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| 1 | Model combining pre-transplant tumor biomarkers and tumor size shows more utility in predicting hepatocellular carcinoma recurrence and survival than the BALAD models显示文摘AIM To assess the performance of BALAD, BALAD-2 and their component biomarkers in predicting outcome of hepatocellular carcinoma(HCC) patients after liver transplant.METHODS BALAD score and BALAD-2 class are derived from bilirubin, albumin, alpha-fetoprotein(AFP), Lens culinaris agglutinin-reactive AFP(AFP-L3), and des-gammacarboxyprothrombin(DCP). Pre-transplant AFP, AFP-L3 and DCP were measured in 113 patients transplanted for HCC from 2000 to 2008. Hazard ratios(HR) for recurrence and death were calculated. Univariate and multivariate regression analyses were conducted. C-statistics were used to compare biomarker-based to predictive models. RESULTS During a median follow-up of 12.2 years, 38 patients recurred and 87 died. The HRs for recurrence in patients with elevated AFP, AFP-L3, and DCP defined by BALAD cut-off values were 2.42(1.18-5.00), 1.86(0.98-3.52), and 2.83(1.42-5.61), respectively. For BALAD, the HRs for recurrence and death per unit increased score were 1.48(1.15-1.91) and 1.59(1.28-1.97). For BALAD-2, the HRs for recurrence and death per unit increased class were 1.45(1.06-1.98) and 1.38(1.09-1.76). For recurrence prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs. 0.64, 0.61, 0.53, and 0.53 for BALAD, BALAD-2, Milan, and UCSF, respectively. Similarly, for death prediction, the combination of three biomarkers had the highest c-statistic of 0.66 vs 0.65,0.61, 0.52, and 0.50 for BALAD, BALAD-2, Milan, and UCSF. A new model combining biomarkers with tumor size at the time of transplant(S-LAD) demonstrated the highest predictive capability with c-statistics of 0.71 and 0.69 for recurrence and death. CONCLUSION BALAD and BALAD-2 are valid in transplant HCC patients, but less predictive than the three biomarkers in combination or the three biomarkers in combination with maximal tumor diameter(S-LAD). | Nicha Wongjarupong Gabriela M Negron-Ocasio Roongruedee Chaiteerakij Benyam D Addissie Essa A Mohamed Kristin C Mara William S Harmsen J Paul Theobald Brian E Peters Joseph G Balsanek Melissa M Ward Nasra H Giama Sudhakar K Venkatesh Denise M Harnois Michael R Charlton Hiroyuki Yamada Alicia Algeciras-Schimnich Melissa R Snyder Terry M Therneau Lewis R Roberts | 2018 | World Journal of Gastroenterology2018，24，12： | 5 |
| 2 | Chronic kidney disease after nephrectomy in patients with renal cortical tumours: a retrospective cohort study显示文摘 | William C Huang Andrew S Levey Angel M Serio Mark Snyder Andrew J Vickers Ganesh V Raj Peter T Scardino Paul Russo | 2006 | Lancet Oncology2006，，9： | 4 |
| 3 | California Simulation of Evapotranspiration of Applied Water and Agricultural Energy Use in California显示文摘The California Simulation of Evapotranspiration of Applied Water (Cal-SIMETAW) model is a new tool developed by the California Department of Water Resources and the University of California, Davis to perform daily soil water balance and determine crop evapotranspiration (ET c ), evapotranspiration of applied water (ET aw ), and applied water (AW) for use in California water resources planning. ET aw is a seasonal estimate of the water needed to irrigate a crop assuming 100% irrigation efficiency. The model accounts for soils, crop coefficients, rooting depths, seepage, etc. that influence crop water balance. It provides spatial soil and climate information and it uses historical crop and land-use category information to provide seasonal water balance estimates by combinations of detailed analysis unit and county (DAU/County) over California. The result is a large data base of ET c and ET aw that will be used to update information in the new California Water Plan (CWP). The application uses the daily climate data, i.e., maximum (T x ) and minimum (T n ) temperature and precipitation (P cp ), which were derived from monthly USDA-NRCS PRISM data (PRISM Group 2011) and daily US National Climate Data Center (NCDC) climate station data to cover California on a 4 km×4 km change grid spacing. The application uses daily weather data to determine reference evapotranspiration (ET o ), using the Hargreaves-Samani (HS) equation (Hargreaves and Samani 1982, 1985). Because the HS equation is based on temperature only, ET o from the HS equation were compared with CIMIS ET o at the same locations using available CIMIS data