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| 1 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 3 |
| 2 | Saccharomyces cerevisiae CNCM I-3856 in irritable bowel syndrome: An individual subject meta-analysis显示文摘AIM To confirm previous conclusions on Saccharomyces cerevisiae(S. cerevisiae) CNCM I-3856 for irritable bowel syndrome(IBS) management.METHODS An individual patient data meta-analysis was performed on two randomized clinical trials studying the effect of S. cerevisiae CNCM I-3856 supplementation on gastrointestinal(GI) symptoms in IBS subjects. A total of 579 IBS subjects were included. Outcomes were the daily Likert scale scores of abdominal pain/discomfort and bloating [area under the curve(AUC) and weekly means], responder status, and bowel movements(stool frequency and consistency). Statistical analyses were conducted in Intent to Treat(ITT) population, IBS-C subjects and IBS-C subjects with an abdominal pain/discomfort score higher than or equal to 2 at baseline('IBS-C ≥ 2 subpopulation').RESULTS S. cerevisiae CNCM I-3856 significantly improved abdominal pain/discomfort and bloating during the second month of supplementation [AUC(W5-W8)]with improvement up to the minimal clinically relevant threshold of 10%: a 12.3% reduction of abdominal pain/discomfort in the ITT population compared to the Placebo group(P = 0.0134) has been observed. In the IBS-C ≥ 2 subpopulation, there were a 13.1% reduction of abdominal pain/discomfort and a 14.9% reduction of bloating compared to the Placebo group(P = 0.0194 and P = 0.0145, respectively). GI symptoms significantly decreased during supplementation but no statistical differences were reported between groups at the end of the supplementation period. Responder status was defined as a subject who experienced a decrease of 1 arbitrary unit(a.u.) or 50% of the abdominal discomfort score from baseline for at least 2 wk out of the last 4 wk of the study. A significant difference between groups was reported in the ITT population, when considering the first definition: subjects in the Active group had 1.510 higher odds to be a responder(reduction of 1 a.u. of abdominal pain/discomfort) compared with subjects in the Placebo group(P = 0.0240). At the end of supplementation period, stool consistency in the Active group of the ITT population was significantly improved and classified as 'normal' compared to Placebo(respectively 3.13 ± 1.197 a.u. vs 2.58 ± 1.020 a.u., P = 0.0003). Similar results were seen in the IBS-C ≥ 2 subpopulation(Active group: 3.14 ± 1.219 a.u. vs Placebo group: 2.59 ± 1.017 a.u., P = 0.0009).CONCLUSION This meta-analysis supports previous data linking S. cerevisiae I-3856 and improvement of GI symptoms, in IBS overall population and in the IBS-C and IBS-C ≥ 2 subpopulations. | Amélie Cayzeele-Decherf Fanny Pélerin Sébastien Leuillet Benoit Douillard Béatrice Housez Murielle Cazaubiel Gunnard K Jacobson Peter Jüsten Pierre Desreumaux | 2017 | World Journal of Gastroenterology2017，23，2： | 2 |
| 3 | A randomized trial comparing uncovered and partially covered self-expandable metal stents in the palliation of distal malignant biliary obstruction显示文摘 | Jennifer J. Telford David L. Carr-Locke Todd H. Baron John M. Poneros Brenna C. Bounds Peter B. Kelsey Robert H. Schapiro Christopher S. Huang David R. Lichtenstein Brian C. Jacobson John R. Saltzman Christopher C. Thompson David G. Forcione Christopher J | 2010 | Gastrointestinal Endoscopy2010，，： | 2 |
| 4 | Oxygen exchange kinetics of epitaxial PrBaCo2O5+δ thin films显示文摘 | KIM G WANG S JACOBSON A J | 2006 | Appl Phys Lett2006，88，02： | 1 |
| 5 | Meta-analysis of comparison of effectiv-eness of lowering apolipoprotein B ver- sus low-density lipoprotein cholesterol and non high-density lipoprotein cholesterol for cardiovascular risk reduction in randomized trims 显示文摘 | ROBINSON J G WANG S JACOBSON T A | 2012 | Am J Cardiol2012，110，10： | 1 |
| 6 | CRH deficiency impairs but does not block pituitaryadrenal responses to diverse stressors显示文摘 | Jacobson L Muglia L J Weninger S C | 2000 | Neuroendocrinology2000，71，： | 1 |
| 7 | Using laboratory experiments in public economics显示文摘 | Aim J Jacobson S | 2007 | National Tax Journal2007，60，1： | 1 |
| 8 | Acoustic phase and amplitude of a signal transmitted through a uniform flow in the deep ocean显示文摘 | WIDTFELDT J A JACOBSON M | 1976 | J Acoust Soc Am1976，59，4： | 1 |
| 9 | Urea utilization by young dairy calves as affixed by chlortetracycline supplementation显示文摘 | Brown L D Jacobson D R Everett J P | 1960 | Journal of Dairy Science1960，43，： | 1 |
| 10 | Thalidomide for the treatment of esophageal aphthous ulcers in patients with human immunodeficiency virus infection显示文摘 | Jacobson JM Spritzler J Fox L | 1999 | J Infect Dis1999，180，1： | 1 |
| 11 | The presence of a specific genotype of Legionella pneumophila serogroup 1 in a hospital and municipal water distribution system over a 12-year period 显示文摘 | Darelid J Bemander S Jacobson K | 2004 | Scand J Infect Dis2004，36，： | 1 |
| 12 | Effuacy of an epidural combination of morphine and detemidine in alleviating experimentally induced hindlimb lameness in horses显示文摘 | Sysel A M Leasant R S Jacobson J D | 1996 | Veterinary Surgery1996，25，6： | 1 |
| 13 | A lubricant model considering wall-slip in EHL line contacts显示文摘 | Stahl J Jacobson Bo O | 2003 | Trans ASME Journal of Tribology2003，125，： | 1 |
| 14 | Retrogradation of starch from different botanical sources显示文摘 | JACOBSON M R OBANNI M BEMILLER J N | 1997 | Cereal Chem1997，74，5： | 1 |
| 15 | Hematoxylin and eosin staining of tissue and cell sections显示文摘 | Fischer AH Jacobson KA Rose J | 2005 | CSI-I Protoc2005，2008，： | 1 |
| 16 | Chronic upper re spiratory tract disease of free-ranging desert tortoises(Xerobates agassizii)显示文摘 | Jacobson E R Gaskin J M Brown M B | 1990 | J Wildl Dis1990，27，： | 1 |
| 17 | Microchip capillary electrophoresis with an integrated postcolumn reactor显示文摘 | Jacobson S C Koutny J M Hergenroeder R | 1994 | Analytical Chemistry1994，66，20： | 1 |
| 18 | Perivascular gene transfer of NADPH oxidase inhibitor suppresses angioplasty-induced neointimal proliferation of rat carotid artery显示文摘 | Dourron H M Jacobson G M Park J L Liu J Reddy D J Scheel M L | 2005 | Am J Physiol Heart Circ Physiol2005，288，： | 1 |
| 19 | Daily variations in odour and gas emissions from animal facilities 显示文摘 | Zhu J Jacobson LD Schmidt DR Nicolai RE | 2000 | T Aase2000，16，2： | 1 |
| 20 | Solvent-programmedmicrochip open-channel electrochromatography显示文摘 | Kutter J P Jacobson S C Matsubara N | 1998 | Anal Chem1998，70，： | 1 |
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