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| 1 | Early palliative care for patients with metastatic non-small-cell lung cancer显示文摘Comments This landmark article demonstrates that integration of early palliative care with standard oncologic practice shortly after diagnosis may improve quality of life,mood,and overall survival for adults with advanced non-small-cell lung cancer(NSCLC).If validated,these findings could support a paradigm shift in the care of adults with metastatic NSCLC and possibly patients with other tumor types characterized by short survival and high symptom burden. | Temel JS Greer JA Muzikansky A Gallagher ER Admane S Jackson VA Dahlin CM Blinderman CD Jacobsen J Pirl WF Billings JA Lynch TJ | 2010 | 中国肺癌杂志2010,13,9: | 165 |
| 2 | Autoimmune pancreatitis: Functional and morphological recovery after steroid therapy显示文摘自体免疫的胰腺炎,慢性胰炎的一种最近公认的类型,不在其它地方在它的日本,而是报告是稀罕的是相对不平常的。我们在匈牙利报导自体免疫的胰腺炎的第一个外科手术前地诊断的案例,它对类固醇处理作出回应很好并且提供了这改进的 X 光线照相术、功能的证据。与周期性的腹上部的疼痛和 5-kg 重量损失的 4 月的历史介绍的 62 岁的女性。口头的葡萄糖耐量测试(OGTT ) 显示糖尿病和烘便的弹性硬蛋白酶测试的结果是反常的。Ultrasonography (美国) 和 CT 扫描表明了广泛地扩大的胰,并且内视镜后退 cholangiopancreatography (ERCP ) 有在头和尾巴的长苛评的不规则的主要的胰腺的管。自体免疫的胰腺炎被诊断。病人每天在 32 mg 氢化尼松上被开始。在 4 wk 以后, OGTT 和排泄物的弹性硬蛋白酶测试结果使正常化。重复美国和 CT 扫描揭示了 diffuse 的显著改进胰腺,在重复 ERCP 上胀大,变窄的主要的胰腺的管被看见被改善。因为 AIP 能临床上类似于 pancreatobiliary 恶意,或长期或尖锐的胰腺炎,知道这疾病和它的诊断是重要的。然而在有慢性胰炎的对比,它的症状并且词法并且实验室改变被口头的类固醇治疗完全颠倒。 | László Czakó (E|')va Hegyk(o|¨)zi Attila Pálinkás János Lonovics | 2006 | World Journal of Gastroenterology2006,12,11: | 3 |
| 3 | 弓形虫感染引起小胶质细胞与神经元的接触以及细胞体周边抑制性突触丧失显示文摘大脑内的感染和炎症会引起神经元连通性和功能的改变。细胞内的原生动物寄生虫,弓形虫,是一种感染脑部的病原体,可引起脑炎和癫痫发作。这种寄生虫的持续感染还与行为改变和发生精神疾病(包括精神分裂症)的风险增加有关。目前来自人类和小鼠模型的研究证据表明,癫痫发作和精神分裂症均由抑制性突触的丧失或功能障碍引起。与此相符,我们最近报道了持续性弓形虫感染改变谷氨酸脱羧酶67(GAD67)的分布,该酶在抑制性突触中催化GABA的合成。这些变化可能反映突触前装置在抑制性神经元中的重新分布或抑制性神经末梢的丧失。为了直接评估后者的可能性,我们采用序列块面扫描电子显微镜(SBFSEM)并量化寄生虫感染后新皮质和海马中的细胞体周边抑制性突触。持续感染不仅导致明显的细胞体周边突触丧失,而且还诱导髓样来源的细胞对神经元细胞体的包封。免疫组织化学、遗传和超微结构分析显示,这些髓样来源的细胞包括活化的小胶质细胞。最后,超微结构分析确定了包膜于细胞体周围神经末梢的髓样来源的细胞,提示它们可能会主动置换或吞噬突触元件。因此,这些结果表明,活化的小胶质细胞有助于寄生虫感染后细胞体周围抑制突触损失,并对于弓形虫的持续感染可能如何导致癫痫发作和精神疾病提供了一种新的机制。 | Carrillo GL Ballard VA Glausen T Boone Z Teamer J Hinkson CL Wohlfert EA Blader IJ Fox MA 杜一星(编译) | 2020 | 神经损伤与功能重建2020,15,3: | 2 |
| 4 | Tip grafts in closed rhiiloplasty:insertion and fixation made easy显示文摘 | FERNANDEZ D E da SIL VA CARVALHO G | 2008 | Plast Reconstr Surg2008,121,3: | 1 |
| 5 | Intracranial percu-taneous transluminal angioplasty for arteriosclerotic stenosis显示文摘 | Alazzaz A Thornton J Aletich VA | 2000 | Arch Neurol2000,57,: | 1 |
