Niels R Holm Yoshinubo Onuma Maria D Radu Michael Joner Bo Yu Haibo Jia Nicolas Meneveau Jose M.de la Torre Hemandez Javier Escaned Jonathan Hill Francesco Prati Antonio Colombo Carlo di Mario Evelyn Regar Davide Capodanno William Wijns Robert A Byme Giulio Guagliumi | 2019 | 中华心血管病杂志2019，47，1： | 17 |
| 3 | 溶栓时间(入院到用药时间)的延迟及其对脑卒中治疗时间与预后的影响显示文摘尽管美国心脏协会/美国脑卒中协会关于脑卒中的治疗均提出了倡议,大量急性缺血性脑卒中患者仍然在到达就诊60min后才开始启动组织型纤溶酶原激活剂(阿替普酶)溶栓治疗。该研究旨在描述延迟的原因及其与患者预后之间的关系。 | 刘莉 叶鹏 Kamal N Sheng S Xian Y Matsouaka R Hill MD Bhatt DL Saver JL Reeves MJ Fonarow GC Schwamm LH Smith EE | 2017 | 中华高血压杂志2017，25，4： | 15 |
| 4 | 20~64岁人群的抗抑郁药使用和心血管结局风险:初级医疗数据库的队列研究显示文摘目的探讨抑郁患者不同抗抑郁治疗方案与3种心血管结局(心肌梗死、中风或短暂性脑缺血发作、心律不齐)比率的关系。设计队列研究。场所为 QResearch 初级医疗数据库贡献数据的英国全科诊所。参与者2000-01-01至2011-07-31首次诊断为抑郁症的年龄为20~64岁的238963例患者。干预抗抑郁药(三环类及相关抗抑郁药、选择性5-羟色胺再摄取抑制剂、其他抗抑郁药)、剂量、使用时间、个体化抗抑郁药。主要结局指标5年随访过程中心肌梗死、中风或短暂性脑缺血发作、心律不齐的首次确诊。采用 Cox 比例风险回归模型估计风险比例,调整潜在混杂变量。结果5年随访期间,772例患者发生心肌梗死,1106例患者发生中风或短暂性脑缺血发作,1452例患者发生心律不齐。未发现抗抑郁药与心肌梗死存在显著关联。随访第1年,使用选择性5-羟色胺再摄取抑制剂患者与未使用选择性5-羟色胺再摄取抑制剂患者相比,心肌梗死风险明显下降〔 HR'=0.58,95% CI (0.42,0.79)〕;在个体化抗抑郁药中,氟西汀能够大幅降低心肌梗死风险〔HR'=0.44,95% CI(0.27,0.72)〕,而洛非帕明则会大幅增加心肌梗死风险〔HR'=3.07,95% CI(1.50,6.26)〕。抗抑郁药或个体化抗抑郁药与中风或短暂性脑缺血发作风险无明显关联。5年随访期间,抗抑郁药与心律失常无明显关联,但是在三环类及相关抗抑郁药治疗期间的前28 d 风险大幅上升〔HR'=1.99,95% CI(1.27,3.13)〕。5年随访期间,氟西汀大幅降低心律不齐的风险〔HR'=0.74,95% CI(0.59,0.92)〕,但是,即使采用高剂量,西酞普兰与心律不齐风险仍无明显关联〔 HR'=1.11,95% CI(0.72,1.71),剂量≥40 mg/ d)。结论选择性5-羟色胺再摄取抑制剂不会增加20~64岁抑郁患者的心律不齐或中风或短暂性脑缺血发作风险,而西酞普兰也不会增加心律不齐风险。选择性5-羟色胺再摄取抑制剂可能会降低心肌梗死风险,尤其是氟西汀,而洛非帕明会增加心肌梗死风险。 | Coupland C Hill T Morriss R 本刊编辑部 | 2016 | 中国全科医学2016，19，15： | 7 |
| 5 | Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial显示文摘 | Yung-Jue Bang Eric Van Cutsem Andrea Feyereislova Hyun C Chung Lin Shen Akira Sawaki Florian Lordick Atsushi Ohtsu Yasushi Omuro Taroh Satoh Giuseppe Aprile Evgeny Kulikov Julie Hill Michaela Lehle Josef Rüschoff Yoon-Koo Kang | 2010 | The Lancet . 2010 (9742)2010，，9742： | 6 |
| 6 | Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomised trial显示文摘 | Matthew T Seymour Sarah R Brown Gary Middleton Timothy Maughan Susan Richman Stephen Gwyther Catherine Lowe Jennifer F Seligmann Jonathan Wadsley Nick Maisey Ian Chau Mark Hill Lesley Dawson Stephen Falk Ann O’Callaghan Kim Benstead Philip Chambers Alfred | 2013 | Lancet Oncology2013，，8： | 6 |
