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| 1 | Orally administered extract from Prunella vulgaris attenuates spontaneous colitis in mdr1a^(-/-) mice显示文摘AIM: To investigate the ability of a Prunella vulgaris(P. vulgaris) ethanolic extract to attenuate spontaneous typhlocolitis in mdr1a-/- mice. METHODS: Vehicle(5% ethanol) or P. vulgaris ethanolic extract(2.4 mg/d) were administered daily by oral gavage to mdr1a-/- or wild type FVBWT mice from 6 wk of age up to 20 wk of age. Clinical signs of disease were noted by monitoring weight loss. Mice experiencingweight loss in excess of 15% were removed from the study. At the time mice were removed from the study, blood and colon tissue were collected for analyses that included histological evaluation of lesions, inflammatory cytokine levels, and myeloperoxidase activity. RESULTS: Administration of P. vulgaris extracts to mdr1a-/- mice delayed onset of colitis and reduced severity of mucosal inflammation when compared to vehicle-treated mdr1a-/- mice. Oral administration of the P. vulgaris extract resulted in reduced(P < 0.05) serum levels of IL-10(4.6 ± 2 vs 19.4 ± 4), CXCL9(1319.0 ± 277 vs 3901.0 ± 858), and TNFα(9.9 ± 3 vs 14.8 ± 1) as well as reduced gene expression by more than two-fold for Ccl2, Ccl20, Cxcl1, Cxcl9, IL-1 α, Mmp10, VCAM-1, ICAM, IL-2, and TNFα in the colonic mucosa of mdr1a-/- mice compared to vehicle-treated mdr1a-/-mice. Histologically, several microscopic parameters were reduced(P < 0.05) in P. vulgaris-treated mdr1a-/-mice, as was myeloperoxidase activity in the colon(2.49 ± 0.16 vs 3.36 ± 0.06, P < 0.05). The numbers of CD4+ T cells(2031.9 ± 412.1 vs 5054.5 ± 809.5) and germinal center B cells(2749.6 ± 473.7 vs 4934.0 ± 645.9) observed in the cecal tonsils of P. vulgaris-treated mdr1a-/- were significantly reduced(P < 0.05) from vehicle-treated mdr1a-/- mice. Vehicle-treated mdr1a-/- mice were found to produce serum antibodies to antigens derived from members of the intestinal microbiota, indicative of severe colitis and a loss of adaptive tolerance to the members of the microbiota. These serum antibodies were greatly reduced or absent in P. vulgaris-treated mdr1a-/- mice. CONCLUSION: The anti-inflammatory activity of P. vulgaris ethanolic extract effectively attenuated the severity of intestinal inflammation in mdr1a-/- mice. | Kelley MK Haarberg Meghan J Wymore Brand Anne-Marie C Overstreet Catherine C Hauck Patricia A Murphy Jesse M Hostetter Amanda E Ramer-Tait Michael J Wannemuehler | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，4： | 8 |
| 2 | 肠道微生态失调与高血压的关系显示文摘新出现的证据表明,肠道菌群是维持生理动态平衡的关键,该研究旨在验证微生态失衡的肠道菌群与高血压相关这一假设,因为遗传、环境和膳食因素对肠道菌群和血压有很大影响。方法:从2种高血压模型大鼠和一个小队列患者人群的粪便样本中提取细菌DNA,用于细菌基因组的分析. | 刘莉 叶鹏 Yang T Santisteban MM Rodriguez V Li E Ahmari N Carvajal JM Zadeh M Gong M Qi Y Zubcevic J Sahay B Pepine CJ Raizada MK Mohamadzadeh M | 2015 | 中华高血压杂志2015，23，5： | 4 |
| 3 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 4 | HMM-Based On-line Handwriting Recognition 显示文摘 | Hu J Brown MK Turin W | 1996 | IEEE Transactions on Pattern Analysis and Machine Intelligence1996，18，10： | 2 |