| 6 | Afatinib versus placebo for patients with advanced ,metastatic non-small- cell lung cancer after failure of erlotinib,gefitinib,or both,and one or two lines of chemotherapy (LUX-Lung 1): a phase 2b/3 randomised trial 显示文摘 | Miller VA Hirsh V Cadranel J | 2012 | Lancet Oncol2012,13,5: | 1 |
| 7 | Preparation and modification of activated carbon fibres by microwave heating显示文摘 | Va|ente Nabais J M Carrott P M J Ribeiro Carrott M M L | 2004 | Carbon2004,42,7: | 1 |
| 8 | Renaming papil- lary mieroeareinoma of the thyroid gland: the Porto proposal显示文摘 | Rosai J Livolsi VA Sobrinho-Simoes M | 2003 | Int J Surg Pathol2003,11,4: | 1 |
| 9 | Regulation of MDR - 1 ( P - glycoprotein) by eyclooxygenase - 2 显示文摘 | Patel VA Dunn M J Sorokin A | 2002 | J Bio! Chem2002,277,38: | 1 |
| 10 | Genotyping anti -hepatitis B virus drug resistance显示文摘 | Bourne EJ Gauthier J Lopez VA | 2004 | Methods Mol Med2004,96,: | 1 |
| 11 | The relation between excitability of the alpha motor neurons in patients with post-stroke spasticity显示文摘 | Bakheit AMO Maynard VA Curnow J | 2003 | J Neurol Neurosurg Psychiatry(S0022-3050)2003,74,: | 1 |
| 12 | Impact of CYP2C19 variant genotypes on clinical efficacy of anti- platelet treatment with clopidogrel: systematic review and meta-analysis显示文摘 | Bauer T Bouman H J Va Wekum JW | 2011 | BMJ2011,343,: | 1 |
| 13 | Antibody detection-based differential ELISA for NDV-infected or vaccinated chickens versus NDV HN-subunit vaccinated chickens显示文摘 | Andrea M Makkay Peter J Krell éva Nagy | 1999 | Veterinary Microbiology1999,,3: | 1 |
| 14 | 显示文摘 | Toscano J Vaβen R Gil A | 2006 | Surface and Coatings Technology2006,201,7: | 1 |
| 15 | High secretion of interfe- rons by human plasmacytoid dendritic cells upon recognition of Middle East respiratory syndrome coronavirus 显示文摘 | Scheuplein VA Seifried J Malczyk AH | 2015 | J Virol2015,89,7: | 1 |
| 16 | Which is the best method of sterilization of tumour bone for reimplantation?A biomechanical and histopathological study显示文摘 | Singh VA Nagalingam J Saad M | 2010 | Biomed Eng Online2010,9,: | 1 |
| 17 | Stimulation of hepa- tocyte glucose metabolism by novel small molecule glucokinase activators显示文摘 | Brocklehurst K J Payne VA Davies RA | 2004 | Diabetes2004,53,3: | 1 |
| 18 | Intraosseous infusion:An alternative route of pediatric intravascular access显示文摘 | Rosetti VA Thompson BM Miller J | 1985 | Ann Emerg Med1985,14,9: | 1 |
| 19 | typology of online shoppers basedon shopping motivations显示文摘 | ROHM A J SWAMINATHAN VA | 2004 | Journal of Business Research2004,57,7: | 1 |
| 20 | DTI measures tract and predict mo- tor function outcomes in stroke rehabilitation utilizing BCI technolo- gy 显示文摘 | Song J Nair VA Young BM | 2015 | Front Hum Neurosci2015,9,: | 1 |