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| 1 | Reactive capillary hemangiomas: a novel dermatologic toxicity following anti-PD-1 treatment with SHR-1210显示文摘Objective: SHR-1210 is a new and promising anti-PD-1 agent for solid tumors. During the phase I study of SHR-1210, we encountered a novel but prevalent immune-related dermatologic toxicity: reactive capillary hemangiomas(RCHs). Thus we tried to summarize the features of RCHs and estimate their relationship with tumor response.Methods: This prospective observational study systematically enrolled 98 patients with advanced solid tumors from April 27th,2016 to June 8th, 2017 in the context of the phase I clinical study of SHR-1210. This report focused on the skin toxicities. Patients underwent entire skin inspection every two weeks while taking medication. The clinical course of RCHs was recorded and their association with tumor response was estimated. The data cut-off date was November 15th, 2017.Results: After a median follow-up of 242(range, 29–567) days, RCHs were observed in 85.7%(84/98) of patients on cutaneous/mucosal surfaces; 84.5%(71/84) of the RCHs were evaluated as grade 1 adverse events. No grade 3 or 4 RCHs were observed. The time of onset of RCHs was dose dependent and shortest in the 400 mg-dose cohort(P < 0.001). Spontaneous and complete regression of RCHs was observed both during and after treatment. The objective response rate of tumors for patients with RCHs was 28.9%(24/83). However, no responders were observed among the patients without RCHs.Conclusions: RCHs were prevalent but manageable during treatment with SHR-1210. It might add to the expanding literature regarding immune-related dermatologic adverse events. | Xuelian Chen Lanying Ma Xi Wang Hongnan Mo Dawei Wu Bo Lan Dong Qu Hongtu Zhang Jing Huang Binghe Xu | 2019 | Cancer Biology & Medicine2019，16，1： | 53 |
| 2 | High-voltage transmission tower-line system subjected to disaster loads显示文摘高电压的力量传播系统是重要救生索结构。它为关于受到地震和环境负担的系统的特征和能力的宽研究是重要的。系统的有希望的繁荣在全世界被表明了。关于 lading 行动,分析方法,试验性的研究大小,结构的颤动控制,疲劳损坏,一生预言,和设计方法的机制的系统的相应进展包括地此处被讨论。最后,在不久的将来进一步在高电压的传播塔线系统的动态反应特征上研究工作被预言。 | LI Hongnan BAI Haifeng | 2006 | Progress in Natural Science:Materials International2006，16，9： | 19 |
| 3 | Aflatoxin B1, zearalenone and deoxynivalenol in feed ingredients and complete feed from different Province in China显示文摘Background: The current study was carried out to provide a reference for monitory of aflatoxin B_1(AFB_1),zearalenone(ZEN) and deoxynivalenol(DON) contamination in feed ingredients and complete feeds were collected from different Province in China from 2013 to 2015.Methods: A total of 443 feed ingredients, including 220 corn, 24 wheat, 24 domestic distillers dried grains with soluble(DDGS), 55 bran, 20 wheat shorts and red dog, 37 imported DDGS, 34 corn germ meal and 29 soybean meal as well as 127 complete feeds including 25 pig complete feed(powder), 90 pig complete feed(pellet), six duck complete feed and six cattle complete feed were randomly collected from different Province in China,respectively, by high-performance chromatography in combined with UV or fluorescence analysis.Results: The incidence rates of AFB_1, ZEN and DON contamination of feed ingredients and complete feeds were80.8, 92.3 and 93.9 %, respectively. The percentage of positive samples for DON ranged from 66.7 to 100 %.Domestic DDGS and imported DDGS presented the most serious contamination AFB_1, ZEN and DON contamination levels of feeds ranged from 61.5 to 100 %, indicated that serious contamination over the studied 3-year period.Conclusion: The current data provide clear evidence that AFB_1, ZEN and DON contamination of feed ingredients and complete feeds in different Province in China is serious and differs over past 3-year. The use of corn, domestic DDGS, imported DDGS and corn germ meal, which may be contaminated with these three mycotoxins, as animal feed may triggered a health risk for animal. Feeds are most contaminated with DON followed by ZEN and AFB_1.Mycotoxins contamination in feed ingredients and complete feeds should be monitored routinely in China. | Li Wu Jianjun Li Yunhu Li Tiejun Li Qinghua He Yulong Tang Hongnan Liu Yongteng Su Yulong Yin Peng Liao | 2017 | Journal of Animal Science and Biotechnology2017，8，2： | 13 |
