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| 1 | Serum MicroRNA Signatures Identified in a Genome-Wide Serum MicroRNA Expression Profiling Predict Survival of Non-Small-Cell Lung Cancer(摘要)显示文摘 | Hu, ZB Chen, X Zhao, Y Tian, T Jin, GF Shu, YQ Chen, YJ Xu, L Zen, K Zhang, CY Shen, HB | 2010 | 南京医科大学学报(自然科学版)2010，30，7： | 141 |
| 2 | Acupuncture Treatment for Idiopathic Trigeminal Neuralgia:A Longitudinal Case-Control Double Blinded Study显示文摘Objective: To evaluate the treatment effect of acupuncture on patients with idiopathic trigeminal neuralgia(ITN) by case-control longitudinal blinded study. Methods: Sixty ITN patients and 30 healthy subjects were included. The ITN patients were randomly assigned to acupuncture group(15 cases), sham-acupuncture group(15 cases) and carbamazepine group(30 cases), respectively. Clinical orofacial evaluation(including pain intensity and medication doses), research diagnostic criteria for temporomandibular disorders(RDC/TMD) and Helkimo indexes(for functional evaluation of the masticatory system), and quantitative sensory testing for sensory thresholds(gustative, olfactory, cold, warm, touch, vibration and superficial and deep pain) were evaluated before treatment, immediately after treatment, and 6 months after treatment. Results: The mean pain intensity by the Visual Analogue Scale only decreased in the acupuncture group at the last evaluation(P=0.012). Patients in the sham-acupuncture group had an increase in carbamazepine doses according to the prescriptions(P<0.01). There was a reduction in secondary myofascial pain and mandibular limitations at the acupuncture and sham-acupuncture groups, however only the acupuncture group kept the changes after 6 months(P<0.01, P=0.023). There was a decrease in mechanical thresholds in the acupuncture group(tactile, P<0.01; vibration, P=0.027) and an increase in deep pain thresholds in both acupuncture and sham-acupuncture groups(P=0.013). Conclusion: Acupuncture can be an option in the treatment of ITN due to its analgesic effect in both ITN and secondary myofascial pain associated with it. | Michelle Cristina Ichida Mariana Zemuner Jorge Hosomi Hong Jin Pai Manoel Jacobsen Teixeira JoséTadeu Tesseroli de Siqueira Silvia R D T de Siqueira | 2017 | Chinese Journal of Integrative Medicine2017，23，11： | 6 |
| 3 | Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy显示文摘BACKGROUND Intraductal papillary mucinous neoplasms(IPMNs)are non-invasive pancreatic precursor lesions that can potentially develop into invasive pancreatic ductal adenocarcinoma.Currently,the International Consensus Guidelines(ICG)for IPMNs provides the basis for evaluating suspected IPMNs on computed tomography(CT)imaging.Despite using the ICG,it remains challenging to accurately predict whether IPMNs harbor high grade or invasive disease which would warrant surgical resection.A supplementary quantitative radiological tool,radiomics,may improve diagnostic accuracy of radiological evaluation of IPMNs.We hypothesized that using CT whole lesion radiomics features in conjunction with the ICG could improve the diagnostic accuracy of predicting IPMN histology.AIM To evaluate whole lesion CT radiomic analysis of IPMNs for predicting malignant histology compared to International Consensus Guidelines.METHODS Fifty-one subjects who had pancreatic surgical resection at our institution with histology demonstrating IPMN and available preoperative CT imaging were included in this retrospective cohort.Whole lesion semi-automated segmentation was performed on each preoperative CT using Healthmyne software(Healthmyne,Madison,WI).Thirty-nine relevant radiomic features were extracted from each lesion on each available contrast phase.Univariate analysis of the 39 radiomics features was performed for each contrast phase and values were compared between malignant and benign IPMN groups using logistic regression.Conventional quantitative and qualitative CT measurements were also compared between groups,viaχ2(categorical)and Mann Whitney U(continuous)variables.RESULTS Twenty-nine subjects(15 males,age 71±9 years)with high grade or invasive tumor histology comprised the'malignant'cohort,while 22 subjects(11 males,age 70±7 years)with low grade tumor histology were included