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| 1 | Immune therapy including dendritic cell based therapy in chronic hepatitis B virus infection显示文摘肝炎 B (HBV ) 感染是一个全球公共卫生问题。全球被感染了的约 20 亿个人,超过 4 亿是 HBV 的慢性带菌者。长期的 HBV 搬运人的可观的数字患进步的肝疾病。另外,所有 HBV 搬运人是这个病毒的永久来源。为长期的 HBV 搬运人没有药品治疗。然而,抗病毒的药为大约 10% 病人被推荐这些药是昂贵的,限制了功效,并且拥有可观的副作用。最近的研究证明了到 HBV 的主人的有免疫力的回答非常在长期的 HBV 感染的每个阶段被包含:(1 ) 这些影响长期的 HBV 带菌状态的获得,(2 ) 他们在肝损坏的上下文是重要的,(3 ) 从长期的 HBV 相关的肝疾病的恢复依赖于 HBV 特定的有免疫力的回答的自然和程度。然而,在长期的 HBV 搬运人的 HBV 特定的有免疫力的回答的足够的层次的正式就职是困难的。在最后一十年期间,肝炎 B 疫苗作为一条治疗学的途径(疫苗的治疗) 予长期的 HBV 搬运人被以。疫苗的治疗的现在的政体是安全、便宜,然而并非那么有效。一支树枝状的基于房间的治疗学的疫苗最近为治疗长期的 HBV 感染被开发了。在这评论,我们将为治疗长期的 HBV 感染包括疫苗的治疗和树枝状的基于房间的疫苗的治疗关于 HBV 特定的有免疫力的治疗的开发的概念,科学逻辑,策略和技术讨论。 | Sk Md Fazle Akbar Norio Horiike Morikazu Onji | 2006 | World Journal of Gastroenterology2006，12，18： | 35 |
| 2 | Prognosis following transcatheter arterial embolization for 121 patients with unresectable hepatocellular carcinoma with or without a history of treatment显示文摘瞄准:回顾地为 HCC 后面的 transcatheter 与肝细胞癌(HCC ) 评估病人的预后与或没有治疗的历史动脉的 embolization (TAE ) 。方法:有在我们的医院里从 1992 ~ 2004 与 TAE 对待的 HCC 的 121 个病人在这研究被注册。84 个病人为 HCC 有治疗的历史,当时 37。在入口,有额外肝的转移的病人,门静脉肿瘤血栓,或孩子呸班的时候, C 被排除。当 HCC 的复发被提高的肿瘤标记,或 ultrasonography 或动态计算断层摄影术调查结果诊断时, TAE 被重复。结果:肿瘤尺寸更大,没有过去的治疗(P<0.01 ) ,肿瘤的数字是在病人的少数。然而,在节点转移(TNM ) 舞台或幸存在 2 个组之间评估的肿瘤没有差别。一个双性人 alpha-fetoprotein (法新社)(>100 ng/mL ) 的小叶片的肿瘤和高水平是与在有 HCC 的历史的病人的差的预后有关的因素。结论:预后追随者 TAE 在有或没有过去的治疗的 HCC 病人之间是类似的。在到一堂重复 TAE 功课的入口能改进预后以前, HCC 或周期性的 HCC 和获得的好本地人的早诊断对 HCC 控制。 | Atsushi Hiraoka Teru Kumagi Masashi Hirooka Takahide Uehara Kiyotaka Kurose Hidehito luchi Yoichi Hiasa Bunzo Matsuura Kojiro Michitaka Seishi Kumano Hiroaki Tanaka Yoshimasa Yamashita Norio Horiike Teruhito Mochizuki Morikazu Onji | 2006 | World Journal of Gastroenterology2006，12，13： | 9 |
| 3 | Trisomy 3 may predict a poor response of gastric MALT lymphoma to Helicobacter pylori eradication therapy显示文摘AIM: To investigate the relation of the response to Helicobacter pylori eradication therapy to the depth of tumor invasion and chromosome abnormalities in patients with mucosaassociated lymphoid tissue (MALT) lymphoma and to determine the clinical value of aneuploidy.METHODS: We studied 13 patients with localized gastric MALT lymphoma of stage E1. Before eradication therapy,the depth of tumor invasion was assessed by endoscopic ultrasonography in 8 patients and by endoscopic examination and gastrointestinal series in the remaining patients. To detect chromosomal abnormalities, paraffin-embedded tissue sections of diagnostic biopsy specimens underwent tissuefluorescence in situ hybridization (FISH), using chromosomespecific α-satellite DNA probes for chromosomes 3,7,12,and 18 and YAC clones for t(11;18)(q21;q21).RESULTS: Seven of the 13 patients had complete regression(CR) in response to H pylori eradication therapy. No patient with CR had submucosal tumor invasion. Trisomy 18 was seen in 1 patient with CR, and both trisomies 12 and 18 were present in another patient with CR. All patients with no response or progressive disease had deep submucosal tumor invasion and showed t(11;18)(q21;q21) or trisomy 3. Trisomy 7 was not detected in this series of patients.CONCLUSION: The depth of tumor invasion is an accurate predictor of the response of stage E1 MALT lymphoma to H pylori eradication therapy and is closely associated with the presence of chromosomal abnormalities. Trisomy 3 may predict the aggressive development of MALT lymphoma. | Sawako Taji Kenichi Nomura Yosuke Matsumoto Hideaki Sakabe Naohisa Yoshida Shoji Mitsufuji Kazuhiro Nishida Shigeo Horiike Shigeo Nakamura Masuji Morita Masafumi Taniwaki | 2005 | World Journal of Gastroenterology2005，11，1： | 6 |