| 4 | Application of fiber Bragg grating based strain sensor in pipeline vortex-induced vibration measurement显示文摘The vortex-induced vibrations(VIV)is an important topic of study in many different scientific and engineering fields.While VIV can be of benefit in some cases,oftentimes,it is an undesirable phenomenon that can be quite dangerous.In particular for offshore pipelines,VIV can lead to fatiguing of the pipe structure and can cause disastrous consequences if left unchecked.A number of different methods have been applied to the measurement of VIV,especially for the elongated,thin cylindrical structures.The use of fiber optic fiber Bragg gratings(FBGs)in particular has gained popularity over the recent years due to their distinct properties.However,FBGs are also very fragile and are susceptible to failure when placed in harsh environments without protection.In this paper,56 FBGs encapsulated in stainless steel tubes were applied to the measurement of VIV in a28-m model pipeline under controlled and uncontrolled conditions.Tests show that the encapsulated sensors possessed good sensitivity as well as fatigue life(>80000 cycles).The measurements from FBGs were also high enough to allow frequency domain analysis of the pipeline VIV under the two conditions.The authors conclude that the encapsulated FBGs are a viable tool for the study of VIV in pipeline structures. | REN Liang JIA ZiGuang HO Michael Siu Chun YI TingHua LI HongNan | 2014 | Science China(Technological Sciences)2014，57，9： | 9 |
| 5 | Rapid repair techniques for severely earthquake-damaged circular bridge piers with flexural failure mode显示文摘In this study, three rapid repair techniques are proposed to retrofit circular bridge piers that are severely damaged by the flexural failure mode in major earthquakes. The quasi-static tests on three 1:2.5 scaled circular pier specimens are conducted to evaluate the efficiency of the proposed repair techniques. For the purpose of rapid repair, the repair procedure for all the specimens is conducted within four days, and the behavior of the repaired specimens is evaluated and compared with the original ones. A finite element model is developed to predict the cyclic behavior of the repaired specimens and the numerical results are compared with the test data. It is found that all the repaired specimens exhibit similar or larger lateral strength and deformation capacity than the original ones. The initial lateral stiffness of all the repaired specimens is lower than that of the original ones, while they show a higher lateral stiffness at the later stage of the test. No noticeable difference is observed for the energy dissipation capacity between the original and repaired pier specimens. It is suggested that the repair technique using the early-strength concrete jacket confined by carbon fiber reinforced polymer(CFRP) sheets can be an optimal method for the rapid repair of severely earthquake-damaged circular bridge piers with flexural failure mode. | Sun Zhiguo Li Hongnan Bi Kaiming Si Bingjun Wang Dongsheng | 2017 | Earthquake Engineering and Engineering Vibration2017，16，2： | 8 |
| 6 | Evaluation of earthquake-induced structural damages by wavelet transform显示文摘The dynamic behavior of inelastic structures during an earthquake is a complicated non-stationary process that is affected by the ran- dom characteristics of seismic ground motions. The conventional Fourier analysis describes the feature of a dynamic process by decom- posing the signal into infinitely long sine and cosine series, which loses all time-located information. However, both time and frequency localizations are necessary for the analysis of an evolutionary spectrum of non-stationary processes. In this paper, an analytical approach for seismic ground motions is developed by applying the wavelet transform, which focuses on the energy input to the structure. The procedure of identification of the instantaneous modal parameters based on the continuous wavelet transform (CWT) is given in detail. And then, a novel method using the auto-regressive moving average (ARMA), called ''prediction extension', is presented to remedy the edge effect during the numerical computation of the CWT. The effectiveness of the method is verified by the use of the benchmark model developed by the American Society of Civil Engineers (ASCE). Finally, a scale model with three-storey reinforced concrete frame-share wall structure is made and tested on a shaking table to investigate the relation between the dynamic properties of structures and energy accumulation and its change rates during the earthquake. The results have shown that the wavelet transform is able to provide a deep insight into the identity of transient signals through time-frequency maps of the time variant spectral decomposition. | Hongnan Li Tinghua Yi Ming Gu Linsheng Huo | 2009 | Progress in Natural Science:Materials International2009，19，4： | 7 |
