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| 1 | Immunopathogenesis of chronic hepatitis B显示文摘Chronic hepatitis B(CHB) is a widespread infectious disease with unfavorable outcomes and life-threatening consequences for patients, in spite of modern vaccination and antiviral treatment modalities. Cutting-edge experimental approaches have demonstrated key pathways that involve cross-talk between viral particles and host immune cells. All events, including penetration of hepatitis B virus(HBV) particles into host cells, establishing persistence, and chronization of CHB infection, and possibility of complete elimination of HBV particles are controlled by the immune system. Researchers have paid special attention to the replication capacity of HBV in host cells, which is associated with cellular changes that reflect presentation of viral antigens and variability of HBV antigen features. In addition, specific HBV proteins have an immune-modulating ability to initiate molecular mechanisms that 'avoid' control by the immune system. The relationship between immunological shifts and chronic infection stages has been intensively studied since it was recognized that the immune system is a direct participant in the recurrent(cyclic) nature of CHB. Understanding the wide diversity of molecular pathways and the crosstalk between innate and adaptive immune system components will provide fresh insight into CHB immune pathogenesis and the possibilities of developing new treatment strategies for this disease. | Irina P Balmasova Nikolay D Yushchuk Ospan A Mynbaev Nageswara R Alla Elena S Malova Zhongjie Shi Chang-Lu Gao | 2014 | World Journal of Gastroenterology2014，20，39： | 15 |
| 2 | Hydroxyethyl Starch Reduces Coagulation Competence and Increases Blood Loss During Major Surgery: Results From a Randomized Controlled Trial显示文摘 | Kirsten C. Rasmussen P?r I. Johansson Michael H?jskov Irina Kridina Thomas Kistorp Peter Thind Henning B. Nielsen Birgitte Ruhnau Tom Pedersen Niels H. Secher | 2014 | Annals of Surgery2014，，2： | 2 |
| 3 | 16S rRNA targeted sandwich hybridization method for direct quantification of mycobacteria in soils 显示文摘 | Timo N Jaakko P Irina T | 2004 | Journal of Microbiological Methods2004，67，： | 1 |
| 4 | Disturbances of Glucose Metabolism in Men Referred for Coronary Arteriography 显示文摘 | Irina K Ida K Jolanta P | 2001 | Diabetes Care2001，24，： | 1 |
| 5 | Chronic peroxisome proliferator-activated receptor γ (PPARγ) activation of epi- didymally derived white adipocyte cultures reveals a popula- tion of thermogenically competent, UCPl-containing adipocytes molecularly distinct from classic brown adipocytes 显示文摘 | Natasa P Tomas BW Irina GS | 2010 | J Biol Chem2010，285，10： | 1 |
| 6 | Frequency and clinical determinants of post-storke depression显示文摘 | Anter L Irina S | 1998 | Stroke1998，29，11： | 1 |
| 7 | Palladium Catalyzed C-C and C-heteroatom Bond Formation Reactions显示文摘 | Irina P | 1997 | Pure and Applied Chemistry1997，，4： | 1 |
| 8 | A GIS-based model for testing effects of restoration measures in wetlands:a case study in the Kampinos National Park,Poland显示文摘 | Mikoaj P Lars G Irina K | 2012 | Ecological Engineering2012，44，： | 1 |
| 9 | Phenanthrene metabolism by Pseudomonas and Burkholderia strains显示文摘 | Natalia V Balashova Irina A Koshelava Nicolai P | 1999 | Process Biochemistry1999，35，： | 1 |
| 10 | Two opposite effects of cofilin on the thermal unfolding of F- actin : a differential scanning calorimetric study 显示文摘 | Irina V Dedova Olga P Nikolaeva Valeria V Mikhailova | 2004 | Biophysical Chemistry2004，110，： | 1 |
| 11 | Frequency and clinical determinants of post - stroke depression显示文摘 | Jcrja P Antero L Irina S | 1998 | Stroke1998，29，11： | 1 |
| 12 | A practical synthetic approach to chiral α-aryl substituted ethylphosphonates 显示文摘 | Natalia S Goulioukina Tatyana M Dolgina Irina P Beletskaya | 2001 | Tetrahedron : Asymmetry2001，12，2： | 1 |
| 13 | Electrochemical propertiesof NaTi2(P04)3 anode for rechargeable aqueous sodium-ion batter-ies显示文摘 | SUN II P IRINA G OKADA S ct al | 2011 | Journal of the Electrochemical Society2011，158，10： | 1 |
| 14 | Carbon source dependence and photostimulation of conidiatiou in Hypocrea atroviridis显示文摘 | MARTINA A F CHRISTIAN P K IRINA S D | 2008 | Applied and Enviroumental Microbiology2008，74，1： | 1 |
| 15 | Integrated Assessment Models and Response Function Models: Pros and Cons for Sustainable Development Indices Design 显示文摘 | MALKINA P IRINA G | 2002 | Ecological Indicators2002，2，： | 1 |
| 16 | Mitochondrial processing of newly synthesized steroidogenic acute regulatory protein (STAR), but not total STAR, mediates cholesterol transfer to cytochrome P450 side Chain cleavage enzyme in adrenal cells显示文摘 | Irina P A Zhao D Dale B H | 2001 | J Biol Chem2001，276，46： | 1 |
| 17 | Oxidation of H2S on activated carbon KAU and influence of the surface state显示文摘 | Dmitrii V B Yuri P Z Irina V B | 2007 | Appl Catal B: Environ2007，70，14： | 1 |
| 18 | Pallacdium cataluzed C-C and c-heteroatom bond formation reactions显示文摘 | | 1997 | Pure and Appl Chem1997，69，4： | 1 |
| 19 | Concentration/purification of Co(Ⅱ) ions reverse osmosis and ultrafiltration combined with sorption on clay mineral montmorillonite and cation-exchange resin KU-2-8n 显示文摘 | Kryvoruchko Antonina P Atamanenko Irina D Yurlova Lyudmila Yu | 2004 | Journal of Membrane Science2004，228，： | 1 |
| 20 | Reactive oxygen species and mitochondria mediate the induction of apoptosis in human hepatoma HepG2 cells by the rodent peroxisome proliferator and hepatocarcino gen, perfluorooctanoic acid显示文摘 | THEOHARIS P IRINA G S DAN G | 2001 | Toxicology and Applied Pharmacology2001，173，1： | 1 |
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