| 7 | 儿童型囊性肾瘤在形态学、免疫表型和基因遗传学方面与成人型囊性肾瘤不同显示文摘传统意义上的囊性肾瘤包括两种肿瘤,一种是成人型囊性肾瘤,属于混合性上皮间质肿瘤(MEST)谱系的一部分;另一种是儿童型囊性肾瘤,与DICER1基因突变相关。目前,尚无有关该肿瘤两种病变在形态学、免疫表型和基因遗传学方面详细的对比性分析。 | Li Y Pawel B R Hill D A 魏建国 许春伟 | 2017 | 临床与实验病理学杂志2017，33，5： | 6 |
| 8 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997，，2： | 6 |
| 9 | Amphibian metamorphosis as a model for studying the developmental actions of thyroid hormone显示文摘The thyroid hormones L-thyroxine and triiodo-L-thyronine have profound effects on postembryonic development of most vertebrates. Analysis of their action in mammals is vitiated by the exposure of the developing foetus to a number of maternal factors which do not allow one to specifically define the role of thyroid hormone (TH)or that of other hormones and factors that modulate its action. Amphibian metamorphosis is obligatorily dependent on TH which can initiate all the diverse physiological manifestations of this postembryonic developmental process(morphogenesis, cell death, re-structuring, etc.) in free-living embryos and larvae of most anurans. This article will first describe the salient features of metamorphosis and its control by TH and other hormones. Emphasis will be laid on the key role played by TH receptor (TR), in particular the phenomenon of TR gene autoinduction, in initiating the developmental action of TH. Finally, it will be argued that the findings on the control of amphibian metamorphosis enhance our understanding of the regulation of postembryonic development by TH in other vertebrate species. | TATA JAMSHED R (National Institute for Medical Research, The Ridgeway,Mill Hill, London NW7 1AA, UK.Tel: +44-181-959 3666 Fax: +JJ-181-913 8583E-mail: jtata@nimr. mrc. ac. uk) | 1998 | Cell Research1998，8，4： | 3 |
| 10 | Tumor necrosis factor-alpha neutralization reduces lung injury after experimental allogeneic bone marrow transplantation显示文摘 | Cooke K R Hill G R Gerbitz A | 2000 | Transplantation2000，70，2： | 2 |
| 11 | Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial显示文摘 | Yung-Jue Bang Eric Van Cutsem Andrea Feyereislova Hyun C Chung Lin Shen Akira Sawaki Florian Lordick Atsushi Ohtsu Yasushi Omuro Taroh Satoh Giuseppe Aprile Evgeny Kulikov Julie Hill Michaela Lehle Josef Rüschoff Yoon-Koo Kang | 2010 | The Lancet2010，，9742： | 2 |
