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| 1 | Elevation of the glycated albumin to glycated hemoglobin ratio during the progression of hepatitis C virus related liver fibrosis显示文摘AIM: To analyze the relationship between the glycated albumin (GA) to glycated hemoglobin (HbA1c) ratio and the histological grading of liver fibrosis.METHODS: The study retrospectively included consecutive hepatitis C virus positive chronic liver disease patients (n = 142) who had undergone percutaneous liver biopsy between January 2008 and March 2010 at our institution. The ratios of GA/HbA1c were calculated in all patients to investigate the relationship with the degree of the liver fibrosis. The values of the aspartate aminotransferase-to-platelet ratio index (APRI), an excellent marker for the evaluation of liver fibrosis, were also calculated. In addition, we combined the ratio of GA/HbA1c and the APRI in order to improve our ability to detect the presence of significant liver fibrosis. RESULTS: Sixty-one (43%) patients had either no fibrosis or minimal fibrosis (METAVIR score: F0-F1), while 25 (17%) had intermediate fibrosis (F2). Fifty-six (39%) patients had severe fibrosis (F3-F4) and 27 of them had cirrhosis (F4). The mean values of the GA/HbA1c increased with the progression of the fibrosis (F0-1: 2.83 ± 0.24, F2: 2.85 ± 0.24, F3: 2.92 ± 0.35, F4: 3.14 ± 0.54). There was a significant dif- ference between the F0-F1 vs F4, F2 vs F4, and F3 vs F4 groups (P < 0.01, P < 0.01, P < 0.01 and P < 0.05, respectively). The GA/HbA1c ratio was significantly higher in the patients with cirrhosis (F4) than in those without cirrhosis (F0-F3) (3.14 ± 0.54 vs 2.85 ± 0.28, P < 0.0001). The GA/HbA1c ratio was also significantly higher in the patients with severe fibrosis (F3-F4) than in those without severe liver fibrosis (F0-F2) (3.03 ± 0.41 vs 2.84 ± 0.24, P < 0.001). Furthermore, the GA/ HbA1c ratio was also significantly higher in the patients with significant fibrosis (F2-F4) than in those without significant liver fibrosis (F0-F1) (2.98 ± 0.41 vs 2.83 ± 0.24, P < 0.001). The diagnostic performance of the increased GA/HbA1c ratio (> 3.0) was as follows: its sensitivity and specificity for the detection of liver cirrhosis (F4) were 59.3% and 70.4%, respectively and its sensitivity and specificity for the detection of severe liver fibrosis (F3-F4) were 50.0% and 74.4%,respectively. With regard to the detection of significant fibrosis (F2-F4), its sensitivity was 44.4% and its specificity was 77.0%. Although even the excellent marker APRI shows low sensitivity (25.9%) for distinguishing patients with or without significant fibrosis, the combination of the APRI and GA/HbA1c ratio increased the sensitivity up to 42.0%, with only a modest decrease in the specificity (from 90.2% to 83.6%). CONCLUSION: The GA/HbA1c ratio increased in line with the histological severity of liver fibrosis, thus suggesting that this ratio is useful as a supportive index of liver fibrosis. | Nobuhiro Aizawa Hirayuki Enomoto Hiroyasu Imanishi Masaki Saito Yoshinori Iwata Hironori Tanaka Naoto Ikeda Yoshiyuki Sakai Tomoyuki Takashima Takashi Iwai Ei-ichiro Moriwaki Soji Shimomura Hiroko Iijima Hideji Nakamura Shuhei Nishiguchi | 2012 | World Journal of Hepatology2012，4，1： | 10 |
| 2 | Experimental Analysis of Flow Structure in Contra-Rotating Axial Flow Pump Designed with Different Rotational Speed Concept显示文摘As a high specific speed pump, the contra-rotating axial flow pump distinguishes itself in a rear rotor rotating in the opposite direction of the front rotor, which remarkably contributes to the energy conversion, the reduction of the pump size, better hydraulic and cavitation performances. However, with two rotors rotating reversely, the significant interaction between blade rows was observed in our prototype contra-rotating rotors, which highly affected the pump performance compared with the conventional axial flow pumps. Consequently, a new type of rear rotor was designed by the rotational speed optimization methodology with some additional considerations, aiming at better cavitation performance, the reduction of blade rows interaction and the secondary flow suppression. The new rear rotor showed a satisfactory performance at the design flow rate but an unfavorable positive slope of the head-flow rate curve in the partial flow rate range less than 40% of the design flow rate, which should be