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| 1 | 尿钠排泄、血压、心血管病与死亡率的关系:社区前瞻性流行病学队列研究显示文摘WHO建议人群钠摄人<2 g/d作为预防心血管病的措施之一,但这一目标在任何国家都没有实现。该建议主要基于短期血压试验的个体水平数据,没有来自随机试验或观察性研究的关于低钠摄入与降低心血管事件的数据。前瞻性城市农村流行病学研究目前正在21个国家进行。该文对其中18个国家的数据进行分析,其中包含了临床结果数据。 | Mente A O'Donnell M Rangarajan S McQueen M Dagenais G Wielgosz A Lear S Ah STL Wei L Diaz R Avezum A Lopez-Jaramillo P Lanas F Mony P Szuba A Iqbal R Yusuf R Mohammadifard N Khatib R Yusoff K Ismail N Gulec S Rosengren A Yusufali A Kruger L Tsolekile LP Chifamba J Dans A Alhabib KF Yeates K Teo K Yusuf S 刘莉 叶鹏 | 2018 | 中华高血压杂志2018，26，12： | 29 |
| 2 | Role of a probiotic (Saccharomyces boulardii) in management and prevention of diarrhoea显示文摘瞄准:估计酵母属 boulardii 的功效和安全(S。boulardii ) 在在减少腹泻的事件的频率在的尖锐水的腹泻和它的角色随后二个月。方法:从 2 瞬间的孩子到 12 岁,在 S 根据包括标准和随机的 ised 与尖锐腹泻被选择。boulardii 组(与 ORS,营养的支持和 S 一起对待。boulardii, 250 mg 出价) 并且在控制组(仅仅与 ORS 和营养的支持一起对待) 。直接疗法阶段是 5 d,每个孩子以后被跟随二个月。象药的安全一样的凳子的频率和一致性在每访问上被估计。二个组的比较以痢疾的事件的数字被做在随后二个月。结果:在每个组有五十个病人。象吝啬的年龄和凳子的平均频率那样的基线特征在 S 是可比较的。boulardii 和控制在试用在包括的时候组织。由 d 3 它分别地并且由 d 每 d 归结为 2.7 和 4.2 张凳子 6 它归结为 1.6 (S。boulardii 组) 并且 3.3 (控制组) 。腹泻的持续时间是在 S 的 3.6 d。而它是在控制组的 4.8 d, boulardii 组织(P = 0.001 ) 。在下列二个月内, S。有的 boulardii 组一显著地, 0.54 个事件的低频率作为与在控制的 1.08 个事件相比组织。这药很好被接受并且容忍。在治疗时期期间没有副作用的报告。结论:S。boulardii 显著地减少尖锐腹泻的频率和持续时间。凳子的一致性也改善。这药是容忍得好的。 | AG Billoo MA Memon SA Khaskheli G Murtaza Khalid Iqbal M Saeed Shekhani Ahson Q Siddiqi | 2006 | World Journal of Gastroenterology2006，12，28： | 22 |
| 3 | Increased hepcidin expression in colorectal carcinogenesis显示文摘AIM:To investigate whether the iron stores regulator hepcidin is implicated in colon cancer-associated anae- mia and whether it might have a role in colorectal car- cinogenesis. METHODS: Mass spectrometry (MALDI-TOF MS and SELDI-TOF MS) was employed to measure hepcidin in urine collected from 56 patients with colorectal cancer. Quantitative Real Time RT-PCR was utilised to determine hepcidin mRNA expression in colorectal cancer tissue. Hepcidin cellular localisation was determined using im- munohistochemistry. RESULTS: We demonstrate that whilst urinary hepcidin expression was not correlated with anaemia it was posi- tively associated with increasing T-stage of colorectal cancer (P < 0.05). Furthermore, we report that hepcidin mRNA is expressed in 34% of colorectal cancer tissue specimens and was correlated with ferroportin repres- sion. This was supported by hepcidin immunoreactivity in colorectal cancer tissue. CONCLUSION: We demonstrate that systemic hepcidin expression is unlikely to be the cause of the systemic anaemia associated with colorectal cancer. However, we demonstrate for the first time that hepcidin is expressed by colorectal cancer tissue and that this may represent a novel oncogenic signalling mechanism. | Douglas G Ward Keith Roberts Matthew J Brookes Howard Joy Ashley Martin Tariq Ismail Robert Spychal Tariq Iqbal Chris Tselepis | 2008 | World Journal of Gastroenterology2008，14，9： | 12 |
| 4 | Is iron overload in alcohol-related cirrhosis mediated by hepcidin?显示文摘In this case report we describe the relationship between ferritin levels and hepcidin in a patient with alcohol-related spur cell anemia who underwent liver transplantation.We demonstrate a reciprocal relation-ship between serum or urinary hepcidin and serum ferritin,which indicates that inadequate hepcidin production by the diseased liver is associated with elevated serum ferritin.The ferritin level falls with increasing hepcidin production after transplantation.Neither inflammatory indices(IL6)nor erythropoietin appear to be related to hepcidin expression in this case.We suggest that inappropriately low hepcidin production by the cirrhotic liver may contribute substantially to elevated tissue iron stores in cirrhosis and speculate that hepcidin replacement in these patients may be of therapeutic benefi t in the future. | Tariq Iqbal Azzam Diab Douglas G Ward Matthew J Brookes Chris Tselepis Jim Murray Elwyn Elias | 2009 | World Journal of Gastroenterology2009，15，46： | 2 |
