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| 1 | Medication adherence in schizophrenia显示文摘Non-adherence is a major problem in the treatment of schizophrenia. Its high prevalence, potentially severe consequences and associated costs make the study of this phenomenon a priority issue. In this article, basic non-adherence concepts of prevalence, consequences, evaluation methods, methodological restrictions of available studies, risk factors and intervention strategies, are reviewed. Studying non-adherence risk factors is a necessary step toward designing adequately oriented intervention strategies. An operative definition of adherence and good knowledge of its evaluation methods are essential to study this phenomenon. Unfortunately, most available studies contain methodological restrictions, especially concerning the evaluation methods, and an agreed operative definition of adherence has only very recently been reached. Knowing non-adherence risk factors, intervention strategies and available evidence on their effectiveness is essential in making treatment decisions in daily clinical practice. | Francisco Javier Acosta José Luis Hernández José Pereira Judit Herrera Carlos J Rodríguez | 2012 | World Journal of Psychiatry2012，2，5： | 5 |
| 2 | Takotsubo syndrome:Advances in the understanding and management of an enigmatic stress cardiomyopathy显示文摘Takotsubo cardiomyopathy is a syndrome mimicking an acute myocardial infarction in absence of obstructive epicardial coronary artery disease to explain the degree of the wall motion abnormalities. Typically more common in the elderly women, this condition is usually triggered by unexpected emotional or physical stress situations, and is associated with electrocardiogram abnormalities and slight elevation of cardiac biomarkers. The pathophysiological mechanism is not clear yet, but it is believed that a high circulating concentration of catecholamines causes an acute dysfunction of the coronary microcirculation and metabolism of cardiomyocytes, leading to a transient myocardial stunning. Typically, it presents with acute left ventricular systolic dysfunction that in most cases is completely resolved at short term. Recurrences are rare and it is thought that the long-term prognosis is good. We present here a review of the clinical features, pathophysiology and management of this enigmatic condition. | Hernán David Mejía-Rentería Iván J Núnez-Gil | 2016 | World Journal of Cardiology2016，8，7： | 2 |
| 3 | Leuprolide acetate induces structural and functional recovery of injured spinal cord in rats显示文摘Gonadotropin-releasing hormone(Gn RH) and its synthetic analog leuprolide acetate, a Gn RH agonist, have neurotrophic properties. This study was designed to determine whether administration of leuprolide acetate can improve locomotor behavior, gait, micturition reflex, spinal cord morphology and the amount of microglia in the lesion epicenter after spinal cord injury in rats. Rats with spinal cord compression injury were administered leuprolide acetate or saline solution for 5 weeks. At the 5th week, leuprolide acetate-treated rats showed locomotor activity recovery by 38%, had improvement in kinematic gait and exhibited voiding reflex recovery by 60%, as compared with the 1st week. By contrast, saline solution-treated rats showed locomotor activity recovery only by 7%, but voiding reflex did not recover. More importantly, leuprolide acetate treatment reduced microglial immunological reaction and induced a trend towards greater area of white and gray matter in the spinal cord. Therefore, leuprolide acetate has great potential to repair spinal cord injury. | Carmen Díaz Galindo Beatriz Gómez-González Eva Salinas Denisse Calderón-Vallejo Irma Hernández-Jasso Eduardo Bautista J Luis Quintanar | 2015 | Neural Regeneration Research2015，10，11： | 2 |
| 4 | Sequential extraction of copper, lead, cadmium and zinc in sediments from Ebro River (Spain): relationship with levels detected in earthworms 显示文摘 | RAMOS L GONZALEZ M J HERN ~NDEZ L M | 1999 | Bulletin of Environment Contamination and Toxicology1999，62，： | 1 |
| 5 | Identification of cellular proteins modified in response to African swine fever virus infection by proteomics显示文摘 | Alfonso P Rivera J Hernáez B | 2004 | Proteomics2004，4，7： | 1 |
| 6 | Hydrodynamic and mass transfer characterization of a flat-panel airlift photobioreactor with high light path显示文摘 | Reyna-Velarde R Cristiani-Urbina E Hernández-Melchor D J | 2010 | Chemical Engineering and Processing:Process Intensification2010，49，1： | 1 |
| 7 | Antineutrophil cytoplasmic antibody-associated vasculitides and respiratory diease显示文摘 | Gómez-Puerta JA Hernández-Rodríguez J López-Soto A | 2009 | Chest2009，136，： | 1 |
| 8 | Carbonyls speciation in a typical European automotive diesel engine using blends显示文摘 | Ballestems R Hern/mdez J J Guill6n-Flores J | 2012 | Fuel2012，95，： | 1 |
| 9 | Synthesis and structure determination of a new microporous zeolite with large cavities connected by small pores显示文摘 | Herná ndez-Rodrí guez M Jordá J L Rey F | 2012 | J Am Chem Soc2012，134，13： | 1 |
| 10 | The zeta potential and surface properties of asphaltenes obtained with different crude oil/n-heptane proportions显示文摘 | Parra-Barraza H Hernández-Montiel D Lizardi J | 2003 | Fuel2003，82，18： | 1 |
| 11 | Relationship between oestrogen receptor status and proliferation in predicting response and long term outcome to neoadjuvant chemo?therapy cancer显示文摘 | Jones RL Salte A'Hern R | 2010 | Cancer Res Treat2010，119，2： | 1 |
| 12 | Real-world data is dirty:data cleansing and the merge/purge problem显示文摘 | Hernández M A Stolfo S J | | 0，，01： | 1 |
| 13 | Study of the dose of thyme essential oil in feed to prolong the shelf life of gilthead seabream (Sparus aurata)显示文摘 | HERN ~NDEZ B A GARCIA M J JORD ~N M D | 2014 | Aquaculture Nutrition2014，65，7： | 1 |
| 14 | Random packing of frictionless particles显示文摘 | HERN C S LANGER S A LIU A J | 2002 | Physical Review Letters2002，88，7： | 1 |
| 15 | DCT-domain watermarking techniques for still images:Detector performance analysis and a new structure显示文摘 | J R Hernández M Amado Femando Pérez-González | 2000 | IEEE Trans on Image-Processing2000，9，1： | 1 |
| 16 | The analysis ofhandsheets from wheat straw following solid substrate fermentation by Streptomyces cyaneus and soda cooking treatment显示文摘 | Berrocal M M Rodríguez J Hernández M | 2004 | Bioresource Technology2004，94，1： | 1 |
| 17 | Denitrogenation of Transportation Fuels by Zeolites at Ambient Temperature and Pressure显示文摘 | Hernández-Maldonado A J Yang R T | | 0，，08： | 1 |
| 18 | Role of fumonisin B1 on the immune system, histopathology, and muscle proteins of white shrimp ( Litopenaeus vannamei) 显示文摘 | Mexl6- Salazar A L Hern6ndez - L6pez J Burgos -Hern~mdez A | 2008 | Food Chem2008，110，2： | 1 |
| 19 | Electrochemical quantiration of DNA immobilization on gold显示文摘 | A B Steel T M Herne M J Tarlov | 1998 | Anal Chem1998，70，22： | 1 |
| 20 | An auxin transport independent pathway is involved in phosphate stress-induced root architectural alterations in Arabidopsis: Identification of BIG as a mediator of auxin in pericycle cell activation 显示文摘 | Lopez-Bucio J Hern/mdez-Abreu E Sainchez-Calderon L | 2005 | Plant Physiol2005，137，2： | 1 |
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