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| 1 | Abnormal liver chemistries as a predictor of COVID-19 severity and clinical outcomes in hospitalized patients显示文摘BACKGROUND Abnormal liver chemistries are common findings in patients with Coronavirus Disease 2019(COVID-19).However,the association of these abnormalities with the severity of COVID-19 and clinical outcomes is poorly understood AIM We aimed to assess the prevalence of elevated liver chemistries in hospitalized patients with COVID-19 and compare the serum liver chemistries to predict the severity and in-hospital mortality.METHODS This retrospective,observational study included 3380 patients with COVID-19 who were hospitalized in the Johns Hopkins Health System(Baltimore,MD,United States).Demographic data,clinical characteristics,laboratory findings,treatment measures,and outcome data were collected.Cox regression modeling was used to explore variables associated with abnormal liver chemistries on admission with disease severity and prognosis RESULTS A total of 2698(70.4%)had abnormal alanine aminotransferase(ALT)at the time of admission.Other more prevalent abnormal liver chemistries were aspartate aminotransferase(AST)(44.4%),alkaline phosphatase(ALP)(16.1%),and total bilirubin(T-Bil)(5.9%).Factors associated with liver injury were older age,Asian ethnicity,other race,being overweight,and obesity.Higher ALT,AST,T-Bil,and ALP levels were more commonly associated with disease severity.Multivariable adjusted Cox regression analysis revealed that abnormal AST and T-Bil were associated with the highest mortality risk than other liver injury indicators during hospitalization.Abnormal AST,T-Bil,and ALP were associated with a need for vasopressor drugs,whereas higher levels of AST,T-Bil,and a decreased albumin levels were associated with mechanical ventilation CONCLUSION Abnormal liver chemistries are common at the time of hospital admission in COVID-19 patients and can be closely related to the patient’s severity and prognosis.Elevated liver chemistries,specifically ALT,AST,ALP,and T-Bil levels,can be used to stratify risk and predict the need for advanced therapies in these patients. | Arunkumar Krishnan Laura Prichett Xueting Tao Saleh A Alqahtani James P Hamilton Esteban Mezey Alexandra T Strauss Ahyoung Kim James J Potter Po-Hung Chen Tinsay A Woreta | 2022 | World Journal of Gastroenterology2022，28，5： | 2 |
| 2 | Gastric hyperplastic polyps causing upper gastrointestinal hemorrhage in a young adult显示文摘Here, we report a case of a young man who presented with a significant upper gastrointestinal bleed treated by endoscopic removal of multiple hyperplastic polyps. Gastric hyperplastic polyps are a relatively uncommon cause of overt gastrointestinal bleeding. While most hyperplastic gastric polyps are asymptomatic, they may present with abdominal pain, iron def iciency anemia or gastric outlet obstruction. These polyps are associated with conditions such as Helicobacter pylori gastritis and atrophic autoimmune gastritis, which predispose the epithelium to chronic inf lammation and epithelial repair.The patient presented to Northwestern Memorial Hospital in July 2011. The polyps were resected by clip-assisted snare polypectomy. Histopathologic assessment of the resected polyps demonstrated multiple, nonulcerative hyperplastic polyps measuring 1.3-1.8 cm in size, without evidence of dysplasia or malignancy. This case describes a young adult patient with multiple, large gastric polyps causing overt gastrointestinal bleeding. This is a rare presentation in a young individual, as these polyps are typically identifi ed in patients older than 60 years of age and less commonly, pediatric populations. | Brian J Secemsky Kenika R Robinson Kumar Krishnan Kristina A Matkowskyj Barbara H Jung | 2013 | World Journal of Clinical Cases2013，1，1： | 2 |
