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| 1 | Neutrophil-lymphocyte ratio:A prognostic tool in patients with inhospital cardiac arrest显示文摘BACKGROUND In-hospital cardiac arrest(IHCA) portends a poor prognosis and survival to discharge rate. Prognostic markers such as interleukin-6, S-100 protein and high sensitivity C reactive protein have been studied as predictors of adverse outcomes after return of spontaneous circulation(ROSC); however; these variables are not routine laboratory tests and incur additional cost making them difficult to incorporate and less attractive in assessing patient's prognosis. The neutrophil-lymphocyte ratio(NLR) is a marker of adverse prognosis for many cardiovascular conditions and certain types of cancers and sepsis. We hypothesize that an elevated NLR is associated with poor outcomes including mortality at discharge in patients with IHCA.AIM To determine the prognostic significance of NLR in patients suffering IHCA who achieve ROSC.METHODS A retrospective study was performed on all patients who had IHCA with the advanced cardiac life support protocol administered in a large urban community United States hospital over a one-year period. Patients were divided into two groups based on their NLR value(NLR < 4.5 or NLR ≥ 4.5). This cutpoint was derived from receiving operator characteristic curve analysis(area under the curve = 0.66) and provided 73% positive predictive value, 82% sensitivity and42% specificity for predicting in-hospital death after IHCA. The primary outcome was death or discharge at 30 d, whichever came first.RESULTS We reviewed 153 patients with a mean age of 66.1 ± 16.3 years; 48% were female.In-hospital mortality occurred in 65%. The median NLR in survivors was 4.9(range 0.6-46.5) compared with 8.9(0.28-96) in non-survivors(P = 0.001). A multivariable logistic regression model demonstrated that an NLR above 4.55[odds ratio(OR) = 5.20, confidence interval(CI): 1.5-18.3, P = 0.01], older age(OR= 1.03, CI: 1.00-1.07, P = 0.05), and elevated serum lactate level(OR = 1.20, CI:1.03-1.40, P = 0.02) were independent predictors of death.CONCLUSION An NLR ≥ 4.5 may be a useful marker of increased risk of death in patients with IHCA. | Vishal H Patel Philip Vendittelli Rajat Garg Susan Szpunar Thomas LaLonde John Lee Howard Rosman Rajendra H Mehta Hussein Othman | 2019 | World Journal of Critical Care Medicine2019，8，2： | 5 |
| 2 | HepG2 cells support viral replication and gene expression of hepatitis C virus genotype 4 in vitro显示文摘瞄准:与丙肝的长期的复制建立一个房间文化系统病毒(HCV ) 染色体和病毒的抗原的表示在试管内。方法:HepG2 房间线被孵化与长期的丙肝从一个病人与浆液为它的危险性测试到 HCV。房间和上层清液在文化期间在各种各样的时间点被收获。文化上层清液为它感染天真的房间的能力被测试。存在减(反感觉) 在房间的核心和 E1 抗原的 RNA 海滨,和察觉被 RT-PCR 和免疫学的技术(流动血细胞计数和西方的污点) 分别地检验。结果:细胞内部的 HCV RNA 首先在 d 上被检测 3 在感染以后然后能一致地在至少三个月的一个时期上在房间和上层清液被检测。新鲜房间能从有教养的感染的房间感染上层清液。流动 cytometric 分析证明表面和在房子里使用的细胞内部的 HCV 抗原表示使 polyclonal 成为了抗体(反核心,和 anti-E1 ) 。西方的污点分析证明在分子量的产生免疫性的肽的簇的表示在一个月内在 31 和 45 kDa 之间延长了感染的房间的旧文化而这簇在 uninfected HepG2 房间是无法发现的。结论:HepG2 房间线产生 HCV 感染而且支持它的复制在试管内不仅。HCV 结构的蛋白质的表示能在感染的 HepG2 房间被检测。这些房间也能够流病毒的粒子进接着对 uninfected 房间变得传染的培养基。 | Mostafa K El-Awady Ashraf A Tabll Yasmine S El-Abd Mahmoud M Bahgat Hussein A Shoeb Samar S Youssef Noha G Bader El Din El-Rashdy M Redwan Maha El-Demellawy Moataza H Omran Wael T El-Garf Said A Goueli | 2006 | World Journal of Gastroenterology2006，12，30： | 2 |
| 3 | The quality of water and sediments of street runoff in Amman, Jordan显示文摘 | Jiries A G Hussein H H Halash Z | 2001 | Hydrological Processes2001，15，： | 2 |
| 4 | Theoretical and Experimental Investigation of Wickless Heat Pipes Flat Plate Solar Collector with Cross Flow Heat Exchanger 显示文摘 | Hussein H M S | 2007 | Energy Conversion & Management2007，48，： | 1 |
| 5 | Toxicology显示文摘 | Hussein H S Brasel J M | 2001 | 167(2) : 1012001，167，2： | 1 |
| 6 | Anti-cyclic citrullinated peptide (anti-CCP) antibody in juvenile idiopathic arthritis (JIA):correlations with discase activity and scverity of joint damage (a multicenter trial)显示文摘 | Omar A Abo-Elyoun I Hussein H | | 0，，： | 1 |
| 7 | Bondbehavior and assessment of design ultimate bond stressof normal and high strength concrete 显示文摘 | Diab A M Elyamany H E Hussein M A | 2014 | AlexandriaEngineering Journal2014，53，2： | 1 |
