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| 1 | 静脉血栓栓塞症的抗血栓治疗:美国《胸科学》杂志指南显示文摘包括深静脉血栓和肺栓塞在内的静脉血栓栓塞症是癌症患者的主要并发症,发生率为4%~20%,并且是常见的潜在致命性急症。本文介绍了美国《胸科学》杂志指南中VET的抗血栓治疗的部分内容,其以第9版《美国胸内科医师学会循证临床实践指南》中的《静脉血栓栓塞症的抗血栓治疗:抗血栓治疗和阻止血栓形成》一文为参照,基于静脉血栓栓塞症治疗的Ⅲ期试验的发表年份,对口服抗凝剂(达比加群、利伐沙班、阿哌沙班、依度沙班)进行先后阐述(但是这一排序并不是指南专家组对药剂的优劣排序),以为临床医生提供参考。 | Kearon C Akl EA Ornelas J Blaivas A Jimenez D Bounameaux H Huisman M King CS MorrisT Sood N Stevens SM Vintch JRE Wells P Woller SC Moores CL 本刊编辑部 | 2016 | 中国全科医学2016，19，9： | 10 |
| 2 | 燃料成本性影响烤烟生产显示文摘烤烟生产需要投入大量的劳动力和燃料。在美国,燃料费用大概占生产烤烟成本的25%,其中大部分用于购买烘干烟叶所使用的由原油提炼的燃料。然而,在其它国家的烤烟生产中同样需要供应同等的能源来烘烤烟叶,这些系统通常使用其它燃料提供能源,例如木材。 | GIVAN W MOORE J M 迟立鹏(翻译) 康婧(校译) 赵百东(校译) | 2008 | 中国烟草学报2008，14，3： | 4 |
| 3 | 涂层和未涂层铝基体上接触应力的有限元模拟显示文摘基于对涂层/基体系统上产生的接触应力的分析,研究了软基体上薄膜的磨损行为。应用有限元法对由压头向涂层或未涂层铝基体施加正压力的情况进行模拟。先在没有薄膜的系统上对模型的精确性进行检验。然后通过改变薄膜的弹性模量比,开发出适用于铝基体上有两层硬薄膜试样的模型。同时还研究了薄膜厚度和载荷的影响。较厚的薄膜降低了模型上某些点的应力,但是增加了另一些点的应力。从弹性模量的角度来说,薄膜内的计算应力主要与薄膜的弹性模量有关,而通过改变薄膜的弹性模量比几乎不会使应力产生差异。 | J J Moore R M Souza G G W Mustoe 徐桂珍 | 2000 | 中国表面工程2000，13，1： | 4 |
| 4 | Epigenetics of gastroenteropancreatic neuroendocrine tumors:A clinicopathologic perspective显示文摘Gastroenteropancreatic neuroendocrine tumors(GEP-NETs) are a heterogeneous group of rare tumors whose site-specific tumor incidence and clinical behavior vary widely. Genetic alterations associated with familial inherited syndromes have been well defined; however, the genetic profile of sporadic tumors is less clear as their tumorigenesis does not appear to be controlled by classic oncogenes such as P53, RB, or KRAS. Even within GEP-NETs, there are no common oncogenic drivers; for example, DAXX/ATRX mutations are strongly implicated in the tumorigenesis of pancreatic but not small bowel NETs. Accordingly, the dysregulation of epigenetic mechanisms has been hypothesized as a potential regulator of GEPNET tumorigenesis and has become a major focus of recent studies. Despite the heterogeneity of tumor cohorts evaluated in these studies, it is obvious that there are methylation patterns, chromatin remodeling alterations, and microR NA and long non-coding RNA(lncR NA) differential expression profiles that are distinctive of GEPNETs, some of which are correlated with significant differences in clinical outcomes. Several translational studies have provided convincing data identifying potential prognostic biomarkers, and some of these have demonstrated preliminary success as serum biomarkers that can be used clinically. Nevertheless, there are many opportunities to further define the mechanisms by which these epigenetic modifications influence tumorigenesis, and this will provide better insight into their prognostic and therapeutic utility. Furthermore, these findings form the foundation for future studies evaluating the clinical efficacy of epigenetic modifications as prognostic biomarkers, as well as potential therapeutic targets. | Brendan M Finnerty Katherine D Gray Maureen D Moore Rasa Zarnegar Thomas J FaheyⅢ | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 4 |
| 5 | Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis显示文摘 | Rayner Katey J Sheedy Frederick J Esau Christine C Hussain Farah N Temel Ryan E Parathath Saj van Gils Janine M Rayner Alistair J Chang Aaron N Suarez Yajaira Fernandez-Hernando Carlos Fisher Edward A Moore Kathryn J | 2011 | Journal of Clinical Investigation2011，，7： | 2 |
