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| 1 | Plasmonics for solid-state lighting: enhanced excitation and directional emission of highly efficient light sources显示文摘Light sources based on reliable and energy-efficient light-emitting diodes (LEDs) are instrumental in the development of solid-statelighting (SSL). Most research efforts in SSL have focused on improving both the intrinsic quantum efficiency (QE) and the stability oflight emitters. For this reason, it is broadly accepted that with the advent of highly efficient (QE close to 1) and stable emitters, thefundamental research phase of SSL is coming to an end. In this study, we demonstrate a very large improvement in SSL emission (above70-fold directional enhancement for p-polarized emission and 60-fold enhancement for unpolarized emission) using nanophotonicstructures. This is attained by coupling emitters with very high QE to collective plasmonic resonances in periodic arrays of aluminumnanoantennas. Our results open a new path for fundamental and applied research in SSL in which plasmonic nanostructures are able tomold the spectral and angular distribution of the emission with unprecedented precision. | Gabriel Lozano Davy J Louwers Said RK Rodrı´guez Shunsuke Murai Olaf TA Jansen Marc A Verschuuren Jaime Gomez Rivas | 2013 | Light(Science & Applications)2013，2，1： | 8 |
| 2 | Proteomics for discovery of candidate colorectal cancer biomarkers显示文摘Colorectal cancer(CRC)is the second most common cause of cancer-related deaths in Europe and other Western countries,mainly due to the lack of wellvalidated clinically useful biomarkers with enough sensitivity and specificity to detect this disease at early stages.Although it is well known that the pathogenesis of CRC is a progressive accumulation of mutations in multiple genes,much less is known at the proteome level.Therefore,in the last years many proteomic studies have been conducted to find new candidate protein biomarkers for diagnosis,prognosis and as therapeutic targets for this malignancy,as well as to elucidate the molecular mechanisms of colorectal carcinogenesis.An important advantage of the proteomic approaches is the capacity to look for multiple differentially expressed proteins in a single study.This review provides an overview of the recent reports describing the different proteomic tools used for the discovery of new protein markers for CRC such as two-dimensional electrophoresis methods,quantitative mass spectrometry-based techniques or protein microarrays.Additionally,we will also focus on the diverse biological samples used for CRC biomarker discovery such as tissue,serum and faeces,besides cell lines and murine models,discussing their advantages and disadvantages,and summarize the most frequently identified candidate CRC markers. | Paula lvarez-Chaver Olalla Otero-Estévez María Páez de la Cadena Francisco J Rodríguez-Berrocal Vicenta S Martínez-Zorzano | 2014 | World Journal of Gastroenterology2014，20，14： | 7 |
| 3 | 帕博利珠单抗联合以铂类为基础的化疗治疗非小细胞肺癌合并稳定性脑转移患者的结局:KEYNOTE-021、-189和-407研究的汇总分析显示文摘背景与目的此项探索性分析回顾评价了晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的结局,旨在确定基线时合并脑转移是否会影响一线应用帕博利珠单抗联合化疗(pembrolizumab plus chemotherapy,PC)比对单用化疗的疗效。患者和方法对KEYNOTE-021队列G(非鳞癌)、KEYNOTE-189(非鳞癌)和KEYNOTE-407(鳞癌)三项研究晚期NSCLC患者的数据进行汇总分析。患者接受含铂两药化疗和/或35个周期帕博利珠单抗治疗(每3周200 mg)。所有研究均纳入了经治或初治的稳定性脑转移患者(KEYNOTE-189与KEYNOTE-407研究纳入初治脑转移患者)。经治的脑转移患者已处于病情稳定的状态≥2周(KEYNOTE-021队列G患者≥4周),无新发或脑转移病灶扩大的证据且入组前至少3天以上未使用激素。初治的无症状脑转移患者需定期接受脑部影像学检查。结果共纳入1298例患者,其中171例有基线脑转移,1127例无脑转移。两组的中位随访时间(范围)在数据截止时分别为10.9(0.1-35.1)个月和11.0(0.1-34.9)个月。合并脑转移和无脑转移患者的总生存期[0.48(95%CI:0.32-0.70)和0.63(95%CI:0.53-0.75)]和无进展生存期[0.44(95%CI:0.31-0.62)和0.55(95%CI:0.48-0.63)]的风险比(PC/化疗)相似。合并脑转移的患者中,PC组和单用化疗组患者的中位总生存期分别为18.8个月和7.6个月,中位无进展生存期分别为6.9个月和4.1个月。无论是否合并脑转移,PC组患者的客观缓解率都高于单用化疗组,且缓解持续时间有显著延长。合并脑转移的患者中,PC组与单用化疗组的治疗相关不良事件发生率分别为88.2%和82.8%;而无脑转移的患者中,两组治疗相关不良事件的发生率分别为94.5%和90.6%。结论无论是否合并脑转移,与单用化疗相比,帕博利珠单抗联合以铂类为基础的组织学特异性化疗可改善所有PD-L1亚组的临床结局,其中包括PD-L1肿瘤比例评分<1%的患者,并且在晚期NSCLC患者中安全性良好。该方案是晚期NSCLC初治患者的标准方案,并可用于合并稳定性脑转移的患者。 | 周清(翻译校对) Steven F Powell Delvys Rodríguez-Abreu Corey J Langer Ali Tafreshi Luis Paz-Ares Hans-Georg Kopp Jeronimo Rodríguez-Cid Dariusz M Kowalski Ying Cheng Takayasu Kurata Mark M Awad Jinaxin Lin Bin Zhao M Catherine Pietanza Bilal Piperdi Marina C Garassino | 2022 | 中国肺癌杂志2022，25，1： | 6 |
