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	题名	作者	年代	出处	被引量
1	High fat diet dysregulates microRNA-17-5p and triggers retinal inflammation:Role of endoplasmic-reticulum-stress显示文摘AIM To elucidate how high diet-induced endoplasmic reticulum-stress upregulates thioredoxin interacting protein expression in Müller cells leading to retinal inflammation. METHODS Male C57Bl/J mice were fed either normal diet or 60% high fat diet for 4-8 wk. During the 4 wk study, mice received phenyl-butyric acid(PBA); endoplasmic reticulum-stress inhibitor; for 2 wk. Insulin resistance was assessed by oral glucose tolerance. Effects of palmitate-bovine serum albumin(BSA)(400 μmol/L) were examined in retinal Müller glial cell line and primary Müller cells isolated from wild type and thioredoxin interacting protein knock-out mice. Expression of thioredoxin interacting protein, endoplasmic reticulum-stress markers, mi R-17-5p m RNA, as well as nucleotide-binding oligomerization domain-like receptor protein(NLRP3) and IL1β protein was determined.RESULTS High fat diet for 8 wk induced obesity and insulin resistance evident by increases in body weight and impaired glucose tolerance. By performing quantitative real-time polymerase chain reaction, we found that high fat diet triggered the expression of retinal endoplasmic reticulum-stress markers(P < 0.05). These effects were associated with increased thioredoxin interacting protein and decreased mi R-17-5p expression, whichwere restored by inhibiting endoplasmic reticulumstress with PBA(P < 0.05). In vitro, palmitate-BSA triggered endoplasmic reticulum-stress markers, which was accompanied with reduced mi R-17-5p and induced thioredoxin interacting protein m RNA in retinal Müller glial cell line(P < 0.05). Palmitate upregulated NLRP3 and IL1β expression in primary Müller cells isolated from wild type. However, using primary Müller cells isolated from thioredoxin interacting protein knock-out mice abolished palmitate-mediated increase in NLRP3 and IL1β.CONCLUSION Our work suggests that targeting endoplasmic reticulumstress or thioredoxin interacting protein are potential therapeutic strategies for early intervention of obesityinduced retinal inflammation.	Maha Coucha Islam N Mohamed Sally L Elshaer Osinakachuk Mbata Megan L Bartasis Azza B El-Remessy	2017	World Journal of Diabetes2017，8，2：	8
2	Estimation of Surface Evaporation Map over Southern Great Plains Using Remote Sensing Data显示文摘	Islam S	2001	Water Resources Research2001，37，2：	1
3	Estimation of Surface Evaporation Map over Southern Great Plains Using Remote Sensing Datar显示文摘	Jiang L Islam S	2001	Water Resources Research2001，37，2：	1
4	High-efficiency-sensitized solar cell with a novel co-adsorbent显示文摘	Han L Y Islam A Chen H Malapaka C Chiranjeevi B Zhang S F Yang X D Yanagida M		0，，03：	1
5	An Intereomparison of Regional Latent Heat Flux Estimation Using Remote Sensing Data显示文摘	Jiang L Islam S	2003	International Journal of Remote Sensing2003，24，11：	1
6	Heavymetal pollution of coal mine-affected agricultural soils inthe northern part of Bangladesh 显示文摘	Bhuiyan MAH Parvez L Islam M A	2010	Journal ofHazardous Materials2010，173，：	1
7	Current state and future applications of active targeting in malignancies using superparamagnetic iron oxide nanoparticles显示文摘	Islam T Josephson L	2009	Cancer Biomark2009，5，：	1
8	Nonlinear dynamics of hourly ozone concentrations: nonparametric short term prediction 显示文摘	CHEN J L ISLAM S BISWAS P	1998	Atmospheric Environment1998，32，11：	1
9	Tropospheric carbon dioxide or ozone enrichments and moisture effects on soil organic carbon quality显示文摘	ISLAM K R MULCHI C L ALl A A	1999	Journal of Environmental Quality1999，28，5：	1
10	Hemostatic resuscitation during surgery improves survival in patients with traumatic-induced coagulopathy显示文摘	Duchesne JC Islam TM Stuke L	2009	J Trauma2009，67，1：	1
11	A methodology for estimation of surface evapotranspiration over large areas using remote sensing observations 显示文摘	Jiang L Islam S	1999	Geophysical Research Letters1999，26，17：	1
12	Polymers Containing Highly Polarizable Conjugated Side Chains as High-perfor- mance All-Organic Nanodielectrics Materials显示文摘	Qiao Y L Islam M S Han K	2013	Advanced Functional Materials2013，23，45：	1
13	Cirrhosis in hepatitis C virus - infected patients can be excluded using an index of standard biochemical serum markers显示文摘	Islam S Antonsson L Westin J	2005	Scand J Gastroenterol2005，40，7：	1
14	Temperature dependency of MOSFET device characteristics in 4H-and 6H-silicon carbide (SiC)显示文摘	Hasanuzzaman M Islam S K Tolbert L M	2004	Solid-state Electronics2004，48，：	1
15	Nonlinear dynamics of hourly ozone concentrations: nonparametric short term predlction显示文摘	CHEN J L ISLAM S BISWAS P	1998	Atmospheric Environment1998，32，11：	1
16	Methodology for estimation of surface evapotranspiration over large areas using remote sensing observations显示文摘	Jiang L Islam S A	1999	Geophysical Research Letters1999，26，：	1
17	Tackling ship pollution from the shore 显示文摘	PETERSON K L CHAVDARIAN P ISLAM M	2009	Industry Applications Magazine IEEE2009，15，1：	1
18	Interactions of tropospheric CO2 and O3 enrichments and moisture variations on microbial biomass and respiration in soil 显示文摘	Islam K R Mulchi C L Ali A A	2000	Global Change Biology2000，6，：	1
19	Hemostatic resuscitation during surgery improves survival in patients with traumatic-induced coagulopathy显示文摘	Duchesne JC Islam TM Stuke L	2009	J Trauma2009，67，1：	1
20	Interactions of tropospheric CO2 and O3 enrichments and moisture variations on microbial biomass and respiration in soil显示文摘	ISLAM K R MULCHI C L ALl A A	2000	Global Change Biology2000，6，34：	1

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