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| 1 | Ellagic acid induces apoptosis through inhibition of nuclear factor κB in pancreatic cancer cells显示文摘AIM:To determine the effect of ellagic acid on apop-tosis and proliferation in pancreatic cancer cells and to determine the mechanism of the pro-survival effects of ellagic acid. METHODS:The effect of ellagic acid on apoptosis was assessed by measuring Phosphatidylserine externalization,caspase activity,mitochondrial membrane potential and DNA fragmentation;and proliferation by measuring DNA thymidine incorporation. Mitochondrial membrane potential was measured in permeabilized cells,and in isolated mitochondria. Nuclear factor kB(NF-kB) activity was measured by electromobility shift assay(EMSA) . RESULTS:We show that ellagic acid,a polyphenolic compound in fruits and berries,at concentrations 10 to 50 mmol/L stimulates apoptosis in human pancreatic adenocarcinoma cells. Further,ellagic acid decreases proliferation by up to 20-fold at 50 mmol/L. Ellagic acid stimulates the mitochondrial pathway of apoptosis associated with mitochondrial depolarization,cytochrome C release,and the downstream caspaseactivation. Ellagic acid does not directly affect mitochondria. Ellagic acid dose-dependently decreased NF-kB binding activity. Furthermore,inhibition of NF-kB activity using IkB wild type plasmid prevented the effect of ellagic acid on apoptosis. CONCLUSION:Our data indicate that ellagic acid stimulates apoptosis through inhibition of the prosu-rvival transcription factor NF-kB. | Mouad Edderkaoui Irina Odinokova Izumi Ohno Ilya Gukovsky Vay Liang W Go Stephen J Pandol Anna S Gukovskaya | 2008 | World Journal of Gastroenterology2008，14，23： | 30 |
| 2 | Genes associated with testicular germ cell tumors and testicular dysgenesis in patients with testicular microlithiasis显示文摘阴囊的 microlithiasis (TM ) 是阴囊的 dysgenesis 症候群(TDS ) 的症状之一。TM 作为阴囊的细菌房间肿瘤(TGCT ) 的一个增进知识的标记特别地有趣。工具包 ligand 基因( KITLG ), BCL2 对手/杀手 1 ( BAK1 ),并且表明对手 4 的 sprouty RTK ( SPRY4 ),基因与 TGCT 的高风险被联系骨头形态基因的蛋白质 7 基因( BMP7 ),转变生长因素贝它受体 3 基因( TGFBR3 ),并且 homeobox D 簇基因( HOXD )与 TDS 有关。使用的聚合酶链反应限制碎片长度多型性( PCR-RFLP )分析,我们为 KITLG 调查了等位基因和遗传型频率( rs995030 , rs1508595 ), SPRY4 ( rs4624820 , rs6897876 ), BAK1 ( rs210138 ), BMP7 ( rs388286 ), TGFBR3 ( rs12082710 ),并且在 142 个 TGCT 病人, 137 个 TM 病人,和 153 个肥沃的人(控制组)的 HOXD ( rs17198432 )。我们在 TM 在 KITLG GG_rs995030 遗传型发现了重要差别(P = 0.01 ) 并且 TGCT 病人(P = 0.0005 ) 与控制相比。我们也揭示了在 KITLG_rs1508595 和 TM 之间的强壮的协会(G 等位基因, P = 0.003;GG 遗传型, P = 0.01 ) 并且在 KITLG_rs1508595 和 TGCT 之间(G 等位基因, P = 0.0001;GG 遗传型, P = 0.0007 ) 。而且,在在 TGCT 组和控制之间的 BMP7_rs388286 有重要差别(T 等位基因, P = 0.00004;TT 遗传型, P = 0.00006 ) 并且在 TM 组和控制之间(T 等位基因, P = 0.04 ) 。HOXD 也与 TGCT 表明了一个强壮的协会(rs17198432 A 等位基因, P = 0.0001;AA 遗传型, P = 0.001 ) 。而且,重要差别在 BAK1_rs210138 G 等位基因在 TGCT 组和控制之间被发现(P = 0.03 ) 并且 GG 遗传型(P = 0.01 ) 。KITLG 和 BMP7 基因,与 TGCT 的发展联系了,可能也与 TM 有关。在摘要, KITLG GG_rs995030, GG_rs1508595, BMP7 TT_rs388286, HOXD AA_rs17198432,和 BAK1 GG_rs210138,遗传型与 TGCT 开发的高风险被联系。 | Ilya S Dantsev Evgeniy V Ivkin Aleksey A Tryakin Dmitriy N Godlevski Oleg Yu Latyshev Victoriya V Rudenko Dmitry S Mikhaylenko Vyacheslav B Chernykh Elena A Volodko Aleksey B Okulov Oleg B Loran Marina V Nemtsova | 2018 | Asian Journal of Andrology2018，20，6： | 4 |
