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| 1 | PD-L1 and PD-L2 expression correlated genes in non-small-cell lung cancer显示文摘Background:Programmed cell death ligand-1(PD-L1)and ligand-2(PD-L2)interaction with programmed cell death protein-1(PD-1)represent an immune-inhibiting checkpoint mediating immune evasion and is,accordingly,an important target for blockade-based immunotherapy in cancer.In non-small-cell lung cancer(NSCLC),improved understanding of PD-1 checkpoint blockade-responsive biology and identification of biomarkers for prediction of a clinical response to immunotherapy is warranted.Thus,in the present study,we systematically described PD-L1 and PD-L2 expression correlated genes in NSCLC.Methods:We performed comparative retrospective analyses to identify PD-L1 and PD-L2 mRNA expression corre-lated genes in NSCLC.For this,we examined available datasets from the cancer cell line encyclopedia(CCLE)project lung non-small-cell(Lung_NSC)and the cancer genome atlas(TCGA)projects lung adenocarcinoma(LUAD)and squamous cell carcinoma(LUSC).Results:Analysis of the CCLE dataset Lung_NSC identified expression correlation between PD-L1 and PD-L2.Moreo-ver,we identified expression correlation between 489 genes and PD-L1,191 genes and PD-L2,and 111 genes for both.PD-L1 and PD-L2 also expression correlated in TCGA datasets LUAD and LUSC.In LUAD,we identified expression corre-lation between 257 genes and PD-L1,914 genes and PD-L2,and 211 genes for both.In LUSC,we identified expression correlation between 26 genes and PD-L1,326 genes and PD-L2,and 13 genes for both.Only a few genes expression correlated with PD-L1 and PD-L2 across the CCLE and TCGA datasets.Expression of Interferon signaling-involved genes converged in particular with the expression correlated genes for PD-L1 in Lung_NSC,for PD-L2 in LUSC,and for both PD-L1 and PD-L2 in LUAD.In LUSC,PD-L1,and to a lesser extent PD-L2,expression correlated with chromosome 9p24 localized genes,indicating a chromosome 9p24 topologically associated domain as an important driver of in particu-lar LUSC PD-L1 expression.Expression correlation analyses of the PD-L1 and PD-L2 receptors programmed cell death protein-1(PD-1),Cluster of differentiation 80(CD80),and Repulsive guidance molecule B(RGMB)showed that PD-1 and CD80 expression correlated with both PD-L1 and PD-L2 in LUAD.CD80 expression correlated with PD-L2 in LUSC.Conclusions:We present gene signatures associated with PD-L1 and PD-L2 mRNA expression in NSCLC which could possess importance in relation to understand PD-1 checkpoint blockade-responsive biology and development of gene signature based biomarkers for predicting clinical responses to immunotherapy. | Trine Vilsbøll Larsen Dianna Hussmann Anders Lade Nielsen | 2019 | Cancer Communications2019，39，1： | 7 |
| 2 | Real-time motion artifact suppression in tof camera systems显示文摘 | HUSSMANN S HENABSKI A EDELER T | 2011 | IEEE Transactionson Instrumentation and Measurement2011，60，5： | 1 |
| 3 | Extended combustion model for single boron particles (Ⅱ) : Validation 显示文摘 | Hussmann B Pfitzner M | 2010 | Combus- tion andFlame2010，157，： | 1 |
| 4 | Study of two-stage processes for the microbial production of 1,3-propanediol from glucose显示文摘 | Hartlep M Hussmann W Prayitno N | 2002 | Appl Microbiol Biotechnol2002，，60： | 1 |
| 5 | Improved power flow control for contact-less moving sensor applications 显示文摘 | HU A P HUSSMANN S | 2004 | IEEE Power Electronics Letters2004，12，4： | 1 |
| 6 | Improved power flow control for con- tactless moving sensor applications显示文摘 | Hu A P Hussmann S | 2004 | IEEE Power Electronics Letters2004，2，4： | 1 |
| 7 | Study of two stage processes for the microbial production of 1,3-propanediol from glucose显示文摘 | Hartlep M Hussmann W Prayitno N | 2002 | Appl Microbiol Biotechnal2002，60，1： | 1 |
| 8 | Prehospital and early in hospital management of severe injuries:changes and trends显示文摘 | Hussmann B Lendemans S | 2014 | Injury2014，45，3： | 1 |
| 9 | Improved power flow control for contact-less moving sensor applications显示文摘 | HU A P HUSSMANN S | 2004 | IEEE Power Electronics Letters2004，12，4： | 1 |
| 10 | Arterialization of epigastric skim flaps in rabbits显示文摘 | Hussmann J | 1986 | Chir Plastics1986，8，2： | 1 |
| 11 | Transport of amino acids with special emphasis on the synthesis and transport of asparagine in the illinois low protein and illinois high protein strains of maize显示文摘 | Lohaus G Büker M Hussmann M | 1998 | Planta1998，205，2： | 1 |
| 12 | Improved power flow control for contactless moving sensor applications显示文摘 | Hu A P Hussmann S | 2004 | IEEE Power Electronics Letters2004，2，4： | 1 |
| 13 | Diagnosis and therapy of calcifying intramuscular hemangiomas of the low extremity显示文摘 | Hussmann J Bosse A Steinau HU | 1997 | Zentralbl Chir1997，122，9： | 1 |
| 14 | A dynamically on-off controlled resonant converter designed for coal mining battery charging applications显示文摘 | Hu A P Chen Z J Hussmann S | 2002 | Power System Technology2002，2，： | 1 |
| 15 | A high-speed subpixel edge detector implementation inside a FPGA 显示文摘 | Hussmann S Ho T H | 2003 | Real-Time Imaging2003，9，5： | 1 |
| 16 | Improved power flow control for contactless moving sensor applications显示文摘 | Hu A P Hussmann S | 2004 | IEEE Power Electronics Letters2004，2，4： | 1 |
| 17 | Arterialization of epigastric skim flaps in rabbits显示文摘 | Hussmann J | 1986 | Chir Plastics1986，8，17： | 1 |
| 18 | Does increased prehospital replacement volume lead to a poor clinical course and an increased mortality? A matched-pair analysis of 1896 patients of the Trauma Registry of the German Society for Trauma Surgery who were managed by an emergency doctor at the accident site显示文摘 | Hussmann B Lefering R Waydhas C | 2013 | Injury2013，44，5： | 1 |
| 19 | A dynamically on-off controlled resonant converter designed for coal mining bat-tery charging applications显示文摘 | Chen Z J Hussmann S etal | 2002 | Power System Technology2002，，2： | 1 |
| 20 | A Miero-computer Controlled ICPT Power Pick-up and Its EMC Considerations for Moving Sen-sor Applieafions显示文摘 | Hu P A | 2002 | Power System Technology2002，，2： | 1 |
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