| 3 | Differential in vivo and in vitro expression of vascular endothelial growth factor (VEGF)-C and VEGF-D in tumors and its relationship to lymphatic metastasis in immunocompetent rats显示文摘 | Kirkin V Steffen A | 2003 | Cancer Res2003，63，3： | 1 |
| 4 | ANTIMIC: a database of antimicrobial sequences 显示文摘 | Brahmaehary M Krishnan S Koh J | 2004 | Nucleic Acids Res2004，32，： | 1 |
| 5 | Respiratory physiologic changes in pregnancy 显示文摘 | Wise RA Polito A J Krishnan V | 2006 | Immunol Allergy Clin North Am2006，26，： | 1 |
| 6 | Audit Committee Quality and Internal Control:An Empirical A nalysis显示文摘 | Krishnan J | | 0，，： | 1 |
| 7 | Primary Non-Hodgkin's Splenic Lymphoma显示文摘 | Dachman AH Buck JL Krishnan J | 1998 | Clin Radiol1998，53，2： | 1 |
| 8 | Primary non-Hodgkin's splenic lymphoma显示文摘 | Dachman AH Buck JL Krishnan J | 1998 | Clin Radiol1998，53，： | 1 |
| 9 | Differential in vivo and in vitro expression of vascular endothelial growth factor VEGF-C and VEG F-D in tumor and its relationship to lymphatic metastaisis in immunocompetent rats显示文摘 | Krishnan J KirKin V Steffen A | 2003 | Cancer Res2003，63，3： | 1 |
| 10 | Immunocytochemical localization of wheat prolamins in the lumen of the rough endoplasmic reticulum显示文摘 | Krishnan H B White J A Pueppke S G | 1991 | Cananian Journal of Botany1991，39，： | 1 |
| 11 | Analysis of exhaust waste heat recovery from a dual fuel low temperature combustion engine using an organic Rankine cycle 显示文摘 | Srinivasan K K Mago P J Krishnan S R | 2010 | Energy2010，35，6： | 1 |
| 12 | Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study 显示文摘 | Kumarasamy KK Toleman MA Walsh TR Bagaria J Butt F Balakrishnan R Chaudhary U Doumith M Giske CG Irfan S Krishnan P Kumar AV Maharjan S Mushtaq S Noorie T Paterson DL Pearson A Perry C Pike R Rao B Ray U Sarma JB Sharma M Sheridan E Thirunarayan MA Turton J Upadhyay S Warner M Welfare W Livermore DM Woodford N | 2010 | Lancet Infect Dis2010，10，9： | 1 |
| 13 | Reflec- tance technique for predicting soil organic matter显示文摘 | Krishnan P Alexander JD Butler B J Hummel JW | 1980 | Soil Science Society of America Journal1980，44，6： | 1 |
| 14 | Differential in vivo and in vitro expression of vascular endothelial growth factor (VEGF)-C and VEGF-D in tumors and its relationship to lymphatic metastasis in immunocompetent rats显示文摘 | Kirkin V Steffen A | 2003 | Cancer Res2003，63，3： | 1 |
| 15 | Accuracy of CT in the diagnosis of pulmonary embolism:a systematic literature review显示文摘 | Krishnan JA Segal JB | 2004 | AJR2004，183，6： | 1 |
| 16 | Alpha-synuclein pathology and Parkinsonism associated with POLG1 mutations and multiple mitochondrial DNA deletions显示文摘 | Betts-Henderson J Jaros E Krishnan KJ | 2009 | Neuropathol Appl Neurobiol2009，35，1： | 1 |
| 17 | Transcallosal interforniceal-transforaminal approach for removing lesions occupying the third ventricular space:clinical and neuropsychological results显示文摘 | Winkler PA Ilmberger J Krishnan KG | 2000 | Neurosurgery2000，46，4： | 1 |
| 18 | primary non-hodgkins splenic lymphoma显示文摘 | Dachman AH BuckJL Krishnan J | 1998 | Clin radiol1998，53，： | 1 |
| 19 | An overall aspect of electroless NiP depositions显示文摘 | Hari K Krishnan S J | 2006 | Metallurgical and Materials Transactions2006，37，6： | 1 |
| 20 | Variation in volatile or-ganic compounds in the breath of normal humans显示文摘 | Phillips M Herrera J Krishnan S | 1999 | J Chroma-togr B Biomed Sci Appl1999，729，： | 1 |
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