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| 1 | Efficient IL-2R signaling differentially affects the stability,function,and composition of the regulatory T-cell pool显示文摘Signaling via interleukin-2 receptor(IL-2R)is a requisite for regulatory T(Treg)cell identity and function.However,it is not completely understood to what degree IL-2R signaling is required for Treg cell homeostasis,lineage stability and function in both resting and inflammatory conditions.Here,we characterized a spontaneous mutant mouse strain endowed with a hypomorphic Tyr129His variant of CD25,theα-chain of IL-2R,which resulted in diminished receptor expression and reduced IL-2R signaling.Under noninflammatory conditions,Cd25Y129H mice harbored substantially lower numbers of peripheral Treg cells with stable Foxp3 expression that prevented the development of spontaneous autoimmune disease.In contrast,Cd25^(Y^(129H))Treg cells failed to efficiently induce immune suppression and lost lineage commitment in a T-cell transfer colitis model,indicating that unimpaired IL-2R signaling is critical for Treg cell function in inflammatory environments.Moreover,single-cell RNA sequencing of Treg cells revealed that impaired IL-2R signaling profoundly affected the balance of central and effector Treg cell subsets.Thus,partial loss of IL-2R signaling differentially interferes with the maintenance,heterogeneity,and suppressive function of the Treg cell pool. | Marc Permanyer Berislav Bošnjak Silke Glage Michaela Friedrichsen Stefan Floess Jochen Huehn Gwendolyn E.Patzer Ivan Odak Nadine Eckert Razieh Zargari Laura Ospina-Quintero Hristo Georgiev Reinhold Förster | 2021 | Cellular & Molecular Immunology2021，18，2： | 2 |
| 2 | The microbiota is dispensable for the early stages of peripheral regulatory T cell induction within mesenteric lymph nodes显示文摘Intestinal Foxp3+regulatory T cell(Treg)subsets are crucial players in tolerance to microbiota-derived and food-borne antigens,and compelling evidence suggests that the intestinal microbiota modulates their generation,functional specialization,and maintenance.Selected bacterial species and microbiota-derived metabolites,such as short-chain fatty acids(SCFAs),have been reported to promote Treg homeostasis in the intestinal lamina propria.Furthermore,gut-draining mesenteric lymph nodes(mLNs)are particularly efficient sites for the generation of peripherally induced Tregs(pTregs).Despite this knowledge,the direct role of the microbiota and their metabolites in the early stages of pTreg induction within mLNs is not fully elucidated.Here,using an adoptive transfer-based pTreg induction system,we demonstrate that neither transfer of a dysbiotic microbiota nor dietary SCFA supplementation modulated the pTreg induction capacity of mLNs.Even mice housed under germ-free(GF)conditions displayed equivalent pTreg induction within mLNs.Further molecular characterization of these de novo induced pTregs from mLNs by dissection of their transcriptomes and accessible chromatin regions revealed that the microbiota indeed has a limited impact and does not contribute to the initialization of the Treg-specific epigenetic landscape.Overall,our data suggest that the microbiota is dispensable for the early stages of pTreg induction within mLNs. | Carolin Wiechers Mangge Zou Eric Galvez Michael Beckstette Maria Ebel Till Strowig Jochen Huehn Joern Pezoldt | 2021 | Cellular & Molecular Immunology2021，18，5： | 2 |
| 3 | Regulation of CXCR3 and CXCR4 expression during terminal differentiation of memory B cells into plasma cells显示文摘 | Ruehlinghaus G Cigliano L Huehn S | 2005 | Blood2005，1，： | 1 |
| 4 | Elevation of plasma high-density lipoprotein concentration reduces interleukin-1- induced expression of E-selectin in an in vivo model of acute inflammation显示文摘 | Cockerill GW Huehns TY Weerasinghe A | 2001 | Circulation2001，103，： | 1 |
| 5 | Elevation of plasma high-density lipoprotein concentration reduces interleukin-1-induced expression of E-selecting in an in vivo model of acute inflammation显示文摘 | Cookerill GW Huehns TY Weerasinghc A | 2001 | Circulation2001，103，1： | 1 |
| 6 | Untersuchungen ueber die wirksamkeit unterschiedlicher PMSG-dosierungen zur brunststimulation yon altsauen in schweinezuchtbetrieben mit duldungsorientierter besamung显示文摘 | Roost H Berseck G Huehn U | 1982 | Mh Vet Med1982，37，： | 1 |
| 7 | 'sense and shoot' approach for photocatalytic degradation of organic contaminants in wa- ter显示文摘 | Kamat P V Huehn R Nicolaescu R A | 2002 | J Phys Chem2002，106，4： | 1 |
| 8 | Restenosis in human vein bypass grafts 显示文摘 | Nikol S Huehns TY Weir I | 1998 | Atherosclerosis1998，139，： | 1 |
| 9 | Homing to suppress:address codes for treg migration 显示文摘 | Huehn J Hamann A | 2005 | Trends Immunol2005，26，12： | 1 |
| 10 | Adventitia as a target for intravascular local drug delivery显示文摘 | Huehns TY Gonschior P Holfling B | 1996 | Heart1996，75，6： | 1 |
| 11 | Molecular Biology and Post-Angioplasty Restenosis显示文摘 | Nrkol S Huehns TY Hoffling B | 1996 | Atherosclerosis1996，，123： | 1 |
| 12 | To be or not to be a Treg cell: lineage de- cisions controlled by epigenetic mechanisms 显示文摘 | TOKER A HUEHN J | 2011 | Sei Signal2011，4，158： | 1 |
| 13 | Influ-ence of different lipid-lowering strategies on plaque volumeand plaque composition in patientswith coronary artery dis-ease:role of intravascular ultrasound imaging显示文摘 | Bocksch W Fateh-Moghadam S Huehns S | 2005 | Kidney Blood Press Res2005，28，56： | 1 |
| 14 | Molecular Biology and Post-Angiop- lasty Restenosis显示文摘 | Nrkol S Huehns TY Hoffiing B | 1996 | Atherosclerosis1996，123，12： | 1 |
| 15 | Needle injection catheter delivery of the gene for an antibacterial agent inhabits neointimal formation 显示文摘 | Nikol S Huehns TY Krausz E | 1999 | Gene Ther1999，6，5： | 1 |
| 16 | Needle injection catheter delivery of the gene for an antibacterial agent inhibits neointimal formation显示文摘 | Nikol S Huehns TY Krausz E | 1999 | Gene Ther1999，6，： | 1 |
| 17 | Virulotyping and antimicrobial resistance typing of Salmonella enterica serovars relevant to human health in Europe显示文摘 | HUEHN S LA RAGIONE R M ANJUM M | 2010 | Foodb Patho Dis2010，7，： | 1 |
| 18 | Prevalence of resistance against activated protein C resulting from factor V Leiden is significantly increased in myocardia infarction:investigation of 507 patients with myocardial infarction显示文摘 | Middendorf K Gohring P Huehns T Y | 2004 | Am Heart J2004，147，5： | 1 |
| 19 | Elevation of plasma high density lipoprotein concentration reduces interleukin-1-induced expression of E-selectin in an in vivo model of acute inflammation显示文摘 | Cockerill GW Huehns TY Weerasinghe A | 2001 | Circulation2001，103，： | 1 |
| 20 | Virulotyping andantimicrobial resistance typing of Salmonella enterica serovars relevant to human health in Europe 显示文摘 | Huehn S La Ragione R M Anjum M | 2010 | Foodborne Pathogens and Disease2010，7，5： | 1 |
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