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| 1 | An Eperimental Study on the Transplantation of Human Fetal Brain Cells into Monkey Models of Parkinson's Disease.显示文摘Unilateral administration of methly-phenyl-tetrahydropyridine(MPTP) into the common carotid | Liu Zhengou, et al. Dept Neur Ruijin, Hospital. Shanghai Second Med Uni, Shanghai 200025, Chin J Neuro Psych 1994 | 1995 | Chinese Medical Journal1995，，2： | 34 |
| 2 | High expression levels of IKK alpha and IKK beta are necessary for the malignant properties of liver cancer显示文摘IKK-NF-kappa B signaling is regarded as an important factor in hepatocarcinogenesis and a potential target for liver cancer therapy.Therefore,in this study,we analyzed the expression of mRNAs encoding components and targets of NF-kappa B signaling including IKK alpha,IKK beta,RANK,RANKL,OPG,CyclinD3,mammary serine protease inhibitor(Maspin),CyclinD1,c-FLIP,Bcl-x1,Stat3,Cip1 and Cip2 by real-time PCR in 40 patients with liver cancer.After statistical analysis,7 indices including IKK alpha,IKK beta,RANK,Maspin,c-FLIP,Cip2 and cyclinD1 were found to show significant differences between tumor tissue and its corresponding adjacent tissue.When IKK alpha and IKK beta were downregulated in the hepatocellular carcinoma(HCC) cell lines of MHCC-97L and MHCC-97H in vitro,the numbers of BrdU positive cells were decreased in both IKK alpha and IKK beta knockdown cells.Levels of apoptosis were also investigated in IKK alpha and IKK beta knockdown cells.The growth of HCC was inhibited in the subcutaneous implantation model,and lung metastatogenesis was also significantly inhibited in the kidney capsule transplantation model.Downregulation of IKK alpha and IKK beta in HCC cultured in vitro revealed that increased Maspin,OPG and RANKL expression was associated with metastasis of HCC.These findings were associated with downregulation of Bcl-XL and c-FLIP,which may be the reason for increased apoptosis.The therapeutic effect of IKK alpha and IKK beta downregulation depends on extent of NF-kappa B inhibition and the malignant nature of the HCC.We anticipate that IKK-targeted gene therapy can be used in the treatment of HCC,a cancer that is notoriously resistant to radiation and chemotherapy. | Jiang,RQ Xia,YX Li,J Deng,L Zhao,L Shi,J Wang,XH Sun,BC Nanjing Med Univ,Liver Transplantat Ctr,Affiliated Hosp 1,Nanjing,Jiangsu Prov,Peoples R China Nanjing Med Univ,Ctr Canc,Nanjing,Jiangsu Prov,Peoples R China | 2010 | 南京医科大学学报(自然科学版)2010，30，5： | 13 |
| 3 | Study on Lymphokine-Activated Killer Cells Induced from Cord Blood显示文摘 | Wang Yi-feng, et al. Affiliated Hospital, Shandong Med Uni, Jinan 250012. Chin J Obst Gynecol 1994 | 1994 | Chinese Medical Journal1994，，8： | 12 |
| 4 | The Relationship between Apolipoprotein B Gene Loci Polymorphisms and Coronary Heart Disease.显示文摘The authors utilized the polymerase chain reaction to rapidly and accurately type a variable number of tandemly repeated loci (VNTR loci) of the 3’ flanking region of apolipoprotein B (apo B) gene, and studied the relationship between this loci polymorphisms and coronary heart disease (CAD); comparisons were made with relative diseases | Qu Wan-yun,et al. Beijing Railway General Hospital, Beijing 100038. Chin J Med Lab Tech 1994 | 1994 | Chinese Medical Journal1994，，7： | 5 |
| 5 | 依那普利与氯沙坦对1型糖尿病患者肾脏及视网膜病变的影响显示文摘 | Mauer M N Engl J Med 张益民(摘) 李幼姬(校) | 2009 | 中国中西医结合肾病杂志2009，10，8： | 3 |
