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| 1 | Role of IL-10 and TGF-β1 in local immunosuppression in HPV-associated cervical neoplasia显示文摘Cervical cancer is a worldwide disease that constitutes a significant public health problem, especially in developing countries, not only due to its high incidence but also because the most affected population comprises women who belong to marginalized socio-economic classes. Clinical and molecular research has identified immunological impairment in squamous intraepithelial cervical lesions and cervical cancer patients. Human Papillomavirus(HPV) has several mechanisms for avoiding the immune system: it down-regulates the expression of interferon and upregulates interleukin(IL)-10and transforming growth factor(TGF)-β1 to produce a local immunosuppressive environment, which, along with altered tumor surface antigens, forms an immunosuppressive network that inhibits the antitumor immune response. In this review we analyzed the available data on several deregulated cellular immune functions in patients with NIC Ⅰ, NIC Ⅱ and NIC Ⅲ and cervical cancer. The effects of immunosuppressive cytokines on innate immune response, T-cell activation and cellular factors that promote tumor cell proliferation in cervical cancer patients are summarized. We discuss the functional consequences of HPV E2, E6, and E7 protein interactions with IL-10 and TGF-β1 promoters in the induction of these cytokines and postulate its effect on the cellular immune response in squamous intraepithelial cervical lesions and cervical cancer patients. This review provides a comprehensive picture of the immunological functions of IL-10 and TGF-β1 in response to HPV in humans. | Kirvis Torres-Poveda Margarita Bahena-Román Claudia Madrid-González Ana I Burguete-García Víctor Hugo Bermúdez-Morales Oscar Peralta-Zaragoza Vicente Madrid-Marina | 2014 | World Journal of Clinical Oncology2014，5，4： | 21 |
| 2 | Determination of the gum Arabic–chitosan interactions by Fourier Transform Infrared Spectroscopy and characterization of the microstructure and rheological features of their coacervates显示文摘 | Hugo Espinosa-Andrews Ofelia Sandoval-Castilla Humberto Vázquez-Torres Eduardo Jaime Vernon-Carter Consuelo Lobato-Calleros | 2009 | Carbohydrate Polymers2009，，3： | 2 |
| 3 | Glucose stimulation of transforming growth factor-beta bioactivity in mesangial cells is mediated by thrombospondin-1 显示文摘 | Poczatek MH Hugo C Darley-Usmar V | 2000 | Am J Pathol2000，157，4： | 1 |
| 4 | Smith Psammoma booties in meningioma显示文摘 | Hugo V R Juno D R Donald R | 1978 | Virchows Archly1978，380，4： | 1 |
| 5 | Rapid and efficient purification of hepatitis A virus from cell culture显示文摘 | Bishop N E Hugo D L Borovec S V | 1994 | J Virol Method1994，47，： | 1 |
| 6 | Rapid and efficient purification of hepatitis A virus from cell culture 显示文摘 | Bishop N E Hugo D L Borovec S V | 1994 | J Virol Method1994，47，： | 1 |
| 7 | Wear particle classifier system based on an artificial neural network显示文摘 | GONCALVES V D ALMEIDA L F HUGO M | 2010 | Journal of Mechanical Engineering2010，56，4： | 1 |
| 8 | Radiographic characteristics of furcation involvements in mandibular molars as prognostic indicators of healing after nonsurgical periodontal therapy显示文摘 | HUGO F D V 6RIEA D P R SANDRO B | 2009 | J Am Dent Assoc2009，140，4： | 1 |
| 9 | Glucose stimulation of transforming growth factor-beta bioactivity in mesangial cells is mediated by thrombospondin-1 显示文摘 | Poczatek MH Hugo C Darley-Usmar V | 2000 | Am J Pathol2000，157，4： | 1 |
| 10 | Rapid and efficient purification of hepatitis A virus from cell culture显示文摘 | Bishop N E Hugo D L Borovec S V | 1994 | J Virol Method1994，47，： | 1 |
| 11 | Mega-eorridors in north-west Eu- rope:Issues for transnational spatial governance显示文摘 | JOCHEM V HUGO P | 2003 | Journal of Transport Geography2003，，11： | 1 |
| 12 | Using mechanical processing in recycling printed wiring boards显示文摘 | HUGO M V ANDREA M B | 2002 | JOM Journal of the Minerals Metals and Materials Society2002，54，6： | 1 |
| 13 | Hydrogen distribution network optimization:a refinery case study显示文摘 | Fonseca André Sá Ví tor Bento Hugo Tavares Manuel L C Pinto Gilberto Gomes Luí sa A C N | 2008 | Journal of Cleaner Production2008，16，16： | 1 |
| 14 | Glucose stimulation of TGF-? activity in MCs is mediated by thrombospondin-1 显示文摘 | Poczatek M Hugo C Darley-Usmar V | 2000 | AmJ Pathol2000，157，4： | 1 |
| 15 | Propofol does not inhibithypoxic pulmonary vasoconstriction in humans 显示文摘 | Luc VK Hugo VA Eugene V | 1989 | J Clin Anesth1989，1，1： | 1 |
| 16 | Distribution of human papillom avirus in a family planning population in nairobi, kenya显示文摘 | HUGO D SOPHIA S T LIEVE V R | 2003 | Sexually Transmitted Diseases2003，30，2： | 1 |
| 17 | T-cell depletion and graft survival induced by anti-human CD3 immunotoxins in human CD3 epsilon transgenic mice 显示文摘 | Weetall M Digan ME Hugo R Mathew S Hopf C Tart-Risher N Zhang J Shi V Fu F Hammond-McKibben D West S Brack R Brinkmann V Bergman R Neville D Jr Lake P | 2002 | Transplantation2002，73，10： | 1 |
| 18 | Influence of relative binding affinity on efficacy in a panel of anti-CD3 scFv immunotoxins显示文摘 | Hexham JM Dudas D Hugo R Thompson J King V Dowling C Neville DM Jr Digan ME Lake P | 2001 | Mol Immunol2001，38，5： | 1 |
| 19 | Leaf gas exchange, chloroplastic pigments and dry matter accumulation in castor bean(Ricinus communis L)seedlings subjected to salt stress conditions 显示文摘 | Hugo A P Jos6 V S Laurcio E | 2008 | Industrial Crops and Products2008，27，3： | 1 |
| 20 | Glucose stimulation of transforming growth factor-beta bioactivity in mesangial cells is mediated by thrombospondin-1 显示文摘 | Poczatek MH Hugo C Darley-Usmar V | 2000 | Am J Pathol2000，157，4： | 1 |
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