| 12 | WONCA研究论文摘要汇编(一百二十七)——全科医疗中腰痛分层治疗(IMPaCT Back)的效果:前瞻性-群组序列对照研究显示文摘目的此研究将明确在全科医疗中腰痛风险-层化治疗对医生的临床行为、患者的治疗效果及成本的作用。方法腰痛分层治疗研究(通过靶向疗法以改善患者的治疗)按照前瞻性-群组序列对照研究方法,将接受全科医疗的患者分为两组,即干预前期组(常规治疗6个月)与干预后期组(层化治疗12个月),此研究有64名全科医生参与并结合了理疗服务,纳入了1 647例患有腰痛的成人。利用风险层化工具将患者按功能障碍分为:低、中、高风险组,并提供风险-匹配治疗。使用罗兰-摩理斯腰背痛生活障碍问卷(Roland-Morris Disability Questionnaire)对治疗6个月患者的功能改善进行初步评估。研究过程将关注医生根据理疗、诊断性检查、用药处方和疾病证明而做出的与风险相应的行为改变。成本效应分析评估了所增加的质量调整寿命年数及腰部-相关医疗的成本。并分析治疗意向。结果 922例患者(干预前期368例,干预后期554例)符合基线标准。在治疗6个月组的随访中,罗兰-摩理斯腰背痛生活障碍问卷(Roland-Morris Disability Questionnaire)分数均差0.7〔95%CI(0.1,1.4)〕,提示与常规治疗相比,层化治疗均差小但获益显著;高危组均差大,为2.3〔95%CI(0.8,3.9)〕,是临床重要差异。而在干预后期组,患者不能工作的平均时间相较于干预前期组要少50%(4 vs 8 days,P=0.03);被给予疾病证明的患者比例也要低30%;医疗成本也有所减少。结论全科医疗中腰痛分层治疗方案的实施,在未增加医疗成本的前提下,显著改善了患者功能障碍的治疗效果,并使其不能工作的时间减半。建议推广应用。 | Foster NE Mullis R Hill JC 周淑新 | 2014 | 中国全科医学2014，17，19： | 2 |
| 13 | Manufacture of large glass honeycomb mirrors显示文摘 | ANGEL J R P HILL J M | 1982 | SPIE1982，332，： | 2 |
| 14 | Streptococcus suis serotypes characterized by analysis of chaperonin 60 gene sequences显示文摘 | Rousseau R Hill J E Prefontaine G | 2001 | Appl Env Microbiol2001，67，： | 2 |
| 15 | SUCCESSFUL WEIGHT LOSS MAINTENANCE显示文摘 | Rena R Wing James O Hill | 2001 | Annual Review of Nutrition2001，，： | 2 |
| 16 | Increasing starter cell lysis in Cheddar cheese using a bacteriocin- producing adjunct显示文摘 | MORGAN S ROSS R P HILL C | 1997 | J Dairy Sci1997，80，： | 2 |
| 17 | Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial显示文摘 | Yung-Jue Bang Eric Van Cutsem Andrea Feyereislova Hyun C Chung Lin Shen Akira Sawaki Florian Lordick Atsushi Ohtsu Yasushi Omuro Taroh Satoh Giuseppe Aprile Evgeny Kulikov Julie Hill Michaela Lehle Josef Rüschoff Yoon-Koo Kang | 2010 | 2010 (9742)2010，，9742： | 2 |
| 18 | Residual stress, stress relief, and inhomogeneity in aluminum plate显示文摘 | Michael B Prime Michael R Hill | 2002 | Scripta Materialia2002，，1： | 2 |
| 19 | 气缸孔粗糙度对机油耗影响的试验研究显示文摘侧重于内燃机机油耗控制中的一个重要因素。以前的研究工作已经通过理论或试验方法建立了气缸孔粗糙度与机油耗之间的关系。在本研究中,利用回归分析和新的瞬态放射性示踪剂机油耗测量法所得到的试验数据用统计学方法推导出了一个数学模型。该模型可预测机油耗随气缸孔粗糙度变化的期望值,并能提出确定和控制最低机油耗的重要气缸孔表面粗糙度参数。 | Hill S H Kantola T C Brown J R 孙书麒 | 1998 | 国外内燃机1998，30，3： | 2 |
| 20 | Cognitive strategies and learning from the world wide Web 显示文摘 | Hill J R Hannafin M J | 1997 | Educational Technology Research and Development1997，45，4： | 1 |
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