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| 1 | Sr-Nd isotopic compositions of the Changjiang sediments: Implications for tracing sediment sources显示文摘The suspended particulate and fine-grained floodplain sediments were collected from the main stream and tributaries of the Changjiang River for Sr-Nd isotopic measurements. The εNd(0) values gradually decrease downstream from -10.8 on average in the upper reaches to -12.3 in the lower reaches, whereas the 87Sr/86Sr ratios increase correspondingly, averaging 0.721899 and 0.725826 respectively in the upper and middle-lower reaches. The compositional variations primarily reflect the complex con- trols of provenance rocks, chemical weathering, and sediment characters between different catchments, among which the abnormal Sr-Nd isotopic compositions of the Yalong, Fujiang, Tuojiang and Yuanjiang rivers indicate the sediment provenance contributions from the Emeishan Basalt in the upper reaches and the old metamorphic and siliceous rocks in the middle-lower reaches. The Sr-Nd isotopic ratios of the Changjiang sediments can better reflect the average composition of weathered continental crust compared to other major rivers in the world because of the unique source rock types in the Changjiang drainage basin. The recognition of the Sr-Nd isotopic systematics of the Changjiang sediments will contribute to our understanding of the Changjiang evolution history and continental weathering processes during the Cenozoic, and also to reconstructing the paleoenvironmental changes in East China and the marginal seas. | YANG ShouYe1?, JIANG ShaoYong2, LING HongFei2, XIA XiaoPing3, SUN Min3 & WANG DeJie4 1 State Key Laboratory of Marine Geology, Tongji University, Shanghai 200092, China 2 State Key Laboratory for Mineral Deposit Research, Nanjing University, Nanjing 210093, China 3 Departmen of Earth Sciences, The University of Hong Kong, Hong Kong SAR, China 4 Development Research Center, China Geological Survey, Beijing 100083, China | 2007 | Science China Earth Sciences2007，50，10： | 32 |
| 2 | APC and K-ras gene mutation in aberrant crypt foci of human colon显示文摘AIM To study the genetic alteration in ACF andto define the possibility that ACF may be a veryearly morphological lesion with molecularchanges, and to explore the relationshipbetween ACF and colorectal adenoma evencarcinoma.METHODS DNA from 35 CRC, 15 adenomas, 34ACF and 10 normal mucus was isolated by meansof microdissection. Direct gene sequencing of K-ras gene including codon 12, 13 and 61 as well asthe mutation cluster region (MCR) of APC genewas performed.RESULTS K-ras gene mutation frequency inACF, adenoma and carcinoma was 17.6% (6/34), 13.3% (2/ 15), and 14.3% (5/ 35)respectively, showing no difference ( P > 0.05)in K-fas gene mutation among three pathologicprocedures. The K-ras gene mutation inadenoma, carcinoma and 4 ACF restricted incodon 12 (GGT→GAT), but the other 2 mutationsfrom ACF located in codon 13 (GGC→GAC). K-res gene mutation was found more frequently inolder patients and patients with polypoidcancer. No mutation in codon 61 was found in thethree tissue types. Mutation rate of APO gene inadenoma and carcinoma was 22.9% (8/35) and26.7% (4/ 15), which was higher than ACF(2.9%) (P < 0.05). APC gene mutation incarcinoma was not correlated with age ofpatients, location, size and differentiation oftumor.CONCLUSION ACF might be a very earlymorphological lesion in the tumorogenesis ofcolorectal tumor. The morphological feature andgene mutation status was different in ACF andadenoma. ACF is possibly putative'microadenoma' that might be the precursor ofadenoma. In addition, the development of asubgroup of colorectal carcinomas mightundergo a way of 'normal epithelium→ ACF→carcinomas'. | Ping Yuan~1 Meng Hong Sun~2 Jin Sheng Zhang~1 Xiong Zeng Zhu~2 Da Ren Shi~2 ~1Department of Pathology,Medical College of Fudan University,~2Department of Pathology,Cancer Hospital/Cancer Institute,Fudan University,Shanghai 200032,ChinaDr.Ping Yuan Studying Province.studying in Medical College of Fudan University,worked in Department of Pathology,Wannan Medical College,having eighteen papers published. | 2001 | World Journal of Gastroenterology2001，7，3： | 20 |
