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| 1 | Functional brain imaging of gastrointestinal sensation in health and disease显示文摘It has since long been known, from everyday experience as well as from animal and human studies, that psychological processes-both affective and cognitive- exert an influence on gastrointestinal sensorimotor function. More specifi cally, a link between psychological factors and visceral hypersensitivity has been suggested, mainly based on research in functional gastrointestinal disorder patients. However, until recently, the exact nature of this putative relationship remained unclear, mainly due to a lack of non-invasive methods to study the (neurobiological) mechanisms underlying this relationship in non-sleeping humans. As functional brain imaging, introduced in visceral sensory neuroscience some 10 years ago, does provide a method for in vivo study of brain-gut interactions, insight into the neurobiological mechanisms underlying visceral sensation in general and the influence of psychological factors more particularly, has rapidly grown. In this article, an overview of brain imaging evidence on gastrointestinal sensation will be given, with special emphasis on the brain mechanisms underlying the interaction between affective & cognitive processes and visceral sensation. First, the reciprocal neural pathways between the brain and the gut (brain- gut axis) will be briefky outlined, including brain imaging evidence in healthy volunteers. Second, functional brain imaging studies assessing the influence of psychological factors on brain processing of visceral sensation in healthy humans will be discussed in more detail. Finally, brain imaging work investigating differences in brain responses to visceral distension between healthy volunteers and functional gastrointestinal disorderpatients will be highlighted. | Lukas Van Oudenhove Steven J Coen Qasim Aziz | 2007 | World Journal of Gastroenterology2007，13，25： | 9 |
| 2 | Effect of B vitamin supplementation on plasma homocysteine levels in celiac disease显示文摘AIM: To investigate the effect of vitamin supplements on homocysteine levels in patients with celiac disease. METHODS: Vitamin B6, folate, vitamin B12, and fasting plasma homocysteine levels were measured in 51 consecutive adults with celiac disease [median (range) age 56 (18-63) years; 40% men, 26 (51%) had villous atrophy, and 25 (49%) used B-vitamin supplements] and 50 healthy control individuals matched for age and sex. Finally, the C677T polymorphism of 5,10-methylene tetrahydrofolate reductase (MTHFR) was evaluated in 46 patients with celiac disease and all control individuals. RESULTS: Patients with celiac disease and using vitamin supplements had higher serum vitamin B6 (P = 0.003),folate (P < 0.001), and vitamin B12 (P = 0.012) levels than patients who did not or healthy controls (P = 0.035, P < 0.001, P = 0.007, for vitamin B6, folate, and vitamin B12, respectively). Lower plasma homocysteine levels were found in patients using vitamin supplements than in patients who did not (P = 0.001) or healthy controls (P = 0.003). However, vitamin B6 and folate, not vitamin B12, were significantly and independently associated with homocysteine levels. Twenty-four (48%) of 50 controls and 23 (50%) of 46 patients with celiac disease carried the MTHFR thermolabile variant T-allele (P = 0.89). CONCLUSION: Homocysteine levels are dependent on Marsh classification and the regular use of B-vitamin supplements is effective in reduction of homocysteine levels in patients with celiac disease and should be considered in disease management. | Muhammed Hadithi Chris JJ Mulder Frank Stam Joshan Azizi J Bart A Crusius Amado Salvador Pea Coen DA Stehouwer Yvo M Smulders | 2009 | World Journal of Gastroenterology2009，15，8： | 3 |
