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| 1 | SFRP4 expression correlates with epithelial mesenchymal transitionlinked genes and poor overall survival in colon cancer patients显示文摘BACKGROUND Colon cancer is among the most commonly diagnosed cancers in the United States with an estimated 97220 new cases expected by the end of 2018.It affects 1.2 million people around the world and is responsible for about 0.6 million deaths every year.Despite decline in overall incidence and mortality over the past 30 years,there continues to be an alarming rise in early-onset colon cancer cases(<50 years).Patients are often diagnosed at late stages of the disease and tend to have poor survival.We previously showed that the WNT“gatekeeper”gene,secreted frizzled-related protein 4(SFRP4),is over-expressed in early-onset colon cancer.SFRP4 is speculated to play an essential role in cancer by inhibiting the epithelial mesenchymal transition(EMT).AIM To investigate the correlation between SFRP4 expression and EMT-linked genes in colon cancer and how it affects patient survival.METHODS SFRP4 expression relative to that of EMT-linked genes and survival analysis were performed using the University of California Santa Cruz Cancer Browser interface.RESULTS SFRP4 was found to be co-expressed with the EMT-linked markers CDH2,FN1,VIM,TWIST1,TWIST2,SNAI1,SNAI2,ZEB1,ZEB2,POSTN,MMP2,MMP7,MMP9,and COL1A1.SFRP4 expression negatively correlated with the EMTlinked suppressors CLDN4,CLDN7,TJP3,MUC1,and CDH1.The expression of SFRP4 and the EMT-linked markers was higher in mesenchymal-like samples compared to epithelial-like samples which potentially implicates SFRP4-EMT mechanism in colon cancer.Additionally,patients overexpressing SFRP4 presented with poor overall survival(P=0.0293).CONCLUSION Considering the implication of SFRP4 in early-onset colon cancer,particularly in the context of EMT,tumor metastasis,and invasion,and the effect of increased expression on colon cancer patient survival,SFRP4 might be a potential biomarker for early-onset colon cancer that could be targeted for diagnosis and/or disease therapy. | Landry E Nfonsam Jana Jandova Hunter C Jecius Pamela N Omesiete Valentine N Nfonsam | 2019 | World Journal of Gastrointestinal Oncology2019，11，8： | 4 |
| 2 | Gut microbiota disturbance during antibiotic therapy: a multi-omic approach显示文摘 | Ana Elena Pérez-Cobas María José Gosalbes Anette Friedrichs Henrik Knecht Alejandro Artacho Kathleen Eismann Wolfgang Otto David Rojo Rafael Bargiela Martin von Bergen Sven C Neulinger Carolin D?umer Femke-Anouska Heinsen Amparo Latorre Coral Barbas Jana | 2013 | Gut2013，，11： | 2 |
| 3 | Decomposition and/or hydrogenation of hydrogen peroxide over Pd/Al2O3 catalyst in aqueous medium: Factors affecting the rate of H2O2 destruction in presence of hydrogen显示文摘 | CHOUDARY V R SAMANTA C JANA P | 2007 | Applied Catalysis A: General2007，332，1： | 1 |
| 4 | Wet chemical synthesis of silver nanorods and nanowires of controllable aspect ratios显示文摘 | Jana N R Gearheart L Murphy C | 2001 | J Chem Commun2001，，： | 1 |
| 5 | Natural fiber composites of high temperature thermo plastic polymers显示文摘 | ALBERTO PRIETO | 2002 | Effects of Coupling Agents J Appl Polym Sci2002，86，9： | 1 |
| 6 | Distortion discriminant analysis for audio fingernintiny 显示文摘 | BURGES C J C PLATT J C JANA S | 2003 | IEEE Transactions on Speech and Auolio Processing2003，11，3： | 1 |
| 7 | Effect of herbicides on decomposition of soil organic matter and mineralization of nitrogen in fluventic ustochrept soil显示文摘 | JANA T K DEBNATH N C BASAK R K | 2004 | Journal of Interacademicia2004，8，2： | 1 |
| 8 | Seed - Mediated Growth Approach for Shape - Controlled Synthesis of Spheroidal and Rod - like Gold Nanoparticles Using a Suffactant Template 显示文摘 | N R Jana L Gearheart C J Murphy | 2001 | Adv Mater2001，13，： | 1 |
| 9 | RNA interference: potential therapeutic targets显示文摘 | JANA S CHAKRABORTY C NANDI S | 2004 | Appl Microbiol Biotechnol2004，65，： | 1 |
| 10 | Characterization of human immunodeficiency virus type 1 replication in immature and mature dendritic cells reveals dissociable cis-and trans-infection显示文摘 | Dong C Janas AM Wang JH | 2007 | J Virol2007，81，11： | 1 |
| 11 | Hygrothermal effects on properties of highly conductive epoxy/graphite composites for applications as bipolar plates显示文摘 | DU L JANA S C | 2008 | Journal of Power Sources2008，182，1： | 1 |
| 12 | Microwave-assisted simple synthesis of quinolines from anilines and alkyl vinyl ketones on the surface of silica gel in the presence of indium(Ⅲ) chloride 显示文摘 | RANU B C HAJRA A JANA U | 2000 | Tetrahedron Letters2000，41，4： | 1 |
| 13 | Fluorescent Carbon Nanoparticles: Synthesis, Characterization,and BioimagingApplication 显示文摘 | RAY S C SAHA A JANA N R | 2009 | Journal of Physical Chemistry C2009，113，18： | 1 |
| 14 | Synthesis of antimicrobial monophase silver-doped hydroxyapatite nanopowders for bone tissue engineering显示文摘 | STANI(C) V JANA(C)KOVI(C) D DIMITRIJEVI(C) S | | 0，，09： | 1 |
| 15 | Synthesis of Water-soluble and Functionalized Nanoparticles by Silica Coating显示文摘 | Jana NR Earhart C Ying JY | 2007 | Chemistry of Materials2007，19，21： | 1 |
| 16 | Indium( Ⅲ) chloride-promoted rearrangement of epoxides : A selective synthesis of substi- tuted benzylic aldehydes and ketones显示文摘 | Ranu B C Jana U | 1998 | J Org Chem1998，63，： | 1 |
| 17 | 7 regulation of the yeast general amino acid control pathway in response to nutrient stress显示文摘 | Ronald C W Kirk A S Jana N | 2004 | Topics in Current Genetics2004，7，： | 1 |
| 18 | A qualita- tive systematic review of head-to-head randomized con- trolled trials of oral analgesics in neuropathic pain显示文摘 | C Peter N Watson Ian Gilron Jana Sawynok | 2010 | Pain Res Manag2010，15，3： | 1 |
| 19 | Fluorescent carbon nano- particles:Synthesis, characterization, and bioimaging appli cation显示文摘 | Ray S C Saha A Jana N R | 2009 | J Phys Chem C2009，113，18： | 1 |
| 20 | Fluorescent carbon nanoparti- cles: Synthesis, characterization, and bioimaging application显示文摘 | Ray S C Saha A Jana N R | 2009 | J Phys Chem C2009，113，18： | 1 |
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