| 3 | Comparative analysis of astaxanthin and its esters in the mutant E1 of Haematococcus pluvialis and other green algae by HPLC with a C30 column显示文摘A gradient reversed-phase high-performance liquid chromatography (HPLC) method using a C30 col-umn was developed for the simultaneous determination of astaxanthin, astaxanthin monoesters and astaxanthin diesters in the green algae Chlorococcum sp., Chlorella zofingiensis, Haematococcus plu-vialis and the mutant E1, which was obtained from the mutagenesis of H. pluvialis by exposure to UV-irradiation and ethyl methanesulphonate (EMS) with subsequent screening using nicotine. The re-sults showed that the contents of total astaxanthins including free astaxanthin and astaxanthin esters ranged from 1.4 to 30.9 mg/g dry biomass in these green algae. The lower total astaxanthin levels (< 2 mg/g dry biomass) were detected in the green algae Chlorococcum sp. and C. zofingiensis. The higher total astaxanthin levels (>16 mg/g dry biomass) were found in the green alga H. pluvialis and its mutant E1. It is notable that the mutant E1 is found to have considerably higher amounts of total astaxanthin (30.9 mg/g) as compared to the wild strain of H. pluvialis (16.1 mg/g). This indicates that UV-irradiation and EMS compound mutagenesis with subsequent screening using nicotine is an effective method for breeding of a high-producing astaxanthin strain of H. pluvialis. In addition, the green alga C. zofingien-sis had a remarkably higher percentage of astaxanthin diesters (76.3% of total astaxanthins) and a re-markably lower percentage of astaxanthin monoesters (18.0% of total astaxanthins) in comparison with H. pluvialis (35.5% for diesters and 60.9% for monoesters), the mutant E1 (49.1% and 48.1%) and Chlorococcum sp. (18.0% and 58.6%). | PENG Juan1, XIANG WenZhou2,1, TANG QuanMing1, SUN Ni1, CHEN Feng1,3 & YUAN JianPing 4 1 South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China 2 Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China 3 School of Biological Sciences, The University of Hong Kong, Hong Kong, China 4 Institute of Oceanology & College of Life Sciences, Sun Yat-Sen University, Guangzhou 510301, China | 2008 | Science China(Life Sciences)2008，51，12： | 12 |
| 4 | Restudies on Body Surface of Dung Beetle and Application of Its Bionics Flexible Technique显示文摘A scanning electron microscope was used to observe the structures of the setae on the surface of a dung beetle Copris ochus, Motschulsky. There are lots of setae on the body surface, especially on the ventral part surface and lateral to the legs which are different in size, arrangement and shape. These setae have different lengths and many thorns on the whole seta. The top ends of these setae stand up without furcations which direct uprightly towards the surface of the touched soil. By the method of removing these setae, getting the insect weight before and after digging into the dung we affirm farther that the setae on the beetle body surface form the anti-stick and non-adherent gentle interface. The soil machines and components made by imitating the gentle body surface of beetles have favorable non-adherent results. | Jiurong Sun 1, Jianqiao Li 2, Hong Cheng 1, Zhendong Dai 3, Luquan Ren 2 1.College of Life Sciences, Peking University, Beijing, 100871,P.R. China 2.Key Laboratory of Terrain-Machine Bionics Engineering (Ministry of Education,China), Jilin University at Nanling Campus, Changchun, 130022,P.R.China 3.College of Mechanical and Electrical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, 210016,P.R.China | 2004 | Journal of Bionic Engineering2004，1，1： | 12 |