| 5 | BCI2 expression is a prognostic marker for the activated B - cell - like type of diffuse large B - cell lymphoma 显示文摘 | Iqbal J Neppalli VT Wright G | 2006 | J Clin Oncol2006，24，6： | 1 |
| 6 | Effect of projectile nose shape,impact velocity and target thickness on the de-formation behavior of layered plates显示文摘 | Gupta N K Iqbal M A Sekhon G S | 2008 | Int J Impact Eng2008，35，1： | 1 |
| 7 | Pancreaticobiliary and duode- nal perforations after periampullary endoscopic proce- dures : diagnosis and management显示文摘 | Fatima J Baron T H Topazian M D Houghton S G Iqbal C W Ott B J | 2007 | Arch Surg2007，142，： | 1 |
| 8 | Gene expression signatures delineate biological and prognostic subgroups in peripheral T-cell lymphoma 显示文摘 | Iqbal J Wright G Wang C | 2014 | Blood2014，123，19： | 1 |
| 9 | Gene expression signatures delineate biological and prognostic subgroups in peripheral T-cell lymphoma显示文摘 | Iqbal J Wright G Wang C | 2014 | Blood2014，123，19： | 1 |
| 10 | UniHI : an entry gate to the human protein interactome 显示文摘 | Chaurasia G Iqbal Y Hunig C | 2007 | Nucleic Acids Res2007，35，： | 1 |
| 11 | Targeting caveolin- 3 for the treatment of diabetic cardiomyopathy显示文摘 | Murfitt L Whiteley G Iqbal MM | 2015 | Pharma- col Ther2015，151，： | 1 |
| 12 | Effect of Ho3+ Substitutions on the Structural and Magnetic Properties of BaFe12019 Hexaferrites显示文摘 | MURTAZA RAI G IQBAL M A KUBRA K T | 2010 | Journal of Al- loys and Compounds2010，495，： | 1 |
| 13 | Microbial biomass, anddissolved organic carbon and nitrogen strongly affect soilrespiration in different land uses: a case study at Three GorgesReservoir Area, South China 显示文摘 | Iqbal J Hu R G Feng M L | 2010 | Agriculture Ecosystems &Environment2010，137，34： | 1 |
| 14 | Immunomodulatory effect of various anti-parasitics:a review显示文摘 | SAJID M S IQBAL Z MUHAMMAD G | 2006 | Parasitology2006，132，3： | 1 |
| 15 | Effect of projectile nose shape, impact velocity and target thickness on de-formation behavior of aluminum plates 显示文摘 | Gupta N K Iqbal M A Sekhon G S | 2007 | International Journal of Solids and Structures2007，44，10： | 1 |
| 16 | Hydrokinetic energy conversion systems and assessment of horizontal and vertical axis turbines for river and tidal applications : A technology status review 显示文摘 | Khan M J Bhuyan G Iqbal M T | 2009 | Applied Energy2009，86，10： | 1 |
| 17 | Responses of Bacopa monniera cultures to cadmium toxicity显示文摘 | Ali G Srivastava P S Iqbal M | 2001 | Bull Environ Contam Toxicol2001，66，3： | 1 |
| 18 | Proline accumulation, protein pattern and photosynthesis in Bacopa monniera regenerants grown under NaCI stress显示文摘 | Ali G Srivastava P S Iqbal M | 1999 | Biol Plant1999，42，1： | 1 |
| 19 | Efficient production of doubled haploid B rassica napus plants bycolchicine treatment of microspores 显示文摘 | Moilers C Iqbal M C M Robbelen G | 1994 | Euphytica1994，75，： | 1 |
| 20 | BCL2 expression is a prognostic marker for the activated B-cell-like type of diffuse large B-cell lymphoma显示文摘 | Iqbal J Neppalli VT Wright G | 2006 | J clin oncol2006，24，6： | 1 |
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