| 7 | Simulation of multi-support depth-varying earthquake ground motions within heterogeneous onshore and offshore sites显示文摘This paper presents a novel approach to model and simulate the multi-support depth-varying seismic motions(MDSMs) within heterogeneous offshore and onshore sites.Based on 1 D wave propagation theory,the three-dimensional ground motion transfer functions on the surface or within an offshore or onshore site are derived by considering the effects of seawater and porous soils on the propagation of seismic P waves.Moreover,the depth-varying and spatial variation properties of seismic ground motions are considered in the ground motion simulation.Using the obtained transfer functions at any locations within a site,the offshore or onshore depth-varying seismic motions are stochastically simulated based on the spectral representation method(SRM).The traditional approaches for simulating spatially varying ground motions are improved and extended to generate MDSMs within multiple offshore and onshore sites.The simulation results show that the PSD functions and coherency losses of the generated MDSMs are compatible with respective target values,which fully validates the effectiveness of the proposed simulation method.The synthesized MDSMs can provide strong support for the precise seismic response prediction and performance-based design of both offshore and onshore large-span engineering structures. | Li Chao Li Hongnan Hao Hong Bi Kaiming Tian Li | 2018 | Earthquake Engineering and Engineering Vibration2018，17，3： | 6 |
| 8 | Compensation effects of coated cysteamine on meat quality, amino acid composition, fatty acid composition, mineral content in dorsal muscle and serum biochemical indices in finishing pigs offered reduced trace minerals diet显示文摘Dear Editor.Trace mineral elements(ME)and amino acids have been demonstrated to be essential bioelements in animal nutrition.If there is a deficiency in ME,a number of biological functions in animals may be affected,including physical growth,psychomotor development,and immunity.Supplementation of pig diets with ME is known to improve the animals'growth,reproduction,and their immunity against oxidative stress and cell damage. | Miaomiao Bai Hongnan Liu Kang Xu Xiaofeng Zhang Baichuan Deng Chengquan Tan Jinping Deng Pingping Bing Yulong Yin | 2019 | Science China(Life Sciences)2019，62，11： | 6 |
| 9 | Effects of different levels of urea supplementation on nutrient intake and growth performance in growing camels fed roughage based complete pellet diets显示文摘The utilization of urea in camels has beneficial and negative effects. The aims of this study were to investigate the effects of different levels of urea supplementation on nutrients intake, digestibility,growth performance, feed efficiency and economics in growing camels fed roughage based complete pellet diets. In the present study, eighteen growing camels with an average live body weight of306.17 ± 2.05 kg were randomly assigned in three treatments: T1 = roughage complete pellet diet without urea,T2 = T1 plus 1% urea,and T3 = T1 plus 2% urea. The results showed that the urea supplementation significantly affected average daily feed and nutrient intake of dry matter(DM), organic matter(OM), crude protein(CP), neutral detergent fiber(NDF), and acid detergent fiber(ADF)(P < 0.05).On the contrary, the average daily intake of nitrogen free extract(NFE) and water were not influenced by increasing urea supplementation(P > 0.05). Similarly, digestion coefficient of DM, CP, ether extract(EE),crude fiber(CF) and ADF was influenced by increasing urea level(P < 0.05), while the digestion coefficient of OM, NFE and NDF was not affected by increasing urea level(P > 0.05). The intake of digestive nutrients was similar among all treatment groups. Total body live weight gain and average daily gain were significantly higher in urea supplemented groups(P < 0.05) than in the control group. The supplementation of urea at 1% in low quality roughage complete pellet diets significantly improved(P < 0.05) the feed efficiency. In conclusion,these results indicated that the incorporation of urea at 1% in roughage based complete pellet diets could positively improve nutrients intake, digestibility, growth performance and feed conversion efficiency of growing camels. | Ntiranyibagira Emmanuel Niteen V.Patil Shekbar R.Bhagwat Abdul Lateef Kang Xu Hongnan Liu | 2015 | Animal Nutrition2015，，4： | 6 |