| 5 | Determination of ocean tide loading displacements in Hong Kong using GPS technique显示文摘Ocean tide loading (OTL) displacements of eight principal constituents at 12 sites in Hong Kong were determined using more than eight years of continuous GPS observations. Parameters of the OTL displacements were estimated using daily GPS solutions obtained with precise point positioning (PPP) technique. The results were compared with predictions from seven latest global ocean tide models. Gravity measurements of OTL in Hong Kong were also used to validate the GPS results. The study shows that the results from both the GPS and gravity measurements agree best with the GOT4.7 and NAO99b models, when the K1 and K2 constituents are excluded. The agreements between the GPS and the model estimates are generally at sub-millimeter level in both the horizontal and vertical directions, except for S2, K2 and K1 constituents that have relatively larger errors. After removing the systematic biases between the GPS and the model estimates, the misfits of M2, S2, N2, O1, P1 and Q1 at all sites are within 0.5 and 1.0 mm in the horizontal and the vertical directions, respectively, whereas K1 and K2 show relatively larger misfits of up to 2.3 mm. Both the GPS and the gravity S2 estimates have large biases with unknown reasons when compared with the modeled values, which needs to be further investigated. The study demonstrates that GPS is capable of estimating the OTL displacements with the same accuracy as the model predictions, especially for coastal areas. | YUAN LinGuo1,3, DING XiaoLi1, SUN HePing2, ZHONG Ping1,3 & CHEN Wu1 1 Department of Land Surveying and Geo-Informatics, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China 2 Key Laboratory of Dynamic Geodesy, Institute of Geodesy and Geophysics, Chinese Academy of Sciences, Wuhan 430077, China 3 Department of Surveying Engineering, School of Civil Engineering, Southwest Jiaotong University, Chengdu 610031, China | 2010 | Science China Earth Sciences2010，53，7： | 10 |
| 6 | Synthesis of Nanoscale Shell-core Titania Coated Silica Particles in the Presence of Polyether Polyamine and the Phase Transition显示文摘The nanoscale titania coated silica was prepared via a two-step precipitating approach, where the nanoscale silica nuclei were first prepared by passing an aqueous solution of sodium silicate through an ion-exchange resin bed, then coated with the precipitation from hydrolyzed butyl titanate in an ethanol-hexane mixture at a low pH value in the presence of poly(ethylene oxide) polyamine salt(PPA) at a high temperature of 90 ℃. In the second-step precipitating process, the spontaneously precipitated titania shell on the silica nuclei was stabilized in the suspension solution with the help of the adsorption of PPA on the particles. A possible precipitating mechanism was suggested. Furthermore, the amorphous titania shell could undergo crystallization from the amorphous to the anatase structure at a high temperature of 650 ℃, and a further phase transition from the anatase to the rutile structure in the different sintering processes at a rising temperature of 750 ℃. | HUA Feng-jun 1, SUN Jun 2, HONG Ke 2, GAO Lian 1 and YANG Yu-liang 1** 1. Key Laboratory of Molecular Engineering of Polymer, Fudan University, Shanghai 200433, P. R. China 2. State Key Laboratory of High Performance Ceramics and Superfine Micros | 2002 | Chemical Research in Chinese Universities2002，18，1： | 6 |
| 7 | Metallomics:An integrated biometal science显示文摘Metallomics is an emerging scientific area integrating the research fields related to the understanding of the molecular mechanisms of metal-associated life processes and the entirety of metal and metalloid species within a cell or tissue type. In metallomics,metalloproteins,metalloenzymes and other metal-containing biomolecules in a biological system are referred to as metallomes,similar to genomes and proteomes in genomics and proteomics,respectively. This review discusses the concept of metallomics with a focus on analytical techniques and methods,particularly the so-called hyphenated techniques which combine a high-resolution separation technique (gel electrophoresis/laser