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| 1 | Nat Genet:单细胞分析解开结直肠癌细胞的神秘面纱显示文摘结合单细胞基因组学和计算机技术,一个研究团队(包括来自杰克逊实验室(JAx)单细胞生物学主任Paul Robson博士在内)鉴定出了11种结直肠癌肿瘤的癌细胞组成及邻近的非癌细胞。这对于更好的肿瘤靶向诊断和治疗很重要。”使用单细胞测序。”JAX科学家、这篇发表在Nature Genetics上的文章共同第一作者Elise Courtois说道。”我们可以根据肿瘤中的细胞组成将结直肠癌进一步分类。因为每种亚型的肿瘤病人生存率存在差别,我们的方法将为肿瘤医生提供更多的关于肿瘤预后和治疗的信息。” | Huipeng Li, Elise T Courtois, Debarka Sengupta, Yuliana Tan Shyam Prabhakar Elise T Courtois, Yuliana Tan Paul Robson Debarka Sengupta Kok Hao Chen, Jolene Jie Lin Goh Paul Jongjoon Choi Say Li Kong, Axel M Hillmer Iain Beehuat Tan Clarinda Chua Iain Beehuat Tan Lim Kiat Hon Wah Siew Tan Mark Wong Lawrence J K Wee Iain Beehuat Tan Paul Robson Paul Robson Paul Robson | 2017 | 现代生物医学进展2017，17，15： | 37 |
| 2 | Proteome analysis of hepatocellular carcinoma by laser capture microdissection显示文摘 | Ai J Tan Y Ying W Hong Y Liu S Wu M Qian X Wang H | 2006 | 第二军医大学学报2006，27，5： | 14 |
| 3 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 4 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997，，2： | 6 |
| 5 | Cyclic rapid warming on centennial-scale revealed by a 2650-year stalagmite record of warm season temperature 显示文摘 | Tan M Liu T S Hou J | 2003 | Geophysical Research Letters2003，30，： | 2 |
| 6 | Handling multi-criteria fuzzy decision-making problems based on vague set theory 显示文摘 | Chen S M Tan J M | 1994 | Fuzzy Sets and Systems1994，67，2： | 2 |
| 7 | Chromosomal location of a wheat osmoregulation gene using RFLP analysis显示文摘 | MORGAN J M TAN M K | 1996 | Aust J Plant Physiol1996，23，： | 1 |
| 8 | Identification and occurrence of tetrad-forming Alphaproteobacteria in anaerobic-aerobic activated sludge processes 显示文摘 | WONG M T TAN F M NG W J | 2004 | Microbiology2004，150，： | 1 |
| 9 | Hyper Hamiltonian laceablility on edge fault star graph显示文摘 | Li T K Tan J M Hsu L | 2004 | Information Sciences2004，165，1： | 1 |
| 10 | P6 aeupoint injec- tion reduce postoperative nausea and vomiting显示文摘 | Shyr M H Hsu J C Wu Y W Hui Y L Tan P P | 1990 | Ma Tsui Hsueh Tsa Chi Anaesthesiol Sinica1990，28，6： | 1 |
| 11 | A practical approach to guide clinicians in the evaluation of male patients with breast masses 显示文摘 | Hines S L Tan W Larson J M | 2008 | Geriatrics2008，63，6： | 1 |
| 12 | The 1982 revised criteria for the classification of systemic lupus erythematosus (SLE)显示文摘 | TAN E M COHEN A S FRIES J F | 1982 | Arthritis Rheum1982，25，11： | 1 |
| 13 | Automatic Representation of Fingerprints for Data Compression by B-Spline Functions显示文摘 | Michael Chong M S Robert Gay K L Tan H N Liu J | 1992 | Pattern Recognition1992，25，10： | 1 |
| 14 | Dynamic continuous recrystallization characteristics in two stage deformation of Mg3Al-1Zn alloy sheet显示文摘 | Tan J C Tan M J | 2003 | Mater Sci Eng A2003，339，： | 1 |
| 15 | Organizational slack and firm performance during economic transitions: Two studies from an emerging economy显示文摘 | Tan J Pen M | 2003 | Strategic Management Journal2003，，24： | 1 |
| 16 | Sympathetic skin response and R-R interval variation in rheumatoidarthritis: two simpie tests for the assess ment of autonomic function 显示文摘 | Tan J Akin S Beyazova M | 1993 | Am J phys reed Rehabil1993，72，： | 1 |
| 17 | Handling multicriteria fuzzy decision-making problems based on vague set theory显示文摘 | Chen S M Tan J M | 1994 | Fuzzy Sets and Systems1994，67，： | 1 |
| 18 | Effect of carbon emission regulations on transport mode selection under stochastic demand显示文摘 | HOEN K M R TAN T FRANSOO J C | 2007 | Flexible Services and Manu- facturing Journal2007，9，5： | 1 |
| 19 | A simple approach to prepare AI/CNT com- posite : Spread-Dispersion (SD) method显示文摘 | Liao J Z Tan M J | 2011 | Materials Letters2011，65，： | 1 |
| 20 | Development of a biomimetic robotic fish and its control algorithm显示文摘 | Yu J Z Tan M Wang S | 2004 | IEEE Transactions on Systems Man and Cybernetics Part B: Cybernetics2004，34，4： | 1 |
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