|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Microbiota-host interactions in irritable bowel syndrome: Epithelial barrier, immune regulation and brain-gut interactions显示文摘Irritable bowel syndrome(IBS) is a common, sometimes debilitating, gastrointestinal disorder worldwide. While altered gut motility and sensation, as well as aberrant brain perception of visceral events, are thought to contribute to the genesis of symptoms in IBS, a search for an underlying aetiology has, to date, proven unsuccessful. Recently, attention has been focused on the microbiota as a possible factor in the pathogenesis of IBS. Prompted by a number of clinical observations, such as the recognition of the de novo development of IBS following enteric infections, as well as descriptions of changes in colonic bacterial populations in IBS and supported by clinical responses to interventions, such as antibiotics and probiotics, that modify the microbiota, various approaches have been taken to investigating the microbiota-host response in IBS, as well as in animal models thereof. From such studies a considerable body of evidence has accumulated to indicate the activation or upregulation of both factors involved in bacterial engagement with the host as well host defence mechanisms against bacteria. Alterations in gut barrier function, occurring in response, or in parallel, to changes in the microbiota, have also been widely described and can be seen to play a pivotal role in generating and sustaining host immune responses both within and beyond the gut. In this manner a plausible hypothesis, based on an altered microbiota and/or an aberrant host response, for the pathogenesis, of at least some instances of IBS, can be generated. | Niall P Hyland Eamonn MM Quigley Elizabeth Brint | 2014 | World Journal of Gastroenterology2014，20，27： | 22 |
| 2 | Hooking the reader:A corpus study of evaluative that in abstracts显示文摘 | HYLAND K TSE P | 2005 | English for Specific Purposes2005，，2： | 1 |
| 3 | Grainyhead-like 2 (GRHL2) distribution reveals novel pathophysiological differences between human idiopathic pulmonary fibrosis and mouse models of pulmonary fibrosis显示文摘 | Varma S Mahavadi P Sasikumar S Cushing L Hyland T Rosser A E | 2014 | Am J Physiol Lung Cell Mol Physiol2014，306，： | 1 |
| 4 | Exploration and exploitation: The interplay between knowledge and continuous innovation显示文摘 | Soosay C Hyland P | 2008 | International Journal of Technology Management2008，42，12： | 1 |
| 5 | Expression of Wilms tumor gene(WT1) in epithelial ovarian cancer显示文摘 | Hylander B Repasky E Shrikant P | 2006 | Gynecol Oncol2006，101，1： | 1 |
| 6 | Comparisons of sediment toxicity with predictions based on chemical guidelines 显示文摘 | Connor T P O Daskalakis K D Hyland J L | 1998 | Environmental Toxicology and Chemistry1998，17，3： | 1 |
| 7 | Hooking the reader: A corpus study of evaluative that in abstracts 显示文摘 | Hyland K & Tse P | 2005 | English for specific purposes2005，，2： | 1 |
| 8 | Metadiscourse in academic writing: a reappraisal 显示文摘 | Hyland K Tse P | 2004 | Applied Linguistics2004，25，2： | 1 |
| 9 | Studies on the biosynthesis of taxol: the taxane carbon skeleton is not of mevalonoid origin 显示文摘 | Eisenreich W Menhard B Hylands P J | 1996 | Proceedings of the National Academy of Sciences1996，93，13： | 1 |
| 10 | Taxoids from cell culture of Taxus chinensis 显示文摘 | MENHARD B EISENREICH W HYLANDS P J | 1998 | Phytochemistry1998，49，1： | 1 |
| 11 | Expression of Wilms tumor gene (WT1) in epithelial ovarian cancer显示文摘 | Hylander B Repasky E Shrikant P | 2006 | Gynecol Oncol2006，101，1： | 1 |
| 12 | Strategy and continuous improvement in small-to-medium Australian manufactures显示文摘 | CHAPMAN R HYLAND P | 2000 | Integrated manufacturing systems2000，11，3： | 1 |
| 13 | Is there an 'academic vocabulary'? 显示文摘 | Hyland K Tse P | 2007 | TESOL Quarterly2007，41，2： | 1 |
| 14 | Organizational Learning Barriers in Distributed Product Development: Observations From a Multinational Corporation 显示文摘 | Gieskes J F B Hyland P W Magnusson M G | 2002 | Journal of Workplace Learning2002，14，78： | 1 |
| 15 | Maternal separation as a model of brain-gut axis dysfunction显示文摘 | O'Mahony S M Hyland N P Dinan T G | 2011 | Psychopharmacology (Berl)2011，214，1： | 1 |
| 16 | Continuous innovation in a complex and dynamic environment: the case of the Australian health service 显示文摘 | Davison G Hyland P | 2006 | International Journal of Technology Management and Sustainable Development2006，5，1： | 1 |
| 17 | Alternative mechanisms of increased eggshell hardness of avian brood parasites relative to host species显示文摘 | Igic B Braganza K Hyland MM Silyn-Roberts H Cassey P Grim T Rutila J Moskát C Hauber ME | | 0，，： | 1 |
| 18 | Evaluative that construc- tions-signaling stance in research abstracts 显示文摘 | HYLAND K TSE P | 2005 | Functions of Language2005，，1： | 1 |
| 19 | Generalguidelines for using the sediment quality triad显示文摘 | Chapman P M Hyland J Ingersoll C | 1997 | Marine Pollution Bulletin1997，，34： | 1 |
| 20 | Ma- ternal separation as a model of brain-gut axis dysfunction 显示文摘 | Siobhain M O' Mahony Niall P Hyland Timothy G | 2011 | Psychopharmacology2011，214，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员