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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | XRCC1 and DNA polymerase β in cellular protection against cytotoxic DNA single-strand breaks显示文摘 | Julie K Horton Mary Watson Donna F Stefanick Daniel T Shaughnessy Jack A Taylor Samuel H Wilson | 2008 | Cell Research2008，18，1： | 17 |
| 3 | Role of the JNK signal transduction pathway in inflammatory bowel disease显示文摘The c-Jun NH2-terminal Kinase (JNK) pathway representsone sub-group of the mitogen-activated protein (MAP)kinases which plays an important role in variousinflammatory diseases states, including inflammatorybowel disease (IBD). Significant progress towardsunderstanding the function of the JNK signaling pathwayhas been achieved during the past few years. Blockadeof the JNK pathway with JNK inhibitors in animal modelsof IBD lead to resolution of intestinal inflammation.Current data suggest specific JNK inhibitors hold promiseas novel therapies in IBD. | Praveen K Roy Farzana Rashid Jack Bragg Jamal A Ibdah | 2008 | World Journal of Gastroenterology2008，14，2： | 10 |
| 4 | Acute effects of rotavirus and malnutrition on intestinal barrier function in neonatal piglets显示文摘AIM: To investigate the effect of protein-energy malnutrition on intestinal barrier function during rotavirus enteritis in a piglet model.METHODS: Newborn piglets were allotted at day 4 of age to the following treatments:(1) full-strength formula(FSF)/noninfected;(2) FSF/rotavirus infected;(3) half-strength formula(HSF)/noninfected;or(4) HSF/rotavirus infected.After one day of adjustment to the feeding rates,pigs were infected with rotavirus and acute effects on growth and diarrhea were monitored for 3 d and jejunal samples were collected for Ussingchamber analyses.RESULTS: Piglets that were malnourished or infected had lower body weights on days 2 and 3 post-infection(P < 0.05).Three days post-infection,marked diarrhea and weight loss were accompanied by sharp reductions in villus height(59%) and lactase activity(91%) and increased crypt depth(21%) in infected compared with non-infected pigs(P < 0.05).Malnutrition also increased crypt depth(21%) compared to full-fed piglets.Villus:crypt ratio was reduced(67%) with viral infection.There was a trend for reduction in transepithelial electrical resistance with rotavirus infection and malnutrition(P = 0.1).3H-mannitol flux was significantly increased(50%;P < 0.001) in rotavirus-infected piglets compared to non-infected piglets,but there was no effect of nutritional status.Furthermore,rotavirus infection reduced localization of the tight junction protein,occludin,in the cell membrane and increased localization in the cytosol.CONCLUSION: Overall,malnutrition had no additive effects to rotavirus infection on intestinal barrier function at day 3 post-infection in a neonatal piglet model. | Sheila K Jacobi Adam J Moeser Anthony T Blikslager J Marc Rhoads Benjamin A Corl Robert J Harrell Jack Odle | 2013 | World Journal of Gastroenterology2013，19，31： | 4 |
| 5 | Novel susceptibility genes in inflammatory bowel disease显示文摘The inflammatory bowel disease, Crohn's disease and ulcerative colitis, are polygenic disorders with important environmental interactions. To date, the most widely adopted approach to identifying susceptibility genes in complex diseases has involved genome wide linkage studies followed by studies of positional candidate genes in loci of interest. This review encompasses data from studies into novel candidate genes implicated in the pathogenesis of inflammatory bowel disease. Novel techniques to identify candidate genes-genome wide association studies, yeast-two hybrid screening, microarray gene expression studies and proteomic profiling, are also reviewed and their potential role in unravelling the pathogenesis of inflammatory bowel disease are discussed. | Colin Noble Elaine Nimmo Daniel Gaya Richard K Russell Jack Satsangi | 2006 | World Journal of Gastroenterology2006，12，13： | 3 |
| 6 | Can Mutual Funds Outguess the Market? 显示文摘 | Jack L Treynor Kay K Mazuy | 1966 | Havard Business Review1966，44，4： | 1 |
| 7 | Ceramics based on the Si-A1-O-N and re- lated systems 显示文摘 | Jack K H Wilson W I | 1972 | Nature Phys Sci (London)1972，238，： | 1 |
| 8 | Mild cognitive impairment and Ahheimer disease: regional diffusivity of water显示文摘 | KANTARCI K JACK CR XU YC | 2001 | Radiology2001，219，： | 1 |
| 9 | NF1 tumor suppressor gene function : narrowing the GAP显示文摘 | Cichowski K Jacks T | 2001 | Cell2001，104，： | 1 |
| 10 | Work,family and health:the expanding role of EAP professionals显示文摘 | BEACH R H STEVEN MARTIN K JACK | 1995 | Employee Counselling Today1995，7，4： | 1 |
| 11 | PIK3CA mutation asso- ciates with improved outcome in breast cancer 显示文摘 | Kalinsky K Jacks LM Heguy A | 2009 | Clin Cancer Res2009，15，16： | 1 |
| 12 | Kriging metamodeling in simulation:A review显示文摘 | JACK P C K | | 0，，3： | 1 |
| 13 | Feature generation using genetic programming with application to fault classification显示文摘 | Guo H Jack L B Nandi A K | 2005 | IEEE Transaction on System Man and Cybernetics2005，35，1： | 1 |
| 14 | Peripheral neuropathy and the risk of cardio- vascularevents in type 2 diabetes mellitus显示文摘 | Jack R W Brownrigg Matthew M Thompson 1 Kausik K Ray | 2014 | Cardiac risk factors and prevention2014，，100： | 1 |
| 15 | Recombinant TBP, transcription factor II B,and RAP30 are sufficient for promoter recognition by mammalian RNA polyrnerase 11显示文摘 | Marie K Benoit C Jack G | 1992 | Biological Chemistry1992，267，14： | 1 |
| 16 | An empirically calibrated framework for including the effects of near-fault directivity in prob- abilistic seismic hazard analysis 显示文摘 | SHREY K SHAHI JACK W BAKER | 2011 | Bulletin of the Seismological Society of America2011，101，2： | 1 |
| 17 | Review-Sialons and Related Nitrogen Ceramics 显示文摘 | Jack K J | 1979 | Journal of Materials Science1979，11，： | 1 |
| 18 | Anterior temporal Lobes and hippocampal formations:normative volumetric measurements from MR imaging in young adults显示文摘 | Jack C R Twomey C K Zinsmeister A R | 1989 | Radiology1989，172，2： | 1 |
| 19 | Overcrowding food and phosphorus limitation effects on the ephipphia production and population dynamics in the invasive species Daphnia lumholtzi显示文摘 | SMITH A S ACHARYA K JACK J | 2009 | Hydrobiologia2009，618，： | 1 |
| 20 | Review sialons and related-nitrogen ceramics显示文摘 | JACK H K | 1976 | Journal of Materials Science1976，11，： | 1 |
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