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| 1 | Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable?显示文摘AIM: To establish the diagnostic performance of sev-eral serological tests, individually and in combination, for diagnosing celiac disease (CD) in patients with different pretest probabilities, and to explore potential se- rological algorithms to reduce the necessity for biopsy. METHODS: We prospectively performed duodenal biopsy and serology in 679 adults who had either high risk (n = 161) or low risk (n = 518) for CD. Blood samples were tested using six assays (enzyme-linked immunosorbent assay) that detected antibodies to tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP). RESULTS: CD prevalence was 39.1% in the high-risk population and 3.3% in the low-risk group. In high-risk patients, all individual assays had a high diagnostic efficacy [area under receiving operator characteristic curves (AU ROC): 0.968 to 0.999]. In contrast, assays had a lower diagnostic efficacy (AU ROC: 0.835 to 0.972) in the low-risk group. Using assay combinations, it would be possible to reach or rule out diagnosis of CD without biopsy in 92% of cases in both pretest populations. We observed that the new DGP/tTG Screen assay resulted in a surplus compared to more conventional assays in any clinical situation. CONCLUSION: The DGP/tTG Screen assay could be considered as the best initial test for CD. Combinations of two tests, including a DGP/tTG Screen, might be able to diagnose CD accurately in different clinical scenarios making biopsy avoidable in a high proportion of subjects. | Emilia Sugai María L Moreno Hui J Hwang Ana Cabanne Adriana Crivelli Fabio Nach-man Horacio Vázquez Sonia Niveloni Julio Argonz Roberto Mazure Graciela La Motta María E Caniggia Edgardo Smecuol Néstor Chopita Juan C Gómez Eduardo Maurińo Julio C Bai | 2010 | World Journal of Gastroenterology2010，16，25： | 4 |
| 2 | Sperm counts and sperm sex ratio in male infertility patients显示文摘在最近的年里,调查者在许多工业化国家向男出生的一个衰退比例注意了一个趋势。当人们忍受决定性的染色体时,它与授精或流产相关的女搭挡的角色可以也改变性比率。我们试图由直接检验他的精子的性染色体决定一个人的第二等的性比率(F1 产生) 。我们为在 situ 杂交(鱼) 经历了精液荧光的所有人检验了我们的男不孕诊所数据库。人口统计的病人和精液参数被记录。摆平 Chi 的分析被用来比较性比率(Y 染色体 / 总数染色体) 。Multivariable 逻辑回归被用来预言在财务以后拥有一个忍受 Y 精子为的机会人口统计并且精液参数。185 个人的一个总数经历了精子鱼。为全部队, Y 忍受染色体的精子的比例是 51.5 %。有不到 500 万个能动精子的人有 Y 忍受染色体的精子的一个显著地更低的比例(50.8 %) 与有更高的精子计数的人相比(51.6 %P=0.02 ) 。在 multivariable 调整以后,更高的精子集中,全部的能动精子计数和精液体积显著地增加了有 Y 的机会忍受染色体的精子(P< 0.01 ) 。作为一个人的精子生产衰落,那么做 Y 忍受染色体的精子的比例。因此,一个人的繁殖潜力可以预言他的能力到陛下男性后代。 | Michael L Eisenberg Lata Murthy Kathleen Hwang Dolores J Lamb Larry I Lipshultz | 2012 | Asian Journal of Andrology2012，14，5： | 3 |
| 3 | Multicenter evaluation of recurrence in endoscopic submucosal dissection and endoscopic mucosal resection in the colon:A Western perspective显示文摘BACKGROUND While colon endoscopic mucosal resection(EMR)is an effective technique,removal of larger polyps often requires piecemeal resection,which can increase recurrence rates.Endoscopic submucosal dissection(ESD)in the colon offers the ability for en bloc resection and is well-described in Asia,but there are limited studies comparing ESD vs EMR in the West.AIM To evaluate different techniques in endoscopic resection of large polyps in the colon and to identify factors for recurrence.METHODS The study is a retrospective comparison of ESD,EMR and knife-assisted endoscopic resection performed at Stanford University Medical Center and Veterans Affairs Palo Alto Health Care System between 2016 and 2020.Knife-assisted endoscopic resection was defined as use of electrosurgical knife to facilitate snare resection,such as for circumferential incision.Patients≥18 years of age undergoing colonoscopy with removal of polyp(s)≥20 mm were included.The primary outcome was recurrence on follow-up.RESULTS A total of 376 patients and 428 polyps were included.Mean polyp size was greatest in the ESD group(35.8 mm),followed by knife-assisted endoscopic resection(33.3 mm)and EMR(30.5 mm)(P<0.001).ESD achieved highest en bloc resection(90.4%)followed by knife-assisted endoscopic resection(31.1%)and EMR(20.2%)(P<0.001).A total of 287 polyps had follow-up(67.1%).On follow-up analysis,recurrence rate was lowest in knife-assisted