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| 1 | Increased secretion of pro-inflammatory cytokines by circulating polymorphonuclear neutrophills and regulation by interleukin 10 during intestinal inflammation显示文摘Increasedsecretionofproinflammatorycytokinesbycirculatingpolymorphonuclearneutrophilsandregulationbyinterleukin10duringintes... | S Nikolaus 1, J Bauditz 1, P Gionchetti 2, C Witt 3, H Lochs 1 and S Schreiber 1 1Charité University Hospital, 4th Medical Department, Humboldt University, Berlin, Germany 2Clinica Media I, Policlinico S. Orsola, University of Bolog | 1998 | World Journal of Gastroenterology1998，4，3： | 17 |
| 2 | High expression levels of IKK alpha and IKK beta are necessary for the malignant properties of liver cancer显示文摘IKK-NF-kappa B signaling is regarded as an important factor in hepatocarcinogenesis and a potential target for liver cancer therapy.Therefore,in this study,we analyzed the expression of mRNAs encoding components and targets of NF-kappa B signaling including IKK alpha,IKK beta,RANK,RANKL,OPG,CyclinD3,mammary serine protease inhibitor(Maspin),CyclinD1,c-FLIP,Bcl-x1,Stat3,Cip1 and Cip2 by real-time PCR in 40 patients with liver cancer.After statistical analysis,7 indices including IKK alpha,IKK beta,RANK,Maspin,c-FLIP,Cip2 and cyclinD1 were found to show significant differences between tumor tissue and its corresponding adjacent tissue.When IKK alpha and IKK beta were downregulated in the hepatocellular carcinoma(HCC) cell lines of MHCC-97L and MHCC-97H in vitro,the numbers of BrdU positive cells were decreased in both IKK alpha and IKK beta knockdown cells.Levels of apoptosis were also investigated in IKK alpha and IKK beta knockdown cells.The growth of HCC was inhibited in the subcutaneous implantation model,and lung metastatogenesis was also significantly inhibited in the kidney capsule transplantation model.Downregulation of IKK alpha and IKK beta in HCC cultured in vitro revealed that increased Maspin,OPG and RANKL expression was associated with metastasis of HCC.These findings were associated with downregulation of Bcl-XL and c-FLIP,which may be the reason for increased apoptosis.The therapeutic effect of IKK alpha and IKK beta downregulation depends on extent of NF-kappa B inhibition and the malignant nature of the HCC.We anticipate that IKK-targeted gene therapy can be used in the treatment of HCC,a cancer that is notoriously resistant to radiation and chemotherapy. | Jiang,RQ Xia,YX Li,J Deng,L Zhao,L Shi,J Wang,XH Sun,BC Nanjing Med Univ,Liver Transplantat Ctr,Affiliated Hosp 1,Nanjing,Jiangsu Prov,Peoples R China Nanjing Med Univ,Ctr Canc,Nanjing,Jiangsu Prov,Peoples R China | 2010 | 南京医科大学学报(自然科学版)2010，30，5： | 13 |
| 3 | Estimation of methane and nitrous oxide emissions from biomass waste in China:A case study in Hebei Province显示文摘Crop residue,animal manure and MSW are selected as representative biomass waste.Greenhouse gas emissions from treatment and disposal process of biomass waste in Hebei province are estimated for the period from 2002 to 2007,using the methodologies recommended by the Intergovernmental Panel on Climate Change.Greenhouse gas emission was about 10 Mt CO2-equivalent annually.About 6% of greenhouse gas emission came from open burning of crop residue,74% from management system of animal manure,and 20% from MSW disposal.Among all the greenhouse gas sources,landfill is the most concentrated one,and has significant potential of emission reduction. | LUO YuXiang1,WANG Wei1,WAN Xiao2,DENG Zhou2 & ZHU CuiPing2 1 Department of Environmental Science and Engineering,Tsinghua University,Beijing 10084,China 2 J&K China Cleaning Energy Technology Company Limited,Beijing 100085,China | 2010 | Science China(Technological Sciences)2010，53，1： | 6 |
