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| 1 | TSC1-mTOR-PLK轴以阶段特异性方式调节从施旺细胞增殖到髓鞘形成的内稳态开关显示文摘恰如其分的外周髓鞘形成取决于雪旺细胞增殖与分化进程间的平衡。丝氨酸/苏氨酸激酶(mTOR)整合多种环境因素,是细胞生长、代谢、发挥作用的中枢调节者。本文报道了一种mTOR的负性调节剂——结节性硬化复合体(TSC1),通过控制细胞增殖和髓鞘稳态,建立了雪旺细胞谱系进展和髓鞘形成的阶段依赖性程序。小鼠雪旺细胞祖细胞中TSC1的解离导致mTOR信号通路激活,继而导致雪旺细胞过量增殖,分化受阻,髓鞘形成减少。转录组分析显示,TSC1突变体中的mTOR活化使得polo样激酶(PLK)依赖性通路和细胞周期调节剂上调。弱化mTOR或者对PLK进行药理抑制部分挽救了因TSC1缺失导致的外周神经发育过程中的髓鞘形成减少。相较之下,成年小鼠成熟雪旺细胞中TSC1缺失可导致髓鞘的过度增殖和过度生长。本文的发现提示了TSC1-mTOR-PLK信号轴在控制雪旺细胞的发育过程中,从增殖到分化和髓鞘内稳态中起到的阶段特异性功能。 | Jiang M Rao R Wang J Wang J1 Xu L Wu LM Chan JR Wang H Lu QR 聂昊(编译) | 2018 | 神经损伤与功能重建2018，13，5： | 2 |
| 2 | Biomechanical evaluation of metacarpal fracture f'Lxation: application of a 90° internal fixation model显示文摘 | Watt A J Ching RP Huang J1 | 2015 | Hand ( N Y)2015，10，1： | 1 |
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| 11 | Multi-genetic events eollabo- ratively contribute to Pten-null leukaemia stem-cell formation 显示文摘 | Guo W Lasky J1 Chang C J | 2008 | Nature2008，453，7194： | 1 |
| 12 | A multimedia electronic patient record (ePR) system for image-assisted minimally invasive spinal surgery 显示文摘 | Documet J1 Le A Liu B Chiu J Huang HK | 2010 | Int J Comput Assist Radiol Surg2010，5，3： | 1 |
| 13 | Fuzzy training in supervised image classification显示文摘 | J1 M JENSEN J R | 1996 | Geographic Information Sciences1996，2，1： | 1 |
| 14 | Enhancement of PCR Amplification of Moderate GC-Containing and Highly GC-Rich DNA Sequences 显示文摘 | Strien J1 Sanft J Mall G | 2013 | Mol Biotechnol2013，54，3： | 1 |
| 15 | Normal protein diet for episodic hepatic encephalopathy: results of a randomized study显示文摘 | C6rdoba J1 L6pez-Hellin J Planas M | 2004 | J Hepatol2004，41，1： | 1 |
| 16 | Polycystic kidney disease with renal calculi treated by percutaneous nephrolithotomy: a report of 11 cases显示文摘 | Zhang J1 Zhang J Xing N | 2014 | Urol Int2014，92，4： | 1 |
| 17 | Tumor inhibitory effect and im munomodulatory activity of fullerol C60 (OH), 显示文摘 | ZHU J D J1 Z Q WANG J | 2008 | Small2008，4，8： | 1 |
| 18 | Treatment and outcomes of primary breast lymphoma显示文摘 | Caon J1 Wai ES Hart J | 2012 | Clin Breast Cancer2012，12，6： | 1 |
| 19 | Survival of human glioma ceils treated with various combination of temozolomide and x-rays 显示文摘 | van Rijn J1 Heimans JJ van den Berg J | 2004 | Int J Radiat Oncol Biol Pys2004，47，3： | 1 |
| 20 | Improved Antireflection Properties of Moth Eye Mimicking Nanopillars on Transparent Glass Flat Antireflection and Color Tuning显示文摘 | J1 S PARK J LIM H | 2012 | Nanoscale2012，4，15： | 1 |
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