| 4 | Pseudomembranous colitis presenting as acute colonic obstruction without diarrhea in a patient with gastric Burkitt lymphoma显示文摘Pseudomembranous colitis (PMC) usually manifests asfever and diarrhea in hospitalized patients treated withsystemic antibiotics. We described a case of PMC withintestinal obstruction but without diarrhea. A 60-yearold man was hospitalized for chemotherapy for the treatment of Burkitt lymphoma of the stomach. The patient became febrile and complained of crampy abdominal pain during the post-chemotherapy nadir. Plain abdominal radiography showed some intestinal gas and niveau. Because stool cytotoxin assay for clostridium difficile was positive and colon fiberscopic examination showed a pseudomembrane at the left side of the colon,and a diagnosis of PMC was made. Treatment with intracolonic vancomycin administration by colonoscopy and nasoileus tube was successful. Physicians should take into account the possibility of bowel obstruction due to PMC occurring in patients undergoing chemotherapy and perform emergency colonoscopy examination of suspected cases. | Kenichi Nomura Kohei Fukumoto Daisuke Shimizu Takashi Okuda Naohisa Yoshida Yuri Kamitsuji Yosuke Matsumoto Hideyuki Konishi Yuji Ueda Shigeo Horiike Takeshi Okanoue Masafumi Taniwaki | 2005 | World Journal of Gastroenterology2005，11，17： | 5 |
| 5 | Recurrent chromosomal rearrangements at bands 8q24 and 11q13 in gastric cancer as detected by multicolor spectral karyotyping显示文摘AIM: To identify chromosomal translocations specific to gastric cancer (GC), spectral karyotyping (SKY) analysis was performed on established cell lines and cancerous ascitic fluids.METHODS: SKY analysis of 10 established cell lines and seven cancerous ascitic fluid samples identified recurrent chromosomal breakpoints and translocations in GC,several of which involved chromosomal loci of oncogenes or tumor suppressor genes.RESULTS: A total of 630 chromosomal breaks were identified. Chromosome no.8 was the most frequently involved in rearrangements (65 breaks), followed by chromosomes no. 11 (53), no. 1 (49), no. 7 (46), no. 13 (37), no. 3 (36), no. 17 (33), and no. 20 (29). Frequent breakpoints were detected in 8q24.1 (30 breaks), 11q13 (29), 13q14 (16), 20q11.2 (14), 7q32 (13), 17q11.2 (13),18q21 (12), 17q23 (9), 18q11.2 (9). SKY analysis identified a total of 242 chromosomal rearrangements including 190 reciprocal and non-reciprocal translocations. The recurrent combinations of chromosomal bands involved in translocations were 8q24.1 and 13q14 (3 cases), 8q24.1 and 11q13 (3), 11q13 and 17q11.2 (2), and 18q11.2 and 20q11.2 (2). Our study validated the ability of SKY to characterize in detail the chromosomal rearrangements in solid tumors and derived cell lines. Moreover,fluorescence in situ hybridization helped to identify the insertions, translocations, and homogeneously staining regions of MYCand CCND1 gene loci.CONCLUSION: The non-random co-localization of certain cytogenetic bands suggests the importance of chromosomal translocations in gastric carcinogenesis, by serving as landmarks for the cloning of GC causing genes. | Yasuhide Yamashita Kazuhiro Nishida Takashi Okuda Kenichi Nomura Yosuke Matsumoto Shoji Mitsufuji Shigeo Horiike Hiroyuki Hata Chohei Sakakura Akio Hagiwara Hisakazu Yamagishi Masafumi Taniwaki | 2005 | World Journal of Gastroenterology2005，11，33： | 4 |
