|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Haplotype of prostaglandin synthase 2/cyclooxygenase 2 is involved in the susceptibility to inflammatory bowel disease显示文摘AIM: Prostaglandin G/H synthase 2 (PTGS2 or COX2) is one of the key factors in the cellular response to inflammation.PTGS2 is expressed in the affected intestinal segments of patients with inflammatory bowel diseases (IBD). In IBD patients, non-steroidal anti-inflammatory drugs, which have been shown to reduce both the production and activity of PTGS2, may activate IBD and aggravate the symptoms.We aimed at examining genetic variants of PTGS2 that may be risk factors for IBD.METHODS: We genotyped 291 individuals diagnosed with IBD and 367 controls from the Dutch population for the five most frequent polymorphisms of the PTGS2 gene.Clinical data were collected on all patients. DNA was extracted via normal laboratory methods. Genotyping was carried out using multiplex PCR followed by the Invader Assay and the 5' exonuclease assay (TaqMan). New polymorphism screening was performed by pre-screening with denaturing high-performance liquid chromatography,followed by fluorescent sequencing.RESULTS: Allele 5209G was weakly associated with Crohn's disease (odds ratio [OR] 1.63, 95% confidence interval [CI] 1.03-2.57), and allele 8473T with ulcerative colitis (OR 1.50, 95%CI 1.00-2.27). The haplotype including both alleles showed a strong association with IBD (OR 13.15, 95%CI 3.17-116.15). This haplotype, while rare (-0.3%) in the general population, is found more frequently in patients (3.5%).CONCLUSION: Our data suggest that this haplotype of PTGS2 contributes to the susceptibility of IBD. | David G Cox J Bart A Crusius Petra HM Peeters H Bas Bueno-de-Mesquita A Salvador Pe(n|~)a Federico Canzian | 2005 | World Journal of Gastroenterology2005，11，38： | 10 |
| 2 | Panitumumab versus cetuximab in patients with chemotherapy-refractory wild-type KRAS exon 2 metastatic colorectal cancer (ASPECCT): a randomised, multicentre, open-label, non-inferiority phase 3 study显示文摘 | Timothy J Price Marc Peeters Tae Won Kim Jin Li Stefano Cascinu Paul Ruff Atilli Satya Suresh Anne Thomas Sergei Tjulandin Kathy Zhang Swaminathan Murugappan Roger Sidhu | 2014 | Lancet Oncology2014，，6： | 2 |
| 3 | Application of a new cubic turbulence model to piloted and bluff-body diffusion flames显示文摘 | Merci B Roekaerts D Peeters T W J | 2001 | Combust Flame2001，126，： | 2 |
| 4 | The influence of 5- HTTLPR and STin2 polymorphisms in the serotonin transporter gene on treatment effect of selective serotonin reuptake inhibitors in depressive patients 显示文摘 | Stairs K M Stairs L J Peeters F P | 2008 | Psyehiatr Genet2008，18，4： | 1 |
| 5 | Structural and functional features of different types of cytoplasmic fatty acid-binding proteins显示文摘 | Veerkamp J H Peeters R A Maatman R G H J | 1991 | Biochim Biophys Aeta1991，1081，1： | 1 |
| 6 | Synthesis of 1-deoxymannojirimycin analogues using N-tosyl and N-nosyl activated aziridines derived {rom 1 amino 1-deoxyglucitol显示文摘 | Mao H Joly G J Peeters K | 2001 | Tetrahedron2001，57，： | 1 |
| 7 | Involvement of two different pathways in the motor effects of erythromycin on the gastric antrum in humans显示文摘 | Coulie B Tack J Peeters T | 1998 | Gut1998，43，3： | 1 |
| 8 | Cetuximab in combination with irinotecan/5- fluorouracil/folinic acid (FOLFIRI) in the initialtreatment of metastatic colorectal cancer: a multi-centre two-part phase I / II study显示文摘 | RAOUL J L Van LAETHEM J L PEETERS M | 2009 | BMC Cancer2009，14，9： | 1 |
