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| 1 | Challenges in the diagnosis and treatment of gestational trophoblastic neoplasia worldwide显示文摘Gestational trophoblastic neoplasia(GTN) is a rare tumor that originates from pregnancy that includes invasive mole, choriocarcinoma(CCA), placental site trophoblastic tumor and epithelioid trophoblastic tumor(PSTT/ETT). GTN presents different degrees of proliferation, invasion and dissemination, but, if treated in reference centers, has high cure rates, even in multi-metastatic cases.The diagnosis of GTN following a hydatidiform molar pregnancy is made according to the International Federation of Gynecology and Obstetrics(FIGO)2000 criteria: four or more plateaued human chorionic gonadotropin(hCG)concentrations over three weeks; rise in hCG for three consecutive weekly measurements over at least a period of 2 weeks or more; and an elevated but falling hCG concentrations six or more months after molar evacuation. However,the latter reason for treatment is no longer used by many centers. In addition,GTN is diagnosed with a pathological diagnosis of CCA or PSTT/ETT. For staging after a molar pregnancy, FIGO recommends pelvic-transvaginal Doppler ultrasound and chest X-ray. In cases of pulmonary metastases with more than 1cm, the screening should be complemented with chest computed tomography and brain magnetic resonance image. Single agent chemotherapy, usually Methotrexate(MTX) or Actinomycin-D(Act-D), can cure about 70% of patients with FIGO/World Health Organization(WHO) prognosis risk score ≤ 6(low risk), reserving multiple agent chemotherapy, such as EMA/CO(Etoposide,MTX, Act-D, Cyclophosphamide and Oncovin) for cases with FIGO/WHO prognosis risk score ≥ 7(high risk) that is often metastatic. Best overall cure rates for low and high risk disease is close to 100% and > 95%, respectively. The management of PSTT/ETT differs and cure rates tend to be a bit lower. The early diagnosis of this disease and the appropriate treatment avoid maternal death,allow the healing and maintenance of the reproductive potential of these women. | Antonio Braga Paulo Mora Andréia Cristina de Melo Angélica Nogueira-Rodrigues Joffre Amim-Junior Jorge Rezende-Filho Michael J Seckl | 2019 | World Journal of Clinical Oncology2019，10，2： | 15 |
| 2 | COVID-19疫苗:Pfizer/BioNTech和Moderna疫苗生物学、药理学特性和不良反应的比较显示文摘2019-nCoV所致的COVID-19已在世界范围内引起一场具有挑战性和威胁性的大流行,给人类健康和经济造成了巨大损失。美国食品和药品监督管理局(Food and Drug Administration,FDA)已经批准Pfizer/BioNTech和Moderna COVID-19疫苗的紧急使用许可。许多人对特定的食物、药物或疫苗有明显的过敏史;因此,世界各国都对这两种疫苗极为关注。本文比较了这两种疫苗的药理学、适应症、禁忌症和不良反应。 | Meo SA Bukhari IA Akram J 吕新军(编译) | 2021 | 中华实验和临床病毒学杂志2021，35，3： | 8 |
| 3 | Expression of anglogenesis factors and selected vascular wall matrix proteins in intracranial saccular aneurysms 显示文摘 | Skirgaudas M Awad IA Kim J | 1996 | Neurosurgery1996，39，3： | 1 |
| 4 | The efficacy and safety of argon plasma coagulation therapy in Barrett's esophagus 显示文摘 | Grade A J Susan IA Medlin SM | 1999 | Gastrointest Endosc1999，50，： | 1 |
| 5 | CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis显示文摘 | Leclercq IA Farrell GC Field J | 2000 | J Clin Invest2000，105，8： | 1 |
| 6 | Heat shock protein 70 gene transfection protects mitochondrail and ventricular function against ischemia-reperfusion injury显示文摘 | Jaykumar J Suzuki k Sammut IA | 2001 | Circulation2001，104，12： | 1 |
| 7 | Cooperative relay to improve diversity in cognitive radio networks显示文摘 | Zhang Qian J ia J uncheng Zhang J in | 2009 | IEEE Com- munications Magazine2009，47，2： | 1 |
| 8 | The role of expectations in the consumer satisfaction forma-tion process:Empirical evidence in the travel agency sector显示文摘 | IA Rodriguez del Bosque H San Martin J Collado | 2006 | Tourism Management2006，，27： | 1 |
| 9 | Volume and densities of chronic subclural haematoma obtained from CT imaging as predictors of postoperative recurrence: a prospective study of 107 operated patients显示文摘 | Stanisic M Hald J Rasmussen IA | 2013 | Acta Neurochir2013，155，2： | 1 |
| 10 | Gut modulator effects of Conyza bonariensis explain its traditional use in constipation and diarrhea显示文摘 | BUKHARI IA SHAH A J KHAN RA | 2013 | Eur Rev Med Pharmacol Sci2013，17，4： | 1 |
| 11 | Anesthetic management of a parturient with placenta previa totalis undergoing preventive uterine artery embolization before placental expulsion during ce- sarean delivery: a case report显示文摘 | Lee JW Song IA Ryu J | 2014 | Korean J Anesthesiol2014，67，4： | 1 |
| 12 | Inhibition of mononuclear cell recruitment in aortic intima by treatment with anti-ICAM- 1 and anti-LFA- 1 monoclonal antibodies in hypercholesterolemic rats: implications of the ICAM- 1 and LFA- 1 pathway in athergenesis 显示文摘 | Nie Qing-hua Fan J ia Haraoka S | 1997 | Lab Invest1997，77，： | 1 |
| 13 | Rivero,Inmaculada Ortiz,Photo-Fenton process as an efficient alternative tothe treatment of landfill leachates显示文摘 | Oscar Primo Mar'Ia J | 2008 | Journal of Hazardous Materials2008，，153： | 1 |
| 14 | Pathology of carcinoma of the prostate显示文摘 | Mostofi F K Davis C J Sesterhenn IA | 1992 | Cancer1992，70，1： | 1 |
| 15 | Estimation of mean left atrial pressure from transesophegeal pulse Doppler echocardiography of pulmonary venous flow显示文摘 | Kuocherer HF Muhiuden IA Oneto J | 1990 | Circulation1990，82，： | 1 |
| 16 | On generalized fuzzy matrices with periods 显示文摘 | Tan Yi- j ia | 2011 | Fuzzy Sets and Systems2011，172，1： | 1 |
| 17 | Laparoscopic ovar- ian transposition before pelvic irradiation: a Saudi tertiary center experience显示文摘 | A1-Badawi IA AI-Aker M AISubhi J | 2010 | Int J Gynecol Cancer2010，20，： | 1 |
| 18 | Clinical and radiographic outcomes of the treatment of adolescent idiopathic scoliosis with segmental pedicle screws and combined local autograft and allograft bone for spinal fusion: a retrospective case series显示文摘 | Yang X Xu H IA M Gu S Fang X Wang J | 2010 | BMC Musculoskelet Disord2010，11，： | 1 |
| 19 | Incidence and mortality of acute pancreatitis between 1985 and 1995 显示文摘 | Eland IA Stuikenboom M J Wilson JH | 2000 | Scand J Gastreenterol2000，35，10： | 1 |
| 20 | Clinical usefulness and prognostic value of el- evated cardiac troponin I levels in acute pulmonary embolism 显示文摘 | Mehta N J Jani K Khan IA | 2003 | Am Heart J2003，145，5： | 1 |
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