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| 1 | 面向21世纪的卒中新定义:美国心脏病学会和美国卒中学会声明显示文摘尽管脑血管病有着全球性影响且对其病理生理学的认识有了很多进步,但是'卒中'这一术语在临床实践、临床研究或公共卫生评估中的定义却不一致。传统的定义依据于临床,却没有考虑到科学技术的进步。美国心脏协会(AHA)和美国卒中协会(ASA)卒中分会组织了写作小组,为21世纪卒中新定义撰写专家共识性声明。中枢神经系统(CNS)梗死,指由缺血所导致的脑、脊髓或视网膜的细胞死亡,是基于持续性损害的神经病理学、神经影像学和(或)临床证据。CNS梗死表现为一个临床谱:缺血性卒中特指伴有明显症状的CNS梗死,而静息性梗死根据定义指未引起已知的症状的梗死。卒中也还包括脑出血和蛛网膜下腔出血。新定义的卒中结合了临床和组织学标准,可被用于实践、研究和公共卫生评估。 | 俞羚 董荃 宋叶平 江静雯 李卉 刘亮贤 苏爱萍 李焰生 Sacco RL Kasner SE Broderick JP Caplan LR Connors JJ Culebras A Elkind MS George MG Hamdan AD Higashida RT Hoh BL Janis LS Kase CS Kleindorfer DO Lee JM Moseley ME Peterson ED Turan TN Valderrama AL Vinters HV | 2013 | 神经病学与神经康复学杂志2013，10，2： | 188 |
| 2 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 3 | Corneal avascularity is due to soluble VEGF receptor-1显示文摘 | Ambati BK Nozaki M Singh N Takeda A Jani PD Suthar T | 2006 | Nature2006，443，7114： | 1 |
| 4 | Changes in vascular permeability and expression of different angiogenie factors following anti-angiogenie treatment in rat glioma 显示文摘 | Ali M M Janie B Babajani-Feremi A | 2010 | PLoS One2010，5，1： | 1 |
| 5 | Nanospheres and microsphere uptake via Peyer's patches:observation of the rate of uptake in the rat after a single oral dose显示文摘 | Jani P Florence A T | 1992 | Int J Pharm1992，86，： | 1 |
| 6 | The Capital Structure of Swiss Companies:an Empirical Analysis Using Dynamic Panel Data显示文摘 | Gaud P Jani E Hoesli M Bender A | 2005 | European Financial Management2005，11，1： | 1 |
| 7 | Gold nanoparticle-decorated Keggin ions/TiO2 photococatalyst for improved solar light photocatalysis显示文摘 | Pearson A Jani H | 2011 | Langmuir2011，27，： | 1 |
| 8 | Urinary interleukin-18 is a marker of human acute tubular necrosis显示文摘 | Parikh C Jani A Melnikov VY | 2004 | Am J Kidney Dis2004，43，3： | 1 |
| 9 | Lipoprotein-cyclodextrin interaction显示文摘 | Sharma A Janis L | 1991 | Clin Chim Acta1991，199，2： | 1 |
| 10 | Protective efficacy of recombinant modified vaccinia virus ankara delivering middle east respiratory syndrome coronavirus spike glycoprotein显示文摘 | Volz A Kupke A Song F Jany S Fux R Shams-El- din H Schmidt J Becker C Eickmann M Becker S Sutter G | 2015 | J Virol2015，89，16： | 1 |
| 11 | Measurement of quantum effciency using correlated photon pairs and a single-detector technique 显示文摘 | CZITROVSZKY A SENGIENKO A JANI P | 2000 | Metrologia B2000，37，： | 1 |
| 12 | Urine NGAL and IL - 18 are predictive biomarkers for delayed graft function following kidney transplantation 显示文摘 | Parikh CR Jani A Mishra J | 2006 | Am J Transplant2006，6，7： | 1 |
| 13 | Statistics age-period-cohort analysis:a review and critique显示文摘 | Kupper LL Janis JM Karmous A etal | 1985 | J ChronDis1985，8，10： | 1 |
| 14 | Timing of lung size assessment in the prediction of survival in fetuses with diaphragmatic hernia显示文摘 | Jani J Nicolaides KH Benachi A | 2008 | Ultrasound Obstet Gynecol2008，31，1： | 1 |
| 15 | Nanoparticle uptake by the rat gastrointestinal mucosa: quantitation and particle size dependency 显示文摘 | Jani P Halbert G W Langridge J Florence A T | 1990 | J Pharm Pharmacol1990，42，12： | 1 |
| 16 | Drug action and celluar calcium regulation显示文摘 | Janis R A Silver P J Triggle D J | 1987 | Adv Drug Res1987，16，： | 1 |
| 17 | Characterization of the xylanase produced by submerged cultivation of Thermomyces lanuginosus DSM 10635显示文摘 | Xiong H R Nyyssola A Janis J | 2004 | Enzyme and Microbial Technology2004，35，： | 1 |
| 18 | The uptake and translocation of latex nanospheres and mierospheres after oral administration to rats显示文摘 | Jani P Halbert G W Langridge J Florence A T | 1989 | J Pharm Pharmacol1989，41，12： | 1 |
| 19 | Requirements engineering and technology transfer: obstacles, incentives and improvement agenga 显示文摘 | HERMAN KAINDL SJAAK BRINKKEMPER JANIS A | 2002 | Requirements Eng2002，10，7： | 1 |
| 20 | Granulusin expression is a mark for acute rejection and steroid resistance in human renal transplantation 显示文摘 | Sarwal MM Jani A Chang S | 2001 | Hum Immunol2001，62，1： | 1 |
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