| 4 | High spin states in stable nucleus ^(84)Sr显示文摘High spin states of 84Sr were populated through the reaction 70Zn(18O,4n)84Sr at 75 MeV beam energy.Measurement of excitation function,γ-γ coincidences,directional correlation from oriented state (DCO) ratios and γ-transition intensities were performed using eight anticompton HPGe detectors and one planar HPGe detector.Based on the measured results,a new level scheme of 84Sr was established in which 12 new states and nearly 30 new γ-transitions were identified in the present work.The positive-parity states of the new level scheme were compared with the results from calculations in the framework of the projected shell model (PSM).One negative-parity band was extended to spin Iπ=19-and it can be found that in the high spin states,the γ-transition energies show the nature of signature staggering.The negative-parity band levels are in good agreement with deformed configuration-mixing shell model (DCM) calculations. | KANG XuZhong1,2,SHEN ShuiFa1,2,3,4*,HAN GuangBing5,PAN Feng3,4,GU JianZhong6,DRAAYER J P4,WU XiaoGuang6,ZHU LiHua6 & WEN TingDun7 1 Key Laboratory of Nuclear Resources and Environment (East China Institute of Technology),Ministry of Education,Nanchang 330013,China 2 School of Nuclear Engineering and Technology,East China Institute of Technology,Fuzhou 344000,China 3 Department of Physics,Liaoning Normal University,Dalian 116029,China 4 Department of Physics and Astronomy,Louisiana State University,Baton Rouge,LA 70803-4001,USA 5 School of Physics,Shandong University,Jinan 250100,China 6 China Institute of Atomic Energy,Beijing 102413,China 7 Department of Physics,North University of China,Taiyuan 030051,China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，10： | 4 |
| 5 | NUMERICAL SIMULATION OF MECHANICAL BEHAVIOR DURING LOCAL POSTWELD HEAT TREATMENT显示文摘Local postweld heat treatment (PWHT)is usually performed when it is impractical to heat treat the whole vessel in a furnace, Many factors have an influence on PWHT procedures, such as size of the pipe,heated widths, insulation conditions, heating rates soak temperatures and hold times, material composition etc,. However up to now the influences these factors have on PWHT are not very clearly understood and different criteria for sizing the parameters can be found in different codes. This study provides a direct method to assess the effectiveness of local PWHT.An axisymmetrical model was used based on the thermal-visco-elastic-plastic Finite Element Method with the consideration of creep phenomena. By using this method both temperature and stress distributions can be simulated during whole local PWHT history. The computation results of temperature distributions and the strain histaries during local PWHT are compared with the experiments, and good agreements are obtained, Investigations show that the thermal stresses induced by local PWHT are much affected by creep behavior and the changes of Young’s Modulus. The study of stress relief history shows that the stresses decrease quickly in the heating stage, then decrease slowly according to creep law in the hold stage and then studdenly increase when the cooling stage starts. The study shows the possibility that through a series of computations the effects of many factors can be assessed and the optimum parnmeters can be found. Compared with the heated widths based apon some applicable codes, it is found that a heated area of 2.5 on either side of the weld seems more reasonable. | J,H, Wang, H. Lu and H. Murakawa 1) Shanghai Jiao Tong University, Shanghai 200030.China 2) Osaka University,Japan | 2000 | Acta Metallurgica Sinica(English Letters)2000，13，2： | 2 |
