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| 1 | Cisplatin ototoxicity involves cytokines and STAT6 signaling network显示文摘我们此处调查了在支持 inflammatory cytokines 和 cisplatin ototoxicity 的生产表明串联的 STAT 的角色。cisplatin 注射引起的一个重要听觉缺陷在 Balb/c 被观察(野类型, WT ) 并且 STAT4 −/−, 然而并非在 STAT6 −/− 老鼠。而且,蛋白质的表示层次和支持 inflammatory cytokines 的 mRNA,包括 TNF-α, IL-1β,并且 IL-6,显著地在 WT 和 STAT4 −/−, 然而并非 STAT6 −/− 老鼠的浆液和蜗被增加。Organotypic 文化表明 stereocilia 捆的形状和在从 STAT6 −/− 鼠标的 Corti 的机关的感觉毛细胞层的数组在有 cisplatin 的处理以后是未经触动的,而那些高度在处理以后从 WT 和 STAT4 −/− 鼠标被弄歪并且弄乱。Cisplatin 在 HEI-OC1 听觉的房间导致了 STAT6 的 phosphorylation,并且由显著地保护的 STAT6 特定的 siRNA 的 STAT6 击倒从导致 cisplatin 的房间死亡的 HEI-OC1 听觉的房间和禁止的支持 inflammatory cytokine 生产。我们进一步证明 cisplatin 导致的 IL-4 和 IL-13 与 IL-4 受体 alpha 和 IL-13Rα 由绑定调制了 STAT6 的 phosphorylation; 1。这些调查结果建议发信号的 STAT6 在调停 cisplatin 的支持 inflammatory cytokine 生产和 ototoxicity 起一个枢轴的作用。 | Hyung-Jin Kim Gi-Su Oh Jeong-Han Lee Ah-Ra Lyu Hye-Min Ji Sang-Heon Lee Jeho Song Sung-Joo Park Yong-Ouk You Jeong-Dug Sul Channy Park Sang-Young Chung Sung-Kyun Moon David J Lim Hong-Seob So Raekil Park | 2011 | Cell Research2011，21，6： | 2 |
| 2 | Global self-esteem in relation to structural models of personality and affectivity显示文摘 | WATSON D SULS J HAIG J | 2002 | J Pers Psychol2002，83，1： | 1 |
| 3 | Impact of Foreign Institutional Investors on Dividend Policy in Korea: A Stock Market Perspective 显示文摘 | Kim S J Sul W Kang S A | 2010 | Journal of Financial Management and Analysis2010，23，1： | 1 |
| 4 | New direct torque control of induction motor for minimum torque ripple and constant switching frequency显示文摘 | Kang J K Sul S K | 1999 | IEEE Trans on Industry Applications1999，33，5： | 1 |
| 5 | Variance component model to account for sample structure in genome-wide association studies显示文摘 | Kang H M Sul J H Service S K | 2010 | Nat Genet2010，42，4： | 1 |
| 6 | Associations of depression with C-reactive protein,显示文摘 | Howren MB Lamkin DM Suls J | 2009 | Psychosom Med2009，71，： | 1 |
| 7 | Associations of depression with C-reactiveprotein, IL-1, and IL-6 :a recta-analysis显示文摘 | Howren MB Lamkin DM Suls J | 2009 | Psy- chosom Med2009，71，2： | 1 |
| 8 | Biofuels production through biom&ss pyrolysis-A technologic&l review显示文摘 | J&hirul M ] P:&sul M Q Chowdhury A A et &l | 2012 | Energies2012，5，12： | 1 |
| 9 | Method Matters : Effects of Explicit Ver- sus Implicit Social Comparisons on Activation 显示文摘 | Stapel D A Suls J | 2004 | Journal of Personality and Social Psychology2004，87，6： | 1 |
| 10 | Hormonal regulation of mouse fatty acid synthase gene transcription in liver显示文摘 | Paulauskis J D Sul H S | 1989 | Journal of Biological Chemistry1989，264，1： | 1 |
| 11 | Synchronous-frame current control of multiphase synchronous motor under asymmetric fault condition due to open phases显示文摘 | Ryu H M Kim J W Sul S K | 2006 | IEEE Transactions on Industry Applications2006，42，4： | 1 |
| 12 | A carrier-based PWM method for three-phase four-leg voltage source converters显示文摘 | Kim a J H Sul S K | 2004 | IEEE Transactions on Power Electronics2004，19，1： | 1 |
| 13 | Sensorless field-orientation conrol of an induction machine by high-frequency signal injection 显示文摘 | Ha J I Sul S K | 1999 | IEEE Transactions on Industry Applications1999，35，1： | 1 |
| 14 | Sensorless drive of surfacemounted permanent-magnet motor by high-frequency signal injection based on magnetic saliency 显示文摘 | Jang J H Sul S k Ha J I | 2003 | IEEE Trans on lnd Appl2003，39，4： | 1 |
| 15 | Flawed Self-assessment:Implications for Health, Education and the Workplace 显示文摘 | Dunning D Heath C Suls J M | 2004 | Psychological Science in the Public Interest2004，，5： | 1 |
| 16 | A Novel Control Algorithm for Static Series Compensators by Use of PQR Instantaneous Power Theory显示文摘 | Lee S J Kim H Sul S K | 2004 | IEEE Trans on Power Electronics2004，19，3： | 1 |
| 17 | The relationship between trait hostility and cardiovascular reactivity:A quantitative analysis显示文摘 | Sul J Wan CK | 1993 | Psychophysiology1993，30，： | 1 |
| 18 | Inverter output voltage synthesis using novel dead time compensation 显示文摘 | CHOI J W SUL S K | 1996 | IEEE Transactions on Power Elec- tronics1996，11，： | 1 |
| 19 | Primary spinal cord glioma:a Surveillance,Epidemiology,and End Results database study显示文摘 | Milano MT Johnson MD Sul J | 2010 | J Neurooncol2010，98，1： | 1 |
| 20 | Sensorless drive of surface-mounted permanent-magnet motor by high- frequency signal injection based on magnetic saliency 显示文摘 | Jang J H Sul S K Ha J I | 2003 | IEEE Transactions on Industry Applications2003，39，4： | 1 |
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