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| 1 | 甲状腺乳头状癌诊断与鉴别的可靠标记物显示文摘目的寻找更好的标记物,用于甲状腺乳头状癌的诊断与鉴别。方法以甲状腺乳头状癌(PTC)为研究组,以甲状腺滤泡状腺瘤(FA)和良性乳头状病变(BPL)作对照组。经自制组织芯片和免疫组化技术,对Twist、Galectin-3、HBME-1、p14ARF和TPO进行标记,并与CK19对比实验。结果6种指标阳性表达率依次为:PTC组100.0%、95.6%、80.0%、28.9%、15.6%和78.0%;FA组0.0、11.1%、6.7%、75.6%、88.9%和0.0;BPL组7.0%、7.5%、2.5%、77.5%、100.0%和0.0。PTC组与FA和BPL组比较差异均有显著性(P<0.05)。6种指标的灵敏度、特异度、准确度分别为100.0%、95.6%、80.0%、71.1%、84.4%、78.0;96.4%、90.1%、95.3%、76.5%、94.1%、100.0%和97.7%、92.3%、90.0%、74.6%、90.8%、91.9%。结论在PTC中6种指标阳性表达率最高的为Twist,其次为Galectin-3,因此临床病理工作中标记Twist和Galectin-3鉴别PTC与FA或BPL有实用意义。Twist的灵敏度和准确度最高,CK19特异度最高。因此该2种指标联合使用对于PTC的鉴别诊断最可靠。 | 何春年 Lili H Jin Q CH 陈士超 赵焕芬 翟金萍 | 2007 | 临床与实验病理学杂志2007，23，6： | 14 |
| 2 | Twist基因蛋白表达在甲状腺乳头状癌诊断与鉴别诊断中的意义显示文摘目的探讨Twist基因蛋白在甲状腺乳头状癌中的表达状况,寻找更特异的标记物,用于甲状腺乳头状癌(PTC)与滤泡状腺瘤(FA)和良性乳头病变(BPL)的鉴别诊断。方法以50例PTC为研究组,以48例FA和47例BPL作对照组。在自制组织芯片上行免疫组织化学(SP法)标记,检测Twist基因蛋白和HBME-1,并以CK19进行对照。结果3种指标(Twist、HBME-1、CK19)阳性表达率:在PTC组分别为100%(48/48)、94.0%(47/50)和78.0%(39/50);在FA组分别为0、6.7%(3/45)和0;在BPL组分别为7.0%(3/43)、2.1%(1/47)和0。PTC组分别与FA和BPL组比较差异均有统计学意义(P=0.000)。3种指标在鉴别诊断甲状腺良、恶性病变的灵敏度分别为:100%、96.4%和97.7%,特异度分别为:94.0%、95.7%和95.1%,准确度分别为:78.0%、100%和91.9%。结论Twist可应用于辅助诊断PTC,并可应用在对FA或BPL的鉴别诊断。 | 何春年 Lili He Jin Q Cheng 陈士超 赵焕芬 翟金萍 张静 | 2008 | 中华病理学杂志2008，37，1： | 14 |
| 3 | Super-resolution dipole orientation mapping via polarization demodulation显示文摘Fluorescence polarization microscopy(FPM)aims to detect the dipole orientation of fluorophores and to resolve structural information for labeled organelles via wide-field or confocal microscopy.Conventional FPM often suffers from the presence of a large number of molecules within the diffraction-limited volume,with averaged fluorescence polarization collected from a group of dipoles with different orientations.Here,we apply sparse deconvolution and least-squares estimation to fluorescence polarization modulation data and demonstrate a super-resolution dipole orientation mapping(SDOM)method that resolves the effective dipole orientation from a much smaller number of fluorescent molecules within a sub-diffraction focal area.We further apply this method to resolve structural details in both fixed and live cells.For the first time,we show that different borders of a dendritic spine neck exhibit a heterogeneous distribution of dipole orientation.Furthermore,we illustrate that the dipole is always perpendicular to the direction of actin filaments in mammalian kidney cells and radially distributed in the hourglass structure of the septin protein under specific labelling.The accuracy of the dipole orientation can be further mapped using the orientation uniform factor,which shows the superiority of SDOM compared with its wide-field counterpart as the number of molecules is decreased within the smaller focal area.Using the inherent feature of the orientation dipole,the SDOM technique,with its fast imaging speed(at sub-second scale),can be applied to a broad range of fluorescently labeled biological systems to simultaneously resolve the valuable dipole orientation information with super-resolution imaging. | Karl Zhanghao Long Chen Xu-San Yang Miao-Yan Wang Zhen-Li Jing Hong-Bin Han Michael Q Zhang Dayong Jin Jun-Tao Gao Peng Xi | 2016 | Light(Science & Applications)2016，5，1： | 11 |
