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| 1 | Increased susceptibility for intrahepatic cholestasis of pregnancy and contraceptive-induced cholestasis in carriers of the 1331T>C polymorphism in the bile salt export pump显示文摘AIM: To study the association of three common ABCB11 and ABCC2 polymorphisms (ABCB11: 1331T>C V444A; ABCC2: 3563T>A V1188E and 4544G>A C1515Y) with intrahepatic cholestasis of pregnancy (ICP) and contraceptive-induced cholestasis (CIC). METHODS: ABCB11 and ABCC2 genotyping data were available from four CIC patients and from 42 and 33 ICP patients, respectively. Allele-frequencies of the studied polymorphisms were compared with those in healthy pregnant controls and Caucasian individuals. Furthermore, serum bile acid levels were correlated with the presence or absence of the 1331 C allele.RESULTS: The ABCB11 1331T>C polymorphism was significantly more frequent in cholestatic patients than in pregnant controls: C allele 76.2% (CI, 58.0-94.4) vs 51.3% (CI 35.8-66.7), respectively (P = 0.0007); and CC allele 57.1% (CI 36.0-78.3) vs 20% (CI 7.6-32.4), respectively (P = 0.0065). All four CIC patients were homozygous carriers of the C allele. In contrast, none of the studied ABCC2 polymorphism was overrepresented in ICP or CIC patients. Higher serum bile acid levels were found in carriers of the 1331CC genotype compared to carriers of the TT genotype.CONCLUSION: Our data support a role for the ABCB11 1331T>C polymorphism as a susceptibility factor for the ←←← development of estrogen-induced cholestasis, whereas no such association was found for ABCC2. Serum bile acid and γ-glutamyl transferase levels might help to distinguish ABCB4- and ABCB11-related forms of ICP and CIC. | Yvonne Meier Tina Zodan Carmen Lang Roland Zimmermann Gerd A Kullak-Ublick Peter J Meier Bruno Stieger Christiane Pauli-Magnus | 2008 | World Journal of Gastroenterology2008，14，1： | 20 |
| 2 | Measurement of calprotectin in ascitic fluid to identify elevated polymorphonuclear cell count显示文摘AIM: To evaluate the diagnostic capability of calprotectin in ascitic fluid for detecting a polymorphonuclear (PMN) cell count > 250/μL ascites. METHODS: In this prospective observational study, a total of 130 ascites samples were analysed from 71 consecutive patients referred for paracentesis. Total and differential leukocyte cell counts were determined manually with a Neubauer chamber and gentianviolet stain. Calprotectin was measured in 1 mL ascetic fluid by enzyme-linked immunosorbent assay (ELISA) and a point-of-care (POC) lateral flow assay with the Quantum Blue Reader (Bühlmann Laboratories). All measurements were carried out in a central laboratory by senior personnel blinded to patient history. A PMN count > 250/μL was the primary endpoint of the study. The diagnostic value of ascitic calprotectin measurement was assessed by comparing to the final diagnosis of each patient that had been adjudicated by investigators blinded to calprotectin values. RESULTS: The PMN count was > 250/μL in 19 samples (14.6%) from 15 patients (21.1%) and varied widely among the study population (range 10-19 800/mL and 1-17 820/mL, respectively). Spontaneous bacterial peritonitis (SBP) was the final diagnosis in four patients (5.6%). All patients with PMN ≤ 250/μL had negative bacterial culture. PMN count was elevated in five patients with peritoneal carcinomatosis, three with lymphoma, one with neuroendocrine carcinoma, and two with secondary peritonitis due to abdominal perforation. PMN cell counts correlated with ascitic calprotectin values (Spearman's rho; r = 0.457 for ELISA, r = 0.473 for POC). A considerable range of ascitic calprotectin concentrations was detected by ELISA [median 0.43 μg/mL, interquartile range (IQR) 0.23-1.23 (range 0.10-14.93)] and POC [median 0.38 μg/mL, IQR 0.38-0.56 (range 0.38-13.31)]. Ascitic calprotectin levels were higher in samples with PMN > 250/μL, by both ELISA [median (IQR) 2.48 μg/mL (1.61-3.65) vs 0.10 μg/mL (0.10-0.36), P < 0.001] and POC [2.78 μg/mL (2.05-5.37) vs 0.38 μg/mL (0.38-0.41), P < 0.001]. The area under the receiver operating characteristics curve for identifying an elevated PMN count was 0.977 (95%CI: 0.933 