| 4 | Medication adherence in schizophrenia显示文摘Non-adherence is a major problem in the treatment of schizophrenia. Its high prevalence, potentially severe consequences and associated costs make the study of this phenomenon a priority issue. In this article, basic non-adherence concepts of prevalence, consequences, evaluation methods, methodological restrictions of available studies, risk factors and intervention strategies, are reviewed. Studying non-adherence risk factors is a necessary step toward designing adequately oriented intervention strategies. An operative definition of adherence and good knowledge of its evaluation methods are essential to study this phenomenon. Unfortunately, most available studies contain methodological restrictions, especially concerning the evaluation methods, and an agreed operative definition of adherence has only very recently been reached. Knowing non-adherence risk factors, intervention strategies and available evidence on their effectiveness is essential in making treatment decisions in daily clinical practice. | Francisco Javier Acosta José Luis Hernández José Pereira Judit Herrera Carlos J Rodríguez | 2012 | World Journal of Psychiatry2012，2，5： | 5 |
| 5 | Effects of cellulase and xylanase enzymes mixed with increasing doses of Salix babylonica extract on in vitro rumen gas production kinetics of a mixture of corn silage with concentrate显示文摘An in vitro gas production(GP) technique was used to investigate the effects of combining different doses of Salix babylonica extract(SB) with exogenous fibrolytic enzymes(EZ) based on xylanase(X) and cellulase(C), or their mixture(XC; 1:1 v/v) on in vitro fermentation characteristics of a total mixed ration of corn silage and concentrate mixture(50:50, w/w) as substrate. Four levels of SB(0, 0.6, 1.2 and 1.8 m L g–1 dry matter(DM)) and four supplemental styles of EZ(1 μL g–1 DM; control(no enzymes), X, C and XC(1:1, v/v) were used in a 4×4 factorial arrangement. In vitro GP(m L g–1 DM) were recorded at 2, 4, 6, 8, 10, 12, 24, 36, 48 and 72 h of incubation. After 72 h, the incubation process was stopped and supernatant p H was determined, and then filtered to determine dry matter degradability(DMD). Fermentation parameters, such as the 24 h gas yield(GY24), in vitro organic matter digestibility(OMD), metabolizable energy(ME), short chain fatty acid concentrations(SCFA), and microbial crude protein production(MCP) were also estimated. Results indicated that there was a SB?EZ interaction(P<0.0001) for the asymptotic gas production(b), the rate of gas production(c), GP from 6 to 72 h, GP2(P=0.0095), and GP4(P=0.02). The SB and different combination of enzymes supplementation influenced(P<0.001) in vitro GP parameters after 12 h of incubation; the highest doses of SB(i.e., 1.8 m L g–1 DM), in the absence of any EZ, quadratically increased(P<0.05) the initial delay before GP begins(L) and GP at different incubation times, with lowering b(quadratic effect, P<0.0001) and c(quadratic effect, P<0.0001; linear effect, P=0.0018). The GP was the lowest(P<0.05) when the highest SB level was combined with cellulose. There were SB?EZ interactions(P<0.001) for OMD, ME, the partitioning factor at 72 h of incubation(PF72), GY24, SCFA, MCP(P=0.0143), and p H(P=0.0008). The OMD, ME, GY24 and SCFA with supp lementation of SB extract at 1.8 m L g–1 DM were higher(P<0.001) than the other treatments, however,PF72 was lower(quadratic effect, P=0.0194) than the other levels. Both C and X had no effect(P>0.05) on OMD, p H, ME, GY24, SCFA and MP. The combination of SB with EZ increased(P<0.001) OMD, ME, SCFA, PF72 and GP24, whereas there was no impact on p H. It could be concluded that addition of SB extract, C, and X effectively improved the in vitro rumen fermentation, and the combination of enzyme with SB extract at the level of 1.2 m L g–1 was more effective than the other treatments. | Abdelfattah Z M Salem German Buendía-Rodríguez Mona M M Elghandour María A Mariezcurrena Berasain Francisco J Pea Jiménez Alberto B Pliego Juan C V Chagoyán María A Cerrillo Miguel A Rodríguez | 2015 | Journal of Integrative Agriculture2015，14，1： | 4 |