to determine correction factors to estimate CIMIS ET o from the HS ET o to account for spatial climate differences. Cal-SIMETAW also employs near real-time reference evapotranspiration (ET o ) information from Spatial CIMIS, which is a model that combines weather station data and remote sensing to provide a grid of ET o information. A second database containing the available soil water holding capacity and soil depth information for all of California was also developed from the USDA-NRCS SSURGO database. The Cal-SIMETAW program also has the ability to generate daily weather data from monthly mean values for use in studying climate change scenarios and their possible impacts on water demand in the state. The key objective of this project is to improve the accuracy of water use estimates for the California Water Plan (CWP), which provides a comprehensive report on water supply, demand, and management in California. In this paper, we will discuss the model and how it determines ET aw for use in water resources planning. | Morteza N Orang Richard L Snyder Shu Geng Quinn J Hart Sara Sarreshteh Matthias Falk Dylan Beaudette Scott Hayes Simon Eching | 2013 | Journal of Integrative Agriculture2013，12，8： | 3 |
| 4 | Increasing diabetes self-management education in community settings显示文摘 | Susan L Norris Phyllis J Nichols Carl J Caspersen Russell E Glasgow Michael M Engelgau Leonard Jack Susan R Snyder Vilma G Carande-Kulis George Isham Sanford Garfield Peter Briss David McCulloch | 2002 | American Journal of Preventive Medicine2002，，4： | 2 |
| 5 | Anatomical differences in the mirror neuron system and social cognition network in autism 显示文摘 | Hadjikhani N Joseph RM Snyder J | 2006 | Cereb Cortex2006，16，： | 1 |
| 6 | The avian influenza virus nucleoprotein gene and a specific constellation of avian and human virus polymerase genes each specify attenuation of avian-human influenza A/ Pintail/79 reassortant viruses for monkeys 显示文摘 | Snyder M H Buckler-White A J London W T | | J Virol0，61，： | 1 |
| 7 | The burden of illness of cancer:economic cost and quality of life显示文摘 | Brown M L Lipscomb J Snyder C | 2001 | Annu Rev Public Health2001，22，： | 1 |
| 8 | Nutrogen/potassium fertilization rations for bermudagrass turf显示文摘 | Snyder G H Cisar J L | 2000 | Crop Science2000，40，6： | 1 |
| 9 | Control ofcolumn temperature in reversed-phase liquid chromatography显示文摘 | Wolcott R G Dolan J W Snyder L R | 2000 | J ChromatogrA2000，869，12： | 1 |
| 10 | Monoclonal autibody to the glycoprotein of VSV显示文摘 | Bricker B J Snyder R W Fox J W | 1997 | Virology1997，161，2： | 1 |
| 11 | Redescription of the frog bladder fluke Gorgoderina attenuata from the north- ern leopard frog, Rana pipiens 显示文摘 | Bolek M G Snyder S D Janovy J Jr | 2009 | J Parasitol2009，95，3： | 1 |
| 12 | Fear fosters flight: A mechanism for fear contagion when perceiving emotion expressed by a whole body显示文摘 | De Gelder B Snyder J Greve D | 2004 | Proceedings of the National Academy of Sciences of the United States of America2004，101，16： | 1 |
| 13 | Thermoelectric microdevice fabricated by a MEMS-like electrochemical process 显示文摘 | Snyder G J Lira J R Huang C K | 2003 | Nature Materials & Design2003，2，5： | 1 |
| 14 | Laparoscopic anatomy of the equine abdomen 显示文摘 | Galuppo L D Snyder J R Pascoe J R | 1995 | Am J Vet Res1995，56，4： | 1 |
| 15 | general anaesthetics selectively modulate glutamatergic and dopaminergic signaling via site-specific phosphorylation in vivo显示文摘 | Snyder GL Galdi S Hendrick J P | 2007 | Neuropharmacology2007，53，5： | 1 |
| 16 | Toxicity and Repellency of Hot Pepper Extracts to Spider Mite显示文摘 | ANTONIOUS G F MEYER J E SNYDER J C | 2006 | Journal of Environmental Science and Health-part B Pesticides Food Contaminants and Agricultural Wastes2006，41，8： | 1 |
| 17 | Reevaluation of PbTel -xlx as High Performance n-type Thermoelectric material 显示文摘 | LaLonde A D Pei Y Snyder G J | 2011 | Energy & Envi- ronmental Science2011，4，6： | 1 |
| 18 | The Effects of Titanium on Submerged Arc Weld Metal显示文摘 | SNYDER J P PENSE A W | 1982 | Welding Journal1982，61，7： | 1 |
| 19 | A virus similar to human hepatitis B virus associated with hepatitis and hepatoma in woodchucks显示文摘 | Summers J Smolec J M Snyder R | 1978 | Proc Natl Acad Sci U S A1978，75，： | 1 |
| 20 | Posttransplant lymphoproliferative disorder following nonmyeloablative allogeneic stem cell transplantation显示文摘 | Snyder M J Stenzel T T Buckley P J | 2004 | Am J Surg Pathol2004，28，： | 1 |
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