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| 1 | Orally administered extract from Prunella vulgaris attenuates spontaneous colitis in mdr1a^(-/-) mice显示文摘AIM: To investigate the ability of a Prunella vulgaris(P. vulgaris) ethanolic extract to attenuate spontaneous typhlocolitis in mdr1a-/- mice. METHODS: Vehicle(5% ethanol) or P. vulgaris ethanolic extract(2.4 mg/d) were administered daily by oral gavage to mdr1a-/- or wild type FVBWT mice from 6 wk of age up to 20 wk of age. Clinical signs of disease were noted by monitoring weight loss. Mice experiencingweight loss in excess of 15% were removed from the study. At the time mice were removed from the study, blood and colon tissue were collected for analyses that included histological evaluation of lesions, inflammatory cytokine levels, and myeloperoxidase activity. RESULTS: Administration of P. vulgaris extracts to mdr1a-/- mice delayed onset of colitis and reduced severity of mucosal inflammation when compared to vehicle-treated mdr1a-/- mice. Oral administration of the P. vulgaris extract resulted in reduced(P < 0.05) serum levels of IL-10(4.6 ± 2 vs 19.4 ± 4), CXCL9(1319.0 ± 277 vs 3901.0 ± 858), and TNFα(9.9 ± 3 vs 14.8 ± 1) as well as reduced gene expression by more than two-fold for Ccl2, Ccl20, Cxcl1, Cxcl9, IL-1 α, Mmp10, VCAM-1, ICAM, IL-2, and TNFα in the colonic mucosa of mdr1a-/- mice compared to vehicle-treated mdr1a-/-mice. Histologically, several microscopic parameters were reduced(P < 0.05) in P. vulgaris-treated mdr1a-/-mice, as was myeloperoxidase activity in the colon(2.49 ± 0.16 vs 3.36 ± 0.06, P < 0.05). The numbers of CD4+ T cells(2031.9 ± 412.1 vs 5054.5 ± 809.5) and germinal center B cells(2749.6 ± 473.7 vs 4934.0 ± 645.9) observed in the cecal tonsils of P. vulgaris-treated mdr1a-/- were significantly reduced(P < 0.05) from vehicle-treated mdr1a-/- mice. Vehicle-treated mdr1a-/- mice were found to produce serum antibodies to antigens derived from members of the intestinal microbiota, indicative of severe colitis and a loss of adaptive tolerance to the members of the microbiota. These serum antibodies were greatly reduced or absent in P. vulgaris-treated mdr1a-/- mice. CONCLUSION: The anti-inflammatory activity of P. vulgaris ethanolic extract effectively attenuated the severity of intestinal inflammation in mdr1a-/- mice. | Kelley MK Haarberg Meghan J Wymore Brand Anne-Marie C Overstreet Catherine C Hauck Patricia A Murphy Jesse M Hostetter Amanda E Ramer-Tait Michael J Wannemuehler | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，4： | 8 |
| 2 | WNT5A signaling directly affects cell motility and invasion of metastatic melanoma显示文摘 | Weeraratna AT Jiang Y Hostetter G | 2002 | Cancer Cell2002，1，： | 1 |
| 3 | Progression of renal disease and renal hypertrophy显示文摘 | Hostetter TH | 1995 | Annu Rev Physiol1995，57，： | 1 |
| 4 | Patbogenesis of diabetic glomerulopathy: Hemodynamic considerations 显示文摘 | Hostetter TH | 1990 | Semin Nephrol1990，10，3： | 1 |
| 5 | Timing is everything: order of administration of 5-aza 2' deoxycytidine, trichostatin A and tamoxifen changes estrogen receptor mRNA expression and cell sensitivity显示文摘 | Hostetter CL Licata LA Keen JC | 2009 | Cancer Lett2009，275，2： | 1 |
| 6 | Renin expression in renal ablation显示文摘 | Correa· Rotter R Hostetter TH Manivel JC | 1992 | Hypertension1992，20，4： | 1 |
| 7 | Oxygen consumption and oxidant stress in surviving nephrons显示文摘 | Nath KA Croat A J Hostetter TH | 1990 | Am J Physiol1990，258，： | 1 |
| 8 | Dietary protein intake and the progressive nature of kidney disease : the role of hemodynami- cally mediated glomerular injury in the pathogenesis of progressive glomerular sclerosis in aging, renal ablation, and intrinsic renal disease显示文摘 | Brenner BM Meyer TW Hostetter TH | 1982 | N Engl J Med1982，，： | 1 |
| 9 | Effect of dietary protein on renin and angiotensinogen gene expression after renal ablation显示文摘 | Correa· Rotter R Hostetter TH Rosenberg ME | 1992 | Am y Physiol1992，262，： | 1 |
| 10 | Paragangliomas Adecade of clininal experience显示文摘 | Somasundar P Krouse R Hostetter R | 2007 | J Surg Oncol2007，74，4： | 1 |
| 11 | Interaction of angiotensin Ⅱ and TGF-β1 in the rat remnant kidney显示文摘 | Junaid A Rosenbers ME Hostetter TH | 1997 | J Am Soc Nephrol1997，8，11： | 1 |
| 12 | Uremia显示文摘 | Meyer TW Hostetter TH | 2007 | N Engl J Med2007，357，13： | 1 |
| 13 | Hip is a pro-survival substrate of granzyme B 显示文摘 | Hostetter DR Loeb CR Chu F | 2007 | J Biol Chem2007，282，27： | 1 |
| 14 | Down-regulation of Yes Associated Protein 1 expression reduces cell proliferation mad clo- nogenicity of pancreatic cancer cells显示文摘 | Diep CH Zucker KM Hostetter G | 2012 | PLoS One2012，7，32： | 1 |
| 15 | Antagonistic anti-uroki- nase plasminogen activator receptor (uPAR) antibodies significant- ly inhibit uPAR-mediated cellular signaling and migration显示文摘 | Duriseti S Goetz DH Hostetter DR | 2010 | J Biol Chem2010，285，26： | 1 |
| 16 | Wnt5a signaling directly affects cell motility and invasion of metastatic melano- ma显示文摘 | Weeraratna AT Jiang Y Hostetter G | 2002 | Cancer Cell2002，1，： | 1 |
| 17 | Aldosterone in renal diease显示文摘 | Ibrahim HN Hostetter TH | 2003 | Curr Opin Nephrol Hypertens2003，12，2： | 1 |
| 18 | Wnt5a signaling directly affects cell motility and invasion of metastatic melano- ma显示文摘 | Weeraratna AT Jiang Y Hostetter G | 2002 | Cancer Cell2002，1，： | 1 |
| 19 | A new broad host spectrum nuclear polyhedrosis virus isolated from a celery looper, Anagrapha falcifera (Kirby), (Lepidoptera: Noctuidae) 显示文摘 | Hostetter D L Putter B | 1991 | Environmental Entomology1991，20，： | 1 |
| 20 | Interaction of angiotensin Ⅱ and TGF-β1 in the rat remnant kidney显示文摘 | Junaid A Rosenberg ME Hostetter TH | 1997 | J Am Soc Nephrol1997，8，： | 1 |
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