ablation,chromatography or capillary electrophoresis) with a highly sensitive detection method such as elemental (inductively coupled plasma,ICP) or molecular (electron spray ionization (ESI) or matrix-assisted laser desorption/ionization (MALDI)) mass spectrometry,or nuclear X-ray fluorescence/absorption spectrometry. The applications of these advanced analytical methods in the identification of metallo-/phospho-/seleno-proteins,probing of relationships between structure and function of metal-loproteins,and study of clinically used metallodrugs will be selectively outlined,along with their advantages and limitations. | GE RuiGuang1,2 & SUN HongZhe1 1 Department of Chemistry and Open Laboratory of Chemical Biology,The University of Hong Kong,Hong Kong,China 2 Laboratory of Integrative Biology,College of Life Sciences,Sun Yat-Sen University,Guangzhou 510006,China | 2009 | Science China Chemistry2009，52，12： | 5 |
| 8 | Microwave-Assisted Solid Phase Organic Synthesis. Application to Indole Library Construction显示文摘 | DAI Wei-Min*1,2, SUN Li-Ping2, GUO Dian-Shun2, HUANG Xiang-Hong2 1.Department of Chemistry, Zhejiang University, Hangzhou 310027, China 2.Combinatorial Chemistry Laboratory, The Biotechnology Research Institute and Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China | 2004 | 合成化学2004，12，z1： | 3 |
| 9 | Oxygen Atom Exchange Mechanism in Reaction of OH Radical with AsO显示文摘Oxygen atom exchange reaction mechanism in the reaction of OH radicals with AsO was investigated by means of the density functional theory (DFT) with 6 311++G( 3df,3pd ) and 6 311++G( d,p ) basis sets. The calculated results suggest that the reaction between OH and AsO should make the oxygen atoms exchange rapidly because the barrier to isomerization is significantly less than the HO-AsO bond dissociation energy. | CHI Yu-juan 1, YU Hai tao 1,2** , FU Hong gang 1,2 HUANG Xu ri 2, LI Ze sheng 2 and SUN Chia chung 21. College of Chemistry and Chemical Engineering, Heilongjiang University, Harbin 150080, P. R. China 2. State Key Laboratory of T | 2002 | Chemical Research in Chinese Universities2002，18，3： | 3 |
| 10 | Stimulus responsive fluorescent hyperbranched polymers and their applications显示文摘Fluorescent hyperbranched polymers (FHBPs),which combine the versatile fluorescent property with unique characteristics of hyperbranched architecture,are desirable candidates for stimulus responsive materials.This review demonstrates the structure and environment-dependent emission behaviors of a series of FHBPs.AEE active FHBPs showing opposite performance to ACQ effect are used to sensitively detect explosives and a superamplification effect is found.Specially designed FHBPs can complex with metal ions,leading to fluorescence turn-off due to complex quenching effect.The protonation of amino-containing FHBPs exhibits pH-dependent fluorescence responses to solution acidity.Some FHBPs containing responsive moieties are photo-and thermo-sensitive,and show potential applications as smart materials. | WANG Jian 1,MEI Ju 1,QIN AnJun 1,SUN JingZhi 1 & TANG Ben Zhong 1,2 1 MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering,Institute of Biomedical Macromolecules,Zhejiang University,Hangzhou 310027,China 2 Department of Chemistry,The Hong Kong University of Science & Technology,Hong Kong,China | 2010 | Science China Chemistry2010，53，12： | 3 |
| 11 | A prototype RF power source for CSNS/RCS显示文摘A prototype RF power source has been built to supply high RF power to a ferrite-loaded cavity, which is a part of R&D of the Rapid Cycling Synchrotron of China Spallation Neutron Source (CSNS/RCS). A direct fast RF feedback amplifier, a 4:1 impedance transformer and auto tuning grid were locally located to compensate the heavy beam loading of CSNS/RCS. Design and commissioning of the RF power source is discussed here, also with some advice on system improvement. | WeiLing Huang (1) Hong Sun (1) HaiQi Zhao (2) Yu Liu (2) YanDong Li (2) ZhiGuang Qiao (2) Xiao Li (1) ChunLin Zhang (1) | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，S2： | 3 |