in the'benign'cohort.Radiomic analysis showed 18/39 precontrast,19/39 arterial phase,and 21/39 venous phase features differentiated malignant from benign IPMNs(P<0.05).Multivariate analysis including only ICG criteria yielded two significant variables:thickened and enhancing cyst wall and enhancing mural nodule<5 mm with an AUC(95%CI)of 0.817(0.709-0.926).Multivariable post contrast radiomics achieved an AUC(95%CI)of 0.87(0.767-0.974)for a model including arterial phase radiomics features and 0.834(0.716-0.953)for a model including venous phase radiomics features.Combined multivariable model including conventional variables and arterial phase radiomics features achieved an AUC(95%CI)of 0.93(0.85-1.0)with a 5-fold cross validation AUC of 0.90.CONCLUSION Multi-phase CT radiomics evaluation could play a role in improving predictive capability in diagnosing malignancy in IPMNs.Future larger studies may help determine the clinical significance of our findings. | Stuart L Polk Jung W Choi Melissa J McGettigan Trevor Rose Abraham Ahmed Jongphil Kim Kun Jiang Yoganand Balagurunathan Jin Qi Paola T Farah Alisha Rathi Jennifer B Permuth Daniel Jeong | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 4 | Biofilm three-dimensional architecture influences in situ pH distribution pattern on the human enamel surface显示文摘To investigate how the biofilm three-dimensional(3D) architecture influences in situ pH distribution patterns on the enamel surface. Biofilms were formed on human tooth enamel in the presence of 1% sucrose or 0.5% glucose plus 0.5% fructose. At specific time points, biofilms were exposed to a neutral pH buffer to mimic the buffering of saliva and subsequently pulsed with 1% glucose to induce re-acidification. Simultaneous 3D pH mapping and architecture of intact biofilms was performed using two-photon confocal microscopy. The enamel surface and mineral content characteristics were examined successively via optical profilometry and microradiography analyses. Sucrose-mediated biofilm formation created spatial heterogeneities manifested by complex networks of bacterial clusters(microcolonies). Acidic regions(pH<5.5) were found only in the interior of microcolonies,which impedes rapid neutralization(taking more than 120 min for neutralization). Glucose exposure rapidly re-created the acidic niches, indicating formation of diffusion barriers associated with microcolonies structure. Enamel demineralization(white spots),rougher surface, deeper lesion and more mineral loss appeared to be associated with the localization of these bacterial clusters at the biofilm-enamel interface. Similar 3D architecture was observed in plaque-biofilms formed in vivo in the presence of sucrose. The formation of complex 3D architectures creates spatially heterogeneous acidic microenvironments in close proximity of enamel surface, which might correlate with the localized pattern of the onset of carious lesions(white spot like) on teeth. | Jin Xiao Anderson T Hara Dongyeop Kim Domenick T Zero Hyun Koo Geelsu Hwang | 2017 | International Journal of Oral Science2017，9，2： | 4 |
| 5 | CD133 expression is not restricted to stem cells, and both CD133^sup +^ and CD133^sup -^ metastatic colon cancer cells initiate tumors显示文摘 | Shmelkov Sergey V Butler Jason M Hooper Andrea T Hormigo Adilia Kushner Jared Milde Till Clair Ryan St Baljevic Muhamed White Ian Jin David K Chadburn Amy Murphy Andrew J Valenzuela David M Gale Nicholas W Thurston Gavin Yancopoulos George | 2008 | Journal of Clinical Investigation2008，，： | 2 |
| 6 | 左心室舒张功能的遗传性和其他影响因素:以家庭为基础的人口研究显示文摘确定遗传因素影响舒张功能多普勒指数的程度,是评估左心室舒张功能障碍与预后关系的一个重要因素。因此,研究人员从一般人群中选出家庭样本,对其家族左心室舒张特性和舒张功能集合评分的遗传度进行评估。方法:随机抽取316个家庭样本,包括452名父母和600名后代,平均年龄分别为58.5和33.3岁, | 刘莉 叶鹏 Kloch-Badelek M Knez J Tikhonoff V Thijs L Sakiewicz W Ryabikov A Stolarz-Skrzypek K Jin Y Malyutina S Casiglia E Narkiewicz K Czarnecka D Kawecka-Jaszcz K Staessen JA Kuznetsova T | 2014 | 中华高血压杂志2014，22，10： | 2 |
| 7 | Thousandfold change in resistivity and magnetoresistance La-Ca-Mn-O film 显示文摘 | Jin S Tiefel T H McCormack M | 1994 | Science1994，264，： | 2 |
| 8 | PHASE TRANSFORMATION OF Al-Ti COATINGS ON Co-BASE SUPERALLOY DZ40M DURING HIGH TEMPERATURE OXIDATION显示文摘INTRODUCTIONThereisaseriousproblemofhightemperatureoxidationonturbinecomponents,hence,variouscoatingswithaluminidearemanufac... | Liu, PS Sun, XF Jin, T Guan, HR Hu, ZQ | 1998 | 中国有色金属学会会刊:英文版1998，8，4： | 2 |