| 6 | Changes of PTH, 1,25(OH)_2D_3 and Biochemistry in Renal Osteodystrophy.显示文摘The changes of plasma PTH, 1,25(OH)2D3, serum calcium, phosphorus and AKP were observed in 55 uremic patients with renal osteodystrophy. The results showed that: in all types of renal osteodystrophy, plasma PTH were markedly higher than normal (P<0.001), while plasma 1,25(OHH)2D3 and serum calcium were lower than normal (P<0.001). In low bone-turnover uremic osteodystrophy (LTO), plasma phosphorus was markedly lower than that of high bone-turnover uremic osteodystrophy (HTO) and mixe d uremic osteodystrophy (MO) (P<0.05), and plasma 1,25(OH)2D3 was significantly lower than that of HTO (P<0.05). In HTO and MO, serum phosphorus was much higher than mormal (P<0.001). Plasma PTH had a negative linear correlation with plasma 1,25(OH)2D3 (P<0.05), a positive linear correlation with serum AKP (P<0.05), but no linear correlation with the duration of hemodialysis, serum calcium, serum aluminum and bone aluminum content. Plasma 1.25(OH)2D3 had no linear correlation with the duration of hemodialysis, | Jia Jing-kang, et al. Renal Unit, 2ndHospital, Zhejiang Med Uni, Hangzhou 310009. Chin J Int Med 1994 | 1994 | Chinese Medical Journal1994，，7： | 3 |
| 7 | Benign Congenital Muscular Dystrophy with Autosomal Dominant Heredity显示文摘Benign congenital muscular dystrophy with autsomal dominant heredity of a pedigree is reported.The grandfather. | Hou Huiguang, et al. Dept Neuro Ganquan Hospital, Shanghai Railway Med Col. Changhai 200061. Chin J Neuro Psych 1994 | 1995 | Chinese Medical Journal1995，，2： | 2 |
| 8 | Quantitative Histological Study on Changes of the Cortical Bones after Internal Fixation with Plates of Different Rigidity显示文摘In an effect to explore the potemtial role of bone microcirculation causing plate-induced reginal | Wang You et al. Dept Orth, Ninth People’s Hospital, Shanghai Second Med Uni, Shanghai 200011. Chin J Orth | 1995 | Chinese Medical Journal1995，，11： | 2 |
| 9 | Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes : a genetic substudy of the Plato trial 显示文摘 | Ticagrelor versus clopidogrel in paN Engl J Med 2009 361(11): Wallentin L James S Storey RF | 2010 | Lancet2010，376，9749： | 1 |
| 10 | A direct efficay and safety comparsion of insulin aspart,human soluble insulin and human premix insulin (70/30) in patients with type 2 diabetes 显示文摘 | Bretzel RG Amolds S Medding J | 2004 | Diabetes Care2004，，27： | 1 |
| 11 | Effects of probiotic therapy in critically ill patients: a randomized, double-blind, placebo-controlled trial显示文摘 | Alberda C Gramlich L Meddings J | 2007 | Am J Clin Nutr2007，85，3： | 1 |
| 12 | The significance of the gut barrier disease显示文摘 | Meddings J | | 0，，04： | 1 |
| 13 | A population-based study of pyogenic liver abscesses in the United States:incidence,mortality,and temporal trends显示文摘 | Meddings L Myers RP Hubbard J | 2010 | Am J Gastroenterol2010，105，1： | 1 |
| 14 | Global strategy for the management, and prevention of chronic obstructive disease: GOLD executive summary显示文摘 | Vestbo J diagnosis pulmonary Care Med Hurd S S Agusti A G | 2012 | Am J Respir Crit2012，92，14： | 1 |
| 15 | Secreted bioactive factors from Bifidobacterium infantis enhance epithelial cell barrier function 显示文摘 | EWASCHUK J B DIAZ H MEDDINGS L e't al | 2008 | Am J Physiol Gastrointest Liver Physiol2008，295，5： | 1 |
| 16 | Secreted bioactive factors from Bifidobacterium infantis enhance epithelial cell barrier function显示文摘 | Ewaschuk J B Diaz H Meddings L | 2008 | American Journal of Physiology-Gastrointestinal and Liver Physiology2008，295，5： | 1 |
| 17 | Reducing unnecessary urinary catheter use and other strategies to prevent catheter associated urinary tract infection= an integrative review显示文摘 | Meddings J Rogers MA Krein SL | 2014 | BMJ Qual Saf2014，23，4： | 1 |
| 18 | A population - basedstndy of pyogenic liver abscesses in the United States: incidence,mortality, and temporal trends显示文摘 | Meddings L Myers RP Hubbard J | 2010 | Am J Gastro- enterol2010，105，1： | 1 |
| 19 | Environmental and biological monitoring of exposures to PAHs and ETS in the general population显示文摘 | Aquilina N J Delgado-Saborit J M Meddings C | 2010 | Environment International2010，36，7： | 1 |
| 20 | Behcet's disease ase and review of the literature显示文摘 | Wallis S Macierewicz J report of a c Med Assoe BM | 2006 | JNMA J Nepal2006，45，164： | 1 |
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