| 6 | Long-term follow-up study of gastroduodenal lesions after radioembolization of hepatic tumors显示文摘AIM:To evaluate the long-term natural history of the gastroduodenal lesions secondary to extrahepatic embolization with Ytrium 90(90 Y) spheres.METHODS:From September 2003 to January 2012,379 procedures of liver radioembolization(RE) using resin microspheres loaded with 90 Y were performed in our center.We have retrospectively compiled the data from 379 RE procedures performed in our center.We report a comprehensive clinical,analytical,endoscopic and histologic long-term follow-up of a series of patients who developed gastroduodenal lesions after the treatment.RESULTS:Six patients(1.5%) developed gastrointestinal symptoms and had gastrointestinal lesions as shown by upper endoscopy in the next 12 wk after RE.The mean time between RE and the appearance of symptoms was 5 wk.Only one patient required endoscopic and surgical treatment.The incidence of gastrointestinal ulcerations was 3.75%(3/80) when only planar images were used for the pre-treatment evaluation.It was reduced to 1%(3/299) when singlephoton emission computed tomography(SPECT) images were also performed.The symptoms that lasted for a longer time were nausea and vomiting,until 25 mo after the treatment.CONCLUSION:All patients were free from severe symptoms at the end of follow-up.The routine use of SPECT has decreased the incidence of gastrointestinal lesions due to unintended deployment of 90 Y particles. | Iago Rodríguez-Lago Cristina Carretero Maite Herráiz José C Subtil Maite Betés Macarena Rodríguez-Fraile Jesús J Sola José I Bilbao Miguel Muoz-Navas Bruno Sangro | 2013 | World Journal of Gastroenterology2013，19，19： | 2 |
| 7 | On the oxidation resistance of carbon-carbon composites:Importance of fiber structure for composite reactivity显示文摘 | P A THROWER and L R RADOVIC | 1995 | Carbon1995，33，4： | 1 |
| 8 | Effect of rosuvastatin on cytokines after traumatic head injury显示文摘 | Sánchez Aguilar M Tapia Pérez J H Sánchez Rodríguez J J | 2013 | J Neurosurg2013，118，3： | 1 |
| 9 | Temperature-and salinity-decoupled overproduction of hydroxyectoine by Chromohalobacter salexigens 显示文摘 | Rodríguez M J Argando?a M Iglesias G F | 2013 | Applied and Environmental Microbiology2013，79，3： | 1 |
| 10 | Bio-ethanol steam reforming and autothermal reforming in 3-μm channels coated with Rh Pd/Ce O2for hydrogen generation显示文摘 | Divins N J López E Rodríguez | 2013 | Chem Eng Process2013，64，： | 1 |
| 11 | Video-nystagmography findings in healthy elderly subjects显示文摘 | Amor Dorado J C Rubio Rodríguez J P Costa Ribas C | 2003 | Acta Otorrinolaringol Esp2003，54，3： | 1 |
| 12 | Breeding system flower visitors and seedling survival of two endangered species of Helianthemum (Cistaceae)显示文摘 | RODRGUEZ-PREZ J | 2005 | Annal of Botany2005，95，7： | 1 |
| 13 | Development of porosity upon chemical activation of kraft lignin with ZnCl2显示文摘 | González-Serrano E Cordero T Rodríguez-Mirasol J | 1997 | Ind Eng Chem Res1997，36，： | 1 |
| 14 | Osteogenesis impeffecta: anthropometrie, skeletal and mineral metabolic effects of long-term intravenous pamidronate therapy 显示文摘 | Vallo A Rodriguez-Leyva F Rodr l guez Soriano J | 2006 | Aeta Paediatr2006，95，3： | 1 |
| 15 | Increased circulating and visceral adipose tissue expression levels of YKL-40 in obesity-associated type 2 diabetes are related to inflammation:impact of conventional weight loss and gastric bypass显示文摘 | Catalán V Gómez-Ambrosi J Rodríguez A | 2011 | J Clin Endocrinol Metab2011，96，1： | 1 |
| 16 | Effect ofbiodiesel fuels on diesel engine emissions显示文摘 | Lapuerta M Armas O Rodríguez-Fernández J | 2008 | Progress in Energyand Combustion Science2008，34，2： | 1 |
| 17 | Characterization of anodized and sealed aluminium by EIS 显示文摘 | Suay J J Gimenez E Rodr guez T | 2003 | Corrosion Sci- en-ce2003，45，3： | 1 |
| 18 | Cloning of the PpNHAD1 transporter of Physcomitrella patens,a chloroplast transporter highly conserved in photosynthetic eukaryotic organisms显示文摘 | Barrero-Gil J Rodríguez-Navarro A Benito B | 2007 | Journal of Experimental Botany2007，58，11： | 1 |
| 19 | A multi-scale approach in thestudy of plant regeneration: Finding bottlenecks is not enough 显示文摘 | Rodríguez-Pérez J Traveset A | 2007 | Perspect Plant Ecol2007，9，1： | 1 |
| 20 | Use of immobilized phospholipase A1-catalyzed acidolysis for the production of structured phosphatidylcholine with an elevated conjugated linoleic acid content显示文摘 | Jiménez R B Rodríguez J G Kim In-H | 2012 | Grasas y Aceites2012，63，1： | 1 |
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