| 9 | Relative frequency and survival of primary cutaneous lymphomas: a retrospective analysis of 98 patients显示文摘 | Liu J Liu YH Jin HZ Ma DL Qu T Wang T S un QN Yu X | 2014 | Chinese Medical Journal2014，，4： | 2 |
| 10 | LDL-C levels,lipid-lowering treatment and recurrent stroke in minor ischaemic stroke or TIA显示文摘Background and purpose Dyslipidaemia is a major risk factor for ischaemic stroke and transient ischaemic attack(TIA).This study aimed to investigate the association between baseline low-density lipoprotein cholesterol(LDL-C)level,lipid-lowering treatment and short-term risk of new stroke in patients with a minor ischaemic stroke or TIA.Methods We derived data from the Clopidogrel in High-risk patients with Acute Non-disabling Cerebrovascular Events trial.Patients with a minor stroke or TIA were categorised by LDL-C level at baseline(<2.6 or≥2.6 mmol/L(100 mg/dL))and with or without lipid-lowering treatment after symptom onset.The primary outcome was a new ischaemic stroke at 3 months.The association of baseline LDL-C level,lowering treatment and outcomes were assessed.Results Among 3027 patients,2154(71.2%)patients had an initial LDL-C≥2.6 mmol/L,of which 1267(41.9%)received lipid-lowering treatment.Elevated LDL-C level was associated with a higher risk of new ischaemic stroke at 3 months in patients without lipid-lowering treatment(adj.HR=1.35,95%CI:1.19 to 1.53),but not in those with lipid-lowering treatment(adj.HR=0.99,95%CI:0.82 to 1.19)(p for interaction=0.007).Patients with LDL-C≥2.6 mmol/L had a numerically higher risk of ischaemic stroke(11.8%vs 8.0%,adj.HR=1.37,95%CI:0.96 to 1.96)in those without lipid-lowering treatment.For patients with LDL-C≥2.6 mmol/L,lipid-lowering treatment was associated with reduced risk of ischaemic stroke at 3 months(7.9%vs 11.8%;adj.HR=0.54,95%CI:0.39 to 0.75).Conclusions Elevated untreated baseline LDL-C level was associated with an increased short-term risk of ischaemic stroke among patients presenting with minor ischaemic stroke or TIA.There was potential benefit of lipid-lowering treatment in minor stroke or TIA patients with LDL-C≥2.6 mmol/L.Trial registration number NCT00979589. | Yuesong Pan Runqi Wangqin Hao Li Aoming Jin Jiejie Li Jinxi Lin Xia Meng Ying Xian Daniel T Laskowitz Yongjun Wang | 2022 | Stroke & Vascular Neurology2022，7，4： | 2 |
| 11 | Thousandfold change in resistivity in magnetoresistive La-Ca-Mn-O films 显示文摘 | Jin S Tiefel T H McCormack M | 1994 | Science1994，264，： | 2 |
| 12 | Metallothionein 2A expression is associated with cell proliferation in breast cancer显示文摘 | Jin R Chow V T Tan P H | 2002 | Carcinogenesis2002，23，1： | 2 |
| 13 | Httperf-a tool for measuring web server performance 显示文摘 | Mosberger D Jin T | 1998 | ACM SIGMETRICS Performance Evaluation Review1998，26，3： | 1 |
| 14 | In vitro differentiation and mineralization of human dental pulp cells induced by dentin extract显示文摘 | Liu J Jin T Ritehie HH | 2005 | In Vitro Cell Dev Biol Anim2005，41，7： | 1 |
| 15 | Extractive fermentation for enhanced propionic acid production from lactose by Propionibacterium acidipropionici 显示文摘 | Jin Z Yang S T | 1998 | Bioteehnoi Progr1998，14，3： | 1 |
| 16 | Deficiency of PAR-2 gene increases acute focal ischemic brain injury 显示文摘 | Jin G Hayashi T Kawagoe J | 2005 | J Cereb Blood Flow Metab2005，25，3： | 1 |
| 17 | Micro structural evolution of a single crystal nickel-base superalloy during thermal exposure显示文摘 | Jin T Zhao N R al | 2003 | Mater Letter2003，57，： | 1 |
| 18 | Development of a novel Chemical - Looping Combustion:Synthesis of a looping material with a double metal oxide of CoO - NiO 显示文摘 | Jin H Okamoto T Ishida M | 1998 | Energy & Fuels1998，12，6： | 1 |
| 19 | Tumorigenic transformation by CPI -17 through inhibition of a merlin phosphatase 显示文摘 | Jin H Sperka T Herrlich P | 2006 | Nature2006，442，： | 1 |
| 20 | Effect of hot air treatment on post- harvest mould decay in Chinese bayberry fruit and the possible mechanisms显示文摘 | Wang K T Cao S F Jin P | 2010 | International Journal of Food Microbiology2010，141，1： | 1 |
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