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| 1 | Update on novel endoscopic therapies to treat gastroesophageal reflux disease: A review显示文摘Endoscopic treatments for gastroesophageal reflux disease(GERD) have become increasingly popular in recent years. While surgical intervention with the Laparoscopic Nissen Fundoplication remains the gold standard, two endoscopic interventions, specifically, are gaining traction in clinical use(Esophy X and Stretta). The Esophy X(Endo Gastric Solutions, Inc., Redmond, WA, United States) was developed as a method of restoring the valve at the GE junction through an endoluminal fundoplication(ELF) technique. Long-term data suggests that transoral incisional fundoplication(TIF) with Esophy X may be effective for symptom control and proton pump inhibitor reduction or cessation for up to 2-6 years. There is no evidence that Esophy X is more effective than surgical intervention. TIF may be most effective for patients with HH < 2 cm and Hill Grade I/II valves. Stretta(Mederi Therapeutics, Greenwich, CT, United States) was approved by the Food and Drug Administration in 2000. It delivers radiofrequency energy to the lower esophageal sphincter and gastric cardia. Published reviews of the literature are conflicted in their recommendations of Stretta in the management of GERD. The literature suggests that the Stretta procedure has an acceptable safety profile and may be effective in reducing symptom burden and quality of life scores up to 8 years post-intervention. However, there does not appear to be any sustained improvement in objective outcomes and there is no evidence that Stretta results in improved outcomes as compared to surgical intervention. Treatment modalities for GERD, as a field, suffer from a lack of standardization in primary and secondary outcomes. Although many studies have looked at health related quality of life, the tools used to do so are markedly heterogeneous. Future directions for the endoscopic treatment of GERD include novel techniques like endoscopic submucosal dissection. | Jessica Hopkins Noah J Switzer Shahzeer Karmali | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，11： | 2 |
| 2 | Reciprocal connections between the amygdala and parabrachial nuclei:ultrastructural demonstration by degeneration and axonal transport of horseradish peroxidase in the cat 显示文摘 | Takeuchi Y McLean J H Hopkins D A | 1982 | Brain Res1982，239，： | 2 |
| 3 | Adipocyte iron regulates adiponectin and insulin sensitivity显示文摘 | Gabrielsen J Scott Gao Yan Simcox Judith A Huang Jingyu Thorup David Jones Deborah Cooksey Robert C Gabrielsen David Adams Ted D Hunt Steven C Hopkins Paul N Cefalu William T McClain Donald A | 2012 | EN2012，，10： | 2 |
| 4 | The theory and development relationship matrix-based approach evaluating E-marketplaces 显示文摘 | Hopkins J L Kehoe D F | 2006 | Electronic Markets2006，16，3： | 1 |
| 5 | Electro-osmosis: A new concept for high-speed liquid chromatography显示文摘 | PRETOUROUS V HOPKINS B J Sehieke J D | 1974 | Chromatogr1974，99，： | 1 |
| 6 | Changes in the content and fatty acid composition of lipid in an isolated population of capelin Malotus villosus during sexual maturation and spawning显示文摘 | Henderson R J Sargent J R Hopkins C E E | 1984 | Mar Biol1984，78，： | 1 |
| 7 | Association of cadmium in durum wheat grain with soil chloride and chelate-extractable soil cadmium显示文摘 | NORVELL W A WU J HOPKINS D G | 2000 | Soil Science Society of America Journal2000，64，： | 1 |
| 8 | The relationship between tenderness,proteolysis,muscle contraction and dissociation of actomyosin显示文摘 | Hopkins D L Thompson J M | 2001 | Meat Sci2001，57，： | 1 |
| 9 | Charaetefization of reservoir lithologies within subunconformity pools : Pekisko formation, Medicine River field, Alberta Canada显示文摘 | Hopkins J C | 1999 | AAPG Bulletin1999，83，11： | 1 |
| 10 | Load carrying capacities for circular plates of perfectly-plastic material with arbitrary yield condition 显示文摘 | Hopkins H G Wang A J | 1954 | Journal of Mechanics and Physics of Solids1954，3，2： | 1 |
| 11 | Direct injection of 90Y Mo Abs into glioma tumor resection cavities leads to limited diffusion of the radioimmunoconjugates into normal brain parenchyma:a model to estimate absorbed radiation dose显示文摘 | Hopkins K Chandler C Eatough J | 1998 | Int J Radiat Oncol Biol Phys1998，40，4： | 1 |
| 12 | Comparison of high - fat and high - protein diets with a high - carbohydrate diet in insulin - resistant obese women 显示文摘 | McAuley KA Hopkins CM Smith K J | 2005 | Diabetologia2005，28，1： | 1 |
| 13 | Nitric oxide-mediated cGMP production in the islands of Calleja in the rat显示文摘 | Vente J Hopkins DA Markerink-van Ittersum M | 1998 | Brain Res1998，789，1： | 1 |
| 14 | Type 2 iodothyronine deiodinase transgene expression in the Mouse Heart Causes cardiac-specific thyrotoxicosis 显示文摘 | Pachucki J Hopkins J Peeters R | 2001 | Endocrinology2001，142，： | 1 |
| 15 | Chicken interferon gene: cloning, expression, and analysis显示文摘 | Sekellick M J Ferrandion A F Hopkins D A | 1994 | J Interferon Res1994，14，： | 1 |
| 16 | Decomposition in soil of tobacco plants with genetic modifications to lignin biosynthesis显示文摘 | Hopkins D W Webster E A Chudek J A 2001 | 2001 | Soil Biology & Biochemistry2001，33，： | 1 |
| 17 | Repetitive segmental structure of the transducin β subunit:homology with the CDC4 gene and identification of related mRNAs显示文摘 | Fong H K Hurley J B Hopkins R S | 1986 | Proc Natl Acad Sci USA1986，83，7： | 1 |
| 18 | Analysis of mortality after hip fracture data from a 5-year patient cohort显示文摘 | Arnander M Hopkins J Khaleel A | | 0，，04： | 1 |
| 19 | Signs of the Post-Rural: Marketing Myths of a Symbolic Countryside显示文摘 | HOPKINS J | 1998 | Geografiska Annaler : Series B Human Geography1998，80，1： | 1 |
| 20 | E - cadherin germline mutations in familial gastric cancer显示文摘 | Guilford P Hopkins J Harraway J | 1998 | Nature1998，392，6674： | 1 |
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