to 0.995) for ELISA and 0.982 (95%CI: 0.942 to 0.997) for POC (P = 0.246 vs ELISA). Using the optimal cut-off value for ELISA (0.63 μg/mL), ascitic calprotectin had 94.8% sensitivity, 89.2% specificity, positive and negative likelihood ratios of 8.76 and 0.06 respectively, positive and negative predictive values of 60.0% and 99.0% respectively, and 90.0% overall accuracy. Using the optimal cut-off value for POC (0.51 μg/mL), the respective values were 100.0%, 84.7%, 6.53, 0.00, 52.8%, 100% and 87.7%. Correlation between ELISA and POC was excellent (r = 0.873, P < 0.001). The mean ± SD of the difference was -0.11 ± 0.48 μg/mL with limits of agreement of + 0.8 μg/mL (95%CI: 0.69 to 0.98) and -1.1 μg/mL (95%CI: -1.19 to -0.91). CONCLUSION: Ascitic calprotectin reliably predicts PMN count > 250/μL, which may prove useful in the diagnosis of SBP, especially with a readily available bedside testing device. | Emanuel Burri Felix Schulte Jürgen Muser Rémy Meier Christoph Beglinger | 2013 | World Journal of Gastroenterology2013，19，13： | 10 |
| 3 | 立止血—蛇毒液制备的止血剂的历史及作用方式显示文摘 | Meier J 吴云林 | 1993 | 国外学者来访报告1993，13，4： | 5 |
| 4 | 显示文摘 | Meier G H Pettit F S Smialek J L | 1995 | Mater Corr1995，46，3： | 2 |
| 5 | Device grade microcrystalline silicon owing to reduced oxygen contamination 显示文摘 | Meier J Luckige R F | 1996 | Appl Phys Lett1996，69，： | 1 |
| 6 | Treatment With 1 -- alpha, 25-- clihydroxyvitamin D3 (vitamin D3) to inhibit ear cinogenesis in the hamster buceal pouch model 显示文摘 | Meier J D Enepekides D J Poirier B | 2007 | Arch Oto- laryngol Head Neck Surg2007，133，11： | 1 |
| 7 | Nerve growth factors from snake venoms:chemical properties,mode of action and biological significance显示文摘 | Kostiza T Meier J | 1996 | Toxicon1996，34，7： | 1 |
| 8 | Stimulation of insulin secretion by intravenous bolus injection and continuous infusion of gastric inhibitory polypeptide in patients with type 2 diabetes and healthy control subjects显示文摘 | MEIER J J GALLWITZ B KASK B | 2004 | Diabetes2004，53，3： | 1 |
| 9 | Validation of functional motor and language MRI with direct cortical stimulation显示文摘 | Meier MP Ilmberger J Fesl G | 2013 | Acta Neurochirurgica2013，155，4： | 1 |
| 10 | Clinical reasoning: rhabdomyolysis after combined treatment with simvastatin and fluconazole显示文摘 | Findling O Meier N Sellner J | 2008 | Neurology2008，71，15： | 1 |
| 11 | Logistics and supply chain management显示文摘 | ISLAM D M Z MEIER J F ADITJANDRA P T | 2012 | Research in Transportation Economics2012，41，1： | 1 |
| 12 | Image processing: global and regional changes with age显示文摘 | Killiany R J Meier D S Guttmann C R | 2004 | Top Magn Reson Imaging2004，15，6： | 1 |
| 13 | Vascular anatomy of the gastric tube used for esophageal reconstruction显示文摘 | LIEBERMANN MEFFERT D M MEIER R SIEWERT J R | 1992 | Ann Thorac Surg1992，54，6： | 1 |
| 14 | Normalization of glucoseconcentrations and deceleration of gastric emptying after solidmeals during intravenous glucagon-like peptide 1in patients withtype 2diabetes显示文摘 | Meier J J Gallwitz B Salmen S | 2003 | J Clin Endocrinol Metab2003，88，6： | 1 |
| 15 | Mechanisms controlling the durability of thermal barrier coatings显示文摘 | EVANS A G MUMM D R HUTCHINSON J W MEIER G H Pettit F S | 2001 | Progress in Materials Science2001，46，5： | 1 |
| 16 | Microcrystalline silicon and the impact on micromorph tandem solar cells显示文摘 | Meier J Dubail S Golay S | 2002 | Solar Energy Materials and Solar Cells2002，74，1： | 1 |
| 17 | Adenosine minetics as in- hibitors of NAD--denpendent histone deacetylases, from ki- nase to sirtuin inhibition 显示文摘 | Trapp J JochumA Meier R | 2006 | J ivied Chem2006，49，25： | 1 |
| 18 | Correlation of molecular resist- ance mechanisms and phenotypic resistance levels in streptomycin- resistant Mycobacterium tuberculosis 显示文摘 | Meier A Sander P Schaper K J | 1996 | Antimicrob Agents Che- mother1996，40，： | 1 |
| 19 | D-dimers predict stroke subtype when assessed early 显示文摘 | Isenegger J Meier N Lammle B et at | 2010 | Cerebrovasc Dis2010，29，1： | 1 |
| 20 | PLIF thermometry based on measurements of absolute concentrations of the OH radical显示文摘 | HEINZE J MEIER U BEHRENDT T | | 0，，： | 1 |
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