avoided for the reliability of pump-pipe systems. In the present research, to understand the internal flow field of new rear rotor and its relation to the performances at the partial flow rates, the velocity distributions at the inlets and outlets of the rotors are firstly investigated. Then, the boundary layer flows on rotor surfaces, which clearly reflect the secondary flow inside the rotors, are analyzed through the limiting streamline observations using the multi-color oil-film method. Finally, the unsteady numerical simulations are carried out to understand the complicated internal flow structures in the rotors. | Linlin Cao Satoshi Watanabe Toshiki Imanishi Hiroaki Yoshimura Akinori Furukawa | 2013 | Journal of Thermal Science2013，22，4： | 3 |
| 3 | Laparoscopic partial resection for hemangioma in the third portion of the duodenum显示文摘Benign duodenal tumors are rare and less commonthan malignant tumors.Furthermore,vascular lesionsof the duodenum,including hemangiomas,are rarecauses of gastrointestinal bleeding.This report describes a case with bleeding hemangiomas in the thirdportion of the duodenum and jejunum and their successful treatment using a laparoscopic approach.Thereis no report of totally laparoscopic resection for tumorin the third portion of duodenum.After performinga laparoscopic Kocher maneuver,the location of theduodenal hemangioma was confirmed by endoscopicand laparoscopic observation.The lesion was excisedusing ultrasonic coagulating shears and the defect inthe duodenal wall was sutured laparoscopically.Thehemangioma of the jejunum was treated extracorporeally through a 3.0 cm umbilical incision.The operatingtime was 241 min and blood loss was negligible.Thepostoperative course was uneventful.For benign duodenal tumors in the third portion,if endoscopic resection is not adapted,this less invasive technique may be a standard treatment. | Shingo Kanaji Tetsu Nakamura Masayasu Nishi Masashi Yamamoto Kiyonori Kanemitu Kimihiro Yamashiita Tatsuya Imanishi Yasuo Sumi Satoshi Suzuki Kenichi Tanaka Yoshihiro Kakeji | 2014 | World Journal of Gastroenterology2014，20，34： | 2 |
| 4 | 利用超导重力仪数据对2004年M_w=9级苏门答腊地震后极低简正模式的高分辨率分析显示文摘2004年12月26日苏门答腊-安达曼地震(Mw=9)强烈地激发了低频地震简正模式,为改善极低地震简正模式频率及阻尼测量提供了难得的机会。为改进地球一维密度模型,需对低于1mHz的地震简正模式的频率分裂进行精确估算。本次地震中,首次在超导重力仪和地震波记录无叠加的情况下观测到2S1。本文报告来自11个观测台测得的超导重力仪数据的分析。单个观测台的超导重力仪记录频谱清晰地显示了0S2分裂成5个完全可分辨的单线,0S3分裂成7个单线。给出的结果表明超导重力仪可为低频地震模式的精确分析提供高质量数据。 | S. Rosat T. Sato Y. Imanishi J. Hinderer Y. Tamura H. McQueen M. Ohashi 尚丹(译) 郑需要(校) | 2006 | 世界地震译丛2006，37，4： | 2 |
| 5 | Growth factors: importance in wound healing and maintenance of transparency of the cornea显示文摘 | Jiro Imanishi Kenji Kamiyama Ikuo Iguchi Masakazu Kita Chie Sotozono Shigeru Kinoshita | 1999 | Progress in Retinal and Eye Research1999，，1： | 2 |
| 6 | 为与窒息肠塞痛联系的肠的局部缺血的察觉的动态 CT 的动脉的阶段的用途显示文摘 AIM:To clarify the usefulness of arterial phase scans in contrast computed tomography (CT) imaging of stran-gulation ileus in order to make an early diagnosis. METHODS:A comparative examination was carried out with respect to the CT value of the intestinal tract wall in each scanning phase, the CT value of the content in the intestinal tract, and the CT value of ascites fluid in the portal vein phase for a group in which ischemia was observed (Group Ⅰ) and a group in which ischemia was not observed (Group N) based on the pathological findings or intra-surgical findings. Moreover, a comparative examination was carried out in Group Ⅰ subjects for each scanning phase with respect to average differences in the CT values of the intestinal tract wall where ischemia was suspected and in the intestinal tract wall in non-ischemic areas. RESULTS:There were 15 subjects in Group Ⅰ and 30 subjects in Group N. The CT value of the intestinal tract wall was 41.8 ± 11.2 Hounsfield Unit (HU) in Group Ⅰ and 69.6 ± 18.4 HU in Group N in the arterial phase, with the CT value of the ischemic bowel wall being significantly lower in Group Ⅰ. In the portal vein phase, the CT value of the ischemic bowel wall was 60.6 ± 14.6 HU in Group Ⅰ and 80.7 ± 17.7 HU in Group N, with the CT value of the ischemic bowel wall being significantly lower in Group Ⅰ; however, no significant differences were observed in the equilibrium phase. The CT value of the solution in the intestine was 18.6 ± 9.5 HU in Group Ⅰ and 10.4 ± 5.1 HU in Group N, being signifi-cantly higher in Group Ⅰ. No significant differences