| 8 | Synthesis and Anfimicrobial Activity of Certain New 1,2,4- Triazolo pyrimidine Derivatives 显示文摘 | MOSTAFA Y A H HUSSEIN M A RADWAN A A | 2008 | Arch Pharmacal Res2008，31，3： | 1 |
| 9 | Cyanidin 3-glucoside modulated cell cycle progression in liver precancerous lesion,in vivo study显示文摘BACKGROUND Cyanidin-3-O-glucoside(cyan)exhibits antioxidant and anticancer properties.The cell cycle proteins and antimitotic drugs might be promising therapeutic targets in hepatocellular carcinoma.AIM To investigate the effect of cyan administration on cell cycle in hepatic precancerous lesion(PCL)induced by diethylnitrosamine/2-acetylaminofluorene(DEN/2-AAF)in Wistar rats.METHODS In vivo,DEN/2-AAF-induced hepatic PCL,rats were treated with three doses of cyan(10,15,and 20 mg/kg/d,for four consecutive days per week for 16 wk).Blood and liver tissue samples were collected for measurement of the followings;alpha fetoprotein(AFP)liver function and RNA panel differential expression was evaluated via real time polymerase chain reaction.Histopathological examination of liver sections stained with H&E and immunohistochemical study using glutathione S-transferase placental(GSTP)and proliferating cell nuclear antigen(PCNA)antibodies were assessed.RESULTS Cyan administration mitigated the effect of DEN/2-AFF induced PCL,decreased AFP levels,and improved liver function.Remarkably,treatment with cyan dose dependently decreased the long non-coding RNA MALAT1 and tubulin gamma 1 mRNA expressions and increased the levels of miR-125b,all of which are involved in cell cycle and mitotic spindle assembly.Of note,cyan decreased GSTP foci percent area and PCNA positively stained nuclei.CONCLUSION Our results indicated that cyan could be used as a potential therapeutic agent to inhibit liver carcinogenesis in rat model via modulation of cell cycle. | Marwa Matboli Amany H Hasanin Reham Hussein Sarah El-Nakeep Eman K Habib Rawan Ellackany Lobna A Saleh | 2021 | World Journal of Gastroenterology2021，27，14： | 1 |
| 10 | Time span and spatial scale of regional new particle formation events over Finland and Southern Sweden 显示文摘 | Hussein T Junninen H Tunved P | 2009 | Atmospheric Chemistry and Physics2009，9，4： | 1 |
| 11 | Phytoremediation of organo mercurial compounds via chloroplast genetic engineering 显示文摘 | Oscar N R Hussein S H Norman T | 2003 | Plant Physiology2003，132，2： | 1 |
| 12 | Effect of dietary protein and energy levels on pullet development 显示文摘 | HUSSEIN A S CANTOR A H PESCATORE A J | 1996 | Poultry Science1996，75，8： | 1 |
| 13 | Enclosure losses in high power systems 显示文摘 | RYFF P F FAWZI T H HUSSEIN A M | 1994 | IEEE Trans1994，30，6： | 1 |
| 14 | Carbapenem resistance among Klebsiella pneumoniae isolates: risk factors, molecular characteristics, and susceptibility patterns显示文摘 | Hussein K Sprecher H Mashiach T | 2009 | Infect Control Hosp gpidemiol2009，30，7： | 1 |
| 15 | A numerical model for calculating vibration from a railway tunnel embedded in a full-space显示文摘 | Hussein M F M Hunt H E M | 2007 | Journal of Sound and Vibration2007，305，3： | 1 |
| 16 | Phytoreme- diation of organomercurial compounds via chloroplast genetic engineering显示文摘 | Oscar N R Hussein S H Norman T | 2003 | Plant Physiology2003，132，13： | 1 |
| 17 | Maximum photovohaic power tracking: an algorithm for rapidly changing atmospheric conditions显示文摘 | HUSSEIN K H MUTA I OSAKADA M | 1995 | IEEE Proceedings- Generation Transmission and Distribution1995，142，1： | 1 |
| 18 | Maximum photovohaic power tracking: an algorithm for rapidly changing atm - ospherie conditions 显示文摘 | HUSSEIN K H | 1995 | IEEE Proceedings of Generation Transmission and Distribution1995，142，1： | 1 |
| 19 | Photo - fabricated un- saturated polyester resin composites reinforced by kenaf fibers, syn- thesis and characterization 显示文摘 | Hussein M A Tay G S Rozman H D | 2012 | Journal of Applied Polymer Sci- ence2012，123，2： | 1 |
| 20 | Tannins from the leaves of Punica granatum显示文摘 | Hussein S A M Barakat H H Merfort I | 1997 | Phyto- chemistry1997，45，4： | 1 |
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