| 10 | Anisotropic metamaterial-assisted all-silicon polarizer with 415-nm bandwidth显示文摘Polarizers have been widely used in various optical systems to reduce polarization cross talk.The polarizers based on the silicon nanowire waveguide can provide chip-scale device size and a high polarization extinction ratio.However,the working bandwidth for the on-chip silicon polarizers is always limited(<~100 nm)by the strong waveguide dispersion.In this paper,an on-chip all-silicon polarizer with an extremely broad working bandwidth is proposed and demonstrated.The device is based on a 180°sharp waveguide bend,assisted with anisotropic subwavelength grating(SWG)metamaterial cladding to enhance the polarization selectivity.For TE polarization,the effective refractive index for SWG is extraordinary,so the incident TE mode can propagate through the sharp waveguide bend.For TM polarization,the effective refractive index for SWG is ordinary,so the incident TM mode will be coupled into the radiation mode regardless of the wavelength.The fabricated polarizer shows low loss(<1 d B)and high polarization extinction ratio(>20 d B)over a>415 nm bandwidth from1.26 to 1.675μm,which is at least fourfold better than what has been demonstrated in all previous works.To the best of our knowledge,such a device is the first all-silicon polarizer that covers O-,E-,S-,C-,L-,and U-bands. | HONGNAN XU DAOXIN DAI YAOCHENG SHI | 2019 | Photonics Research2019，7，12： | 5 |
| 11 | Influences of wide-narrow seeding on soil properties and winter wheat yields under conservation tillage in North China Plain显示文摘In order to promote the winter wheat yield and guarantee seeding quality in double-cropping system,no-tillage or reduced tillage planting modes with different row spacing have been implemented to result in different levels of yield.A three-year(2012-2015)field experiment was conducted on the experimental farm at Zhuozhou of Hebei Province in North China Plain to compare winter wheat yield from the two planting modes:wide-narrow row space planting mode(WN)and uniform row space planting mode(UR)Both planting modes were performed under reduced tillage conditions with straw mulching.The results showed that in North China Plain WN had positive impacts on crop yield,yield components,leaf area index(LAI)and intercepted photosynthetically active radiation(IPAR)index.Comparing with the UR,IPAR and LAI index for WN were enhanced by 4.8%and 5.2%,respectively.The average yield for WN was 7.2%,significantly greater than that of UR under the same quantity and density.In addition,for WN mode,machinery could pass through with less blocking under large amount of straw mulching,which largely improved tillage efficiency and potentially popularized the conservation tillage technology in North China plain.It is therefore recommended that wide-narrow row space planting mode(WN)combined with reduced tillage and straw mulching be more suitable for conservation tillage in double-cropping pattern areas in North China Plain. | Hongnan Hu Caiyun Lu Qingjie Wang Hongwen Li Jin He Dijuan Xu Xianliang Wang | 2018 | International Journal of Agricultural and Biological Engineering2018，11，4： | 4 |
| 12 | Correlation of ADC value with pathologic indexes in colorectal tumor homografts in Balb/c mouse显示文摘Objective: Noninvasive diffusion-weighted magnetic resonance imaging(DWI) is a well-studied MR imaging technique for quantifying water diffusion especially in tumor area. The correlation between apparent diffusion coefficient(ADC) value and apoptosis or proliferation is not clear by now. This study aimed to investigate whether DWI-ADC value could be used as an imaging marker related with pathologic indexes of tumors.Methods: A total of 30 Balb/c mice with HT29 colorectal carcinoma were subjected to DWI and histologic analysis. The percentage of ADC changes and the apoptotic and proliferating indexes were calculated at predefined time points. Kolmogorov-Smirnov distances were considered to determine whether the percentage of ADC changes, and the apoptotic and proliferating indexes were normally distributed. An independent-samples t-test was used to analyze the difference between apoptotic and proliferating indexes in the two groups.Results: There was a statistically significant difference in proliferating index between the radiotherapy and control groups(mean proliferating index: 49.27% vs. 83.09%), and there was a statistically significant difference in apoptotic index between the two groups(mean apoptotic index: 37.7% vs. 2.71%). A significant positive correlation was found between the percentage of ADC changes of the viable tissue and apoptotic index. Pearson's correlation coefficient was 0.655(P=0.015). A significant negative correlation was found between the percentage of ADC changes of the viable tissue and ki-67 proliferation index. Pearson's correlation coefficient was 0.734(P<0.001).Conclusions: Our results suggest that ADC value may be used in measurement of cell apoptotic and proliferating indexes in colorectal carcinoma. | Xiaojun Li Hongnan Jiang Jinliang Niu Ying Zheng | 2014 | Chinese Journal of Cancer Research2014，26，4： | 4 |