were observed in the CT value of the accumulation of ascites fluid. The average difference in the CT values between the ischemic bowel wall and the non-ischemic bowel wall for each subject in Group Ⅰ was 33.7 ± 20.1 HU in the arterial phase, being significantly larger compared to the other two phases. CONCLUSION:This is a retrospective study using a small number of subjects; however, it suggests that there is a possibility that CT scanning in the arterial phase is useful for the early diagnosis of strangulation ileus. | Gaku Ohira Kiyohiko Shuto Tsuguaki Kono Takayuki Tohma Hisashi Gunji Kazuo Narushima Shunsuke Imanishi Takeshi Fujishiro Tohru Tochigi Toshiharu Hanaoka Hideaki Miyauchi Naoyuki Hanari Hisahiro Matsubara Noriyuki Yanagawa | 2012 | World Journal of Radiology2012，4，11： | 2 |
| 7 | Imaging biomarkers for the treatment of esophageal cancer显示文摘Esophageal cancer is known as one of the malignant cancers with poor prognosis.To improve the outcome,combined multimodality treatment is attempted.On the other hand,advances in genomics and other“omic”technologies are paving way to the patient-oriented treatment called“personalized”or“precision”medicine.Recent advancements of imaging techniques such as functional imaging make it possible to use imaging features as biomarker for diagnosis,treatment response,and prognosis in cancer treatment.In this review,we will discuss how we can use imaging derived tumor features as biomarker for the treatment of esophageal cancer. | Koichi Hayano Gaku Ohira Atsushi Hirata Tomoyoshi Aoyagi Shunsuke Imanishi Toru Tochigi Toshiharu Hanaoka Kiyohiko Shuto Hisahiro Matsubara | 2019 | World Journal of Gastroenterology2019，25，24： | 2 |
| 8 | Apoptosis of vascular smooth muscle cells is induced by Fas ligand derived from monocytes/macrophage显示文摘 | Imanishi T Han DK Hofstra L | 2002 | Atherosclerosis2002，161，1： | 1 |
| 9 | Oxidized low-density lipoprotein inhibits vascular endothelial growth factor induced endothelial progenitor cell differentiation 显示文摘 | Imanishi T Hano T Matsuo Y | 2003 | Clin Exp Pharmacol Physiol2003，30，9： | 1 |
| 10 | Association of monocyte subsets with vulnerability characteristics of coronary plaques as assessed by 64-slice multidetector computed tomography in patients with stable angina pectoris显示文摘 | Kashiwagi M Imanishi T Tsujioka I-I | 2010 | Atherosclerosis2010，212，1： | 1 |
| 11 | Lnl-x,SrxCoO3, CoO3(Ln = Sm,Dy)for the electrode of solid oxide fuel cells显示文摘 | Tu H Y Takeda Y Imanishi N | 1997 | Solid State lonics1997，100，： | 1 |
| 12 | Detection of influenza virus in throat swab by using polymerase chain reaction显示文摘 | Yamada A Imanishi J Nakajima E | 1991 | Microbiol Immunlol1991，35，3： | 1 |
| 13 | All solid lithium polymer batteries with a novel composite polymer electrolyte 显示文摘 | LI Q ITOH T IMANISHI N | 2003 | Solid State Ionics2003，159，： | 1 |
| 14 | Ln1-xSrxCoO3 (Ln = Sm,Dy) for the electrode of solid oxide fuel cells显示文摘 | Tu H Y Takeda Y Imanishi N | 1997 | Solid State Ionics1997，100，： | 1 |
| 15 | Parathyroid hormone regulates fibroblast growth factor-23 in a mouse model of primary hyperparathyroidism显示文摘 | Kawata T Imanishi Y Kobayashi K | 2007 | J AmSoc Nephrol2007，18，： | 1 |
| 16 | Primary hy-perparathyroidism caused by parathyroid-targeted overexpres-sion of cyclin Dl in transgenic mice 显示文摘 | Imanishi Y Hosokawa Y Yoshimoto K | 2001 | J Clin Invest2001，107，： | 1 |
| 17 | Endothelial progenitor cell differentiation and senescence in an angiotensin Ⅱ-infusion rat model显示文摘 | Kobayashi K Imanishi T Akasaka T | | Hypertension Res0，29，6： | 1 |
| 18 | Assessment ofculprit lesion morphology in acute myocardial infarction : abilityof optical coherence tomography compared with intravascularultrasound and coronary angioscopy 显示文摘 | KUBO T IMANISHI T TAKARADA S | 2007 | J Am Coll Cardiol2007，50，10： | 1 |
| 19 | Assessment of culprit le- sion morphology in acute myocardial infarction~ ability of optical coherence tomography compared with intra vascular ultrasound and coronary angioscop显示文摘 | KuboT Imanishi T TakaradaS | 2007 | AmJCardiol2007，50，： | 1 |
| 20 | Genetic relationships among Japanese, Northern Han, Hui, Uygur, Kazakh, Greek, Saudi Arabian, and Italian populations based on allelic frequencies at four VNTR (D1S80, D4S43, COL2A1, D17S5) and one STR (ACTBP2) loci显示文摘 | Katsuyama Y Inoko H Imanishi T | 1998 | Hum Hered1998，48，48： | 1 |
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