endoscopic resection(0.0%)and ESD(1.3%)and highest in EMR(12.9%)(P=0.0017).En bloc polyp resection had significantly lower rate of recurrence(1.9%)compared to non-en bloc(12.0%,P=0.003).On multivariate analysis,ESD(in comparison to EMR)adjusted for polyp size was found to significantly reduce risk of recurrence[adjusted hazard ratio 0.06(95%CI:0.01-0.57,P=0.014)].CONCLUSION In our study,EMR had significantly higher recurrence compared to ESD and knife-assisted endoscopic resection.We found factors including resection by ESD,en bloc removal,and use of circumferential incision were associated with significantly decreased recurrence.While further studies are needed,we have demonstrated the efficacy of ESD in a Western population. | Mike T Wei Margaret J Zhou Andrew A Li Andrew Ofosu Joo Ha Hwang Shai Friedland | 2023 | World Journal of Gastrointestinal Endoscopy2023，15，6： | 2 |
| 4 | Electrical properties of the 85% Bi2 Te3 - 15% Bi2 Se3 thermoelectric material doped with SbI3 and CuBr显示文摘 | Hyun D B Hwang J S Oh T S | 1998 | J Phys Chem Solids1998，59，67： | 2 |
| 5 | Ultrasonic tissue characterization evaluates myocardial viability and ischemia in patients with coronary artery disease显示文摘 | LIN L C YEN R F HWANG J J | 2000 | Ultrasound Med Biol2000，26，5： | 2 |
| 6 | Radium tracing of submarine groundwater discharge (SGD) and associated nutrient fluxes in a highly-permeable bed coastal zone, Korea 显示文摘 | Kim G Ryu J W Hwang D W | 2008 | Marine Chemistry2008，，109： | 1 |
| 7 | Improvements in sintered density and dimensional stability of powder injection-molded 316L compacts by adjusting the alloying compositions显示文摘 | Shu G J Hwang K S Pan Y T | 2006 | Acta Materialia2006，54，2006： | 1 |
| 8 | Identification and differential expression of novel human cervical cancer oncogene HCCR-2 in human cancers and its involvement in P53 stabilization显示文摘 | KO J LEE Y H HWANG S Y | 2003 | Oncogene2003，22，： | 1 |
| 9 | Finite element modeling of magnetic field/defect interactions 显示文摘 | Hwang J H Lord W | 1975 | Journal of Testing & Evaluation (S0090-3973)1975，3，1： | 1 |
| 10 | An anti-apoptotic protein human survivin is a direct inhibitor of Caspase-3 and-7显示文摘 | Sung B J Cho YS Kim H J Ha NC Hwang JI | 2001 | Biochenistry2001，40，4： | 1 |
| 11 | Human papillomavirus type 16 E7 binds to E2F1 and activates E2F1-driven transcription in a retinoblastoma protein-independent manner显示文摘 | Lee D Kim J | 2002 | J Biol Chem2002，277，4： | 1 |
| 12 | Improved set estimators for a multivariate normal mean显示文摘 | Casella G | 1984 | Statistics & Decisions Supplement Issue1984，，1： | 1 |
| 13 | Wind-induced vibration of high-rise building with tuned mass damper including soil-structure interaction显示文摘 | Liu M Y Chiang W L Hwang J H Chu C R | 2008 | Journal of Wind Engineering and Industrial Aerodynamics2008，96，： | 1 |
| 14 | Spectroscopic and chemical-kinetic analysis of the phases of HCCI autoignition and combustion for single-and two-stage ignition fuels 显示文摘 | Hwang W Dec J Sjoberg M | 2008 | Combustion and Flame2008，154，： | 1 |
| 15 | Landscape ecological approach to the relationships of land use patterns in watersheds to water quality characteristics 显示文摘 | Lee S W Hwang S J Lee S B | 2009 | Landscape and Urban Planning2009，92，： | 1 |
| 16 | Comparison of ecotourism policies and implications for China's ecotourism development 显示文摘 | Wang S Heo J Yamada N Hwang S T | 2009 | Journal of China Tourism Research2009，5，3： | 1 |
| 17 | Design of integrated chassis control logics for AFS and ESP显示文摘 | Hwang T H Park K Heo S J | 2008 | International Journal of Automotive Technology2008，9，1： | 1 |
| 18 | TGF-beta1 induces cardiac hypertrophic responses via PKC-dependent ATF-2 activation显示文摘 | LIM J Y PARK S J HWANG H Y | 2005 | J Mol Cell Cardiol2005，39，4： | 1 |
| 19 | Fabrication of WC- Co coatings by cold spray deposition 显示文摘 | Kim H J Lee C H Hwang S Y | 2005 | Surface and Coatings Technology2005，191，23： | 1 |
| 20 | Enhanced production of manganese per-oxidase from immobilized Phanerochaete chrysosporium due to the increased autolysis of chlamydospore-like cells显示文摘 | Chung Oh J Hwang S | 2005 | Biotechnology Letters2005，27，： | 1 |
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