| 3 | 二甲双胍长期治疗2型糖尿病患者以及维生素B12缺乏的危险性:随机安慰剂对照研究(摘要)显示文摘目的 研究接受胰岛素治疗的2型糖尿病患者中,二甲双胍所致维生素B12缺乏(〈150pmol/L)、低浓度维生素B12(150—220pmol/L)的发生率,以及叶酸和同型半胱氨酸的浓度。 | Jolien de Jager Adriaan Kooy Philippe Lehert Michiel G Wulffele Jan van der Kolk Daniel Bets Joop Verburg Ab J M Donker Coen D A Stehouwer 许翎岭(译) | 2010 | 英国医学杂志中文版2010，13，5： | 2 |
| 4 | The crystal structure of an unusual processivity factor, herpes simplex virus UL42, bound to the C terminus of its cognate polymerase 显示文摘 | ZUCCOLA H J FILMAN D J COEN D M | 2000 | Mol Cell2000，5，2： | 1 |
| 5 | Clogging of biliary endoprosthesis: a new perspective显示文摘 | Coene P Groen A Cheng J | 1990 | Gut1990，31，： | 1 |
| 6 | Floricaula:a homeotic gene required for flower development in Antirrhinum majus显示文摘 | Coen E S Romero J M Doyle S | 1990 | Cell1990，63，： | 1 |
| 7 | An integrated metabonomic investigation of acetaminophen toxicity in the mouse using NMR spectroscopy 显示文摘 | Coen M Lenz E M Nicholson J K | 2003 | Chem Res Toxicol2003，16，3： | 1 |
| 8 | Dry lightning显示文摘 | Coen J | 2010 | Southern California Fire Journal2010，1，： | 1 |
| 9 | Supercontinuum generation in photonic crystal fiber显示文摘 | Dudley J M Genty G Coen S | 2006 | RevMod Phys2006，78，： | 1 |
| 10 | A method for using WEPS to map wind erosion risk of Alberta soils 显示文摘 | Coen G M Tatarko J Martin T C | 2004 | Environmental Modelling and Software2004，19，18： | 1 |
| 11 | Improving HRTEM performance by digital processing of focal image series: Results from the CM20 FEG-Super TWIN显示文摘 | COENE W JANSSEN A J E M op de BEECK M van DYCK D | 1992 | Electron Opt Bull1992，132，： | 1 |
| 12 | Phase retrieval through focus variation for ultra-resolution in field-emission transmission electron microscopy显示文摘 | COENE W JANSSEN A J E M op de BEECK M van DYCK D | 1992 | Phys Rev Lett1992，69，： | 1 |
| 13 | Focal-series reconstruction in HRTEM: Simulation studies on non-periodic objects显示文摘 | THUST A COENE W M J op de BEECK M van DYCK D | 1996 | Ultramicroscopy1996，64，14： | 1 |
| 14 | Thymidine kinase-negative herpes simplex virus mutants establish latency in mouse trigeminal but do not reactivate 显示文摘 | Coen D M Jaeobson J G | 1989 | Proe Natl Acad Sei USA1989，86，12： | 1 |
| 15 | Simulation of the Big Elk Fire using coupled atmosphere-fire modeling显示文摘 | Coen J L | 2005 | International Journal of Wildland Fire2005，14，1： | 1 |
| 16 | Radical radiation for localized prostate cancer: local persistence of disease results in a late wave of metastases 显示文摘 | Coen J J Zietman AL Thakral H et el | 2002 | J Clin Oncol2002，20，15： | 1 |
| 17 | An integrated metabonomic investigation of acetaminophen toxicity in the mouse using NMR spectroscopy 显示文摘 | COEN M LENZ E M NICHOLSON J K | 2003 | Chem Res Toxicol2003，16，3： | 1 |
| 18 | NMR-based metabolic profiling and metabonomic approaches to problems in molecular toxicology 显示文摘 | COEN M HOLMES E LINDON J C | 2008 | Chem Res Toxicol2008，21，1： | 1 |
| 19 | Diagnosis, assessment, and treatment of bone turnover abnormalities in renal osteodystrophy显示文摘 | Kevin J Martin Klaus Olgaard Jack W Coburn Giorgio M Coen Masafumi Fukagawa Craig Langman Hartmut H Malluche James T McCarthy Shaul G Massry Otto Mehls Isidro B Salusky Justin M Silver Miroslaw T Smogorzewski Eduardo M Slatopolsky Linda McCann | 2004 | American Journal of Kidney Diseases2004，，3： | 1 |
| 20 | Acommon gene regulates pigmentation pattern in diverse plant species显示文摘 | Goodrich J Carpenter R and Coen E S | 1992 | Cell1992，68，： | 1 |
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