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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Immobilized cell technologies for the dairy industry显示文摘 | CHAMPAGNE C P LACROIX C ISABELLE S G | 1994 | Critical Reviews in Biotcchnology1994，，121： | 1 |
| 3 | Efficient inhibition of hepatitis B virus infection by acylated peptides derived fa'om the large viral surface protein显示文摘 | Philippe G Isabelle C and Stephan U | 2005 | J Virol2005，79，3： | 1 |
| 4 | Immobilized Cell Technologies for the Dairy Industry显示文摘 | Champagne C P Lacroix C Isabelle S G | 1994 | Critical Reviews in Biotechnology1994，14，2： | 1 |
| 5 | Fusarium as a model for studying virulence in soilborne plant pathogens显示文摘 | Isabel M Roncero G Hera C | 2003 | Physiological and Molecular Plant Pathology2003，62，： | 1 |
| 6 | Does Intracoronary Abciximab Improve the Outcome of Percutaneous Coronary Interventions? A Randomized Controlled Trial显示文摘 | Jose G Juan SR Isabel C | 2006 | Rev Esp Cardiol2006，59，6： | 1 |
| 7 | Synthesis and pharmacological evaluation of thieno pyridine derivatives as novel c-src inhibitors 显示文摘 | Isabelle P Arnaud G Francisco C | 2011 | Bioorg Med Chem2011，19，： | 1 |
| 8 | Relationship between watershed infarcts and recent intra plaque haemorrhage in carotid atherosclerotic plaque显示文摘 | Isabel C Lecler A Turc G | 2014 | Plo S One2014，9，10： | 1 |
| 9 | Genetic variability related to serum uric acid concentration and risk of Parkinson’s disease显示文摘 | Isabel González‐Aramburu Pascual Sánchez‐Juan Silvia Jesús Ana Gorostidi Eduardo Fernández‐Juan Fátima Carrillo María Sierra Pilar Gómez‐Garre María T. Cáceres‐Redondo José Berciano Javier Ruiz‐Martínez Onofre Combarros Pablo Mir Jon Infante | 2013 | Mov Disord2013，，： | 1 |
| 10 | Effect of the partial replacement of Fe by Ni and/or Mn on the electrocatalytic activity for oxygen evolution of the CoFe2O4 spinel oxide elecprode 显示文摘 | Isabel G M Alice C M Da Silva Pereira M I | 2002 | Electrochem Acta2002，，47： | 1 |
| 11 | Efficient inhibition of hepa titis B virus infection by aeylated peptides derived from the large viral surface protein显示文摘 | Philippe G Isabelle C Stephan U | 2005 | J V iro2005，79，3： | 1 |
| 12 | Innate invariant NKT cells recognize mycobacterium tuberculosis-infected macrophages, produce interferon-γ, and kill intracellular bacteria显示文摘 | Isabel SO Asako C Adaena G | 2008 | Plos Pathogens2008，4，12： | 1 |
| 13 | Effects of psychophysical stress( competitive rafting )on saliva interleukin-1 beta 显示文摘 | HARDO C TONIOLO A M ISABELLE A G | 2001 | Stress Health2001，17，1： | 1 |
| 14 | Nutritional program- ming affects hypothalamic organization and early response to Leptin 显示文摘 | Berengere C Valwnie A Isabelle G | 2010 | Endocrinology2010，151，2： | 1 |
| 15 | Combined Fourier Transform Infrared and Raman Spectroscopic Approach for Identification of Multidrug Resistance Pbenotype in Cancer Cell Lines显示文摘 | Krishna C M Kegelaer G Isabelle A D T et ol | 2006 | Biopolymers2006，82，5： | 1 |
| 16 | Determination of tin and titanium in soils,sediments and sludges using electrothermal atomic absorption spectrometry with slurry sample introduction显示文摘 | Ignacio L G Isabel A J Natalia C | 2004 | Talanta2004，62，： | 1 |
| 17 | A novel ther- moreversible gelling product made by enzymatic modifica- tion of starch显示文摘 | Marc J E C Isabelle C Euverink G W | 2005 | Starch2005，57，： | 1 |
| 18 | Targeted Recombination within the Spike Gene of Murine Coro- navirus Mouse Hepatitis Virus-A59:Q159 Is a Deter- minant of Hepatotropism显示文摘 | Isabelle L G Susan T H MING M C | 1998 | J Virol1998，72，12： | 1 |
| 19 | Characterization of poly ( dimethylsiloxane ) -poly ( methylhydrogen siloxane ) composite membranes for organic water pervaporation separation 显示文摘 | Marta O G Alicia I C Isabel A M | 2001 | Journal of Applied Polymer Science2001，81，： | 1 |
| 20 | Solvent Effects on the Reduction Potentials of Nitroanilines 显示文摘 | Maria A S Isabel C Guillermo G | 1985 | J Chem Soc Perkin Trans1985，2，11： | 1 |
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