| 9 | Type 2 iodothyronine deiodinase transgene expression in the Mouse Heart Causes cardiac-specific thyrotoxicosis 显示文摘 | Pachucki J Hopkins J Peeters R | 2001 | Endocrinology2001，142，： | 1 |
| 10 | Determination of the number of automated guided vehicles required at a semi-automated container terminal显示文摘 | Vis I F A de Koster R Roodbergen K J Peeters L W P | 2001 | Journal of the operation research society2001，52，： | 1 |
| 11 | Complete nucleotide sequence of Newcastle disease virus:evidence for the existence of a new genus within the subfamily Paramyxovirinae显示文摘 | De Leeuw O Peeters B J | 1999 | J Gen Virol1999，80，1： | 1 |
| 12 | Personality and Team Performance : A Meta - Analysis 显示文摘 | Miranda A G Peeters Harrie F J M Vantuijl Christel G Rutte Isabelle M M J Reymen | 2006 | European Journal of Personality2006，，20： | 1 |
| 13 | Vibration- based Damage Detection in Civil Engineering: Excita- tion Sources and Temperature Effectst显示文摘 | PEETERS B MAECK J DE ROECK G | 2001 | Smart Ma terial and Structures2001，10，3： | 1 |
| 14 | The Arabi- dopsis aldehyde oxidase 3 (AAO3) gene productcatalyzes the final step in abseisic acid biosynthesis in leaves 显示文摘 | Seo M Peeters A J Koiwai H | 2000 | Proc Natl Acad Sci2000，97，12： | 1 |
| 15 | Erythromycin impromives delayed gastricemptying in diabetic gastroparesis显示文摘 | Janssens J Peeters T Van Trappen G | 1990 | N Engl J Med1990，322，： | 1 |
| 16 | Air pollution and lung cancer incidence in 17 European cohorts: prospective analyses from the European Study of Cohorts for Air Pollution Effects (ESCAPE) 显示文摘 | Raaschou-Nielsen 0 Andersen ZJ Beelen R Samoli E Stafoggia M Weinmayr G Hoffmann B Fischer P Nieuwenhuijsen MJ Brunekreef B Xun WW Katsouyanni K Dimakopoulou K Sommar J Forsberg B Modig L Oudin A Oftedal B Schwarze PE Nafstad p De Faire U Pedersen NL Ostenson CG Fratiglioni L Penell J Korek M Pershagen G Eriksen KT Serensen M Tjenneland A Ellermann T Eeftens M Peeters PH Meliefste K Wang M Bueno-de-Mesquita B Key TJ de Hoogh K Concin H Nagel G Yilier A Grioni S Krogh y Tsai MY Ricceri F Sacerdote C Galassi C Migliore E Ranzi A Cesaroni G Badaloni C Forastiere F Tamayo I Amiano P Dorronsoro M Trichopoulou A Bamia C Yineis p Hoek G | 2013 | Lancet Oncol2013，14，9： | 1 |
| 17 | Prognostic relevance of occult tumor cells-in lymph nodes in colorectal cancer显示文摘 | Doekhie FS Kuppen P J Peeters KC | 2006 | Eur J Surg Oneo12006，32，3： | 1 |
| 18 | Randomised comparison of combined step-down prednisolone, methotrexate and sulphasalazine with sulphasalazine alone in early rheumatoid arthritis显示文摘 | Maarten Boers Arco C Verhoeven Harry M Markusse Mart AFJ van de Laar Rene Westhovens J Christiaan van Denderen Derkjen van Zeben Ben AC Dijkmans Andre J Peeters Piet Jacobs Hans R van den Brink Hubert JA Schouten Désirée MFM van der Heijde Annelies Boonen | 1997 | The Lancet1997，，9074： | 1 |
| 19 | Complete nucleotide sequence of Newcastle disease virus:evidence for the existence of a new genus within the subfamily Paramyxovirinae 显示文摘 | De Leeuw O Peeters B J | 1999 | J Gen Virol1999，80，1： | 1 |
| 20 | Involvement of two dif-ferent pathways in the motor effects of erythromycin onthe gastric antrum in humans 显示文摘 | Coulie B Tack J Peeters Ty | 1998 | Gutf1998，43，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员