| 13 | Hydrocarbon accumulation characteristics of beachbar sandstones in the southern slope of the Dongying Sag, Jiyang Depression, Bohai Bay Basin, China显示文摘A number of beach-bar sandstone reservoir beds are developed in the upper fourth member of the Eocene Shahejie Formation(Ess4) on the southern slope of the Dongying Sag. Based on the analysis of seismic and logging data, with characterization and petrographic studies of core and cutting samples, this paper analyzes the hydrocarbon accumulation characteristics in two typical blocks of the Boxing and Wangjiagang oilfields, especially reservoir bed heterogeneity and migration conditions that influence oil and gas distribution, calculates the index of reservoir bed quality(IRQ) with a mathematical method, and discusses the relationship between driving force and resistance of hydrocarbon accumulation. Taking into account the characteristics of thin interbeds in beach-bar sandstones, an experimental model simulated the characteristics of hydrocarbon migration and accumulation in thin interbedded sandstones with reservoir bed heterogeneity. The results showed that hydrocarbon distribution and properties were extremely non-uniform. Reservoir bed and migration conditions controlled hydrocarbon accumulation in beach-bar sandstones. IRQ is above 0.4 in the main hydrocarbon region. Sand body distribution, structural configuration and fault systems controlled the direction of regional migration and location of hydrocarbon accumulation. Simulation experiments indicated that the change of driving force for hydrocarbon migration affected selective accumulation mechanisms. Hydrocarbon moved vertically along fault zones to the reservoir and resulted in the distribution of hydrocarbon in the reservoir. Two kinds of hydrocarbon accumulation models exist in the study area. One is a hydrocarbon accumulation model controlled by reservoir bed heterogeneity and the second is a hydrocarbon accumulation model controlled by a complex migration system with faults connecting sandbodies. Finally, different exploration strategies should be adopted for the detailed exploration for beach-bar sandstone reservoirs according to different geological backgrounds. | Guo Song Tan Lijuan Lin Chengyan Li Hongnan Lü Xiuxiang Wang Hongtao | 2014 | Petroleum Science2014，11，2： | 4 |
| 14 | Design and experiment of anti-vibrating and anti-wrapping rotary components for subsoiler cum rotary tiller显示文摘The commonly used subsoiling cum rotary tiller machine(SRT)in Northern China is a combination of subsoiler and horizontal rotary tiller,however backfilling of the subsoiling slot,excessive vibration and plant residue wrapping on rotary components has been rarely considered.Therefore,the rotary components and assembly were redesigned to address these issues and to an SRT fitted with IT225 short curve rotary blades behind the V-shape subsoiling slots and IIT245 long curve rotary blades between the tines.Long and short blades were fitted on a rotor in a double helix,with optimal spiral angles of 65° and 90°,and phase angle of 147°and 180°,respectively.Compared with the commonly used SRT(CSRT),the additional anti-wrapping cutting blades in the circumferential and axial direction of ASRT could remove hanging residue on the blade holders,wrapping on the rotor and formation of an isolation layer.Moreover,the cutting edge curve of anti-wrapping cutting blades was an exponential curve.Field tests demonstrated that the redesigned SRT with anti-vibrating and anti-wrapping rotary components(ASRT)had was a significant advancement over the CSRT.Moreover,the working depth of rotary tillage was more stable,while other observations confirmed that backfilling of the subsoiling slot was also improved. | Kan Zheng Allen D.McHugh Hongwen Li Qingjie Wang Caiyun Lu Hongnan Hu Wenzheng Liu Zhiqiang Zhang Peng Liu Jin He | 2019 | International Journal of Agricultural and Biological Engineering2019，12，4： | 4 |
