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	题名	作者	年代	出处	被引量
1	Biofilm three-dimensional architecture influences in situ pH distribution pattern on the human enamel surface显示文摘To investigate how the biofilm three-dimensional(3D) architecture influences in situ pH distribution patterns on the enamel surface. Biofilms were formed on human tooth enamel in the presence of 1% sucrose or 0.5% glucose plus 0.5% fructose. At specific time points, biofilms were exposed to a neutral pH buffer to mimic the buffering of saliva and subsequently pulsed with 1% glucose to induce re-acidification. Simultaneous 3D pH mapping and architecture of intact biofilms was performed using two-photon confocal microscopy. The enamel surface and mineral content characteristics were examined successively via optical profilometry and microradiography analyses. Sucrose-mediated biofilm formation created spatial heterogeneities manifested by complex networks of bacterial clusters(microcolonies). Acidic regions(pH<5.5) were found only in the interior of microcolonies,which impedes rapid neutralization(taking more than 120 min for neutralization). Glucose exposure rapidly re-created the acidic niches, indicating formation of diffusion barriers associated with microcolonies structure. Enamel demineralization(white spots),rougher surface, deeper lesion and more mineral loss appeared to be associated with the localization of these bacterial clusters at the biofilm-enamel interface. Similar 3D architecture was observed in plaque-biofilms formed in vivo in the presence of sucrose. The formation of complex 3D architectures creates spatially heterogeneous acidic microenvironments in close proximity of enamel surface, which might correlate with the localized pattern of the onset of carious lesions(white spot like) on teeth.	Jin Xiao Anderson T Hara Dongyeop Kim Domenick T Zero Hyun Koo Geelsu Hwang	2017	International Journal of Oral Science2017，9，2：	4
2	Electrical properties of the 85% Bi2 Te3 - 15% Bi2 Se3 thermoelectric material doped with SbI3 and CuBr显示文摘	Hyun D B Hwang J S Oh T S	1998	J Phys Chem Solids1998，59，67：	2
3	A numerical study of three dimensional natural convection in a differentially heated cubical enclosure 显示文摘	Fusegi T Hyun J M Kuwahara K	1991	International Journal of Heat Mass Transfer1991，34，：	2
4	Evaluation of recovery characteristic of acidic and alkaline solutions from NaNO3 using conventional eleetrodialysis and eleetrodialysis with bipolar membranes显示文摘	KIM K W HYUN J T LEE K Y	2013	Korean Journal of Chemical Engineering2013，30，9：	1
5	HIPI and HIPlr stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domains显示文摘	Hyun T S Rao D S Saint-Dic D Michael L E Kumar P D Bradley S V Mizukami I F		0，，14：	1
6	Comparative ge- nomic analysis of mitogen activated protein kinase gene family in grapevine显示文摘	Hyun T K Kim J S Kwon S Y	2010	Genes & Oenomics2010，32，：	1
7	A novel control method for three-phase PWM rectifiers using a single current sen- sor显示文摘	LEE W C HYUN D S LEE T K	2000	IEEE Transactions on Power Electronics2000，15，5：	1
8	Expression of survivin and matrix metalloproteinases in adenocarcinoma and squamous cell carcinoma of the uterine cervix显示文摘	Yoshida H Sumi T Hyun Y	2003	Oncol Rep2003，10，1：	1
9	Trienzyme extraction in combination with microbiologic assay in food folate L analysis: an updated review 显示文摘	HYUN T H TAMURA T	2005	Exp Biol Med (Maywood)2005，230，7：	1
10	Comparison of singlesensor current control in the DC link for three phase voltage-source PWM converters显示文摘	LEE W C LEE T K HYUN D S	2001	IEEE Transactions on Industrial Electronics2001，48，3：	1
11	High performance speed control of electric machine using low-precision shaft encoder显示文摘	Kweon T J Hyun D S	1999	IEEE Transactions on Power Electronics1999，14，5：	1
12	Expression of survivin and matrix met alloproteinases in adenocarcinoma and squamous cell carcinoma of the uterine cervix 显示文摘	Yoshida H Sumi T Hyun Y	2003	Oncol Rep2003，10，1：	1
13	FLT3 receptors with intenal Tandem dup lications promote cell viability and proliferation by signaling through Foxo proteins显示文摘	Blanea Scheijen Hai T Ngo Hyun Kang	2004	J Oncogene2004，23，19：	1
14	Peroxisome proliferator-activated receptor- activation ameliorates albuminuria by preventing nephrin loss and restor- ing podocyte integrity in type 2 diabetes显示文摘	Lee E Y Kim G T Hyun M	2012	Nephrology Dialysis Transplantation2012，27，11：	1
15	Synthesis of ceramic microfihration membranes for oil/water separation显示文摘	Hyun H H Gye T K	1997	Separation Science Technology1997，32，18：	1
16	Performance evaluation of discharge plasma process for gaseous pollutant removal显示文摘	Hyun H K Graeiela P Kazunori T	2002	Journal of Electrostatics2002，55，1：	1
17	CBR Revision Model for Improving Cost Prediction Accuracy in Muhifamily Housing Projects显示文摘	Ji C Y Hong T H Hyun C T	2010	Journal of Management in Engineering2010，26，4：	1
18	Fabrication of lotus-type porous metals and their physical properties 显示文摘	NAKAJIMA H IKEDA T HYUN S K	2004	Advanced Engineering Materials2004，6，6：	1
19	Performance evaluation of discharge plasma process for gaseous pollutant removal显示文摘	Hyun H K Graciela P Kazunori T	2002	Journal of Electrostatics2002，55，1：	1
20	Rheological properties and interfaeial tension of polypropylene-poly(styrene-eo-aery- lonitrile) blend containing eompatibilize r 显示文摘	SUNG Y T HAN M S HYUN J C etc	2003	Polymer2003，44，：	1

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