| 12 | MECHANICAL MODELING OF THE BISTABLE BACTERIAL FLAGELLAR FILAMENT显示文摘We extend the 2D Landau phase transition theory to the bacterial flagellar filament which displays the phase transition between the left handed normal form and the right handed semi-coiled form. The bacterial flagellar filament is treated as an elastic thin rod based on the Kirchhoff's thin rod theory. Mechanical analysis is performed on the periodical phase transition of the filament between the two helical structures of the opposite charity. The curvature and twist are chosen as the order parameters in constructing the phase transition model of the filament. The established model is applied to study the instability properties of the filament and to investigate the loading and deformation conditions of the phase transition. In addition, the curvature and twist gradient energy are considered to describe the interface properties of the two phases. | Xiaoling Wang 1 Qingping Sun 2 1 ( 1 School of Mechanical Engineering, University of Science & Technology Beijing, Beijing 100083, China) ( 2 Department of Mechanical Engineering, The Hong Kong University of Science & Technology, Clear Water Bay, Kowloon, Hong Kong, China) | 2011 | Acta Mechanica Solida Sinica2011，24，S1： | 1 |
| 13 | Combined perturbation bounds:Ⅱ.Polar decompositions显示文摘In this paper,we study the perturbation bounds for the polar decomposition A=QH where Q is unitary and H is Hermitian.The optimal (asymptotic) bounds obtained in previous works for the unitary factor,the Hermitian factor and singular values of A areσr2||ΔQ||F2≤||ΔA||F2, 1/2||ΔH||F2≤||ΔA||F2 and ||Δ∑||F2≤||ΔA||F2,respectively,where∑=diag(σ1,σ2,...,σr,0,...,0) is the singular value matrix of A andσr denotes the smallest nonzero singular value.Here we present some new combined (asymptotic) perturbation boundsσr2||ΔQ||F2+1/2||ΔH||F2≤||ΔA||F2 andσr2||ΔQ||F2+||Δ∑||F2≤||ΔA||F2 which are optimal for each factor.Some corresponding absolute perturbation bounds are also given. | Wen LI~(1+) Wei-wei SUN~2 1 School of Mathematical Sciences,South China Normal University,Guangzhou 510631,China 2 Department of Mathematics,City University of Hong Kong,Hong Kong,China | 2007 | Science China Mathematics2007，50，9： | 1 |
| 14 | Research on Hot Gunning Repairing in Laboratory显示文摘The lining of blast furnace may be damaged partly,so that gunning repair is needed. The bonding strength of boundary surface between the repairing layer and remained lining of blast furnace has been studied by thermal simulation.The factors influencing the bonding strength are the ingredient gunning repair temperature,remained lining condition and water content of gunning refractory.The bonding strength decreases with the increases of remained lining temperature. | CAO Feng, LONG Shigang, MENG Qingmin, SUN Jialin and HONG Yanruo(1 Institute of Metallurgy and Materials, Anhui University of Technology, Ma’ anshan, China) (2 Institute of Metallurgy, University of Science and Technology Beijing, Beijing 100083, China) | 2003 | China's Refractories2003，12，1： | 1 |
| 15 | Response of Spring Phenology of Main Gymnosperm to Climate Change in Harbin City Proper显示文摘Global climate change has caused phenology change of vegetation.This is especially obvious in urban area.This paper reveals response mechanism of spring phenology of main gymnosperm in Harbin City proper to climate change based on relationship study between two typical phenophases(beginning of bud burst and beginning of leaf expansion) of Korean pine(Pinus koraiensis),Koyama spruce(Picea koraiensis Nakai),needle fir(Abies nephrolepis) and Pinus sylvestnis var.mongolica Litv.and the temperature of every ten days in winter and spring through the phenology observation in Harbin proper from 1963 to 2008 and meteorological observation data from 1951 to 2008.Study conclusion shows the advancing trend of the beginning date of accumulated temperature that meets plant germination in Harbin