| 15 | 3-D consistency dynamic constitutive model of concrete显示文摘Based on the consistency-viscoplastic constitutive model,the static William-Warnke model with three-parameters is modified and a consistency-viscoplastic William-Warnke model with three-parameters is developed that considers the effect of strain rates. Then,the tangent modulus of the consistency viscoplastic model is introduced and an implicit backward Elure iterative algorithm is developed. Comparisons between the numerical simulations and experimental data show that the consistency model properly provides the uniaxial and biaxial dynamic behaviors of concrete. To study the effect of strain rates on the dynamic response of concrete structures,the proposed model is used in the analysis of the dynamic response of a simply-supported beam and the results show that the strain rate has a significant effect on the displacement and stress magnitudes and distributions. Finally,the seismic responses of a 278 m high arch dam are obtained and compared by using the linear elastic model,as well as rate-independent and rate-dependent William-Warnke three-parameter models. The results indicate that the strain rate affects the first principal stresses,and the maximal equivalent viscoplastic strain rate of the arch dam. Numerical calculations and analyses reveal that considering the strain rate is important in the safety assessments of arch dams located in seismically active areas. | Xiao Shiyun,Li Hongnan and Lin Gao School of Hydraulic Engineering,Dalian University of Technology,Dalian 116024,China | 2010 | Earthquake Engineering and Engineering Vibration2010，9，2： | 4 |
| 16 | Efficacy of irinotecan-based chemotherapy after exposure to an anti-PD-1 antibody in patients with advanced esophageal squamous cell carcinoma显示文摘Objective:Several anti-programmed cell death 1(anti-PD-1)antibodies have demonstrated potential efficacy in the treatment of advanced esophageal squamous cell cancer(ESCC).However,the response to subsequent chemotherapy after the failure of PD-1 blockade in ESCC patients has not been reported,and the optimal sequencing of immunotherapy and chemotherapy remains controversial.The aim of the present study was to evaluate responses to irinotecan-based subsequent chemotherapy in advanced ESCC patients who had progressed after treatment with camrelizumab(SHR-1210),a novel anti-PD-1 antibody.Methods:We retrospectively reviewed the medical records of patients with advanced ESCC treated with camrelizumab at a single institution.Consecutive patients who received subsequent irinotecan-based chemotherapy were selected for data collection and analysis.Results:Overall,a total of 28 patients were included.All patients had received at least two lines of systemic treatment prior to irinotecan salvage.The most common regimen that was administered after PD-1 blockade was irinotecan in combination with 5-fluorouracil(5-Fu)(or its derivatives),which was given to 19 patients.The objective response rate(ORR)and disease control rate(DCR)were 17.9%(5/28)and 64.3%(18/28),respectively,with 5(17.9%)patients achieving a partial response and 13(46.4%)having stable disease.The median progressionfree survival(PFS)was 3.18[95%confidence interval(95%CI),2.48-3.88]months and the median overall survival(OS)was 6.23(95%CI,4.71-7.75)months.No new safety issues,either immune-related or otherwise,were observed.Conclusions:Our results suggested that the response to irinotecan-based chemotherapy after PD-1 blockade in advanced ESCC patients appeared similar to that previously observed in patients who had not received PD-1 antibodies,and further study in larger cohorts or randomized trials is warranted to verify our observation. | Bo Zhang Xi Wang Qun Li Hongnan Mo Xingyuan Wang Yan Song Jianping Xu Tao Qu Jing Huang | 2019 | Chinese Journal of Cancer Research2019，31，6： | 3 |
| 17 | A new framework for evaluating along-wind responses of a transmission tower显示文摘In this paper, an analytical framework to evaluate the along-wind-induced dynamic responses of a transmission tower is presented. Two analytical models and a new method are developed: (1) a higher mode generalized force spectrum (GFS) model of the transmission tower is deduced; (2) an analytical model that includes the contributions of the higher modes is further derived as a rational algebraic formula to estimate the structural displacement response; and (3) a new approach, applying load with displacement (ALD) instead of force, to solve the internal force of transmission tower is given. Unlike conventional methods, the ALD method can avoid calculating equivalent static wind loads (ESWLs). Finally, a transmission tower structure is used as a numerical example to verify the feasibility and accuracy of the ALD method. | Liu Guohuan and Li Hongnan School of Civil and Hydraulic Engineering, Dalian University of Technology, Dalian 116023, China PhD Professor | 2009 | Earthquake Engineering and Engineering Vibration2009，8，1： | 3 |
