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| 1 | Label-free visualization of cholesteatoma in the mastoid and tympanic membrane using CARS microscopy显示文摘Objective:The present study aimed to evaluate the possibility of using coherent anti-Stokes Raman spectroscopy(CARS) microscopy to determine the specific molecular morphology of cholesteatoma by detecting the natural vibrational contrast of the chemical bonds without any staining.Materials and methods:Specimens from the mastoid and tympanic membrane with and without cholesteatoma were analyzed using CARS microscopy,two-photon excited fluorescence(TPEF) microscopy,and the second harmonic generation(SHG) microscopy.Results:In cholesteatoma tissues from the mastoid,a strong resonant signal at 2845 cm^(-1) was observed by CARS,which indicated the detection of the CH_2 hydro-carbon lipid bonds that do not generate visible signals at 2940 cm^(-1) suggestive of CH_3 bonds in amino acids.A strong resonant signal at 2940 cm^(-1) appeared in an area of the same specimen,which also generated abundant signals by TPEF and SHG microscopy at 817 nm,which was suggestive of collagen.In the tympanic membrane specimen with cholesteatoma,a strong resonant signal with corrugated morphology was detected,which indicated the presence of lipids.A strong signal was detected in the tympanic membrane with chronic otitis media using TPEF/SHG at 817 nm,which indicated collagen enrichment.The CARS and TPEF/SHG images were in accordance with the histology results.Conclusion:These results suggest the need to develop a novel CARS microendoscope that can be used in combination with TPEF/SHG to distinguish cholesteatoma from inflammatory tissues. | Jing Zou Antti Isomaki Timo Hirvonen Antti Aarnisalo Jussi Jero Ilmari Pyykko | 2016 | Journal of Otology2016，11，3： | 4 |
| 2 | ZnO-SiO_2体系的热力学评价(英文)显示文摘含ZnO炉渣是贱金属和钢的火法冶金过程中常见的炉渣,这导致人们对于ZnO-SiO_2体系热力学的兴趣。本文作者对ZnO-SiO_2体系进行全面的文献评述,对现有实验数据进行批判性评价,对体系相平衡进行热力学优化,给出了ZnO-SiO_2体系在1.013×10~5Pa总压力下的热力学性质。将熔融氧化物视为缔合溶液,重新评估了液相的性质。对固体Zn_2SiO_4吉布斯自由能的焓项重新进行拟合,使之与硅锌矿初晶区的新数据相符。所得热力学数据与新近的实验观测结果吻合良好。这些结果可用于预测热力学性质和相图中的相区,如液相混溶区的临界点,预测准确度优于以往的方法。获得了一组优化的模型参数,在整个组成范围内,温度从298 K到液相线温度,重新生成了可靠的热力学和相平衡数据,其误差在实验误差范围内。建立的数据库可用于Gibbs自由能最小化软件中热力学性质和有关相图截面的计算。 | Iikka ISOMAKI Rui ZHANG 夏隆巩 Niko HELLSTEN Pekka A.TASKINEN | 2018 | Transactions of Nonferrous Metals Society of China2018，28，9： | 2 |
| 3 | Svnovial fluid T cells from patients with rheumatoid arthritis ate refractory to the T helper type 2 diferentiation inducing efeets of interleukin-4 显示文摘 | Isomaki P Luukkainen R Lassila O | 1999 | Immunology1999，96，： | 1 |
| 4 | The expression of SOCS is altered in rheumatoid arthritis显示文摘 | Isomaki P Alanara T Isohanni P | 2007 | Rheumatology2007，46，15： | 1 |
| 5 | Regulation of CD154-induced interleukin 12 production in synovial fluid macrophages显示文摘 | Mottonen M Isomaki P Luukkainen R | 2002 | Arthritis Res2002，4，5： | 1 |
| 6 | Regulation of CD154-induced interleuldn-12 production in synovial fluid macrophages显示文摘 | Mottonen M Isomaki P Luukkainen R | 2002 | Arthritis Res2002，4，5： | 1 |
| 7 | Elevated cancer incidence in patients with der- matomyositis: a population based study 显示文摘 | Airio A Pukkala E Isomaki H | 1995 | J Rheumatol1995，22，7： | 1 |
| 8 | Synovial fluid T cells from patients with rheumatoid arthritis are refractory to the T helper type 2 differentiation-inducing effects of interleukin-4 显示文摘 | Luukkainen R Lassila O | 1999 | Immunology1999，96，： | 1 |
| 9 | Interleukin-10 functions as an antiinflammatory cytokine in rheumatoid synovium 显示文摘 | Isomaki P Luukkainen R Saario R | 1996 | Arthritis Rheum1996，39，3： | 1 |
| 10 | Thinning intensity and long-term changes in increment and stem form of Norway spruce trees 显示文摘 | Harri Makinen Antti Isomaki | 2004 | Forest Ecology and Management2004，201，3： | 1 |
| 11 | JAlloy Compd显示文摘 | Isomaki I | 2006 | 416:1202006，416，： | 1 |
| 12 | Increased type Icollagen degradation in early rheumatoid arthritis显示文摘 | KOTANIEMI A ISOMAKI H HAKALA M | 1994 | J Rheumatol1994，21，： | 1 |
| 13 | Clear cell sarcoma of tendons and aponeuroses (malignant melanoma of soft parts) in the duode- num: the first visceral case显示文摘 | Ekfors T O Kujari H Isomaki M | 1993 | Histopathology1993，22，3： | 1 |
| 14 | Thermodynamic evaluation of the Co-Zn system显示文摘 | ISOMAKI I HAMALAINEN M | 2004 | Journal of Alloys and Compounds2004，375，12： | 1 |
| 15 | Interleukin-lO functions as an antiinflammatory cytokine in rheumatoid syn- ovium显示文摘 | Isomaki P Luukkainen R Saario R | 1996 | Arthritis Rheum1996，39，3： | 1 |
| 16 | Discontinuous Change in Multilevel Hierarchical Systems 显示文摘 | Rosser J B Jr Folke C Gunther F Isomaki H Perrings C Puu T | 2004 | Systems Research2004，，11： | 1 |
| 17 | Synovial fluid T cells from patients with rheumatoid arthritis are refractory to the T helper type 2 differentiation-inducing effects of interleukin-4 显示文摘 | Isomaki P Luukkainen R Lassila O | 1999 | Immunology1999，，96： | 1 |
| 18 | Regulation of CD154 - induced interleukin - 12 production in synovial fluid macrophages 显示文摘 | Mottonen M Isomaki P Luukkainen R | 2002 | Arthritis Res2002，4，5： | 1 |
| 19 | The expression of SOCS is altered in rheumatoid arthritis显示文摘 | Isomaki P Alan?r? T Isohanni P | 2007 | Rheumatology (Oxford)2007，46，10： | 1 |
| 20 | Interleukin-10 functions as an antiinflammatory cytokine in rheumatoid synovium显示文摘 | Isomaki P Luukkainen R Saario R | 1996 | Arthritis Rheum1996，39，3： | 1 |
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