| 6 | A New Triterpenoid Saponin from the Seeds of Deccaria segetalis显示文摘A new triterpenoid saponin, named segetoside k, has been isolated from the seeds of Vaccaria segetalis. On the basis of chemical reaction and spectral analysis, the structure of segetoside K was established as:olean-12-ene-23a, 286-dioic acid 36, 16a-dihydroxy-28-O- [βD-glucopyranosyl-(1 →3)]-β-D-glucopyra-nosyl-(l →2)-β-D-glucopyranosyl-(l→6)-β-D- glucopyranoside(1). | Sheng Min SANG Min Liang ZOU Ai Na LAO Zhong Liang CHEN Jun UZAWA and Yasuo FUJIMOTO (Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 20003 1 The Institute of Physical and Chemical Research (RIKEN), Wako, Saitama 351-01, J | 2000 | Chinese Chemical Letters2000，11，1： | 2 |
| 7 | Apoptosis in developing anthers and the role of ABA in this process during androgenesis in Hordeum vulgate L显示文摘 | WANG M HOEKSTRA S VAN BERGEN S LAMERS GEM OPPEDIJK B J VAN DER HEUDEN M W DE PRIESTER W SCHILPEROORT RA 1 | 1999 | Plant Mol Biol1999，39，： | 1 |
| 8 | Early experience in robot -assisted laparoscopic Heller myotomy显示文摘 | Ruurda J P Gooszen H G Broeders 1 A | 2004 | Scand J Gastroenterol Suppl2004，，241： | 1 |
| 9 | Experimental plant and the technological transfer centre: urban wastewater treatment experimental platforms for the small rural communities in the mediterranean area显示文摘 | FAHD K MARTIN 1 SALAS J | 2007 | Desalination2007，215，： | 1 |
| 10 | Prognostic factors in adult patients up to 60 years old with acute myeloid leukemia and translocations of chromosome band I lq23: individual patient data-based meta-analysis of the German Acute Myeloid Leukemia Intergroup显示文摘 | Krauter J Wagner K Schafer 1 | 2009 | J Clin Oncol2009，27，18： | 1 |
| 11 | Electrical triggering of metal-insulator transition in nanoscale vanadium oxide junctions显示文摘 | Ruzmeto 1 D Gnpalakrisbnan G Deng J D | 2009 | Journal of Applied Physics2009，106，08： | 1 |
| 12 | Efficacy of CFRP- based techniques for the flexural and shear strengthening of concrete beams 显示文摘 | Barros J A O Dias S J E Lima J 1 T | 2007 | Cement and Concrete Composites2007，29，3： | 1 |
| 13 | Multi-sensor image fusion in remotesensing : concepts , methods and applications 显示文摘 | Poh 1 C Genderen J L | 1998 | International Journal of Remote Sensing1998，19，5： | 1 |
| 14 | Determination of organophosphate pesticides at a carbon nanotube/organophosphorus hydrolase electrochemical biosensor 显示文摘 | Deo R P Wang J Block 1 | 2005 | Analytica Chimica Acta2005，530，2： | 1 |
| 15 | Power Distribution Networks for System on Package: Status and Challenges 显示文摘 | Swaminathan M Kim J Novak 1 | 2004 | IEEE Transactions on Advanced Packaging2004，27，2： | 1 |
| 16 | Intra-abdominal hypertension and abdominal compartment syndrome 显示文摘 | De Waele J J De Laet 1 Kirkpatrick AW | 2011 | Am J Kidney Dis2011，57，1： | 1 |
| 17 | Diet and light intensity effects on survival,growth and pigmentation of southern flounder Paralich- thys lethostigma 显示文摘 | DENSON M R SM1TH T 1 J | 1997 | J World Aquacult Soc1997，28，4： | 1 |
| 18 | A review on market power in deregulated electricity market 显示文摘 | KARTHIKEYAN S P RAGLEND 1 J KOTHARI D P | 2013 | International Journal of Electrical Power and Energy Systems2013，48，： | 1 |
| 19 | An exploratory investigation of responses elicited by music varying in tempo, tonality, and texture显示文摘 | Kellaris 1 J Kent R J | 1993 | Journal of Consumer Psychology1993，2，4： | 1 |
| 20 | Growth of CH3NH3PbI3 cuboids with controlled size for high-efficiency per- ovskite solar cells显示文摘 | Im J H Jang 1 H Pellet N | 2014 | Nature Nanoteclmology2014，9，11： | 1 |
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