| 18 | Seismic performance evaluation of large-span offshore cable-stayed bridges under non-uniform earthquake excitations including strain rate effect显示文摘This paper presents a novel and precise seismic performance evaluation method for large-span offshore cable-stayed(LSOCS)bridge by considering the strain rate effect of RC materials and the spatial variation effect of seafloor seismic motions. Threedimensional finite element(FE) model of a LSOCS bridge located in the southeast coast of China is constructed in the ABAQUS platform. The non-uniform ground motions at the offshore site beneath the bridge are stochastically simulated and used as seismic inputs. Moreover, a subroutine for considering the rate-dependent properties of RC materials in a fiber-based beamcolumn element model is developed to account for the strain rate effect of RC materials in the nonlinear time-history analysis.The numerical results indicate that seismic responses and fragilities of the LSOCS bridge are both considerably affected by the non-uniform seafloor seismic motions and strain rate effect. The seismic performance evaluation approach presented in this paper can provide vital support for earthquake resistant design of LSOCS bridges. | LI Chao LI HongNan ZHANG Hao SU JunSheng LI RouHan DING YiMing | 2020 | Science China(Technological Sciences)2020，63，7： | 3 |
| 19 | Role of hydrogen peroxide in stress-induced programmed cell death during somatic embryogenesis in Fraxinus mandshurica显示文摘We examined how reactive oxygen species, in the form of hydrogen peroxide (H2O2), affect osmotic stress–induced programmed cell death during somatic embryogenesis from cotyledon explants of Manchurian ash (Fraxinus mandshurica Rupr.). We found that substantial osmotic stress was essential for Manchurian ash somatic cells to obtain embryogenic competence. The explant cells displayed hallmarks of programmed cell death, chromatin condensation, and DNA fragmentation to oligonucleotides during somatic embryogenesis. Increasing concentrations of plant growth regulators and sucrose in the medium increased osmotic stress thereby inducing H2O2 accumulation in the explant cells. We found that H2O2 concentration was significantly decreased in explant cells when the induction medium was modified, i.e., when reducing the concentration of sucrose, which reduces the osmotic pressure of the medium, or by withdrawing plant growth regulators at mid-culture. These treatments also decreased the proportion of explant cells undergoing programmed cell death. Accordingly, a decreased rate of somatic embryo induction was observed. These results show that PCD occurred during tissue browning and death of some explant cells during somatic embryogenesis in F. mandshurica. The ROS contributed to PCD in abiotic stress stimulated F. mandshurica cells. | Ling Yang Cheng Wei Chao Huang Hongnan Liu Dongyan Zhang Hailong Shen Yuhua Li | 2019 | Journal of Forestry Research2019，30，3： | 2 |
| 20 | Effects of a nitric oxide donor and nitric oxide scavengers on Sorbus pohuashanensis embryo germination显示文摘The effects of an exogenous nitric oxide donor(sodium nitroprusside, SNP), a NO scavenger 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxode(PTIO) and carboxy-PTIO potassium salt(c PTIO) on the embryo germination of Sorbus pohuashanensis were studied in a petri dish test. SNP at 0.5–5 mmol L-1 increased germination percentage, mean time to germination, germination index and germination energy compared with the control to different degrees. Treatment with 2 mmol L-1 SNP improved germination most significantly; embryo germination percentage for mother tree 1(91.11%) and mother tree 2(64.44%) were much higher than the control. In addition,excessive SNP levels did not enhance embryo germination.Combined treatment with SNP and an NO scavenger delayed embryo germination. Treatment with c PTIO inhibited embryo germination; germination percentage was 42.22% and was lower than that of the control. These results show that low concentrations of exogenous NO can enhance the embryo germination of S. pohuashanensis,providing a simple, effective way for promoting germination of S. pohuashanensis. | Ling Yang Dongyan Zhang Hongnan Liu Cheng Wei Jianan Wang Hailong Shen | 2018 | Journal of Forestry Research2018，29，3： | 2 |
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