| 3 | Bioleaching of metals from electronic scrap by moderately thermophilic aeidophilic bacteria 显示文摘 | Ilyas S Anwar M A Niazi S B | 2007 | Hydrometallurgy2007，88，14： | 1 |
| 4 | Image segmentation and edge enhancement with stabilized inverse diffusion equations显示文摘 | Ilya Pollak Alan S Willsky Hamid Krim | 2000 | IEEE Transaction on Image Processing2000，9，2： | 1 |
| 5 | Sterilization affects soil organic matter chemistry and bioaccumulation of spiked p, p' - DDE and anthracene by earthworms 显示文摘 | Jason W K Ilya B S Richard D P | 2010 | Environmental Pol- lution2010，158，： | 1 |
| 6 | Tunable split-ring resonators for nonlinear negative-index metamaterials显示文摘 | Ilya V Shadrivov Steven K Morrison Yuri S Kivshar | 2006 | Optics Express2006，14，20： | 1 |
| 7 | Chromenoflavones from Macaranga indica 显示文摘 | Sultana S Ilyas M | 1986 | Phytochemistry1986，25，4： | 1 |
| 8 | Expression and activity of paraoxonase 1 in human cataractous lens tissue 显示文摘 | Hashim Z Ilyas A Saleem A Salim A Zarina S | 2009 | Free Radic Biol Med2009，46，8： | 1 |
| 9 | Bioleaching of metals from electronic scrap by moderately thermophilic acidophilic bacteria 显示文摘 | Ilyas S Anwar M A Niazi S B | 2007 | Hydrometallurgy2007，88，1234： | 1 |
| 10 | Laparoscopic management of small bowel obstruction in children显示文摘 | Aguayo P Fraser JD Ilyas S | 2011 | J Laparoendosc Adv Surg Tech A2011，21，1： | 1 |
| 11 | Bioinformatics Analysis of Envelope Glyeoprotein E epitopes of Dengue Virus Type 3 显示文摘 | Ilyas M Rahman Z Shamas S | 2011 | Aft J Biotechnol2011，10，18： | 1 |
| 12 | Development of mathematical model for cooling the fish with ice显示文摘 | JAIN D ILYAS S M PATHARE P | 2005 | Journal of Food Engineering2005，71，： | 1 |
| 13 | Chemieal analysis of essential oils from turmeric ( Curcuma longa ) Rhizome through GCMS 显示文摘 | Naz S Ilyas S Palveen Z | 2010 | Asian Journal of Chemistry2010，22，4： | 1 |
| 14 | Bioleaching of metals from electronic scrap by moderately thermophilic acidophil- ic bacteria显示文摘 | Ilyas S Anwar M A Niazi S B | 2007 | Hvdrometallurv2007，88，14： | 1 |
| 15 | A cornucopia of screening and diagnostic techniques for human papillomavirus associated cervical carcinomas 显示文摘 | Ramzan M Ain NU Ilyas S | 2015 | J Virol Methods2015，222，： | 1 |
| 16 | Bhattacharyya coefficient in correlation of gray-scale objects 显示文摘 | Khalid M S Ilyas M U Sarfaraz M S | 2006 | Journal of Multimedia2006，1，1： | 1 |
| 17 | Primary Malignant Fibrous Histiocytoma of the Small Intestine Presenting as an Intussusception: Report of a Case显示文摘 | Cetin Kotan Mustafa Kosem Süleyman Alici Mahmut Ilhan Ilyas Tuncer Mustafa Harman | 2002 | Surgery Today2002，，12： | 1 |
| 18 | Air core imaging in cyclonic separators:implications for separator design and modelling显示文摘 | Williams R A Ilyas O M Dyakowski T Dickin F J Gutierrez J A Wang M Beck M S Shah C Rushton A | | 0，，3： | 1 |
| 19 | Mimosine attenuates Serine hydroxymethyltransferase transcription by chelating zinc:implications for inhibition of DNA replication显示文摘 | CHERYLL P RENUKA S ILYA M N | 2005 | J Biol Chem2005，280，1： | 1 |
| 20 | Leaf area and ion contents of Sesbania grandiflora under NaCl and Na2SO4 salinity显示文摘 | Dhanapackiam S Muhammad - Ilyas M H | 2010 | Inidan Journal of Science and Technology2010，3，5： | 1 |
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