| 6 | Recurrence of autoimmune hepatitis after liver transplantation without elevation of alanine aminotransferase显示文摘It is controversial whether steroid therapy should be continued to prevent the recurrence of autoimmune hepatitis(AIH)in patients who have undergone liver transplantation(LTx)due to AIH.We report a case of recurrent autoimmune hepatitis after LTx despite a persistently normal range of alanine aminotransferase(ALT).A 50-year-old woman was admitted to our hospital because of jaundice and severe liver dysfunction,where she was diagnosed with liver failure due to AIH.Steroid therapy was not effective enough and the patient received living-donor LTx in 1999.Following the operation,the level of ALT was maintained within a normal range and anti-nuclear antibody(ANA)became negative,however,the serum level of IgG gradually elevated and ANA became positive,while platelets decreased.A liver biopsy performed 6 years after LTx showed histological findings of AIH and she was diagnosed with recurrent AIH.A recurrence of AIH may occur after LTx even if the level of ALT remains within a normal range.We consider that a protocol liver biopsy should be performed in patients who undergo LTx due to AIH to decide the indication for steroid therapy. | Huaiqi Yao Kojiro Michitaka Yoshio Tokumoto Yosuke Murata Toshie Mashiba Masanori Abe Yoichi Hiasa Norio Horiike Morikazu Onji | 2007 | World Journal of Gastroenterology2007，13，10： | 3 |
| 7 | Calore restriction enhances cell adaptation to hypoxia through Sirtl-dependent mitochondrial autophagy in mouse aged kidney 显示文摘 | Kume S Uzu T Horiike M | 2010 | J Clin Invest2010，120，： | 1 |
| 8 | Mechanism and therapeutic potential of DNA-based immunization against the envelope proteins of hepatitis B virus in normal and transgenic mice显示文摘 | Oka Y Akbar SM Horiike N | 2001 | Immunology2001，103，1： | 1 |
| 9 | Comparison of genotypes C and D of the hepatitis B virus in Japan : a clinical and molecular biological study 显示文摘 | DUONG T N HORIIKE N MICHITAKA K | 2004 | J Med Virol2004，72，4： | 1 |
| 10 | Phase I study of lenvatinib combined with earboplatin and paclitaxel in patients with non-small-cell lung cancer显示文摘 | Nishio M Horai T Horiike A | 2013 | Br J Cancer2013，109，3： | 1 |
| 11 | Existence of TT Virus and TTV-like mini virus DNA in infant cord blood:mother-to-neonatal transmission显示文摘 | Matsubara H Michitaka M Horiike N | 2000 | Intervirology2000，43，： | 1 |
| 12 | Safety and immuno- genicity of hepatitis B surface antigen-pulsed dendritic cells in patients with chronic hepatitis B显示文摘 | Akbar S M Furukawa S Horiike N | 2011 | J Viral Nepal2011，18，6： | 1 |
| 13 | Protein synthesis and Neurotrophin-dependent structural plasticity of single dendritic spines 显示文摘 | Tanaka J Horiike Y Matsuzaki M | 2008 | Science2008，319，： | 1 |
| 14 | Tandem duplications of the Flt3 receptor gene are associated with leukemia transformation of myelodysplasia 显示文摘 | Horiike S Yokotas Nakao M | 1997 | Leukemia1997，11，： | 1 |
| 15 | 显示文摘 | Nageta S Takahiro K Horiike S | 1999 | J Nucl Mater1999，，： | 1 |
| 16 | Characteristics of lamivudine-resistant hepatitis B vitus (HBV) strains with and without breakthrough hepatitis in patients with chronic hepatitis B evaluated by serial HBV fall-genome sequences 显示文摘 | Horiike N Du ong TN Michitaka K | 2007 | Med Virol2007，79，7： | 1 |
| 17 | Intercellular adhesion molecule- 1 expression on the hepatocyle membrane of patients with chronic hepatitis B and C显示文摘 | Horiike N Onji M Kumon t | 1993 | Liver1993，13，1： | 1 |
| 18 | Expression of master regulators of helper T-cell differentiation in peripheral T-cell lymphoma , not otherwise specified , by immunohistochemical analysis显示文摘 | Matsumoto Y Horiike S Ohshiro M | 2010 | Am J Clin Pathol2010，133，2： | 1 |
| 19 | Prognostic importance of antigen presenting dentritic cells during vaccine therapy in murine hepatitis B virus显示文摘 | HORIIK N ONJI M | 1999 | Immunology1999，6，4： | 1 |
| 20 | Novel loss-of-function mutations of the haematopoiesis-related transcription factor,acute myeloid leukaemia 1/runt-related transcription factor 1,detected in acute myeloblastic leukaemia and myelodysplastic syndrome显示文摘 | Nakao M Horiike S Fukushima-Nakase Y | 2004 | Br J Haematol2004，125，6： | 1 |
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