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| 1 | 人小梁网的氧化DNA损害——与原发性开角青光眼患者的临床相关性显示文摘目的:评价氧化的分子损害的强度及其临床相关性:视野(VF)损害、眼压、年龄和病程长短。
方法:从17例行标准滤过手术的青光眼患者收集的人小梁网标本中提取DNA。与21只角膜移植收集的健康眼标本作对照。氧化DNA损害由测定8-羟基-2’-脱氧鸟苷(8-OH-dG)水平来估价。所有患者术前均经Humphrey 30-2视野检查和日间眼压测量。
结果:在青光眼患者和对照组中,DNA氧化损害的均数±标准差分别为8.51±5.44和1.75±1.80 8-OH-dG个分子/10。正常核苷酸。在人小梁网DNA氧化损害、视野损害和眼压之间发现了统计学上显著的相关性。没有发现其他统计学上的显著相关性。
结论:氧化应激在原发性开角青光眼代表着一个重要的致病步骤。因为它诱发了人小梁网的变性,有助于眼压升高。由此启动了青光眼的发病级联过程。 | Sergio Claudio Sacca Antonio Pascotto Paola Camicione Paolo Capris Alberto Izzotti 林旭初(译) 惠延年(校) | 2005 | 美国医学会眼科杂志(中文版)2005，17，4： | 10 |
| 2 | Mechanisms of N-acetylcysteine in the prevention of DNA damage and cancer with special reference to smoking-related end-points upregulation 显示文摘 | DE FLORA S IZZOTTI A D AGOSTINI F | 2001 | Carcinogenesls2001，22，7： | 1 |
| 3 | Molecular epidemiology of atherosclerosis显示文摘 | De Flora S Izzotti A Walsh D | 1997 | FASEB J1997，11，： | 1 |
| 4 | Cancer biomarkers in human atherosclerotic lesions:detection of DNA adducts显示文摘 | Izzotti A De Flora S Petrilli GL | 1995 | Cancer Epidemiol Biol Prev1995，4，： | 1 |
| 5 | Mechanism of N-acetyleysteine in the prevention of DNA damage and caner, with special reference to smoking-related end-points 显示文摘 | De Flora S Izzotti A D Agostini F | 2001 | Carcinogenesis2001，22，7： | 1 |
| 6 | Interaction between Helicobact- er pylori, diet, and genetic polymorphisms as related to non-cancer dis- eases显示文摘 | Izzotti A Durando P Ansaldi F | 2009 | Mutat Res2009，667，12： | 1 |
| 7 | Drug metabolism polymorphisms as modulators of cancer susceptibility 显示文摘 | Taningher M Malacame D Izzotti A | 1999 | Mutat Res1999，436，3： | 1 |
| 8 | Gene expression in the lung of p53 mutant mice exposed to cigarette smoke 显示文摘 | Izzotti A Cartiglia C Longobardi M | 2004 | Cancer Res2004，64，： | 1 |
| 9 | Interplay between Helicobacter pylori and host gene polymorphisms in inducing oxidative DNA damage in the gastric mucosa显示文摘 | Izzotti A de Flora S Cartiglia C | 2007 | Carcinogenesis2007，28，4： | 1 |
| 10 | Downregulation of microRNA expression in the lungs of rats exposed to cigarette smoke显示文摘 | Izzotti A Calin G A Arrigo P | 2009 | FASEB J2009，23，3： | 1 |
| 11 | The role of oxidative stress in glaucoma显示文摘 | Izzotti A Bagnis A Saecd SC | 2006 | Mutat Res2006，612，2： | 1 |
| 12 | Downregulation of microRNA expression in the lungs of rats exposed to cigarette smoke显示文摘 | Izzotti A Calin GA Arrigo P | 2009 | FASEB J2009，23，3： | 1 |
| 13 | Formation of adducts by bisphenol A, an endocrine disruptor, in DNA in vitro and in liver and mammary tissue of mice显示文摘 | Izzotti A Kanitz S D'Agostini F | 2009 | Murat Res2009，679，： | 1 |
| 14 | Mechanisms of N-acetyl-cysteine in the prevention of DNA damage and cancer, with special reference to smoking-related end-points 显示文摘 | De Flora S Izzotti A D' Agostini F | 2001 | Carcinogenesis2001，22，7： | 1 |
| 15 | Mechanism of N-acetyl-Cysteine in the prevention of DNA damage and cancer, with special reference to smoking-related endpoints显示文摘 | De Flora S Izzotti A D Agostini F | 2001 | Carcinogenesis2001，22，7： | 1 |
| 16 | Mutagenicity of sediments along the Po River and genotoxicity biomarkers in fish from polluted areas显示文摘 | Vigano L Camoirano A Izzotti A | 2002 | Mutat Res2002，515，： | 1 |
| 17 | Community address: Drug metabolism polymorphisms as modulators of cancer susceptibility显示文摘 | Taningher M Malacarne D Izzotti A | 1999 | Mutat Res1999，436，2： | 1 |
| 18 | Downregulation of mieroRNA expression in the lungs of rats exposed to ciga- rette smoke显示文摘 | Izzotti A Calin GA Arrigo P | 2009 | FASEB J2009，83，： | 1 |
| 19 | Downregulation of microRNA expression in the lungs of rats exposed to cigarette smoke 显示文摘 | Izzotti A Calin GA Arrigo P | 2009 | FASEB J2009，23，3： | 1 |
| 20 | Mechanisms of N-acetylcysteine in the prevention of DNA damage and cancer, with special reference to smoking-related end-points显示文摘 | De Flora S Izzotti A D' Agostini F | 2001 | Carcinogenesis2001，22，7： | 1 |
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