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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | Inhibition of methionine adenosyltransferase II induces FasL expression, Fas-DISC formation and caspase-8-dependent apoptotic death in T leukemic cells显示文摘蛋氨酸 adenosyltransferase II (地席 II ) 是在细胞的新陈代谢的关键酶并且从 L 蛋氨酸和 ATP 催化 S-adenosylmethionine (一样) 的形成。正常休息 T 淋巴细胞举办最小的地席 II 活动,而白血病的房间显著地显示出的激活的增殖的 T 淋巴细胞和转变 T 提高了地席 II 活动。这个工作被执行在白血病的 T 房间的幸存检验地席 II 活动和一样的生合成的角色。在一样的层次的地席 II 和结果的减少的抑制提高了 FasL mRNA 和蛋白质的表示,并且导致了圆盘(导致发信号的建筑群的死亡) 有 FADD (联系船边交货的死亡域) 和 procaspase-8 招募的形成,以及 caspase-8 激活的伴随物增加和在 c 扭动的减少铺平。开始船边交货的发信号由地席 II 抑制导致了被观察经由出价劈开连接到 mitochondrial 小径并且最终在这些房间导致增加的 caspase-3 激活和 DNA 破碎。而且,堵住地席 2A mRNA 表示,它编码地席 II 的催化子单元,用一条小介入的 RNA 途径提高了 FasL 表示和房间死亡,验证在 T 白血病的房间的幸存的地席 II 活动的必要性质。 | Tanvi S Jani Leila Gobejishvili Prachi T Hote Aditya S Barve Swati Joshi-Barve Giorgi Kharebava Jill Suttles Theresa Chen Craig J McClain Shirish Barve | 2009 | Cell Research2009，19，3： | 5 |
| 3 | Catheter-based radiotherapy to inhibit restenosis after coronary stenting显示文摘 | Teirstein PS Massullo V Jani S | 1997 | N Engl J Med1997，336，： | 1 |
| 4 | Catheter-based radiotherapy to inhibit restenosis after coronary stenting显示文摘 | Teirstein PS Beets Massullo V Jani S | 1997 | N Engl J Med1997，336，： | 1 |
| 5 | Catheter-based radiotherapy to inhibit restenosis after coronary stenting显示文摘 | Teirstein PS Massullo V Jani S | 1997 | N Engl J Med1997，336，： | 1 |
| 6 | Molecular characterization of tiny ring X chromosomes from females with functional X chromosome disomy and lack of cis X inactivation显示文摘 | JANI M M TORCHIA B S PAI G S | 1995 | Genomics1995，27，1： | 1 |
| 7 | The role of ultrasound examination in the first trimester and at 16 weeks’ gestation to predict fetal complications in monochorionic diamniotic twin pregnancies显示文摘 | Liesbeth Lewi Paul Lewi Anke Diemert Jacques Jani Leonardo Gucciardo Tim Van Mieghem Elisa Doné Eduardo Gratacós Agnes Huber Kurt Hecher Jan Deprest | 2008 | American Journal of Obstetrics and Gynecology2008，，5： | 1 |
| 8 | Catheter-based radiotherapy to inhibit restenosis after coronary stenting显示文摘 | Teirstein PS Massullo V Jani S | 1997 | N Engl J Med1997，336，： | 1 |
| 9 | Protective efficacy of recombinant modified vaccinia virus ankara delivering middle east respiratory syndrome coronavirus spike glycoprotein显示文摘 | Volz A Kupke A Song F Jany S Fux R Shams-El- din H Schmidt J Becker C Eickmann M Becker S Sutter G | 2015 | J Virol2015，89，16： | 1 |
| 10 | Molecular characterization oftiny ring X chromosomes from females with functional X chromosome di-somy and lack of cis X inactivation显示文摘 | Jani M M Torchia B S Pai G S | 1995 | Genomics1995，27，1： | 1 |
| 11 | Three-year clinical and angiographic follow-up after intracoronary radiation:results of a randomized clinical trial显示文摘 | Eirstein PS Massullo V Jani S | 2000 | Circulation2000，101，4： | 1 |
| 12 | Chemical regulators ofcarotenogenesis by Blakeslea trispora显示文摘 | Dandekar S Madi VV Jani UK | 1980 | Phytaehem1980，19，： | 1 |
| 13 | Active and low-active forms of serum phospholipid transfer protein in a normal finnish population sample显示文摘 | JANIS M T SIGGINS S TAHVANAINEN E | 2004 | J Lipid Res2004，45，12： | 1 |
| 14 | Biochemical and phar- macological characterization of human c-Met neutralizing monoclonal antibody CE-355621显示文摘 | Michaud NR Jani JP Hillerman S | 2012 | MAbs2012，4，6： | 1 |
| 15 | Catalytic wet air oxidation of industrial aqueous streams 显示文摘 | BHARGAVA S TARDIO J JANI H | 2007 | Catalysis Surveys from Asia2007，11，1： | 1 |
| 16 | Do current wear particle isola- tion procedures utlderestimate the number of particles gener- ated by prosthetie bearing components? 显示文摘 | Widding M Scott K Jani S | 2001 | Wear2001，25，： | 1 |
| 17 | Granulusin expression is a mark for acute rejection and steroid resistance in human renal transplantation 显示文摘 | Sarwal MM Jani A Chang S | 2001 | Hum Immunol2001，62，1： | 1 |
| 18 | An insight into the emerging exopolysaccharide gellan gum as a novel polymer显示文摘 | Prajapati V D Jani G K Zala B S | 2013 | Carbohydrate Polymers2013，93，2： | 1 |
| 19 | Germination and seedling surviv- al of Argan ( Argania spinosa) under experimental saline conditions 显示文摘 | Fouzia B A Janis S M | 2001 | Journal of Arid Environments2001，49，： | 1 |
| 20 | Two-year follow-up after catheter-based radiotherapy to inhibit coronary restenosis显示文摘 | Teirstein PS Massullo V Jani S | 1999 | Circulation1999，99，2： | 1 |
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