| 6 | Systems biology approaches for studying the pathogenesis of non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD) is a progressive disease of increasing public health concern.In western populations the disease has an estimated prevalence of 20%-40%,rising to 70%-90% in obese and type Ⅱ diabetic individuals.Simplistically,NAFLD is the macroscopic accumulation of lipid in the liver,and is viewed as the hepatic manifestation of the metabolic syndrome.However,the molecular mechanisms mediating both the initial development of steatosis and its progression through non-alcoholic steatohepatitis to debilitating and potentially fatal fibrosis and cirrhosis are only partially understood.Despite increased research in this field,the development of non-invasive clinical diagnostic tools and the discovery of novel therapeutic targets has been frustratingly slow.We note that,to date,NAFLD research has been dominated by in vivo experiments in animal models and human clinical studies.Systems biology tools and novel computational simulation techniques allow the study of large-scale metabolic networks and the impact of their dysregulation on health.Here we review current systems biology tools and discuss the benefits to their application to the study of NAFLD.We propose that a systems approach utilising novel in silico modelling and simulation techniques is key to a more comprehensive,better targeted NAFLD research strategy.Such an approach will accelerate the progress of research and vital translation into clinic. | Ciarán P Fisher Andrzej M Kierzek Nick J Plant J Bernadette Moore | 2014 | World Journal of Gastroenterology2014，20，41： | 2 |
| 7 | On definition of reactive power under non-sinusoidal conditions显示文摘 | Kusters N I Moore W J M | 1980 | IEEE Transactions on Power Apparatus and Systems1980，99，5： | 2 |
| 8 | Noninvasive chemical enucleation of mouse oocytes显示文摘 | Fulka J J Moor R M | 1993 | Molecular Reproduction and Development1993，34，： | 1 |
| 9 | An n Job, one machine sequencing algorithm for minimizing the number of late jobs 显示文摘 | Moore J M | 1968 | Management Science1968，15，1： | 1 |
| 10 | Plasma endothelin immunoreactivity in liver disease and the hepatorenal syndrome显示文摘 | Wendon J Frazer M | 1992 | N Engl J Med1992，327，25： | 1 |
| 11 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 12 | Effect of supplemental folic acid in pregnancy on childhood asthma: a prospective birth cohort study显示文摘 | HITROW M J MOORE V M RUMBOLD A R | 2009 | Am J Epidemiol2009，170，12： | 1 |
| 13 | ARMAX modal parameter identification in the presence of unmeasured excitation-Ⅰ:theoretical background显示文摘 | Moore S M Lai J C S | 2007 | Mechanical Systems and Signal Processing2007，，21： | 1 |
| 14 | Separate pathways for cellular uptake of ferric and fer- rous iron显示文摘 | CONRAD M E UMBREIT J N MOORE E G | 2000 | American Journal of Physiology : Gastro- intestinal and Liver Physiology2000，279，： | 1 |
| 15 | SPAD-chlorophy Ⅱ response to nitrogen status in dryland and irrigated pumokins 显示文摘 | SWIADER J M MOORE A | 2000 | Plant Nutri2000，255，： | 1 |
| 16 | Gemcitabine plus cisplatin, an active regimen in advanced urothelial cancer: a phase Ⅱ trial of the National Cancer Institute of Canada Clinical Trials Group显示文摘 | Moore M J Winquist EW Murray N | 1999 | J Clin Oncol1999，17，9： | 1 |
| 17 | Invasive Pneumococcal Disease in Children 5 Years After Conjugate Vaccine Introduction - Eight States, 1998-2005显示文摘 | Reingold A Hadler J Farley M M Harrison L Lynfield R Lexau C Bennett N Thomas A Craig A S Smith P J Beall B Whitney C G Moore M Pilishvili T | 2008 | MMWR Morbidity and Mortality Weekly Report2008，，6： | 1 |
| 18 | A novel tryptase inhibitor, APC 366, inhibits allergeninduced airway and inflammatory responses in allergic sheep 显示文摘 | Clark J M Moore W R Fishman C E | 1995 | Am J Respir Crit Care Med1995，152，6： | 1 |
| 19 | Mobilization of metal-- contaminated sediment by ice jam floods 显示文摘 | Moore J N Landrigan E M | 1999 | Environmental Geology1999，37，12： | 1 |
| 20 | Simulated Reflectance Technique for ATM Image Enhancement 显示文摘 | Moore J M Haigh J D | 1997 | International Journal of Remote Sensing1997，18，： | 1 |
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