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| 1 | Distribution and effects of polymorphic RANTES gene alleles in HIV/HCV coinfection - A prospective cross-sectional study显示文摘AIM: Chemokines and their receptors are crucial for immune responses in HCV and HIV infection. RANTES gene polymorphisms lead to altered gene expression and influence the natural course of HIV infection. Therefore,these mutations may also affect the course of HIV/HCV coinfection.METHODS: We determined allele frequencies of RANTES-403 (G→A), RANTES-28 (C→G) and RANTESIN1.1 (T→C) polymorphisms using real-time PCR and hybridization probes in patients with HIV (n = 85), HCV (n= 112), HIV/HCV coinfection (n = 121), and 109 healthy controls. Furthermore, HIV and HCV loads as well as CD4+ and CD8+ cell counts were compared between different RANTES genotypes.RESULTS: Frequencies of RANTES-403 A, RANTES-28 G and RANTES-IN1.1 C alleles were higher in HIV infected patients than in healthy controls (-403: 28.2% vs 15.1%,P = 0.002; -28: 5.4% vs 2.8%, not significant; IN1.1:19.0% vs 11.0%, P = 0.038). In HIV/HCV coinfected patients, these RANTES alleles were less frequent than in patients with HIV infection alone (15.4% P = 0.002;1.7%; P = 0.048; 12.0%; not significant). Frequencies of these alleles were not significantly different between HIV/HCV positive patients, HCV positive patients and healthy controls.CONCLUSION: All three RANTES polymorphisms showed increased frequencies of the variant allele exclusively in patients with HIV monoinfection. The finding that the frequencies of these alleles remained unaltered in HIV/HCV coinfected patients suggests that HCV coinfection interferes with selection processes associated with these alleles in HIV infection. | Golo Ahlenstiel Agathe Iwan Jacob Nattermann Karin Bueren Jürgen K Rockstroh Hans H Brackmann Bernd Kupfer Olfert Landt Amnon Peled Tilman Sauerbruch Ulrich Spengler Rainer P Woitas | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 2 | Entrapment of phenylalanine ammonia-lyase in silk fibroin for protection from proteolytic attack显示文摘 | INOUE S MATSUNAGA Y IWANE H | 1986 | Biochem Bio-Phys Res Commun1986，141，1： | 2 |
| 3 | Nature显示文摘 | Kitarnura K Tokunaga M Iwane A H | 1999 | 397: 121999，397，： | 1 |
| 4 | Ultrasound assisted extraction of anthraquinones from roots of Morinda citrifolia显示文摘 | Surasak H Prasert P Art iwan S | 2006 | Ult rasonic Sonochem2006，13，6： | 1 |
| 5 | Trace gas detection with cavity ring down spectroscopy 显示文摘 | Jongma Rienk T Boogaarts Maarten G H Holleman Iwan | 1995 | Review of Scientific Instruments(S0034-6748)1995，66，4： | 1 |
| 6 | Response of systems with uncertain parameters to stochastic excitation显示文摘 | Jensen H Iwan W D | 1992 | Journal of Engineering Mechanics Division ASCE1992，118，5： | 1 |
| 7 | Direct observation of stray crystal formation in unidirectional solidification of Sn-Bi alloy by X-ray imaging显示文摘 | Yasuda H Ohnaka I Kawasaki K Sugiyama A Ohmichi T Iwane J Umetani K | 2004 | Journal of Crystal Growth2004，262，14： | 1 |
| 8 | Single molecular assay of individual ATP turnover by a myosin-GFP fusion protein expressed in vitro显示文摘 | IWANE A H | 1997 | FEBS Lett1997，407，： | 1 |
| 9 | Noninvasive measures of oxidative metabolism on working human muscle by measured by near infrared spectroscopy显示文摘 | Hamaoka T Iwane H Shimomitsu T | 1996 | J Appl Physiol1996，81，3： | 1 |
| 10 | The catalytic life of CdBr2- KBr and its affect on the rate of indole formation from aniline and eth- ylene glycol显示文摘 | Seto T Kujira K Iwane H | 1995 | Bull Chem Soc Jpn1995，68，12： | 1 |
| 11 | Trace element levels in drinking water and the incidence of colorectal cancer 显示文摘 | Kikuchi H Iwane S Munakata A | 1999 | Tohoku J Exp Med1999，188，3： | 1 |
| 12 | Noninvasive measures of oxidative metabolism on working human mus-cles by near - infrared spectroscopy 显示文摘 | Iwane H Hamaoka T Shimomitsu T | 2006 | J Appl Physiol2006，，81： | 1 |
| 13 | Mechanical properties and cell cultural response of polycaprolactone scaffolds designed and fabricated via fused deposition modeling 显示文摘 | Dietmar W H Thorsten S Iwan Z | 2001 | J Biomedical Materials Research2001，55，2： | 1 |
| 14 | A large step for Myosin显示文摘 | Toshio Yanagida Atsuko H Iwane | 2000 | Commentary2000，97，： | 1 |
| 15 | Noninvasive measures of oxidative metabolism on working human muscles by near-infrared spectroscopy显示文摘 | Hamaoka T Iwane H Shimomitsu T | 1996 | J Appl Physiol1996，81，3： | 1 |
| 16 | Hepatitis C virus E2 and CD81 interaction may be associated with altered trafficking of dendritic cells in chronic hepatitis C 显示文摘 | Nattermann J Zimmermann H Iwan A | 2006 | Hepatology2006，44，4： | 1 |
| 17 | Customer segmentation revisited: The case of the airline indus- try显示文摘 | Thorsten T Edlira S H Iwan W | 2008 | Transportation Research Part A2008，42，： | 1 |
| 18 | MyosinV makes two Brownian 90 degrees rotations per 362nm step显示文摘 | Komori Y Iwane A H Yanagida T | | 0，，10： | 1 |
| 19 | Response of systems with uncertain parameters to stochastic excitation 显示文摘 | JENSEN H IWAN H D | 1992 | Journal of Engineering Mechanics1992，118，5： | 1 |
| 20 | 显示文摘 | SAITO K TOKUNAGA M IWANE A H | 1997 | J Microsc1997，188，： | 1 |
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