City.The beginning of bud burst of P.koraiensis is mainly subject to temperature in middle and late February and the beginning pf leaf expansion is subject to temperature in middle and late March.The beginning of bud burst of P.koraiensis Nakai is mainly subject to temperature from late January to middle of February and leaf expansion is subject to temperature mainly in March and April.The beginning of bud burst of A.nephrolepis is mainly subject to temperature from January to March and leaf expansion time is subject to temperature in May.The beginning of bud burst of P.sylvestnis var.mongolica Litv.is mainly subject to the middle of March and the middle of April.The spring phenology of all these 4 selected species showed tremendous advancement.However the advancing trend of different species is varied.The impact level of temperature in each phase to spring phenology of different species is different.The spring phenology of all 4 selected species is prominently relevant to the temperature in earlier period before occurrence of phenology.Low temperature is a favor for breaking dormancy of plants.Suitable lower temperature is good for advancing spring phenology of plants.Temperature in Harbin is relatively lower in winter.Increase of temperature in winter is propitious to advancing of spring phenology of plants. | PEI Shunxiang 1,3 LI Changhai2 GUO Quanshui3 XIN Xuebing1 SUN Jianxin4 HONG Ming3 1.Experimental Centre of Forestry in North China,Chinese Academy of Forestry,Beijing 102300,R.P.China 2.Forest Botanical Garden,Hei Longjiang Province,Harbin 150040,R.P.China 3.Research Institute of Forest Ecology,Chinese Academy of Forestry,Beijing 100091,R.P.China 4.Beijing Forestry University,Beijing 100083,R.P.China | 2010 | Chinese Forestry Science and Technology2010，9，3： | 0 |
| 16 | ^(207)Pb/^(206)Pb determination of zircons by laser probe-inductively coupled plasma mass spectrometry显示文摘Laser probe_inductively coupled plasma mass spectrometry (LP_ICP_MS) was used to determine 207 Pb/ 206 Pb ratios in single zircon grains. A Nd∶YAG laser operating at 1 064 nm and a Fisons_VG PQII Turbo ICP_MS were employed. For the known zircons, the 207 Pb/ 206 Pb results of LP_ICP_MS are close to the thermal ionization mass spectrometry (TIMS) results. The spatial resolution of this method is 40-50 μm and the sensitivities for lead isotopes are about 300-400 cps/ppm. The precision of 207 Pb/ 206 Pb ratio is 0.3%-4% and depends on the lead concentration of the sampling pits. LP_ICP_MS provides a simple, rapid and economic method for zircon 207 Pb/ 206 Pb determination. | YAN Xin\+1, CHU Zhuyin\+1, SUN Min\+2, XU Ping\+1 and ZHOU Xinhua\+11. Institute of Geology, Chinese Academy of Sciences, Beijing 100029, China 2. Department of Geosciences, Hong Kong University, Hong Kong, China | 1998 | Chinese Science Bulletin1998，43，23： | 0 |
| 17 | Simulation of bacterial flagellar phase transition by non-convex and non-local continuum modeling显示文摘Bacterial flagellar filament can undergo a stress-induced polymorphic phase transition in both vitro and vivo environments.The filament has 12 different helical forms(phases) characterized by different pitch lengths and helix radii.When subjected to the frictional force of flowing fluid,the filament changes between a left-handed normal phase and a right-handed semi-coiled phase via phase nucleation and growth.This paper develops non-local finite element method(FEM) to simulate the phase transition under a displacement-controlled loading condition(controlled helix-twist).The FEM formulation is based on the Ginzburg-Landau theory using a one-dimensional non-convex and non-local continuum model.To describe the processes of the phase nucleation and growth,viscosity-type kinetics is also used.The non-local FEM simulation captures the main features of the phase transition:two-phase coexistence with an interface of finite thickness,phase nucleation and phase growth with interface propagation.The non-local FEM model provides a tool to study the effects of the interfacial energy/thickness and loading conditions on the phase transition. | Xiaoling Wang,1,a) Yongjun He,2,b) and Qingping Sun 3,c) 1) School of Mechanical Engineering,University of Science and Technology Beijing,Beijing 100083,China 2) UME-MS,ENSTA-ParisTech,Chemin de la Huni`ere,91761 Palaiseau Cedex,France 3) Department of Mechanical Engineering,The Hong Kong University of Science and Technology,Clear Water Bay,Kowloon,Hong Kong,China | 2011 | Theoretical & Applied Mechanics Letters2011，1，4： | 0 |
