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| 1 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 2 | Macrophage secretory products induce an inflammatory phenotype in hepatocytes显示文摘AIM:To investigate the influence of macrophages on hepatocyte phenotype and function.METHODS:Macrophages were differentiated from THP-1 monocytes via phorbol myristate acetate stimulation and the effects of monocyte or macrophageconditioned medium on HepG2 mRNA and protein expression determined.The in vivo relevance of these findings was confirmed using liver biopsies from 147 patients with hepatitis C virus(HCV)infection.RESULTS:Conditioned media from macrophages,but not monocytes,induced a transient morphological change in hepatocytes associated with upregulation of vimentin(7.8±2.5-fold,P=0.045)and transforming growth factor(TGF)-β1(2.6±0.2-fold,P<0.001)and downregulation of epithelial cadherin(1.7±0.02-fold,P=0.017)mRNA expression.Microarray analysis revealed significant upregulation of lipocalin-2(17-fold,P <0.001)and pathways associated with inflammation,and substantial downregulation of pathways related to hepatocyte function.In patients with chronic HCV,realtime polymerase chain reaction and immunohistochemistry confirmed an increase in lipocalin-2 mRNA(F0 1.0 ±0.3,F1 2.2±0.2,F2 3.0±9.3,F3/4 4.0±0.8,P= 0.003)and protein expression(F1 1.0±0.5,F2 1.3± 0.4,F3/4 3.6±0.4,P=0.014)with increasing liver injury.High performance liquid chromatography-tandem mass spectrometry analysis identified elevated levels of matrix metalloproteinase(MMP)-9 in macrophageconditioned medium,and a chemical inhibitor of MMP-9 attenuated the change in morphology and mRNA expression of TGF-β1(2.9±0.2 vs 1.04±0.1,P<0.001) in macrophage-conditioned media treated HepG2 cells.In patients with chronic HCV infection,hepatic mRNA expression of CD163(F0 1.0±0.2,F1/2 2.8±0.3,F3/4 5.3±1.0,P=0.001)and MMP-9(F0 1.0±0.4,F1/2 2.8±0.3,F3/4 4.1±0.8,P=0.011)was significantly associated with increasing stage of fibrosis.CONCLUSION:Secreted macrophage products alter the phenotype and function of hepatocytes,with increased expression of inflammatory mediators,suggesting that hepatocytes actively participate in liver injury. | Michelle Melino Victoria L Gadd Gene V Walker Richard Skoien Helen D Barrie Dinesh Jothimani Leigh Horsfall Alun Jones Matthew J Sweet Gethin P Thomas Andrew D Clouston Julie R Jonsson Elizabeth E Powell | 2012 | World Journal of Gastroenterology2012，18，15： | 3 |
| 3 | Analysis of operative versus nonoperative treatment of displaced scapular fractures显示文摘 | Jones C B Sietsema D L | | 0，，12： | 2 |
| 4 | Low-copy plasmids can perform as weU as or better than high-copy plasmids for metabolic engineering of bacteria 显示文摘 | Jones K L Kim S W Keasling J D | 2000 | Metabolic Engineering2000，2，： | 1 |
| 5 | Plant pathogens and integrated defenee responses to infection显示文摘 | Jonathan D G Jones Jeflbry L Dangl | 2001 | Nature2001，411，： | 1 |
| 6 | A resolution comparison of several time-frequency represenlations显示文摘 | Jones D L Parks T W | 1992 | IEEE Transac- tions on Signal Processing1992，40，2： | 1 |
| 7 | The human papillomavirus E7 oncoprotein can uncouple celluar differentiation and proliferation in human keratinocytes by abrogating p21Cip1-mediated inhibition of cdk2显示文摘 | Jones D L Alani R M | 1997 | Genes1997，11，： | 1 |
| 8 | Influence of sorption on the biological utilization of two simple carbon substrates显示文摘 | JONES D L EDWARDS A C | 1998 | Soil Biology & Biochemistry1998，30，： | 1 |
| 9 | Aluminum inhibition of the inositol 1,4,5-triphosphate signal transduction pathway in wheat roots:A role in aluminum toxicity?显示文摘 | JONES D L KOCHIAN L V | 1995 | Plant Cell1995，7，： | 1 |
| 10 | Effects of crude protein content,degradability and energy concentration of the diet on growth and carcass characteristics of market Iambs fed high concentrate diets 显示文摘 | Beauchemin K A McCeland L A Jones D | 1995 | Can J Anita Sci1995，75，： | 1 |
| 11 | Nicotinic acetycholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection 显示文摘 | BUCKINGHAM S D JONES A K BROWN L A | 2009 | Pharmacol Rev2009，61，1： | 1 |
| 12 | Plant pathogens and integrated defence responses to infection显示文摘 | Dang J L Jones J D G2 | | 0，，6839： | 1 |
| 13 | Identifying geographically diverse routes for the transportation of hazardous materials显示文摘 | Dadkar Y Jones D Nozick L | 2008 | Transportation Re- search Part E2008，44，： | 1 |
| 14 | Organic acid in the rhizosphere-a critical review 显示文摘 | Jones D L | 1998 | Plant and Soil1998，205，： | 1 |
| 15 | Comparison of particle packing models for proportioning concrete constituents for minimum voids ratio显示文摘 | Jones M R Zheng L Newlands M D | 2002 | Materials and Structures2002，35，2： | 1 |
| 16 | Organic acids in the rhizosphere:a critical review显示文摘 | Jones D L | 1998 | Plant and Soil1998，205，： | 1 |
| 17 | Biodegradation of low molecular weight organic acids in coniferous forest Podzolic soil显示文摘 | VAN HEES P A W JONES D L GODBOLD D L | 2002 | Soil Biology &Biochemistry2002，34，： | 1 |
| 18 | Switching barrier and repurchase intention in service显示文摘 | JONES M A MOTHERSBAUGH D L BEATTY S E | 2000 | Journal of Retailing2000，76，2： | 1 |
| 19 | Twenty-four hour energy expenditure in critically ill patients 显示文摘 | Swinamer D L Phange P T Jones R L | 1987 | Crit Care Med1987，15，7： | 1 |
| 20 | Free amino sugar reactions in soil in relation to soil carbon and nitrogen cycling 显示文摘 | ROBERTS P BOL R JONES D L | 2007 | Soil Biology and Biochemistry2007，39，： | 1 |
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