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	题名	作者	年代	出处	被引量
1	Innovative immunohistochemistry identifies MMP-9 expressing macrophages at the invasive front of murine HCC显示文摘AIM:To investigate the proteolytic contribution of tumor-associated macrophages(TAM)in tumor invasion,we analyzed whether TAM at the invasive front of small HCC in Abcb4-/--mice show an enhanced expression of MMP-9. METHODS:Liver cryosections of the hepatocellular carcinoma(HCC)invasive front from 12 mo old Abcb4-/--mice were stained for collagen typeⅠand MMP-9 using Alexa488 and Alexa568 labeled secondary antibodies.Afterwards,the Alexa568 dye was bleached and the macrophage marker F4/80 was visualized using Alexa568 labeled secondary antibodies.Finally, photographs of the invasive tumor front were digitally overlaid and analyzed. RESULTS:After complete bleaching of the primary dye,specific fluorescence staining of a third antigen, here F4/80,was successfully performed on the same histological section.With this method,we were able to identify conglomerates of matrix metalloproteinase (MMP-9)expressing macrophages within the tumor capsule of HCC. CONCLUSION:MMP-9 expressing macrophages are involved in matrix remodelling at the invasive tumor front of HCC.The described staining protocol provides a simple yet powerful extension of conventional immuno-histochemistry,facilitating visualization of at least three different antigens plus nuclei in one single histological section.	Martin Roderfeld Timo Rath Frank Lammert Christian Dierkes Jürgen Graf Elke Roeb	2010	World Journal of Hepatology2010，2，5：	6
2	Ultrastructural findings after intraarticular application of hyaluronan in a canine model of arthropathy显示文摘	Wenz W Breusch SJ Graf J		Journal of Orthopaedic Research0，，：	2
3	Matrix metalloproteinase-13 is regulated by toll-like receptor-9 incolorectal cancer cells and mediates cellular migration显示文摘	Timo Rath Julia St?ckle Martin Roderfeld Annette Tschuschner Jürgen Graf Elke Roeb	2011	Oncology Letters2011，，3：	2
4	The reduction of radar glint by diversity techniques显示文摘	Sims R J Graf E R	1971	IEEE Trans on AP1971，19，4：	1
5	An expandable percutaneous catheter pump for left ventricular support:Proof of concept显示文摘	Schmitz-Rode T Graf J Pfeffer JG	2005	J Am Coll Cardiol2005，45，：	1
6	Matrix metalloproteinases in inflammatory bowel disease-from basic research to clinical significance显示文摘	Rath T Roderfeld M Graf J	2009	ZGastroenterol2009，47，8：	1
7	A randomized double-blind comparison of epidural sufentanil versus intravenous sufentanil or epidural fentanyl analgesia after major abdominal surgery显示文摘	Geller E Chrubasik J Graf R	1993	Anesth Analg1993，76，：	1
8	Serotonin promotes tumor growth in human hepatocellular cancer显示文摘	SOLL C JANG J H RIENER M O MORITZ W WILD P J GRAF R	2010	Hepatology2010，51，：	1
9	Mucormycoses显示文摘	Euckr J Sezer O Graf B	2001	Mycoses2001，44，78：	1
10	Brain natriuretic peptide levels predict functional capacity in patients with chronic heart failure显示文摘	Kruger S Graf J Kunz D		0，，04：	1
11	Coal solubility and swelling: 3 A model for coal swelling显示文摘	PAINTER P C GRAF J COLEMAN M M	1990	Energy Fuels1990，4，4：	1
12	Statin treatment after onset of sepsis in a murine model improves survival显示文摘	Merx M W Liehn E A Graf J	2005	Circulation2005，112，1：	1
13	Lattice dynamics and the high-pressure equation of state of Au显示文摘	Creeff C W Graf M J	2004	Phys Rev B2004，69，05：	1
14	Medulloblastoma with extensive nodularity in nevoid basal cell carcinoma syndrome显示文摘	Aliani S Brunner J Graf N	2003	Med Pediatr Oncol2003，40，4：	1
15	Studies on the Coulter Counter Part Ⅱ:Investigations into the Effect of Flow Direction and Angle of Entry of a Particle on Both Particle Volume and Pulse Shape显示文摘	Davies R Karuhn R Graf J	1975	Powder Technology1975，12，2：	1
16	Electrophysiological properties of human mesenchymal stem cells显示文摘	Heubach JF Graf EM Leutheuser J	2004	J Physiol2004，554，3：	1
17	Caveolins, liquidordered domains and signal transduction 显示文摘	Smart E J Graf G A McNiven M A	1999	Molecular and Cellular Biology1999，19，：	1
18	Electrophysiological properties of human mesenchymal stem cells 显示文摘	Heubach J F Graf E M Judith Leutheuser	2003	J Physiol2003，554，：	1
19	Matrix metalloprotei- nase inflammatory bowel disease from basic research to clinical sig- nify cance显示文摘	RATH T RODERFELD M GRAF J	2009	Z Gastroenterol2009，47，8：	1
20	1 Matrixmetallop roteinases in inflamm a- tory bowel disease-from basic research to clinical significance显示文摘	Rath T Roderfeld M Graf J et a	2009	Zgas- troen tero2009，47，8：	1

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