| 18 | Expression of connexin 43 and E-cadherin in choroidal melanoma显示文摘·AIM:To investigate the expression of connexin 43 and epithelial cadherin (E-cadherin) in choroidal melanoma,to explore the clinical and pathological implications of expression of these proteins,and to determine their relations with malignant features.·METHODS:The expression of connexin 43 and E-cadherin in choroidal melanoma were detected by immunohist-ochemistry and correlated with clinicopathological features.·RESULTS:Positive rates of connexin 43 in choroidal melanomas and benign pigmented nevus tissues were 75% and 40% respectively with significant differences between the two groups (χ2=5.607,P =0.009).Positive rates of E-cadherin in choroidal melanomas and benign pigmented nevus tissues were 40￡$ and 75% respectively with significant differences between the two groups (χ2=5.214,P=0.010).Significant overexpression of connexin 43 and reduction of E-cadherin expression was associated with the invasion to the sclera,and there were respectively significant differences between without and with scleral invasion groups (χ2=2.880,P=0.040;χ2=2.778,P =0.046).Overexpression of connexin 43 were correlated with tumor cell types and the expression of connexin 43 and E-cadherin may be correlated with each other.·CONCLUSION:The increased expression of connexin 43 and the decreased expression of E-cadherin may be involved in the process of invasion of choroidal melanoma.The overepression of connexin 43 and reduction of E-cadherin may contribute to the development of choroidal melanoma.· | Ying-Ying Mou, and Wei-Rong Sun | 2011 | International Journal of Ophthalmology(English edition)2011，4，2： | 0 |
| 19 | The Study on Produce and Properties ofF-Heparin Surface Modified IOLs显示文摘Objective:To study the biocompatibility of F heparin surface modified IOLs (F HSM IOLs) and provide theoretical and experimental basis for clinical use and new IOL development. Methods The technique of carrier energy ion beam combined with low temperature and low pressure plasma was used to modify the surface of PMMA IOLs. The physicochemical and optical properties of F HSM IOLs were examined. In vitro, the cultured cells adherence and growth on IOLs were studied. In vivo, F HSM IOLs were implanted into rabbits and Rhesus Monkeys eyes. The biocompatibility of F HSM IOLs, PMMA IOLs and HSM IOLs was compared. Results There were fewer adhered cells on the surface of F HSM IOLs with no toxicity to the cultured fibroblasts. F HSM IOLs caused less inflammatory reaction, broke BAB more slightly and decreased posterior capsular opacity. F HSM IOLs possessed better biocompatiblity. Our research also suggested that the brownish F HSM IOLs could prevent the short wave length light and ultraviolet rays from injuring the retina. Conclusion F HSM IOLs possessed better biocompatibility than conventional PMMA IOLs and can be used in clinical works after further inspection and approval. | GU Han qing 1,YUAN Jia qin 2,SUN Hui min 2,ZHANG Hai wen 1,LU Mo gu 1,WANG Gui qin 3,GUO Hong yu 3,XU Yan shan 2This work is funded in part by the National 10th Five Year Plan on Capture Key of Science and Technolog (2001 BA706B17) 1 Tianjin Institute of Urological Surgery,Tianjin 300211,China,2 Tianjin Medical University Eye Center,Tianjin 300070,China 3 Tianjin Medical University,Tiangjin 300070,China | 2003 | Chinese Journal of Biomedical Engineering(English Edition)2003，12，1： | 0 |
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