| 4 | A novel therapeutic approach to 6-OHDA-induced Parkinson's disease in rats via supplementation of PTD-conjugated tyrosine hydroxylase显示文摘 | Wu SP Fu AL Wang YX Yu LP Jia PY Li Q Jin GZ Sun MJ | 2006 | 中国生物学文摘2006，20，10： | 9 |
| 5 | 脂蛋白a水平与冠状动脉粥样硬化性心脏病患者复发事件的关系显示文摘脂蛋白a是否是冠状动脉粥样硬化性心脏病(冠心病)患者复发性心血管事件(recurrent cardiovascular events,RCVEs)的预测因子尚未确定。本研究旨在探讨脂蛋白a对一个真实世界、大规模首诊心血管事件(cardiovascular event,CVE)患者队列中RCVEs的潜在影响。方法:本实验为多中心的前瞻性研究,纳入经血管造影诊断的冠心病并经历首次CVE的患者7562例。入院时测量所有患者的脂蛋白a浓度. | 周卫(译) 叶鹏(校) Liu HH Cao YX Jin JL Zhang HW Hua Q Li YF Guo YL Zhu CG Wu NQ Gao Y Xu RX Hong LF | 2020 | 中华高血压杂志2020，28，5： | 5 |
| 6 | DETERMINATION OF BORON BY MICROWAVE PLASMA TORCH ATOMIC EMISSION SPECTROMETRY USING ON-LINE SEPARATION AND PRECONCENTRATION TECHNIQUE显示文摘DETERMINATIONOFBORONBYMICROWAVEPLASMATORCHATOMICEMISSIONSPECTROMETRYUSINGON-LINESEPARATIONANDPRECONCENTRATIONTECHNIQUE￥QunJIN... | Jin, Q Zhang, HQ Liang, F Yang, WJ Jin, QH | 1996 | Chinese Chemical Letters1996，7，3： | 2 |
| 7 | Response of antioxidative enzymes in cucumber chloroplasts to cadmium toxicity显示文摘 | Zhang F Q Shi W Y Jin Z X | 2003 | J Plant Nutr2003，26，： | 2 |
| 8 | Genetic variations of the paraoxonase gene in patients with coronary artery disease显示文摘 | Seung Ho Hong Junghan Song Won Ki Min Jin Q Kim | 2001 | Clinical Biochemistry2001，，6： | 2 |
| 9 | Biosorption removal of cadmium from aqueous solution by using pretreated fungal biomass cultured from starch waste water显示文摘 | Yin P H Yu Q M Jin B | 1999 | Wat Res1999，33，8： | 2 |
| 10 | Behavioral and histological neuroprotection by tamoxifen after reversible focal cerebral ischemia显示文摘 | Zhang Y H Jin Y Q Behr M J | 2005 | Exp Neurol2005，196，1： | 1 |
| 11 | Influence of CaCl2 on the hydrothermal modification of Mg(OH)2 显示文摘 | WU Q L XIANG L JIN Y | 2006 | Powder Technology2006，165，： | 1 |
| 12 | CO-releasing molecules (CORM-2)-liberated CO attenuates leukocytes infiltration in the renal tissue of thermally injured mice显示文摘 | Sun B Sun Z Jin Q | 2008 | Int J Biol Sci2008，4，3： | 1 |
| 13 | A perfect marker for fragrance genotyping in rice显示文摘 | Bradbury L M T Henry R J Jin Q S | 2005 | Molecular Breeding2005，16，： | 1 |
| 14 | The value of maltidetector-row CT in the preoperative detection of pancreatic insulinomas显示文摘 | Liu Y Song Q Jin HT | 2009 | Radiol Med2009，114，8： | 1 |
| 15 | Endothelial ceils stimulate self-renewal and expand neurogenesis of neural stem cells显示文摘 | SHEN Q GODERIE S K JIN L | 2004 | Science2004，304，5675： | 1 |
| 16 | S100AI4 stimulates cell proliferation and induces cell apoptosis at different concentrations via receptor for advanced glyeation end products (RAGE) 显示文摘 | Jin Q Chen H Luo A | 2011 | PLoS One2011，6，19： | 1 |
| 17 | Color-encoded digital firinge projection technique for high-speed three-dimensional surface contouring显示文摘 | HUANG P S HU Q JIN F | 1999 | Optical Engineering1999，38，6： | 1 |
| 18 | High-Pressure Synthesis and Superconducting Properties of the Oxychloride Superconductor (Sr, Ca)3Cu2O4+δCl2-y显示文摘 | Jin C Q Wu X J Adachi S | 2000 | Phys Rev B2000，61，： | 1 |
| 19 | Nano-fibrous scaffold for controlled delivery of recombinant human PDGF-BB显示文摘 | Wei G Jin Q Giannobile W V | 2006 | J Control Release2006，112，1： | 1 |
| 20 | Cross-talk between the ErbB/I-IER family and the type I insulin-like growth factor receptor signaling pathway in breast cancer 显示文摘 | Jin Q Esteva FJ | 2008 | J Mammary Gland Biol Neoplasia2008，13，4： | 1 |
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