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| 1 | Efficacy of thioguanine treatment in inflammatory bowel disease: A systematic review显示文摘AIM To critically assess the available literature regarding the efficacy of thioguanine treatment in inflammatory bowel disease(IBD) patients, irrespective of the(hepato-) toxicity profile.METHODS A systematic literature search of the MEDLINE database using Pub Med was performed using the keywords 'thioguanine', '6-TG', 'thioguanine', 'inflammatory bowel disease', 'IBD', 'Crohn's disease', 'Ulcerative colitis' and 'effectiveness' in order to identify relevant articles published in English starting from 2000. Reference lists of the included articles were crosschecked for missing articles. Reviewed manuscripts concerning the effectiveness of thioguanine treatment in IBD were reviewed by the authors and the data were extracted. Data were subsequently analyzed with descriptive statistics. Due to the lack of standardized outcomes, a formal meta-analysis was not performed.RESULTS A total of 11 applicable studies were found that involved the effectiveness of thioguanine therapy in IBD. Eight studies were conducted in a prospectivemanner, in the remaining three studies, data was collected retrospectively. In total, 353 IBD-patients(225 patients with Crohn's disease, 119 with ulcerative colitis and nine with unclassified IBD) with prior azathioprine/mercaptopurine resistance and/or intolerance(n = 321) or de novo thioguanine administration(n = 32) were included for analysis, of which 228(65%) had clinical improvement on thioguanine therapy, based on standard IBD questionnaires, biochemical parameters or global physician assessments. Short-term results were based on 268 treatment years(median follow-up 9 mo, range 3-22 mo) with a median daily dose of 20 mg(range 10-80 mg). Discontinuation, mostly due to adverse events, was reported in 72 patients(20%). CONCLUSION The efficacy of thioguanine therapy in IBD patients intolerant to conventional thiopurine therapy is observed in 65%, with short term adverse events in 20% of patients. | Berrie Meijer Chris JJ Mulder Godefridus J Peters Adriaan A van Bodegraven Nanne KH de Boer | 2016 | World Journal of Gastroenterology2016，22，40： | 5 |
| 2 | Aspirin responsive platelet thrombophilia in essential thrombocythemia and polycythemia vera显示文摘Essential thrombocythemia(ET) and polycythemia vera(PV) frequently present with erythromelalgia and acrocyanotic complications, migraine-like microvascular cerebral and ocular transient ischemic attacks(MIAs) and/or acute coronary disease. The spectrum of MIAs in ET range from poorly localized symptoms of transient unsteadiness, dysarthria and scintillating scotoma to focal symptoms of transient monocular blindness, transient mono- or hemiparesis or both. The attacks all have a sudden onset, occur sequentially rather than simultaneously, last for a few seconds to several minutes and are usually associated with a dull, pulsatile or migraine-like headache. Increased hematocrit and blood viscosity in PV patients aggravate the microvascular ischemic syndrome of thrombocythemia to major arterial and venous thrombotic complications. Phlebotomy to correct hematocrit to normal in PV significantly reduces major arterial and venous thrombotic complications, but fails to prevent the platelet-mediated erythromelalgia and MIAs. Complete long-term relief of the erythromelalgic microvascular disturbances, MIAs and major thrombosis in ET and PV patients can be obtained with low dose aspirin and platelet reduction to normal, but not with anticoagulation. Skin punch biopsies from the erythromelalgic area show fibromuscular intimal proliferation of arterioles complicated by occlusive plateletrich thrombi leading to acrocyanotic ischemia. Symptomatic ET patients with erythromelalgic microvascular disturbances have shortened platelet survival, increased platelet activation markers β-thromboglobulin(β-TG), platelet factor 4(PF4) and thrombomoduline(TM), increased urinary thromboxane B2(TXB2) excretion, and no activation of the coagulation markers