| 5 | 益生菌抑制自发性高血压大鼠的菌群失调和血压升高:短链脂肪酸的作用显示文摘该研究旨在评估益生菌短双歧杆菌CECT7263(BFM)及发酵乳酸杆菌CECT5716(LC40)、短链脂肪酸丁酸盐及醋酸盐对自发性高血压大鼠(spontaneously hypertensive rat,SHR)心血管的作用。方法和结果:5周龄的Wistar Kyoto大鼠(WKY)10只和周龄匹配的SHR 50只随机分为6组:对照WKY、对照SHR、BFM干预的SHR、LC40干预的SHR、丁酸盐干预的SHR和醋酸盐干预的SHR。 | 袁源(译) 练桂丽(审校) Robles-Vera I Toral M de la Visitación N Sánchez M Gómez-Guzmán M Romero M Yang T Izquierdo-Garcia JL Jiménez R Ruiz-Cabello J Guerra-Hernández E Raizada MK Pérez-Vizcaíno F Duarte J | 2020 | 中华高血压杂志2020，28，9： | 2 |
| 6 | The IL-12/IL-12receptor system: role in normal and pathologic immune responses显示文摘 | Gately MK Renzetti LM Magram J | 1998 | Annu Rev Immunol1998，16，： | 1 |
| 7 | Evaluation of patients with pulmonary nodules: when is it lung cancer: ACCP evidence - based clinical practice guidelines (2nd edition) 显示文摘 | Gould MK Fletcher J Iannettoni MD | 2007 | Chest2007，132，3： | 1 |
| 8 | Hydrogen peroxide stimulates mitogenactivated protein kinase in bovine tracheal myocytes: implications for human airway disease显示文摘 | Abe MK Chao TS Solway J | 1994 | Am J Respir Cell Mol Biol1994，11，5： | 1 |
| 9 | Haploglobin is a Sertoli cell product in the rat seminiferous epithelium: its purification and regulation显示文摘 | OBryan MK Grima J Mruk D el al | 1997 | J Androl1997，18，6： | 1 |
| 10 | Floating knee injuries: long-term results of four treatment methods 显示文摘 | Dwyer A J Paul R Mam MK | 2005 | Int Orthop2005，29，5： | 1 |
| 11 | Mutations with loss of heterozygosity of p53 are common in therapy-related myelodysplasia and acute myeloid leukemia after exposure to alkylating agents and significantly associated with deletion or loss of 5q, a complex karyotype, and a poor prognosis显示文摘 | Christiansen DH Andersen MK Pedersen-Bjergaard J | 2001 | J Clin Oncol2001，19，5： | 1 |
| 12 | Crystalloid topacked red blood cell transfusion ratio in the massivelytransfused patient:when a little goes along way显示文摘 | Neal MD Hoffman MK Cuschieri J | 2012 | JTrauma Acute Care Surg2012，72，4： | 1 |
| 13 | Differential susceptibility to human immu- nodeficiency virus type 1 infection of myeloid and plasmacytoid dendritic cells显示文摘 | Smed-S6rensen A Lore K Vasudevan J Louder MK Andersson J Mascola JR | 2005 | J Virol2005，79，14： | 1 |
| 14 | Expression of LAG-3 by tumor infiltrating lymphocytes is coincident with the suppression of latent membrane antigen-specific CD8 + T-cell function in Hodgkin lymphoma patients 显示文摘 | GANI)HI MK LAMBLEY E DURAISWAMY J | 2006 | Blood2006，108，7： | 1 |
| 15 | The many faces of posterior reversible encephalopathy syndrome显示文摘 | Stevens C J Heran MK | 2012 | Br J Radiol2012，85，： | 1 |
| 16 | Odontoplasty associated with clinical crown lengthening in management of extensive crown destruction显示文摘 | da Cruz MK Martos J Silveira LF | 2012 | J Conserv Dent2012，15，1： | 1 |
| 17 | Sex differences in stroke care and outcomes:results from the Registry of the Canadian Stroke Network显示文摘 | Kapral MK Fang J Hill MD | 2005 | Stroke2005，36，25： | 1 |
| 18 | Recovery and utilization of deceased donor kidneys from small pediatric donors 显示文摘 | Pelletier S J Guidinger MK Merion RM | 2006 | Am J Transplant2006，6，7： | 1 |
| 19 | Faecal calprotectin: a novel test for the diagnosis of colorectal cancer 显示文摘 | Roseth AG Kristinsson J Fagerhol MK | 1993 | Scand J Gastroenterol1993，28，12： | 1 |
| 20 | Early detection and prognosis of ovarian cancer using serum YKL-40 显示文摘 | Dupont J Tanwar MK Thaler HT | 2004 | J Clin Oncol2004，22，16： | 1 |
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