thrombin fragments F1+2 and fibrin degradation products. Inhibition of platelet cyclooxygenase(COX1) by aspirin is followed by the disappearance and no recurrence of microvascular disturbances, increase in platelet number, correction of the shortened platelet survival times to normal, and reduction of increased plasma levels of β-TG, PF4, TM and urinary TXB2 excretion to normal. These results indicate that platelet-mediated fibromuscular intimal proliferation and platelet-rich thrombi in the peripheral, cerebral and coronary end-arterial microvasculature are responsible for the erythromelalgic ischemic complica-tions, MIAs and splanchnic vein thrombosis. Baseline platelet P-selectin levels and arachidonic acid induced COX1 mediated platelet activation showed a highly significant increase of platelet P-selectin expression(not seen in ADP and collagen stimulated platelets), which was significantly higher in JAK2V617 F mutated compared to JAK2 wild type ET. | Jan Jacques Michiels Fibo WJ Ten Kate Peter J Koudstaal Perry JJ Van Genderen | 2013 | World Journal of Hematology2013，2，2： | 4 |
| 3 | Rheological properties of contraceptive gels显示文摘 | Owen DH Peters JJ Katz DF | 2000 | Contraception2000，62，： | 2 |
| 4 | 查看详情显示文摘 | Crowley JJ Santos RM Peter GH | | 0，，： | 1 |
| 5 | Outcomes of an Australian testing programme for epidermal growth factor receptor mutations in non-small cell lung cancer显示文摘 | Peters MJ Bowden JJ Carpenter P | 2014 | Intern Med J2014，44，6： | 1 |
| 6 | Effects of CRP infusion on endothelial function and coagulation in normocholesterolemic and hyper-cholesterolemia subjects显示文摘 | Bisoendial RJ Kastelein JJ Peters SL | 2007 | J Lipid Res2007，48，4： | 1 |
| 7 | Analysis of pulmonary inflammation and function in the mouse and baboon after exposure to Mycoplasma pneumoniae CARDS toxin 显示文摘 | Hardy RD Coalson JJ Peters J | 2009 | PLoS One2009，4，10： | 1 |
| 8 | Effects of fine and ultrafine particles on cardiorespiratory symptoms in elderly subjects with coronary heart disease 显示文摘 | Hartog JJ Hoek G Peters A | 2003 | Am J Epidemiol2003，157，： | 1 |
| 9 | Conditionally replicating mycobacteriophages: a system for transposon delivery to Mycobacterium tuberculosis显示文摘 | Belleli D Lambert JJ Peters JA | 1997 | Proc Nat Acad Sci USA1997，94，11： | 1 |
| 10 | Neointimized Gore-Tex graft for ureteral prostesis in the dog显示文摘 | Peters JJ Shingleton WB Morgan D | 1996 | Urology1996，48，： | 1 |
| 11 | Effects of fine and uhrafine particles on cardiorespiratory symptoms in elderly subjects with coronary heart disease 显示文摘 | De Hartog JJ Hoek G Peters A | 2003 | Am J Epidemiol2003，157，： | 1 |
| 12 | Helicobacterpylori is not associated with the mangnifestations of gastrooesophageal refluxdisease显示文摘 | Oberg S Peters JH Nigro JJ | | 0，，07： | 1 |
| 13 | Carbetocin for the prevention of postpartum hemorrhage:a systematic review显示文摘 | Peters NC Duvekot JJ | 2009 | Obstet Gynecol Surv2009，64，2： | 1 |
| 14 | Progression of renal artery stenosis in patients undergoing cardiac catheterization显示文摘 | Crowley JJ Santos RM Peter RH | 1998 | Am Heart J1998，136，5： | 1 |
| 15 | Cleft lip and palate显示文摘 | Peter A Mossey JJ Ron GM | 2009 | Lancet2009，374，： | 1 |
| 16 | Fulminant hypertension in transgenic rats 29, harbouring the mouse Ren-2 gene显示文摘 | Mullins JJ Peters J Canten D | 1990 | Nature1990，344，： | 1 |
| 17 | Helicobacter pylory is not associ- ated with the manifestation of gastroesophageal reflux disease 显示文摘 | Oberg S Peters JH Nigro JJ | 1999 | Arch Surg1999，134，3： | 1 |
| 18 | Characterization of impurities formed by interaction of duloxetine HCl with enteric polymers hydroxypropyl methylcellulose acetate succinate and hydroxypropyl methylcellulose phthalate显示文摘 | Patrick JJ Peter LO Craig ZK | 1998 | J Pharm Sci1998，87，1： | 1 |
| 19 | Progression of renal artery stenosis in patients undergoing cardiac catheterization显示文摘 | Crowley JJ Santos RM Peter RH | 1998 | Am Heart J1998，136，5： | 1 |
| 20 | Carbetocin for the prevention of postpartum hemorrhage显示文摘 | Peters NC Duvekot JJ | | 0，，02： | 1 |
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